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The map label for this gene is yeiG [H]

Identifier: 51595853

GI number: 51595853

Start: 1822077

End: 1822919

Strand: Reverse

Name: yeiG [H]

Synonym: YPTB1516

Alternate gene names: 51595853

Gene position: 1822919-1822077 (Counterclockwise)

Preceding gene: 51595854

Following gene: 51595852

Centisome position: 38.42

GC content: 50.89

Gene sequence:

>843_bases
GTGAATACGTCACTTGAACTTCTCGAAGAGCATCGGATGTTTGGCGGCTGGCAACAGCGCTACCGCCATGCTGCCAGCAG
CCTGAATTGTCATATGACCTTCAGTATCTATCTGCCACCGCCACGGGACGATAACCCACCACCAGTCCTTTATTGGCTAT
CGGGCCTAACCTGTAATGATGAGAACTTTACGCTGAAAGCGGGCGCACAGCGGGTTGCTGCAGAACTCGGGCTGGTACTG
GTTATGCCTGATACCAGCCCCCGCGGTGATAATGTTCCCAACGATGACAGCTATGATTTAGGTCAGGGAGCGGGCTTCTA
CCTTAATGCGACGCAGGAGCCGTGGTCTGATCATTTCCAGATGTATGACTATATCAGCCAGGAATTGCCCTCACTGATCC
GCCAACATTTTAGCGTCAGTGAACGGCAATCAATCAGTGGTCATTCAATGGGCGGCCATGGTGCACTGATGCTGGCTCTG
CGTAATCCGCAACAATATCAGTCTGTTTCTGCTTTTGCGCCAATAGTTAACCCATGCCAAGTACCATGGGGCCGAAAAGC
CTTTACCGCTTATCTTGGCAGTGATGAAAACCAATGGCTGCAATATGATAGCTGCCATTTACTGACCCATGCACAGCATC
AGTTGCCTATATTGGTGGATCAGGGGGATGGTGATCAATTTCTTGCCGATCAACTCCAACCGGCAAAATTGGCGGAGCTG
GCGCGCCAGCGAGACTGGCCACTGATGTTGCGTATTCAGCCGGGTTATGATCACAGCTATTTTACCATAGCTACATTTAT
TGAAGATCACCTGCGCTTTCATGCTGCACACCTACAGCCGTAA

Upstream 100 bases:

>100_bases
ACGAAGCCTTTGATTTAATGCACGAGGGTAAATCTATCCGCAGTGTGATCCATTTTAATCACTCTTCCGAAAGCAAATAA
AGCAAGGAGGCAGACAAAAC

Downstream 100 bases:

>100_bases
CATTTGTCATTAGCCTAATTATTACACATAAAACCCCAAGCCCTTTCGAGGGCTTTTTATTCGATAGATAAAACCCCTCA
CATTAAAACCTCGTTTAAGA

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQMYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLAL
RNPQQYQSVSAFAPIVNPCQVPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP

Sequences:

>Translated_280_residues
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQMYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLAL
RNPQQYQSVSAFAPIVNPCQVPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP
>Mature_280_residues
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQMYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLAL
RNPQQYQSVSAFAPIVNPCQVPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=51.0714285714286, Blast_Score=308, Evalue=3e-84,
Organism=Escherichia coli, GI1788477, Length=276, Percent_Identity=73.5507246376812, Blast_Score=419, Evalue=1e-119,
Organism=Escherichia coli, GI1786551, Length=274, Percent_Identity=54.014598540146, Blast_Score=331, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=46.9750889679715, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=43.7710437710438, Blast_Score=239, Evalue=4e-64,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=48.7632508833922, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24648347, Length=281, Percent_Identity=48.7544483985765, Blast_Score=270, Evalue=7e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31780; Mature: 31780

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCND
CCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCEEEEECCEEECC
ENFTLKAGAQRVAAELGLVLVMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQ
CCEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLALRNPQQYQSVSAFAPIVNPCQ
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCC
VPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
CCCCCHHEEEEECCCCCCEEEECCEEEEECCCCCCCEEEECCCCCHHHHHCCCHHHHHHH
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP
HHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCND
CCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCEEEEECCEEECC
ENFTLKAGAQRVAAELGLVLVMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQ
CCEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLALRNPQQYQSVSAFAPIVNPCQ
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCC
VPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
CCCCCHHEEEEECCCCCCEEEECCEEEEECCCCCCCEEEECCCCCHHHHHCCCHHHHHHH
ARQRDWPLMLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP
HHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA