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The map label for this gene is pdhR

Identifier: 51595062

GI number: 51595062

Start: 852641

End: 853405

Strand: Direct

Name: pdhR

Synonym: YPTB0712

Alternate gene names: 51595062

Gene position: 852641-853405 (Clockwise)

Preceding gene: 51595060

Following gene: 51595063

Centisome position: 17.97

GC content: 51.11

Gene sequence:

>765_bases
ATGGCCTACAACAAAATACGTCAACCCAAACTATCAGATGTAATCGAGCAGCAGCTCGAATACTTGATCTTGGAAGGGAC
GCTGCGTCCGGGTGAAAAGTTACTGCCTGAACGTGAGTTGGCGAAGCAATTTGATGTTTCCCGACCTTCTTTGAGAGAAG
CTATTCAGCGATTAGAGGCTAAAGGCTTGCTGTTGCGCCGTCAGGGAGGGGGTACCTTCGTTCAGACCAATCTGTGGCAA
AGCTTTAGCGATCCGTTAGCTGAACTGCTGGCAGACCATCCAGAATCACAATTCGACCTGCTTGAAACCCGTCATGCCCT
TGAAGGTATTGCCGCCTATTACGCTGCATTACGTGGCACTGATGAAGATCTGCAACGTATCCGTGAGTGCCATACTGTCA
TCCAGCAAGCGCAGGATAACGGTGATTTGGATGCTGAAGCCGATGCGGTGATGCAGTATCAAGTGGCGGTCACAGAGGCT
GCACATAATGTGGTCTTGCTGCATTTACTCCGTTGCATGGGGCCAATGCTGGAACAAAACGTCAGACAAAACTTTGAATT
GCTCTACTTGCGCCGCGAAATGTTGGCCACTGTGAGCAGTCACCGAGCCAGGATTTTCGAGGCGATTGTGGCACGTGAAC
CAGAAAAAGCACGAGAAGCATCGCACCGTCACTTGGCGTTTATTGAGGAGATTCTGTTGGATCTTAGCCGGGAGCACAGT
CGCCGTGAGCGATCTTTGCGTCGGCTCCAACAGCGCAAGGAGTAG

Upstream 100 bases:

>100_bases
AATACTTTGTTACTTTATCGTCACGTTTTTGAAATTGGTATTACCAATTGACTCCGCGCCACTCGCAGAGACGATTCACT
CAATACGGCTTACACCAAAT

Downstream 100 bases:

>100_bases
AAACGAATCATTCGGGTTGCGCCTCTGCAAGACCTCAATAACTCGTTTTGGATTCTCATTTGAGAATTATTAGCGGCAAC
TAAACTGATGGGCCTATCTT

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MAYNKIRQPKLSDVIEQQLEYLILEGTLRPGEKLLPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQTNLWQ
SFSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGTDEDLQRIRECHTVIQQAQDNGDLDAEADAVMQYQVAVTEA
AHNVVLLHLLRCMGPMLEQNVRQNFELLYLRREMLATVSSHRARIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHS
RRERSLRRLQQRKE

Sequences:

>Translated_254_residues
MAYNKIRQPKLSDVIEQQLEYLILEGTLRPGEKLLPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQTNLWQ
SFSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGTDEDLQRIRECHTVIQQAQDNGDLDAEADAVMQYQVAVTEA
AHNVVLLHLLRCMGPMLEQNVRQNFELLYLRREMLATVSSHRARIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHS
RRERSLRRLQQRKE
>Mature_253_residues
AYNKIRQPKLSDVIEQQLEYLILEGTLRPGEKLLPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQTNLWQS
FSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGTDEDLQRIRECHTVIQQAQDNGDLDAEADAVMQYQVAVTEAA
HNVVLLHLLRCMGPMLEQNVRQNFELLYLRREMLATVSSHRARIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHSR
RERSLRRLQQRKE

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=234, Percent_Identity=86.3247863247863, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1790032, Length=242, Percent_Identity=35.1239669421488, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1789353, Length=236, Percent_Identity=30.5084745762712, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1790780, Length=221, Percent_Identity=31.6742081447964, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI48994955, Length=214, Percent_Identity=29.9065420560748, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29409; Mature: 29278

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYNKIRQPKLSDVIEQQLEYLILEGTLRPGEKLLPERELAKQFDVSRPSLREAIQRLEA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLLRRQGGGTFVQTNLWQSFSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGT
HCHHEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DEDLQRIRECHTVIQQAQDNGDLDAEADAVMQYQVAVTEAAHNVVLLHLLRCMGPMLEQN
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQNFELLYLRREMLATVSSHRARIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRERSLRRLQQRKE
HHHHHHHHHHHHCC
>Mature Secondary Structure 
AYNKIRQPKLSDVIEQQLEYLILEGTLRPGEKLLPERELAKQFDVSRPSLREAIQRLEA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLLRRQGGGTFVQTNLWQSFSDPLAELLADHPESQFDLLETRHALEGIAAYYAALRGT
HCHHEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DEDLQRIRECHTVIQQAQDNGDLDAEADAVMQYQVAVTEAAHNVVLLHLLRCMGPMLEQN
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQNFELLYLRREMLATVSSHRARIFEAIVAREPEKAREASHRHLAFIEEILLDLSREHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRERSLRRLQQRKE
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]