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The map label for this gene is dld

Identifier: 51595562

GI number: 51595562

Start: 1452868

End: 1454583

Strand: Reverse

Name: dld

Synonym: YPTB1218

Alternate gene names: 51595562

Gene position: 1454583-1452868 (Counterclockwise)

Preceding gene: 51595564

Following gene: 51595557

Centisome position: 30.66

GC content: 45.45

Gene sequence:

>1716_bases
TTGATGAGCCAGTTCAATAATGAAAAAATCCAGCTCTTGCTGACTCAATTACAGCATATAGTGGGTACACGCTATTTACT
GACCGGTGAACGGCAGACTGAACGCTACCGAACCGGTTTCCGCTCCGGTAAAGGGGTGGCCCTCGCCGTGGTATTTCCGT
CAACACTACTGCAACAATGGCAGTTACTGCAGGCTTGTGTGGCTGCTGATACCATCATTATCATGCAAGCCGCCAATACT
GGGCTGACAGAAGGCTCGACGCCAAGTGGTGATGATTATGATCGCCCTATCGTCATCTTGAATACCTTACGTCTTAACAA
CATTCAGCTATTGGATGATGGCAAACAAGTTATAGGATTCCCTGGAAGCACACTGAATCAATTAGAAAAACGCTTAAAAC
CTTATGGTCGCGAACCCCATTCGGTTATTGGCTCCTCCTGTATTGGTGCCTCGGTCGTAGGCGGTATTTGCAATAATTCA
GGCGGTTCATTGGTCCAAAGAGGCCCGGCATACACCGAAATGGCTCTGTATGCACAAATTGATGCACAAGGTGAGTTGCA
GTTAATTAATCATTTAGGCATCAGCTTGGGAAATACACCAGAAGAGATTCTACAACGTTTGGAACAAGGCCAATATGGTG
CTGAAGATATCGAACAGACCGGGCAGCAAACCTCAGATAGTGAATATGCTACGCGGGTAAGAGATATTGATGCAACGACC
CCTTCGCGTTTTAACGCCGACCCCAGACGTTTATTTGAAGCCTCCGGCTGTGCCGGTAAATTGGCAATATTTGCCGTGCG
GCTGGATACCTTCCCCAGTGAGAAACAACAACAAGTTTTTTATATCGGCACCAACCAAACCCAGGTATTGACTGAGTTAC
GCCGTATTATTCTCCGCGACTTTAAACATTTACCTATCGCGGGTGAATATCTGCACCGTGATATTTTTGATATTGCGGAA
ACCTATGGCAAAGATACATTTGTGATGATTAACAGTATGGGCACCAATAACATGCCCCGATTCTTCACGTTAAAAGGTAA
AATTGATGCTCGCCTCAATAAAATTCCGCATTTAGTCGATCACCTGACCGATCGTGTAATGCAAGGCTTTAGTCAGATAT
TGCCTAACCATTTACCTAAGCGCCTTAAGACTTACCGTAATCAATATGAACATCATCTGCTGCTCAAAATGTCAGGCGAT
GGTATTACCGAAGCGCAACAACATCTACGCGCCTTTTTTGCCACTGCGGAAGGTAACTTTATTGCCTGCACGGCTGATGA
AGGTAAAAAGGCTTTTCTACACCGTTTTGCGGCGGCAGGTGCGGCAGTGCGCTATCACGCGGTCCACGCCGATCAAGTGG
AAGATATTTTGGCACTGGATATCGCCCTGCGCCGTAATGAAAAACAGTGGTTTGAAACCTTACCACCAGAAATAGAAAAA
TGTCTGATCGCGAAGCTCTATTATGGACATTTTCTGTGCCACGTCTTTCATCAAGACTATATCGTTAAGAAAGGGGTTGA
TGTAAAAGCGCTAAAAGAAAAAATGTTATCGCTCCTCAATGACAAAGGTGCGGAATACCCCGCAGAACATAATGTCGGCC
ACCTCTATCTGGCAAAACCCGCATTAAAAGATTTTTATCAACAGATCGACCCAACCAACAGTTTTAATCCGGGGATTGGT
AAAACCTCAAAACGTAAGCGTTGGCAGCAAGACTGA

Upstream 100 bases:

>100_bases
GATAATCAACGTCGATATATTAAACGGTTAAGGGAGTAAAAGGTTGATGTAGTAAAAAGCTAATGCAGTAAAAGGCTAAT
GTCACTAACAGGGAACCACA

Downstream 100 bases:

>100_bases
AGCTATTAGCCAGAAATAGCACCATTAGGCTTAGGCATTATCTGAAAGCAAACAATTAGTCACTAAAGCGGAATTTGCCT
CTGCTAGCAAATTCCGCTTC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MMSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQLLQACVAADTIIIMQAANT
GLTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFPGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNS
GGSLVQRGPAYTEMALYAQIDAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATT
PSRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAE
TYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGD
GITEAQQHLRAFFATAEGNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEK
CLIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIG
KTSKRKRWQQD

Sequences:

>Translated_571_residues
MMSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQLLQACVAADTIIIMQAANT
GLTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFPGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNS
GGSLVQRGPAYTEMALYAQIDAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATT
PSRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAE
TYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGD
GITEAQQHLRAFFATAEGNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEK
CLIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIG
KTSKRKRWQQD
>Mature_571_residues
MMSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQWQLLQACVAADTIIIMQAANT
GLTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGFPGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNS
GGSLVQRGPAYTEMALYAQIDAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATT
PSRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRDFKHLPIAGEYLHRDIFDIAE
TYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVDHLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGD
GITEAQQHLRAFFATAEGNFIACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEK
CLIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKPALKDFYQQIDPTNSFNPGIG
KTSKRKRWQQD

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=569, Percent_Identity=65.0263620386643, Blast_Score=801, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 64203; Mature: 64203

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQW
CCCCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHH
QLLQACVAADTIIIMQAANTGLTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGF
HHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCEEEEC
PGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSGGSLVQRGPAYTEMALYAQI
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEEEEEE
DAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATT
CCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCC
PSRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRD
CCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
FKHLPIAGEYLHRDIFDIAETYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVD
HHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHH
HLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDGITEAQQHLRAFFATAEGNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCE
IACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEK
EEEECCCCHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHH
CLIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECH
ALKDFYQQIDPTNSFNPGIGKTSKRKRWQQD
HHHHHHHHCCCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MMSQFNNEKIQLLLTQLQHIVGTRYLLTGERQTERYRTGFRSGKGVALAVVFPSTLLQQW
CCCCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHH
QLLQACVAADTIIIMQAANTGLTEGSTPSGDDYDRPIVILNTLRLNNIQLLDDGKQVIGF
HHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCEEEEC
PGSTLNQLEKRLKPYGREPHSVIGSSCIGASVVGGICNNSGGSLVQRGPAYTEMALYAQI
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEEEEEE
DAQGELQLINHLGISLGNTPEEILQRLEQGQYGAEDIEQTGQQTSDSEYATRVRDIDATT
CCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCC
PSRFNADPRRLFEASGCAGKLAIFAVRLDTFPSEKQQQVFYIGTNQTQVLTELRRIILRD
CCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHH
FKHLPIAGEYLHRDIFDIAETYGKDTFVMINSMGTNNMPRFFTLKGKIDARLNKIPHLVD
HHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHH
HLTDRVMQGFSQILPNHLPKRLKTYRNQYEHHLLLKMSGDGITEAQQHLRAFFATAEGNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCE
IACTADEGKKAFLHRFAAAGAAVRYHAVHADQVEDILALDIALRRNEKQWFETLPPEIEK
EEEECCCCHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHH
CLIAKLYYGHFLCHVFHQDYIVKKGVDVKALKEKMLSLLNDKGAEYPAEHNVGHLYLAKP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECH
ALKDFYQQIDPTNSFNPGIGKTSKRKRWQQD
HHHHHHHHCCCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]