Click here to switch to the map view.

The map label for this gene is ddc [H]

Identifier: 51595878

GI number: 51595878

Start: 1854657

End: 1856204

Strand: Direct

Name: ddc [H]

Synonym: YPTB1541

Alternate gene names: 51595878

Gene position: 1854657-1856204 (Clockwise)

Preceding gene: 51595877

Following gene: 51595879

Centisome position: 39.09

GC content: 42.64

Gene sequence:

>1548_bases
ATGTACAAAGATATCTATGAGGAAAACCATTTTATAGATCAAGGTAATGATATAACTGATGTGCTTTGTTTAGGAAACTT
CTTAAATAAAGATAGCGCTGAACACTATTATGAGAGCGTGAATAATATCACTGCAAGGATTAAGGCTATATTCACCCTAG
TAGATAAACCTTTTAGCGGGATATTACCCTCTGAACTATCACCTGATTTTTATTGTATTGATTTAAATCAGCCACTAACG
TCATTGGATAGCGCATTAGATGAATTACAGCAGCTATATATTAAGGATGCTATATACTTTCATCACCCTAAATATGTTGC
GCATCTTAATTGCCCGGTTGTTCTCCCTGCAGTTCTGGCAGAAAGCATTATTAGTACCCTTAATTCTTCGTTGGATACCT
GGGATCAAAGTGCCGGTGCGACCTTAATTGAGCAGAAAGTTCTGGATTGGACCCGCGATAAAATGGCCCTAGGTAGCCAG
GGCGACGGTATTTTCACCAGCGGTGGAACACAGTCAAATCTTATGGCGATACTGCTGGCCCGTGATCATTTTTGCCACCA
ACGTGATGCTAACCACCAGAATAAATTGCAGGGATTACCCGCTGATTCTCATAAATTTCGTATCTTTACTTCGGTGGTTA
GCCATTTCAGTACACAAAAAGCCGCAGCACTATTGGGCCTTGGCTATAACGCGGTTGTTGCCGTGCCCTATGACAGTGAA
TTCAAGATGGATGCGCAGGCATTGGATCAAAGCATTGCGCTCTGTTTATCACAAGGCAATATTCCCTTAGCCATTGTTGC
TACCACCGGAACGACTGACTTTGGCAGTATTGACCCCTTGCACACTATTTCGACGTTGGCCAAACAGTACGGTCTTTGGT
TACATGTGGATGCTGCCTACGGCTGTGGCCTATTAGTTTCCTCACACTATGAACAGCTACTTTCCGGTATTGAAATGGCT
GATTCTGTGACGGTGGATTATCACAAGTCCTTTTTTCAACCGGTAAGTTGCAGTGCTTTTTTTGTTAAAGATAAACAGCA
TTTTTCTTATCTGACTTATCACGCGGAATACCTCAATCCATTAAGTGCATCACTGGAAGGTACGCCGAATTTAGTGAACA
AAAGTATTCAGACCACCCGTCGCTTTGATGCGCTAAAGCTGTGGTTAACGCTACGGATTATGGGAGCCAAACAGCTTGGT
TTGGCTTTTGAACATGTTATGGATACGGCACAGCAGGCTTATCAACTTATGTTGCCTAATCCGTATTTTGAACTAATACA
TCGCCCGGTATTAAGCACGCTGGTATTTCGTTTTATGCCGGAACAGCCTCGCAGCGATGACGATATCGATCGAACCAATG
CCTATATTCGCAAAGCGTTATTCCGTGAGGGGCATACGGTTATTGCAGGTACCAAAGTAAATGGTAAACAGTATTTGAAA
TTTACCTTCCTTAATCCGACGACCACACTCCAGCACCTGAACGAAATTGTGGATGCCATTATTACCGAGGGTAAAAACTA
TCCGACTCTCTATAACAGTCAATCATGA

Upstream 100 bases:

>100_bases
GCATTTATATCTACGTCTTATATTTATCTACAGTTAATTATAATAAAAAATATAATAAATATAGCGTCACTAAATGCCAC
TTTATATTTAAGGATATATT

Downstream 100 bases:

>100_bases
GATTGATGTTGTTTGATCAGGAGTAATTAGAACAATGCGACCTTATGACTTTATTGGCATCGGTATTGGCCCGTTTAACC
TCGGGCTAGCATGTTTAACC

Product: decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSGILPSELSPDFYCIDLNQPLT
SLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLAESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQ
GDGIFTSGGTQSNLMAILLARDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAYGCGLLVSSHYEQLLSGIEMA
DSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHAEYLNPLSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLG
LAFEHVMDTAQQAYQLMLPNPYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS

Sequences:

>Translated_515_residues
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSGILPSELSPDFYCIDLNQPLT
SLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLAESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQ
GDGIFTSGGTQSNLMAILLARDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAYGCGLLVSSHYEQLLSGIEMA
DSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHAEYLNPLSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLG
LAFEHVMDTAQQAYQLMLPNPYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS
>Mature_515_residues
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSGILPSELSPDFYCIDLNQPLT
SLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLAESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQ
GDGIFTSGGTQSNLMAILLARDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAYGCGLLVSSHYEQLLSGIEMA
DSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHAEYLNPLSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLG
LAFEHVMDTAQQAYQLMLPNPYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=431, Percent_Identity=29.0023201856148, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI4503875, Length=431, Percent_Identity=29.0023201856148, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI194294551, Length=427, Percent_Identity=29.9765807962529, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI197383062, Length=429, Percent_Identity=28.4382284382284, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI58331246, Length=426, Percent_Identity=28.4037558685446, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI92110055, Length=439, Percent_Identity=25.5125284738041, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI4503281, Length=406, Percent_Identity=24.6305418719212, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI132814448, Length=406, Percent_Identity=24.6305418719212, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17555682, Length=418, Percent_Identity=28.2296650717703, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71993062, Length=418, Percent_Identity=28.2296650717703, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71993058, Length=344, Percent_Identity=31.3953488372093, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17534819, Length=435, Percent_Identity=23.2183908045977, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17534817, Length=435, Percent_Identity=22.9885057471264, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17551992, Length=482, Percent_Identity=24.0663900414938, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71981211, Length=505, Percent_Identity=22.970297029703, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI133931025, Length=446, Percent_Identity=22.6457399103139, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71981217, Length=514, Percent_Identity=21.9844357976654, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136594, Length=417, Percent_Identity=30.9352517985612, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24657193, Length=383, Percent_Identity=31.8537859007833, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24657185, Length=383, Percent_Identity=31.8537859007833, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24657188, Length=383, Percent_Identity=31.8537859007833, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21356415, Length=387, Percent_Identity=27.906976744186, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17136190, Length=401, Percent_Identity=25.1870324189526, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24585135, Length=414, Percent_Identity=24.6376811594203, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24652373, Length=415, Percent_Identity=25.7831325301205, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24585139, Length=418, Percent_Identity=24.8803827751196, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI221476190, Length=418, Percent_Identity=24.8803827751196, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24585143, Length=418, Percent_Identity=24.8803827751196, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24586044, Length=433, Percent_Identity=22.8637413394919, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28573972, Length=443, Percent_Identity=23.9277652370203, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 57631; Mature: 57631

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSG
CCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ILPSELSPDFYCIDLNQPLTSLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLA
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCHHHHHHHH
ESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQGDGIFTSGGTQSNLMAILLA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHEEEEEH
RDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
HHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAY
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
GCGLLVSSHYEQLLSGIEMADSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHAEYLNP
CCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCH
LSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLGLAFEHVMDTAQQAYQLMLPN
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
PYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEE
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS
EEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MYKDIYEENHFIDQGNDITDVLCLGNFLNKDSAEHYYESVNNITARIKAIFTLVDKPFSG
CCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ILPSELSPDFYCIDLNQPLTSLDSALDELQQLYIKDAIYFHHPKYVAHLNCPVVLPAVLA
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCHHHHHHHH
ESIISTLNSSLDTWDQSAGATLIEQKVLDWTRDKMALGSQGDGIFTSGGTQSNLMAILLA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHEEEEEH
RDHFCHQRDANHQNKLQGLPADSHKFRIFTSVVSHFSTQKAAALLGLGYNAVVAVPYDSE
HHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
FKMDAQALDQSIALCLSQGNIPLAIVATTGTTDFGSIDPLHTISTLAKQYGLWLHVDAAY
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
GCGLLVSSHYEQLLSGIEMADSVTVDYHKSFFQPVSCSAFFVKDKQHFSYLTYHAEYLNP
CCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCH
LSASLEGTPNLVNKSIQTTRRFDALKLWLTLRIMGAKQLGLAFEHVMDTAQQAYQLMLPN
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
PYFELIHRPVLSTLVFRFMPEQPRSDDDIDRTNAYIRKALFREGHTVIAGTKVNGKQYLK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEE
FTFLNPTTTLQHLNEIVDAIITEGKNYPTLYNSQS
EEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]