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The map label for this gene is betA

Identifier: 51595539

GI number: 51595539

Start: 1422860

End: 1424563

Strand: Reverse

Name: betA

Synonym: YPTB1195

Alternate gene names: 51595539

Gene position: 1424563-1422860 (Counterclockwise)

Preceding gene: 51595540

Following gene: 51595533

Centisome position: 30.02

GC content: 53.23

Gene sequence:

>1704_bases
ATGGAATACGATTACATCATCATTGGTGCCGGTTCTGCAGGCAACGTGCTGGCAGCCCGTTTAACAGAAGATGCGGATGT
CACCGTACTCTTGCTCGAAGCGGGTGGACCAGACTATCGGCTGGATTTTCGGACACAAATGCCTGCGGCGCTCGCCTTTC
CACTTCAGGGTAAACGTTATAATTGGGCTTATGAAACCGATCCGGAGCCGCATATGAACAACCGCCGCATGGAGTGCGGA
CGCGGTAAAGGTTTGGGCGGTTCATCATTAATTAATGGCATGTGTTACATCCGCGGCAACGCCATGGATTTTGACCACTG
GGCCAGTTTATCGGGTCTGGAGGACTGGAGTTATCTTGATTGCCTGCCGTACTTTCGTAAGGCAGAAACACGCGACGTCG
GCCCAAATGATTTCCACGGTGGTGAAGGCCCTGTCAGCGTGACCACACCTAAAATCGACAACAACCCGTTATTTCATGCG
ATGGTCGCTGCGGGTGTGCAGGCCGGTTATCCGCGTACTGATGACCTGAATGGCTATCAGCAGGAGGGTTTTGGCCCGAT
GGATCGTACTGTGACGCCGAAGGGTCGTCGTGCCAGTACTGCGCGCGGCTATCTTGATCAGGCGCGCCCACGCAATAACC
TAACCATTATTACGCACGCCCTGACGGACCGGATCCTATTTGAAGGGAAACGAGCCACTGGCGTCAGCTACCTCAAAGGT
GATGCTGGCACCGGCCAAACCGCCCATGCTCGCCGTGAAGTTTTATTGTGTGGGGGTGCTATCGCGTCACCACAAATTTT
ACAGCGCTCGGGTATTGGCCCTGCGGAATTACTGCAACGCCTGGATATTCCGTTGGTGCAGGCGTTGCCCGGCGTCGGGG
AGAATTTGCAAGATCACCTTGAGATGTATCTGCAATATAGCTGTAAACAGCCGGTGTCACTTTACCCTGCTCTGCTGTGG
TTTAATCAGCCCAAAATCGGTATCGAATGGTTATTCAACGGTACGGGCGTGGGTGCCAGCAATCAATTCGAAGCCGGTGG
GTTTATCCGCAGTCGCGATGCATTTACCTGGCCGAATATTCAGTACCACTTCCTGCCCGTCGCCATTAATTACAATGGGA
GCAACGCTGTAAAAGAGCATGGTTTTCAGGCGCATGTTGGCTCGATGCGTTCACCAAGCCGTGGCCGCATTCAGGTAAAA
TCGAAAGATCCGCGCCAGCATCCGAGTATCTTGTTCAACTACATGTCGAACGAACAGGATTGGCATGAGTTCCGTGATGC
TATCCGCATCACCCGCGAGATTATCGCGCAGCCTGCACTGGATCCATATCGTGGTCGAGAGATAAGCCCTGGGGCCAATG
TTCAAAGCGATGACGAACTGGATGCCTTCATCCGCGAACATGCCGAGACGGCATATCATCCTTCGTGCTCATGTAAAATG
GGTGACGACAAGATGGCGGTGGTTGATGGGCAAGGCCGGGTGCACGGTGTGCAAGGGCTACGGGTGGTCGATGCATCTAT
CATGCCGCAAATCATTACCGGCAACCTCAATGCCACGACCATCATGATTGCAGAGAAAATAGCGGATCGTATTCGTGGCT
GCCAACCACTGGCAAAAAGCAACGCCGCGTATTTTATCGCCGGAGATACTCCTGCCCGTACATCTCCCGTAAGGCATTCA
TTACCCGTAACATCATATCCGTAA

Upstream 100 bases:

>100_bases
GGTATCAGCACGCTGGAACATTACACGCAAATCAAATCAATTCAGGTTGAGTTAAGCAGCTTCAATTCTGTTTTTTAATC
CAACACCAGAGGGACATCCA

Downstream 100 bases:

>100_bases
AGAAAATCACGAAATACGTAGAGGATCGTTAACCACATTGATCATCGATACAAACCGTTGCTCAGCGCATCAAACGGCAA
CTTCTACATAGAAACGGTGA

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRYNWAYETDPEPHMNNRRMECG
RGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLDCLPYFRKAETRDVGPNDFHGGEGPVSVTTPKIDNNPLFHA
MVAAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVSYLKG
DAGTGQTAHARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHLEMYLQYSCKQPVSLYPALLW
FNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVK
SKDPRQHPSILFNYMSNEQDWHEFRDAIRITREIIAQPALDPYRGREISPGANVQSDDELDAFIREHAETAYHPSCSCKM
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKSNAAYFIAGDTPARTSPVRHS
LPVTSYP

Sequences:

>Translated_567_residues
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRYNWAYETDPEPHMNNRRMECG
RGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLDCLPYFRKAETRDVGPNDFHGGEGPVSVTTPKIDNNPLFHA
MVAAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVSYLKG
DAGTGQTAHARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHLEMYLQYSCKQPVSLYPALLW
FNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVK
SKDPRQHPSILFNYMSNEQDWHEFRDAIRITREIIAQPALDPYRGREISPGANVQSDDELDAFIREHAETAYHPSCSCKM
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKSNAAYFIAGDTPARTSPVRHS
LPVTSYP
>Mature_567_residues
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRYNWAYETDPEPHMNNRRMECG
RGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLDCLPYFRKAETRDVGPNDFHGGEGPVSVTTPKIDNNPLFHA
MVAAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVSYLKG
DAGTGQTAHARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHLEMYLQYSCKQPVSLYPALLW
FNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVK
SKDPRQHPSILFNYMSNEQDWHEFRDAIRITREIIAQPALDPYRGREISPGANVQSDDELDAFIREHAETAYHPSCSCKM
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKSNAAYFIAGDTPARTSPVRHS
LPVTSYP

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=539, Percent_Identity=50.278293135436, Blast_Score=523, Evalue=1e-148,
Organism=Escherichia coli, GI1786503, Length=553, Percent_Identity=79.2043399638336, Blast_Score=931, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=551, Percent_Identity=45.9165154264973, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642048, Length=593, Percent_Identity=36.424957841484, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI45551458, Length=572, Percent_Identity=35.3146853146853, Blast_Score=298, Evalue=7e-81,
Organism=Drosophila melanogaster, GI45549471, Length=572, Percent_Identity=35.3146853146853, Blast_Score=298, Evalue=7e-81,
Organism=Drosophila melanogaster, GI24642042, Length=572, Percent_Identity=35.8391608391608, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24642059, Length=573, Percent_Identity=35.6020942408377, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24642055, Length=581, Percent_Identity=35.2839931153184, Blast_Score=272, Evalue=6e-73,
Organism=Drosophila melanogaster, GI17137792, Length=553, Percent_Identity=34.5388788426763, Blast_Score=261, Evalue=9e-70,
Organism=Drosophila melanogaster, GI24650267, Length=574, Percent_Identity=33.1010452961672, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI18859995, Length=569, Percent_Identity=34.2706502636204, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24642039, Length=568, Percent_Identity=33.9788732394366, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24642035, Length=583, Percent_Identity=33.7907375643225, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24642037, Length=576, Percent_Identity=33.5069444444444, Blast_Score=243, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24642051, Length=570, Percent_Identity=30.8771929824561, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI18859993, Length=574, Percent_Identity=33.7979094076655, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24645930, Length=582, Percent_Identity=27.8350515463918, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24642057, Length=586, Percent_Identity=30.7167235494881, Blast_Score=149, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 62451; Mature: 62451

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRY
CCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCCEEECCCCCCEE
NWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLD
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCHHH
CLPYFRKAETRDVGPNDFHGGEGPVSVTTPKIDNNPLFHAMVAAGVQAGYPRTDDLNGYQ
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVSYLKG
HCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHCCCCCCCCCEEEEC
DAGTGQTAHARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHL
CCCCCCCHHHHCEEEEECCCCCCCHHHHHCCCCHHHHHHHCCCCHHHHCCCCCCCHHHHH
EMYLQYSCKQPVSLYPALLWFNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNI
HHHHHHHCCCCHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCC
QYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVKSKDPRQHPSILFNYMSNEQD
EEEEEEEEEEECCCCHHHHCCCHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCH
WHEFRDAIRITREIIAQPALDPYRGREISPGANVQSDDELDAFIREHAETAYHPSCSCKM
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCCEEEHHHHHHHHHHHCCCCHHHC
NAAYFIAGDTPARTSPVRHSLPVTSYP
CCEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRY
CCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCCEEECCCCCCEE
NWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLD
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCHHHHHCCCCCCCCCHHH
CLPYFRKAETRDVGPNDFHGGEGPVSVTTPKIDNNPLFHAMVAAGVQAGYPRTDDLNGYQ
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVSYLKG
HCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHCCCCCCCCCEEEEC
DAGTGQTAHARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHL
CCCCCCCHHHHCEEEEECCCCCCCHHHHHCCCCHHHHHHHCCCCHHHHCCCCCCCHHHHH
EMYLQYSCKQPVSLYPALLWFNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNI
HHHHHHHCCCCHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCC
QYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVKSKDPRQHPSILFNYMSNEQD
EEEEEEEEEEECCCCHHHHCCCHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCH
WHEFRDAIRITREIIAQPALDPYRGREISPGANVQSDDELDAFIREHAETAYHPSCSCKM
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
GDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKS
CCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCCEEEHHHHHHHHHHHCCCCHHHC
NAAYFIAGDTPARTSPVRHSLPVTSYP
CCEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA