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The map label for this gene is ddc [H]

Identifier: 51595578

GI number: 51595578

Start: 1469260

End: 1470675

Strand: Direct

Name: ddc [H]

Synonym: YPTB1234

Alternate gene names: 51595578

Gene position: 1469260-1470675 (Clockwise)

Preceding gene: 51595577

Following gene: 51595580

Centisome position: 30.97

GC content: 47.95

Gene sequence:

>1416_bases
ATGACTCCTGAAGAGTTTCGCCGCCATGGCTATGCCATGATCGACCTGATTGCTGATTACCGACAAAATATCGAATTGCG
TGGCGTTAATCCCACGACAGCACCCGGTGAGATTAAATCTCGTCTGTCGTTAAATGCACCTGAAAAAGCAGAACCTTTCG
AACACATTATTTCTGACATAGAAGAGCTCATCATGCCAGGGCTATTACATTGGCAACATCCTGACTTTTTTGGTTATTTT
CCTTCTAATGTAGAGTTATCCTCCGTTCTTGGGGATTGCTTGAGTACTGGGCTGGGGGTGATAGGTCTGTCTTGGCAATC
CAGCCCGGCCCTGACAGAAATTGAAGAGGTGGCCACCAATTGGTTGCTAAAAATGCTTGGTCTTAGCGTTGCCTGGAGTG
GCGTGATTCAGGATTCCGCCTCAACCGCCACGTTAGTGGCGCTGATCAGCGGCCGAGAGCGAACATCTAACTATGCATTA
ATGAATAAAGGGATGCAAAACAGTGATGCACCTTTGATTGTCTACACTTCATCAGAAGCCCATAGCGGAGTGAATAAAGC
CGCTCTGCTCGCTGGGTTTGGTCATAATAATACCCGTTTAGTGCCCACCGATGAGCACAATGCCATGTCACCCTTGGCAT
TAAAAAAGATCATTCAACAGGATTTGGTGAAGGGAAACCGGCCTTGTATCGTTGTTGCTACGACAGGTACTACCGCTGCG
ACAGCGATGGATCCCCTTGATGCGATTGGTGATATTACTCAGCGTTATGGTTTATGGCTGCATGTGGATTCTGCTATGGC
TGGTTCAGCGATGATTTTGCCAGAATGCCGTCATCTGTGGTGCGGTATAGAAAAGGCTGATTCTGTGGTGATAAATCCGC
ATAAATGGCTGGGTGCTGCTTTTGATTGTTCGGTTTATTGTGTACAAGATTCAGAGCATTTGATTCGTATCATGAGTACT
AACCCCAGTTTCTTACAATCCGATGCCGATGGGAAAGTGAGAAATTACCGCGATTGGGGGATCCCCCTGGGTCGTCGTTT
TCGTGCGCTTAAGCTATGGTTTCTAATCCGTGAGCAAGGGGGGGAAGGGCTGCAGGCGCGTTTGCGTCGTGATATTGCCA
ATGCTAATTGGTTAGCAGAACAAATTAAAAACAGCGATGATTGGAAACTGGTCGCACCTGTAGTGTTGCAAACCTTGTGT
ATTCGTCATGAACCGGGTGGGCTGATGGGCGACGCGTTGGATAATTATACCCGCAGTTGGGCCGAGAAACTCAATCAATC
TGGTAAGGGTTATGTTACACCAGCCACGCTTGGTGGCCGCTGGATGGTGCGGGTTTCCATCGGCACTTTGGGTACGGAAC
GTCATCACGTTGAGAAGTTGTGGTTGTTGTTGCAGTCTTTGGTTAAGGAGAGATAA

Upstream 100 bases:

>100_bases
TTGATTCAGGCAAACGAATCAGCATGCAGTCATTTATAGGTTACAACACGAACCAGCCGTTCTATTTCTGGTGTTAATGA
CTTCAAAATGAGAGCTTTTT

Downstream 100 bases:

>100_bases
AAGGGCCTTACCATATTAAGAATTGAGCAATGAGCAATGAGCAATGAGCAATGAGCAATGAGCAATGAGCAATGAGCAAT
GAGCAATGAGCAATGAGCAA

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDIEELIMPGLLHWQHPDFFGYF
PSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATNWLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYAL
MNKGMQNSDAPLIVYTSSEAHSGVNKAALLAGFGHNNTRLVPTDEHNAMSPLALKKIIQQDLVKGNRPCIVVATTGTTAA
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAAFDCSVYCVQDSEHLIRIMST
NPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQGGEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLC
IRHEPGGLMGDALDNYTRSWAEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER

Sequences:

>Translated_471_residues
MTPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDIEELIMPGLLHWQHPDFFGYF
PSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATNWLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYAL
MNKGMQNSDAPLIVYTSSEAHSGVNKAALLAGFGHNNTRLVPTDEHNAMSPLALKKIIQQDLVKGNRPCIVVATTGTTAA
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAAFDCSVYCVQDSEHLIRIMST
NPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQGGEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLC
IRHEPGGLMGDALDNYTRSWAEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER
>Mature_470_residues
TPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDIEELIMPGLLHWQHPDFFGYFP
SNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATNWLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYALM
NKGMQNSDAPLIVYTSSEAHSGVNKAALLAGFGHNNTRLVPTDEHNAMSPLALKKIIQQDLVKGNRPCIVVATTGTTAAT
AMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAAFDCSVYCVQDSEHLIRIMSTN
PSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQGGEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLCI
RHEPGGLMGDALDNYTRSWAEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=491, Percent_Identity=37.0672097759674, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI132814448, Length=491, Percent_Identity=37.0672097759674, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI92110055, Length=480, Percent_Identity=35, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI194294551, Length=379, Percent_Identity=31.6622691292876, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI197383062, Length=424, Percent_Identity=30.6603773584906, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI58331246, Length=357, Percent_Identity=27.1708683473389, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI197276620, Length=324, Percent_Identity=27.7777777777778, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI4503875, Length=324, Percent_Identity=27.7777777777778, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17534817, Length=461, Percent_Identity=38.6117136659436, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI17534819, Length=461, Percent_Identity=38.6117136659436, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI71981211, Length=499, Percent_Identity=28.0561122244489, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71981217, Length=508, Percent_Identity=27.9527559055118, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17551992, Length=500, Percent_Identity=28.6, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI133931025, Length=479, Percent_Identity=27.7661795407098, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71993058, Length=394, Percent_Identity=26.3959390862944, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17555682, Length=394, Percent_Identity=26.3959390862944, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71993062, Length=327, Percent_Identity=27.5229357798165, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193205882, Length=389, Percent_Identity=23.1362467866324, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28573972, Length=482, Percent_Identity=38.7966804979253, Blast_Score=324, Evalue=8e-89,
Organism=Drosophila melanogaster, GI24652373, Length=479, Percent_Identity=37.3695198329854, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24585139, Length=480, Percent_Identity=36.6666666666667, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI221476190, Length=480, Percent_Identity=36.6666666666667, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24585143, Length=480, Percent_Identity=36.6666666666667, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24586044, Length=485, Percent_Identity=35.0515463917526, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI17136190, Length=480, Percent_Identity=35, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24585135, Length=480, Percent_Identity=34.1666666666667, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17136594, Length=361, Percent_Identity=30.1939058171745, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24657193, Length=396, Percent_Identity=28.030303030303, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24657185, Length=396, Percent_Identity=28.030303030303, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24657188, Length=396, Percent_Identity=28.030303030303, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21356415, Length=380, Percent_Identity=26.3157894736842, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52115; Mature: 51984

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00123 ALKALINE_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDI
CCCHHHHHCCHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHH
EELIMPGLLHWQHPDFFGYFPSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATN
HHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
WLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYALMNKGMQNSDAPLIVYTSSEA
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCEEEEECCHH
HSGVNKAALLAGFGHNNTRLVPTDEHNAMSPLALKKIIQQDLVKGNRPCIVVATTGTTAA
HCCCCCEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAA
HHCCHHHHHHHHHHHCCEEEEECCCCCCCEEECHHHHHHHCCCCCCCEEEECCHHHHCCE
FDCSVYCVQDSEHLIRIMSTNPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQG
ECCEEEEEECCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCC
GEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLCIRHEPGGLMGDALDNYTRSW
CCHHHHHHHHHHCCHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER
HHHHCCCCCCEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDI
CCHHHHHCCHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHH
EELIMPGLLHWQHPDFFGYFPSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATN
HHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
WLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYALMNKGMQNSDAPLIVYTSSEA
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCEEEEECCHH
HSGVNKAALLAGFGHNNTRLVPTDEHNAMSPLALKKIIQQDLVKGNRPCIVVATTGTTAA
HCCCCCEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAA
HHCCHHHHHHHHHHHCCEEEEECCCCCCCEEECHHHHHHHCCCCCCCEEEECCHHHHCCE
FDCSVYCVQDSEHLIRIMSTNPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQG
ECCEEEEEECCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCC
GEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLCIRHEPGGLMGDALDNYTRSW
CCHHHHHHHHHHCCHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER
HHHHCCCCCCEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]