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The map label for this gene is trxA [H]

Identifier: 50843751

GI number: 50843751

Start: 2513992

End: 2514471

Strand: Reverse

Name: trxA [H]

Synonym: PPA2314

Alternate gene names: 50843751

Gene position: 2514471-2513992 (Counterclockwise)

Preceding gene: 50843752

Following gene: 50843750

Centisome position: 98.21

GC content: 59.58

Gene sequence:

>480_bases
GTGGTGCGTGATGCATCCTTCGACCGGGATTTTTCGCACCGGGTGATGGCTGCCTCATGCAGCACTCCGAGAGTCCGCTT
GGCTTTCGTGAACGAGAGGTGCCGTTCGAACCGCCACGACTTAGACTCGTCTGGTCGTCTTAGAAAGGCTGTCATGAACA
ACGTCATCGAGGTCACTGATGCGACCTTCGCTTCCGAGGTTCTCGGTGCCTCCAAGCCGGTCCTCGTCGACTACTGGGCC
GACTGGTGTGCCCCATGCAAACAGCTCTCCCCGATCATCGAGGAGCTTGCTGGGACCTACGGCGACCGGATGGTCTTCGC
TAAGGTCGACACCAACGCCAACACCCGGGTTGCCGCGGAGCAGGGGATCATGTCACTGCCCACCATCCAGGTCTGGCAGG
GTGGCCAGCTCGTCAAGTCGCTGCAAGGCGGCAAGACGAAGAAGGCGCTGGTCAAAATCATCGAAGAGTTTGTCGCCTAA

Upstream 100 bases:

>100_bases
TGACGTTGGGTGACCGGAGTCGGAACACCGTGTCGAGGTACTCAGATGTCCTCAGCGGCGTGTGTGCGAAAAATACCGGC
CTAGGTGGGGTCCGGGTACT

Downstream 100 bases:

>100_bases
GGAGGGATCATGCCGTCTGCCACTAAGAAGGTTTCCCTGGTCCGTCGTAGTGAAGGCCACTACACCGCCACCAATGCTCG
TGGTGGGCAAATTCGGTTTG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MVRDASFDRDFSHRVMAASCSTPRVRLAFVNERCRSNRHDLDSSGRLRKAVMNNVIEVTDATFASEVLGASKPVLVDYWA
DWCAPCKQLSPIIEELAGTYGDRMVFAKVDTNANTRVAAEQGIMSLPTIQVWQGGQLVKSLQGGKTKKALVKIIEEFVA

Sequences:

>Translated_159_residues
MVRDASFDRDFSHRVMAASCSTPRVRLAFVNERCRSNRHDLDSSGRLRKAVMNNVIEVTDATFASEVLGASKPVLVDYWA
DWCAPCKQLSPIIEELAGTYGDRMVFAKVDTNANTRVAAEQGIMSLPTIQVWQGGQLVKSLQGGKTKKALVKIIEEFVA
>Mature_159_residues
MVRDASFDRDFSHRVMAASCSTPRVRLAFVNERCRSNRHDLDSSGRLRKAVMNNVIEVTDATFASEVLGASKPVLVDYWA
DWCAPCKQLSPIIEELAGTYGDRMVFAKVDTNANTRVAAEQGIMSLPTIQVWQGGQLVKSLQGGKTKKALVKIIEEFVA

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=30.9278350515464, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI21361657, Length=100, Percent_Identity=32, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI5031973, Length=111, Percent_Identity=31.5315315315315, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=32.7102803738318, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=35.2941176470588, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI87081747, Length=109, Percent_Identity=30.2752293577982, Blast_Score=71, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17510299, Length=99, Percent_Identity=35.3535353535354, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=29.8969072164948, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=105, Percent_Identity=32.3809523809524, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=82, Percent_Identity=35.3658536585366, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639826, Length=90, Percent_Identity=36.6666666666667, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=31, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24664269, Length=113, Percent_Identity=30.0884955752212, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 17577; Mature: 17577

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRDASFDRDFSHRVMAASCSTPRVRLAFVNERCRSNRHDLDSSGRLRKAVMNNVIEVTD
CCCCCCCCCCHHHHHHEECCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
ATFASEVLGASKPVLVDYWADWCAPCKQLSPIIEELAGTYGDRMVFAKVDTNANTRVAAE
HHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHH
QGIMSLPTIQVWQGGQLVKSLQGGKTKKALVKIIEEFVA
CCCCCCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHC
>Mature Secondary Structure
MVRDASFDRDFSHRVMAASCSTPRVRLAFVNERCRSNRHDLDSSGRLRKAVMNNVIEVTD
CCCCCCCCCCHHHHHHEECCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
ATFASEVLGASKPVLVDYWADWCAPCKQLSPIIEELAGTYGDRMVFAKVDTNANTRVAAE
HHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHH
QGIMSLPTIQVWQGGQLVKSLQGGKTKKALVKIIEEFVA
CCCCCCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9795152; 10671452; 12000953 [H]