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The map label for this gene is ppiD

Identifier: 51595313

GI number: 51595313

Start: 1158319

End: 1160205

Strand: Direct

Name: ppiD

Synonym: YPTB0963

Alternate gene names: 51595313

Gene position: 1158319-1160205 (Clockwise)

Preceding gene: 51595312

Following gene: 51595314

Centisome position: 24.41

GC content: 45.52

Gene sequence:

>1887_bases
ATGATGGACAATTTACGCGCGGCTGCTAATAACGTCGTGCTCAAAATCATTCTGGCCCTGATCATGTTGTCCTTTATCCT
GACTGGGGTTGGCAGCTATTTGATTGGTGGCTCCAACGATTACGCAGCCAAAGTTAATGACCAAGACATTAGCCGGGCTC
AGTTAGAACAGGCTATGCAAAGTGAACGTGGTCGCCTGCAACAAAAATTAGGTGAACAGTTCTCTGTGCTGGCCGCGAAT
GAAGGCTATATGCAACAGTTGCGTCAGCAGGTGCTGGGGCAATTGATCAACAATGTGTTACTTGACCAATATGCTAGAAA
ATTGGGTCTGACTGTCAGTGATGAACAAGTAAAAGAGTCTATCCGCCAGATACCTGATTTCCAAACAGGTGAACATTTCG
ACAATAACCGATATCTCGCACTGATTAACCAACTGGGCTACACCCCAGAGCAATTTGCTCAATTACAGCGTCAGCAGTTG
ATCAACCAGCAATTGCTGAAAGCCTTTAGTGATACCGGTTTTGTGCTGCCTATTGAAGTGCAGGCAATGTCAGCGTTGGT
TTTACAACAACGTGATGTCCGCTTGGCTACTTTGGACCTCAAAGCACTTCAAGCAGAGCAGAAAGTTACTGATGAAGAGC
TACAAGCTTATTACGATCAGAACAAACATAATTTCATTGCACCGGAACAGATGAAAGTCAGTTTTATTGCAATGGATGCA
GCGGCAATGCAGAGCAATATCACGGTGACTGAAGAGGATATTGCAGCGTATTACGATCAAAACCGCAGCAGTTACACCCA
ACCTGAACGCCGTAATTACAGCGTCATTCAGTTTAAAACAGAAGCCGAAGCTAAAGCGGCGCTTGATGAGCTGAAAAAAG
GTGCTGATTTTGCTGTGATAGCTAAAGAAAAATCCACCGATATTATTTCTCGTAATAATGGTGGCGAACTCGGTTGGCTG
GAGCCAGAAACAACACCTGATGAGGTGAAAGCTGCCAATCTGAGCGAGAAAGGCCAACTGTCTGATGTGATCAAATCTTC
TGTCGGTTATTTAATTGTTCGCTTAAATGATATCAAACCAGAATTAGTTAAACCGCTATCAGAAGTGCATGATGAGTTGG
CTAAAAAGCTTAAGCAGGAAAAAGCGCTTGACGCTTATTATGCGCTACAGCAAAAAGTCAATGATGCGGCAACTAGCGAT
AACGAATCTCTGGCTTCAGCCGAAGAGGTCGCGGGGACTAAAGCTCAACAAACAGGTTGGTTCACCCGTGACACGGTACC
GGCTGAAATTAATTTCAAACCGGTAGTCCAGGCAATCTTTGATGGTCGCCTGGTGGGTGAGAACGGTTCTGCGGGGAGTA
ACTCTGAGGTTATTACCGTGGATGGTGATCGTGCTTTTGTCATCCGTATTGATGGTCACAAGCCTGAAGGTATTGAGCCA
TTCGATCAGGTTCGCGATCAAATTAGTGAGCTGGTGAAACGCCAAAAAGCGGAACAACAGGCGCGTGTCGATGGTGAAAA
GATTCTAACCGCGTTGAAACAAGGTAAAGGCGAAGAAGCGATGAAGTCCGCGGGTATCAGCTTCGGGGAAAAGAAAACGC
TGTCATATGCATCGGTTGATGATCAACTTATGCAGACAATCTTCGCTCTGGCGCATCCACAGAAAGACCAGCCGGTTTAT
GGTTTATCTCAGGACCGTCAAGGCAACATCGTATTGATCGAGCTGTTATCGGTGACTCCGGGTAAATTGCAGGAAAGTGA
AACGAAGATCTTTATTGAGAAGATGCAGGAAGAGTCCGTTAGCATGATATTTGATGCGTTGATGGCTAATCTGCATAAGC
AGGCAACCATTAAAATAGGCCCTGCAGAGCAACAACAACCGCAATAA

Upstream 100 bases:

>100_bases
TTAACGCGCAGCAGCACGAAGGGCTGTCGCAAGGAATGCTGGTTTTATTTAGACCTGCGCAAGAGTTTTAATCCACATTA
CAGCGGAGTATTGTCACATT

Downstream 100 bases:

>100_bases
GCTTCGCATTCATTTGCAAACCGATGTAATAAAAGAAAGGTCGCTTTGGCGACCTTTCGCATATCTGTGATCTGCCCTTT
GCGTTGAGCCAAGGGGTACG

Product: peptidyl-prolyl cis-trans isomerase (rotamase D)

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MMDNLRAAANNVVLKIILALIMLSFILTGVGSYLIGGSNDYAAKVNDQDISRAQLEQAMQSERGRLQQKLGEQFSVLAAN
EGYMQQLRQQVLGQLINNVLLDQYARKLGLTVSDEQVKESIRQIPDFQTGEHFDNNRYLALINQLGYTPEQFAQLQRQQL
INQQLLKAFSDTGFVLPIEVQAMSALVLQQRDVRLATLDLKALQAEQKVTDEELQAYYDQNKHNFIAPEQMKVSFIAMDA
AAMQSNITVTEEDIAAYYDQNRSSYTQPERRNYSVIQFKTEAEAKAALDELKKGADFAVIAKEKSTDIISRNNGGELGWL
EPETTPDEVKAANLSEKGQLSDVIKSSVGYLIVRLNDIKPELVKPLSEVHDELAKKLKQEKALDAYYALQQKVNDAATSD
NESLASAEEVAGTKAQQTGWFTRDTVPAEINFKPVVQAIFDGRLVGENGSAGSNSEVITVDGDRAFVIRIDGHKPEGIEP
FDQVRDQISELVKRQKAEQQARVDGEKILTALKQGKGEEAMKSAGISFGEKKTLSYASVDDQLMQTIFALAHPQKDQPVY
GLSQDRQGNIVLIELLSVTPGKLQESETKIFIEKMQEESVSMIFDALMANLHKQATIKIGPAEQQQPQ

Sequences:

>Translated_628_residues
MMDNLRAAANNVVLKIILALIMLSFILTGVGSYLIGGSNDYAAKVNDQDISRAQLEQAMQSERGRLQQKLGEQFSVLAAN
EGYMQQLRQQVLGQLINNVLLDQYARKLGLTVSDEQVKESIRQIPDFQTGEHFDNNRYLALINQLGYTPEQFAQLQRQQL
INQQLLKAFSDTGFVLPIEVQAMSALVLQQRDVRLATLDLKALQAEQKVTDEELQAYYDQNKHNFIAPEQMKVSFIAMDA
AAMQSNITVTEEDIAAYYDQNRSSYTQPERRNYSVIQFKTEAEAKAALDELKKGADFAVIAKEKSTDIISRNNGGELGWL
EPETTPDEVKAANLSEKGQLSDVIKSSVGYLIVRLNDIKPELVKPLSEVHDELAKKLKQEKALDAYYALQQKVNDAATSD
NESLASAEEVAGTKAQQTGWFTRDTVPAEINFKPVVQAIFDGRLVGENGSAGSNSEVITVDGDRAFVIRIDGHKPEGIEP
FDQVRDQISELVKRQKAEQQARVDGEKILTALKQGKGEEAMKSAGISFGEKKTLSYASVDDQLMQTIFALAHPQKDQPVY
GLSQDRQGNIVLIELLSVTPGKLQESETKIFIEKMQEESVSMIFDALMANLHKQATIKIGPAEQQQPQ
>Mature_628_residues
MMDNLRAAANNVVLKIILALIMLSFILTGVGSYLIGGSNDYAAKVNDQDISRAQLEQAMQSERGRLQQKLGEQFSVLAAN
EGYMQQLRQQVLGQLINNVLLDQYARKLGLTVSDEQVKESIRQIPDFQTGEHFDNNRYLALINQLGYTPEQFAQLQRQQL
INQQLLKAFSDTGFVLPIEVQAMSALVLQQRDVRLATLDLKALQAEQKVTDEELQAYYDQNKHNFIAPEQMKVSFIAMDA
AAMQSNITVTEEDIAAYYDQNRSSYTQPERRNYSVIQFKTEAEAKAALDELKKGADFAVIAKEKSTDIISRNNGGELGWL
EPETTPDEVKAANLSEKGQLSDVIKSSVGYLIVRLNDIKPELVKPLSEVHDELAKKLKQEKALDAYYALQQKVNDAATSD
NESLASAEEVAGTKAQQTGWFTRDTVPAEINFKPVVQAIFDGRLVGENGSAGSNSEVITVDGDRAFVIRIDGHKPEGIEP
FDQVRDQISELVKRQKAEQQARVDGEKILTALKQGKGEEAMKSAGISFGEKKTLSYASVDDQLMQTIFALAHPQKDQPVY
GLSQDRQGNIVLIELLSVTPGKLQESETKIFIEKMQEESVSMIFDALMANLHKQATIKIGPAEQQQPQ

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=626, Percent_Identity=58.9456869009585, Blast_Score=744, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 69865; Mature: 69865

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDNLRAAANNVVLKIILALIMLSFILTGVGSYLIGGSNDYAAKVNDQDISRAQLEQAMQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCHHHHHHHHHHHH
SERGRLQQKLGEQFSVLAANEGYMQQLRQQVLGQLINNVLLDQYARKLGLTVSDEQVKES
HHHHHHHHHHCCHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IRQIPDFQTGEHFDNNRYLALINQLGYTPEQFAQLQRQQLINQQLLKAFSDTGFVLPIEV
HHHCCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
QAMSALVLQQRDVRLATLDLKALQAEQKVTDEELQAYYDQNKHNFIAPEQMKVSFIAMDA
HHHHHHHHHHCCCEEEEEHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHEEEEEEEHH
AAMQSNITVTEEDIAAYYDQNRSSYTQPERRNYSVIQFKTEAEAKAALDELKKGADFAVI
HHHHCCCEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEE
AKEKSTDIISRNNGGELGWLEPETTPDEVKAANLSEKGQLSDVIKSSVGYLIVRLNDIKP
ECCCCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCEEEEEEECCCH
ELVKPLSEVHDELAKKLKQEKALDAYYALQQKVNDAATSDNESLASAEEVAGTKAQQTGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHCCC
FTRDTVPAEINFKPVVQAIFDGRLVGENGSAGSNSEVITVDGDRAFVIRIDGHKPEGIEP
CCCCCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCH
FDQVRDQISELVKRQKAEQQARVDGEKILTALKQGKGEEAMKSAGISFGEKKTLSYASVD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHH
DQLMQTIFALAHPQKDQPVYGLSQDRQGNIVLIELLSVTPGKLQESETKIFIEKMQEESV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
SMIFDALMANLHKQATIKIGPAEQQQPQ
HHHHHHHHHHHCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MMDNLRAAANNVVLKIILALIMLSFILTGVGSYLIGGSNDYAAKVNDQDISRAQLEQAMQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCHHHHHHHHHHHH
SERGRLQQKLGEQFSVLAANEGYMQQLRQQVLGQLINNVLLDQYARKLGLTVSDEQVKES
HHHHHHHHHHCCHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IRQIPDFQTGEHFDNNRYLALINQLGYTPEQFAQLQRQQLINQQLLKAFSDTGFVLPIEV
HHHCCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
QAMSALVLQQRDVRLATLDLKALQAEQKVTDEELQAYYDQNKHNFIAPEQMKVSFIAMDA
HHHHHHHHHHCCCEEEEEHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHEEEEEEEHH
AAMQSNITVTEEDIAAYYDQNRSSYTQPERRNYSVIQFKTEAEAKAALDELKKGADFAVI
HHHHCCCEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEE
AKEKSTDIISRNNGGELGWLEPETTPDEVKAANLSEKGQLSDVIKSSVGYLIVRLNDIKP
ECCCCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCEEEEEEECCCH
ELVKPLSEVHDELAKKLKQEKALDAYYALQQKVNDAATSDNESLASAEEVAGTKAQQTGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHCCC
FTRDTVPAEINFKPVVQAIFDGRLVGENGSAGSNSEVITVDGDRAFVIRIDGHKPEGIEP
CCCCCCCCCCCHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCH
FDQVRDQISELVKRQKAEQQARVDGEKILTALKQGKGEEAMKSAGISFGEKKTLSYASVD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHH
DQLMQTIFALAHPQKDQPVYGLSQDRQGNIVLIELLSVTPGKLQESETKIFIEKMQEESV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
SMIFDALMANLHKQATIKIGPAEQQQPQ
HHHHHHHHHHHCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]