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The map label for this gene is tkt [H]

Identifier: 50843753

GI number: 50843753

Start: 2516637

End: 2518700

Strand: Reverse

Name: tkt [H]

Synonym: PPA2318

Alternate gene names: 50843753

Gene position: 2518700-2516637 (Counterclockwise)

Preceding gene: 50843754

Following gene: 50843752

Centisome position: 98.38

GC content: 63.13

Gene sequence:

>2064_bases
GTGGCAACCGAACTGACGTGGACCGACACCGATAGGCTCGCTGTCGACACCGCTCGAGTGCTGGCGGCCGATGCCGTCGA
GAAGACTGGTAACGGTCACCCCGGCACCGCTATTTCCCTAGCGCCGCTGGGCTACCTGCTTTACCACAAGGTCATGTCTA
TCGATCCGTCGGACCCGAATTGGCTCGGACGCGATCGCTTCATCATGTCGGCAGGACATTCCTCGCTGACCCAGTACACC
CAGTTATACCTAGCAGGGCTGGGACTCGAGCTGTCCGACCTGGAGTCCCTGCGTACCTGGGGATCCCTGACCCCCGGCCA
CCCCGAATATGGCTTGACGAAGTTCGTCGAGACCACCACCGGCCCGCTCGGCGCCGGTGTTGCCAACGCCGTCGGCATGG
CCATGGCAGCTCGTCGTGAACGCGGCCTGCTCGACCCGGACGCCGCTCCCGGTACGAGCCTCTTCGACCACTACATTTAC
GCCATTGCCGGTGACGGCTGTATGCAGGAAGGCATTGCATCTGAGGCTTCGTCTCTGGCGGGGACCCAGGAGCTGGGCAA
CCTCATCATGTTCTACGACGACAACCGGATCACCATCGAAGGTGATACCGCCATCGCCTTCTCTGAGAACGTCGAGGCCC
GCTATGAGGCCTACGGTTGGCATGTCCAGCACGTCGATTTCACCAACGGCGGAACGACCTACGAGGAGAATGTCGAAGCC
CTCATGGAGGCCATCGACAACGCCAAGACTGTTACCGACAAGCCGTCTTTCATCCGTCTCACCACCGTCATTGGTTGGCC
GATTCCGAAGCTCGCCGGTCTGGCCCAGGTACACGGTGCGAAGATTGGCGCTGAGGGGGTCAGTGCCCTCAAGGAGAAGC
TTGGCTTTGAAGACAAGCCGTTTGCCATCGACCTTGAGATGGTGCAACAGGTCCGCGCTGCTTTCGCTGAGCGCGGCAAG
GGTCTGCGCGAGGTCTGGGACGAGAAGTTCGCCGCCTGGCATGACGCCAACCCAGACGGCGCTGCCCTGCTCGAGCGGAT
GCTCGCCCACAAGCTGCCCGACGACCTCGACATTCCCACTTTTGAGCCGGGCAAGATGAGCACCCGTAAGGCTTCGGGAG
CGGTCCTGAGCGCTCTGGGTCCGCAGCTTCCCGAGCTGTGGGGCGGATCGGCCGACCTCGCCGGGTCGAACAACACGACC
ATGAAGGGGGCCGACTCCTTCCTGCCTGAAGATCGCTGCTCCGAGAAAGATCCAGGTGGTCCTTACGGGCGTACTATCCA
CTTCGGTGTTCGCGAGCACGCCATGGGTGGCATCCTCAACGGCATCACCTTGGCGGGCCTGACCCGCTGCTACGGCGGAA
CCTTCTTTGTCTTCTCCGATTACATGCGTCCGTCGGTGCGTCTTGCGGCCCTCATGAAGATCCCGTCGATCTTCGTGTGG
ACCCACGATTCTATCGGCGTTGGTGAAGATGGACCCACCCACCAGCCAGTCGAGCACCTAGCCTCCTACCGAGCCATCCC
GGGACTCGACATCGTCCGTCCCGCCGACGCCAACGAGACCGCCGTGGCATGGCGCACCATCGTGGAGCACACCGACCGTC
CCGCCGGCCTAGTGCTGTCGCGTCAGGACCTGCCGACGATTGACCGCAGCAAATACGCCTCTGCCGAAGGCGTCGCCAGG
GGTGCCTACGTGGTTTGCGAGGCTAGCGCCGAGCCCAAAGTCATCCTCATCGGTACTGGGTCCGAGCTGTCGGTGGCCCT
CGAAGCACGCGAGAAGCTTGAGGCCGACGGGATCGCGACCCGCGTCGTCTCGATGCCGTGCCAAGAGTGGTTCGACGAGC
AGGACGAGGAGTACCGCGAGTCGGTGCTACCCAGCTCAGTGACTGCCCGAGTGAGCGTCGAGGCCGGCATCGCCATGGGC
TGGGCAAAGTATGTCGGCTGCAAGGGCGCCTCGGTGTCCCTCGAGCACTTCGGCGCCTCGGCCTCTGGGGCGCTGCTGTT
CGAGAAGTTCGGATTCACCGCTGACCACGTCGCGGAGGTCGCTCACACCGTGTTCATGGAGTGA

Upstream 100 bases:

>100_bases
CGAATAGGGTTGTGATGATGACCTGACCCCCACCCACCGCCCTGACGAGCGAAAACACATCACACACATCAGGCCTATAA
GCCAATACGAGAGGAATATC

Downstream 100 bases:

>100_bases
GGCATACCGATGTCGAACCGACGCCGGGCAAATCAAGACAAGGAGATGCTCCACGTCGCGGAGATGTACTACTTCGAGCA
GATGACCCATGCCGCCATCG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MATELTWTDTDRLAVDTARVLAADAVEKTGNGHPGTAISLAPLGYLLYHKVMSIDPSDPNWLGRDRFIMSAGHSSLTQYT
QLYLAGLGLELSDLESLRTWGSLTPGHPEYGLTKFVETTTGPLGAGVANAVGMAMAARRERGLLDPDAAPGTSLFDHYIY
AIAGDGCMQEGIASEASSLAGTQELGNLIMFYDDNRITIEGDTAIAFSENVEARYEAYGWHVQHVDFTNGGTTYEENVEA
LMEAIDNAKTVTDKPSFIRLTTVIGWPIPKLAGLAQVHGAKIGAEGVSALKEKLGFEDKPFAIDLEMVQQVRAAFAERGK
GLREVWDEKFAAWHDANPDGAALLERMLAHKLPDDLDIPTFEPGKMSTRKASGAVLSALGPQLPELWGGSADLAGSNNTT
MKGADSFLPEDRCSEKDPGGPYGRTIHFGVREHAMGGILNGITLAGLTRCYGGTFFVFSDYMRPSVRLAALMKIPSIFVW
THDSIGVGEDGPTHQPVEHLASYRAIPGLDIVRPADANETAVAWRTIVEHTDRPAGLVLSRQDLPTIDRSKYASAEGVAR
GAYVVCEASAEPKVILIGTGSELSVALEAREKLEADGIATRVVSMPCQEWFDEQDEEYRESVLPSSVTARVSVEAGIAMG
WAKYVGCKGASVSLEHFGASASGALLFEKFGFTADHVAEVAHTVFME

Sequences:

>Translated_687_residues
MATELTWTDTDRLAVDTARVLAADAVEKTGNGHPGTAISLAPLGYLLYHKVMSIDPSDPNWLGRDRFIMSAGHSSLTQYT
QLYLAGLGLELSDLESLRTWGSLTPGHPEYGLTKFVETTTGPLGAGVANAVGMAMAARRERGLLDPDAAPGTSLFDHYIY
AIAGDGCMQEGIASEASSLAGTQELGNLIMFYDDNRITIEGDTAIAFSENVEARYEAYGWHVQHVDFTNGGTTYEENVEA
LMEAIDNAKTVTDKPSFIRLTTVIGWPIPKLAGLAQVHGAKIGAEGVSALKEKLGFEDKPFAIDLEMVQQVRAAFAERGK
GLREVWDEKFAAWHDANPDGAALLERMLAHKLPDDLDIPTFEPGKMSTRKASGAVLSALGPQLPELWGGSADLAGSNNTT
MKGADSFLPEDRCSEKDPGGPYGRTIHFGVREHAMGGILNGITLAGLTRCYGGTFFVFSDYMRPSVRLAALMKIPSIFVW
THDSIGVGEDGPTHQPVEHLASYRAIPGLDIVRPADANETAVAWRTIVEHTDRPAGLVLSRQDLPTIDRSKYASAEGVAR
GAYVVCEASAEPKVILIGTGSELSVALEAREKLEADGIATRVVSMPCQEWFDEQDEEYRESVLPSSVTARVSVEAGIAMG
WAKYVGCKGASVSLEHFGASASGALLFEKFGFTADHVAEVAHTVFME
>Mature_686_residues
ATELTWTDTDRLAVDTARVLAADAVEKTGNGHPGTAISLAPLGYLLYHKVMSIDPSDPNWLGRDRFIMSAGHSSLTQYTQ
LYLAGLGLELSDLESLRTWGSLTPGHPEYGLTKFVETTTGPLGAGVANAVGMAMAARRERGLLDPDAAPGTSLFDHYIYA
IAGDGCMQEGIASEASSLAGTQELGNLIMFYDDNRITIEGDTAIAFSENVEARYEAYGWHVQHVDFTNGGTTYEENVEAL
MEAIDNAKTVTDKPSFIRLTTVIGWPIPKLAGLAQVHGAKIGAEGVSALKEKLGFEDKPFAIDLEMVQQVRAAFAERGKG
LREVWDEKFAAWHDANPDGAALLERMLAHKLPDDLDIPTFEPGKMSTRKASGAVLSALGPQLPELWGGSADLAGSNNTTM
KGADSFLPEDRCSEKDPGGPYGRTIHFGVREHAMGGILNGITLAGLTRCYGGTFFVFSDYMRPSVRLAALMKIPSIFVWT
HDSIGVGEDGPTHQPVEHLASYRAIPGLDIVRPADANETAVAWRTIVEHTDRPAGLVLSRQDLPTIDRSKYASAEGVARG
AYVVCEASAEPKVILIGTGSELSVALEAREKLEADGIATRVVSMPCQEWFDEQDEEYRESVLPSSVTARVSVEAGIAMGW
AKYVGCKGASVSLEHFGASASGALLFEKFGFTADHVAEVAHTVFME

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=598, Percent_Identity=25.9197324414716, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI4507521, Length=598, Percent_Identity=25.9197324414716, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI133778974, Length=595, Percent_Identity=25.0420168067227, Blast_Score=120, Evalue=6e-27,
Organism=Escherichia coli, GI48994911, Length=675, Percent_Identity=45.9259259259259, Blast_Score=567, Evalue=1e-162,
Organism=Escherichia coli, GI1788808, Length=679, Percent_Identity=46.5390279823269, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17539652, Length=592, Percent_Identity=26.8581081081081, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6325331, Length=682, Percent_Identity=44.8680351906158, Blast_Score=531, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6319593, Length=682, Percent_Identity=42.6686217008798, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI45551847, Length=586, Percent_Identity=26.7918088737201, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45550715, Length=586, Percent_Identity=26.7918088737201, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645119, Length=559, Percent_Identity=26.8336314847943, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24666278, Length=588, Percent_Identity=25.1700680272109, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73833; Mature: 73702

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00061 ADH_SHORT ; PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATELTWTDTDRLAVDTARVLAADAVEKTGNGHPGTAISLAPLGYLLYHKVMSIDPSDPN
CCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCC
WLGRDRFIMSAGHSSLTQYTQLYLAGLGLELSDLESLRTWGSLTPGHPEYGLTKFVETTT
CCCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCC
GPLGAGVANAVGMAMAARRERGLLDPDAAPGTSLFDHYIYAIAGDGCMQEGIASEASSLA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEECCHHHHHHHHHHHHHHC
GTQELGNLIMFYDDNRITIEGDTAIAFSENVEARYEAYGWHVQHVDFTNGGTTYEENVEA
CHHHHCCEEEEEECCEEEEECCEEEEECCCCCHHHHHCCEEEEEEEECCCCCCHHHHHHH
LMEAIDNAKTVTDKPSFIRLTTVIGWPIPKLAGLAQVHGAKIGAEGVSALKEKLGFEDKP
HHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
FAIDLEMVQQVRAAFAERGKGLREVWDEKFAAWHDANPDGAALLERMLAHKLPDDLDIPT
EEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
FEPGKMSTRKASGAVLSALGPQLPELWGGSADLAGSNNTTMKGADSFLPEDRCSEKDPGG
CCCCCCCCCHHCCHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCC
PYGRTIHFGVREHAMGGILNGITLAGLTRCYGGTFFVFSDYMRPSVRLAALMKIPSIFVW
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCHHHHHHHHHCCEEEEE
THDSIGVGEDGPTHQPVEHLASYRAIPGLDIVRPADANETAVAWRTIVEHTDRPAGLVLS
ECCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEE
RQDLPTIDRSKYASAEGVARGAYVVCEASAEPKVILIGTGSELSVALEAREKLEADGIAT
CCCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCEEEEHHHHHHHHHCHHHH
RVVSMPCQEWFDEQDEEYRESVLPSSVTARVSVEAGIAMGWAKYVGCKGASVSLEHFGAS
HHHHCCHHHHCCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCCCEEEHHHCCCC
ASGALLFEKFGFTADHVAEVAHTVFME
CCCCHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATELTWTDTDRLAVDTARVLAADAVEKTGNGHPGTAISLAPLGYLLYHKVMSIDPSDPN
CCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCC
WLGRDRFIMSAGHSSLTQYTQLYLAGLGLELSDLESLRTWGSLTPGHPEYGLTKFVETTT
CCCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCC
GPLGAGVANAVGMAMAARRERGLLDPDAAPGTSLFDHYIYAIAGDGCMQEGIASEASSLA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEECCHHHHHHHHHHHHHHC
GTQELGNLIMFYDDNRITIEGDTAIAFSENVEARYEAYGWHVQHVDFTNGGTTYEENVEA
CHHHHCCEEEEEECCEEEEECCEEEEECCCCCHHHHHCCEEEEEEEECCCCCCHHHHHHH
LMEAIDNAKTVTDKPSFIRLTTVIGWPIPKLAGLAQVHGAKIGAEGVSALKEKLGFEDKP
HHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
FAIDLEMVQQVRAAFAERGKGLREVWDEKFAAWHDANPDGAALLERMLAHKLPDDLDIPT
EEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
FEPGKMSTRKASGAVLSALGPQLPELWGGSADLAGSNNTTMKGADSFLPEDRCSEKDPGG
CCCCCCCCCHHCCHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCC
PYGRTIHFGVREHAMGGILNGITLAGLTRCYGGTFFVFSDYMRPSVRLAALMKIPSIFVW
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCHHHHHHHHHCCEEEEE
THDSIGVGEDGPTHQPVEHLASYRAIPGLDIVRPADANETAVAWRTIVEHTDRPAGLVLS
ECCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEE
RQDLPTIDRSKYASAEGVARGAYVVCEASAEPKVILIGTGSELSVALEAREKLEADGIAT
CCCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCEEEEECCCCEEEEHHHHHHHHHCHHHH
RVVSMPCQEWFDEQDEEYRESVLPSSVTARVSVEAGIAMGWAKYVGCKGASVSLEHFGAS
HHHHCCHHHHCCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCCCEEEHHHCCCC
ASGALLFEKFGFTADHVAEVAHTVFME
CCCCHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]