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The map label for this gene is alr

Identifier: 51594730

GI number: 51594730

Start: 449597

End: 450676

Strand: Direct

Name: alr

Synonym: YPTB0376

Alternate gene names: 51594730

Gene position: 449597-450676 (Clockwise)

Preceding gene: 51594729

Following gene: 51594731

Centisome position: 9.48

GC content: 54.72

Gene sequence:

>1080_bases
ATGAAAGCGGCAACAGCAGTCATCGACCGCCATGCTCTGCGACATAACTTACAACAAATTCGGCGTCTGGCACCGCAAAG
CCGGTTGGTGGCTGTTGTGAAAGCAAATGCTTATGGCCACGGGTTATTAGCCGCAGCACACACATTACAGGATGCTGATT
GTTATGGCGTGGCCCGTATTAGCGAGGCGCTGATGTTGCGAGCGGGTGGAATAGTTAAACCTATTTTGCTGCTGGAAGGG
TTCTTTGATGCAGAAGACCTGCCGGTATTGGTGGCTAACCACATTGAAACCGCCGTTCACAGCCTGGAACAGCTCGTGGC
ATTGGAAGCGGCTACGCTTTCTGCGCCGATTAATGCCTGGATGAAATTGGATACGGGGATGCACCGCCTGGGGGTTCGCC
CAGATCAGGCCGAAGCGTTTTATCAGCGTTTGAGCGCATGCCGTAACGTCATCCAGCCGGTCAATATCATGAGTCACTTT
AGCCGTGCCGATGAACCTGAAGTGGCGGCCACGCAACAGCAACTGGCGTGTTTTGATGCGTTTGCTGCAGGTAAACCTGG
GAAACAATCTATCGCTGCTTCGGGCGGTATTCTGCGGTGGCCACAAGCGCACCGTGATTGGGTGCGCCCAGGGATTGTGC
TGTATGGGGTTTCGCCGTTTGATACGCCCTATGGCCGTGATTTCGGTTTATTGCCCGCCATGACCCTGAAATCCAGTCTG
ATCGCGGTGCGTGAACATAAAGCCGGTGAATCGGTCGGGTATGGCGGCACCTGGGTCAGTGAGCGCGATACGCGTTTAGG
TGTGATCGCGATAGGCTATGGTGATGGCTACCCACGTAGCGCCCCGTCAGGGACACCGGTATGGCTTAATGGCCGTGAAG
TGAGCATCGTTGGCCGGGTATCGATGGACATGATCTCCATTGATCTTGGCCCGGAAAGTACAGATAAGGTGGGCGATGAA
GCCCTGATGTGGGGAGCCGAATTACCGGTTGAACGCGTGGCTGCCTGCACCGGTATCAGCGCGTATGAATTGATCACTAA
TCTGACCTCCCGCGTAGCGATGGAATATCTAGGGGAATAA

Upstream 100 bases:

>100_bases
GTAGTGAATAGCCTCTTGGTATTTGATACTGCCGAGGTGAGCACGGACTACCTGCAACGCCAATCATGTTGGGAATAATA
TCAATTATTAAGGATAAGAA

Downstream 100 bases:

>100_bases
GGTAAGCTGCAAGAGCGACCCATTTCCATATACCCGCCATATTTCAAATTGCAGGCGTGCTGGCTGTCTGCGTCCCCCTT
GGTCACTTACTCATGTAAGC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARISEALMLRAGGIVKPILLLEG
FFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINAWMKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHF
SRADEPEVAATQQQLACFDAFAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDTPYGRDFGLLPAMTLKSSL
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRVSMDMISIDLGPESTDKVGDE
ALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE

Sequences:

>Translated_359_residues
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARISEALMLRAGGIVKPILLLEG
FFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINAWMKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHF
SRADEPEVAATQQQLACFDAFAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDTPYGRDFGLLPAMTLKSSL
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRVSMDMISIDLGPESTDKVGDE
ALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE
>Mature_359_residues
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARISEALMLRAGGIVKPILLLEG
FFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINAWMKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHF
SRADEPEVAATQQQLACFDAFAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDTPYGRDFGLLPAMTLKSSL
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRVSMDMISIDLGPESTDKVGDE
ALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE

Specific function: Provides the D-alanine required for cell wall biosynthesis [H]

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family [H]

Homologues:

Organism=Escherichia coli, GI1790487, Length=358, Percent_Identity=71.7877094972067, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI1787439, Length=350, Percent_Identity=42.5714285714286, Blast_Score=273, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622 [H]

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 38734; Mature: 38734

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
SEALMLRAGGIVKPILLLEGFFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINAW
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHFSRADEPEVAATQQQLACFDA
HHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDTPYGRDFGLLPAMTLKSSL
HHCCCCCCHHHHCCCCEEECCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRV
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCEEEEEEEE
SMDMISIDLGPESTDKVGDEALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE
EEEEEEEECCCCCCHHCCCHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
SEALMLRAGGIVKPILLLEGFFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINAW
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHFSRADEPEVAATQQQLACFDA
HHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDTPYGRDFGLLPAMTLKSSL
HHCCCCCCHHHHCCCCEEECCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRV
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCEEEEEEEE
SMDMISIDLGPESTDKVGDEALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE
EEEEEEEECCCCCCHHCCCHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]