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The map label for this gene is fabG [C]

Identifier: 51596311

GI number: 51596311

Start: 2340757

End: 2341437

Strand: Reverse

Name: fabG [C]

Synonym: YPTB1985

Alternate gene names: 51596311

Gene position: 2341437-2340757 (Counterclockwise)

Preceding gene: 51596312

Following gene: 51596310

Centisome position: 49.35

GC content: 40.53

Gene sequence:

>681_bases
ATGTCCTGTAATTTTAAAATAATACTCACCGGTGCGTCAGGATTAATTGGTTCTGCCATTGCTGATGCACTGTATAAATC
AGGTATGAATCTTGTTCTTGCTTGTAAACGTTCCCAAAAATTACAAGACAGATATCTTAGCGATGATAAGTCCAAAAGAG
CTTATTTTTGGTATGGCGATCTTACCAACGAAAAAGCCTGTCGTGAATTAGTGGAGTATGCTGTTCAGCAAATGGGGGGG
GTGGATGTATTGATCAATTGTGCCGGCGTCTTTAATTTTTCTGCTCTCGAAGAGATGACCTATAGTAGAATTACCGATAC
CATCAGTACCAACCTTCTCGCCCCTATTCATCTTACACATCTTGTATTACCTTATATTAAGACCAGTGCCTGCCCAATAA
TCGTGAATATATCCTCAATTGCTGGTTTCTCCAGTTTGCCTGAAGGCGCGTGCTACGCAGCATCTAAATGGGGGCTTAAT
GGCTTTATCCACAGCATCCGCGAAGAATTACGCAAAAAATCAATTCACATCTGTAATATATCGCCTTGTCAGGTTAAAAC
ACTGTCCCATCATTCTGATACGGCAATCAGAACCATAGCACCGGAAAATATCGCTAATGCGGTTATTTTAGTTTTGTCAT
ATGTACAAAAAACGTCGTCTTCAATTGACGTAGTGCTGTAG

Upstream 100 bases:

>100_bases
TTGTTCCAATAATCTTCACATAACTTAGTGACTCAAGCCGGGAGTGGCGGTCTTCTCACACCCGGCTTTTATCTAATAGC
CAAAAATGAATTGAGGAAGT

Downstream 100 bases:

>100_bases
CCATTTCCCATGAAATCCATATGGTTATGTGTTTTTTCTATTTGATCTCTACCCCATAGGTTGATTTAATAAGCACTGTA
ACGAAATAATAACGGAATAT

Product: dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSCNFKIILTGASGLIGSAIADALYKSGMNLVLACKRSQKLQDRYLSDDKSKRAYFWYGDLTNEKACRELVEYAVQQMGG
VDVLINCAGVFNFSALEEMTYSRITDTISTNLLAPIHLTHLVLPYIKTSACPIIVNISSIAGFSSLPEGACYAASKWGLN
GFIHSIREELRKKSIHICNISPCQVKTLSHHSDTAIRTIAPENIANAVILVLSYVQKTSSSIDVVL

Sequences:

>Translated_226_residues
MSCNFKIILTGASGLIGSAIADALYKSGMNLVLACKRSQKLQDRYLSDDKSKRAYFWYGDLTNEKACRELVEYAVQQMGG
VDVLINCAGVFNFSALEEMTYSRITDTISTNLLAPIHLTHLVLPYIKTSACPIIVNISSIAGFSSLPEGACYAASKWGLN
GFIHSIREELRKKSIHICNISPCQVKTLSHHSDTAIRTIAPENIANAVILVLSYVQKTSSSIDVVL
>Mature_225_residues
SCNFKIILTGASGLIGSAIADALYKSGMNLVLACKRSQKLQDRYLSDDKSKRAYFWYGDLTNEKACRELVEYAVQQMGGV
DVLINCAGVFNFSALEEMTYSRITDTISTNLLAPIHLTHLVLPYIKTSACPIIVNISSIAGFSSLPEGACYAASKWGLNG
FIHSIREELRKKSIHICNISPCQVKTLSHHSDTAIRTIAPENIANAVILVLSYVQKTSSSIDVVL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=192, Percent_Identity=29.6875, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI7706318, Length=187, Percent_Identity=31.5508021390374, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI109715829, Length=229, Percent_Identity=30.5676855895196, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI32455239, Length=198, Percent_Identity=29.7979797979798, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI5031765, Length=198, Percent_Identity=29.7979797979798, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI22507405, Length=187, Percent_Identity=31.0160427807487, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4503817, Length=203, Percent_Identity=25.1231527093596, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=226, Percent_Identity=28.3185840707965, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789378, Length=188, Percent_Identity=25, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787820, Length=180, Percent_Identity=24.4444444444444, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082160, Length=175, Percent_Identity=24, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17570069, Length=188, Percent_Identity=30.8510638297872, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997402, Length=189, Percent_Identity=29.1005291005291, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=182, Percent_Identity=29.6703296703297, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=194, Percent_Identity=29.8969072164948, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=186, Percent_Identity=28.494623655914, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=188, Percent_Identity=30.8510638297872, Blast_Score=92, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322861, Length=233, Percent_Identity=26.1802575107296, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322795, Length=119, Percent_Identity=34.453781512605, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI23397609, Length=191, Percent_Identity=30.3664921465969, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644339, Length=179, Percent_Identity=30.7262569832402, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357041, Length=184, Percent_Identity=29.3478260869565, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358495, Length=187, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24641232, Length=213, Percent_Identity=26.7605633802817, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28571526, Length=187, Percent_Identity=28.8770053475936, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007236, Length=219, Percent_Identity=26.9406392694064, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24663911, Length=231, Percent_Identity=26.8398268398268, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24649181, Length=185, Percent_Identity=29.1891891891892, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643142, Length=181, Percent_Identity=28.7292817679558, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571387, Length=225, Percent_Identity=27.1111111111111, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24580925, Length=185, Percent_Identity=27.5675675675676, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24725; Mature: 24594

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCNFKIILTGASGLIGSAIADALYKSGMNLVLACKRSQKLQDRYLSDDKSKRAYFWYGD
CCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEEECC
LTNEKACRELVEYAVQQMGGVDVLINCAGVFNFSALEEMTYSRITDTISTNLLAPIHLTH
CCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LVLPYIKTSACPIIVNISSIAGFSSLPEGACYAASKWGLNGFIHSIREELRKKSIHICNI
HHHHHHHCCCCEEEEEEHHHCCCCCCCCCCEEHHHHCCHHHHHHHHHHHHHHCCEEEECC
SPCQVKTLSHHSDTAIRTIAPENIANAVILVLSYVQKTSSSIDVVL
CCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEC
>Mature Secondary Structure 
SCNFKIILTGASGLIGSAIADALYKSGMNLVLACKRSQKLQDRYLSDDKSKRAYFWYGD
CCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEEECC
LTNEKACRELVEYAVQQMGGVDVLINCAGVFNFSALEEMTYSRITDTISTNLLAPIHLTH
CCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LVLPYIKTSACPIIVNISSIAGFSSLPEGACYAASKWGLNGFIHSIREELRKKSIHICNI
HHHHHHHCCCCEEEEEEHHHCCCCCCCCCCEEHHHHCCHHHHHHHHHHHHHHCCEEEECC
SPCQVKTLSHHSDTAIRTIAPENIANAVILVLSYVQKTSSSIDVVL
CCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA