Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 50843718

GI number: 50843718

Start: 2473674

End: 2475104

Strand: Direct

Name: mutL [H]

Synonym: PPA2281

Alternate gene names: 50843718

Gene position: 2473674-2475104 (Clockwise)

Preceding gene: 50843717

Following gene: 50843719

Centisome position: 96.62

GC content: 64.01

Gene sequence:

>1431_bases
ATGACCGTGCTCACGACTCTGGAGATCGGCTCCACCATCACCAAAGCCAACGCCTTCCGCATGGAGTCCGGGCTACTGCA
CCACATCGGGCAGGGATTCGCCCCCACCTCGGTGGCCGCCGGCGACGTGCGTATCGGCGCGGATGCCGCGATCGCTCAGA
TGCGTGAGCAATGCGCCTCACCTCCGGCCGCCGGGGAGATCTTCGTGAACTCCTCGGCGGCCGGTGGACTGCGTATGAGC
GTCCATGGCCTCACTCGGTCCATGACGGCCAGGGCTGCCCGCGAAGCGGCTCTGGGCGCCGGGGCCATTGTCACTATGAC
CACCGTCGGGGCAATGGACGAGTTCGACCTGGAAGATCTCCAGGAGAATCGCCCCAGCATCATCTTGCTGGCCGGTGGAG
TCGATGACGGAGAGAAACGCATCGTTGTCGAGAACGCGAAAGTCATTGCGTCCGCCCAGCTTGGGGTGCCAGTGGTCTAT
GCCGGAAATTCCCGAGTGAGGCGGCGGGTCGAGCACATTTTTGTCGATGCCGGCCAGCCGCTGACATGCGTTGACAATGT
CTTCCCTGACGTCGACGTGCTGCGTGTCGAACCGGTGCGCGCCGTCATTCACGACGTCTTCAACGACCACATCACCGCTG
CCCCAGGCATGCACGGCCTAGTTGAGCTGACCAACCACGAGATCCTGCCAACCCCAGGAGCCGTACTGCTCGCCACTGAG
TTGTTCGCCGATGCTGTGGGCGATGCGGTGGTGGTCGACGTTGGCGGTGCCACAACTGACGTTCACAGCGTCACCGACGG
GTCCTCGGAGTGGTCGGCTCGGGTGATCGACCCCGAACCACGTACCAAGAGAACCGTCGAGGGAGACCTCGGCGTCTTCG
TTAACGCACGTCGCGTCGCGGCGATGACTGACGAGGGAGAGGACGAGGAGCGTCTGGAGTGGCTACGCGCCATTCCCAGC
GACGAGCGGGAAGCCGAGGTGACTCGGTGGCTTGCCCGGGAGGCTGTCGAGGCTGGGGTAGGCCGTCACGCCGGGACGGT
GACCGAGATCTTCACCCCGACCGGCAAGACCCAGGTGGTGCGTGGCAAAGACCTCAGCGCGGTCCGCTGGGTGGTGGGAA
CCGGTGGGGCCCTGACTCGAGTGCCGGGCGGTGCGGATATTCTCCGTCGAATCTGTACCGGAGCTGGCGCCCAACTGTTG
CCCAGCCCTGAAGCCACCATTGTCATCGACCGCGACTATCGATTCTCCGCCCTCGGGACGGTAGCCCAGTGCTACCCCGA
CGAGGTCCGTCGTACCTTCGCGGCCTGGATCGAATCCCTCACTGGCAACACAAAACTGCCCAGCGACGAGGGGGTAGGTG
TCAATGATGACGCTGCCCCACCCGACGTGACAAAAAACGACACCCCACACGGGTTGGAAAGCACATCATGA

Upstream 100 bases:

>100_bases
AGACCGGCTTGGACGCCACCTTCGGGCGCGGCACCAAGGGCATCGACGTCCTTGACGCCATCGTGCGCACTATGCGGACC
CGCGCGGAAGCCTGATCGAT

Downstream 100 bases:

>100_bases
ACCGCTCCACTCCCCGGTTGGAGATTTTCGCCGACCGTATCCGCGACAACGCGCGAGCAATCGTCACTCAATGCGCCAAA
CACGGCGTTCAGGTCGCAGC

Product: methylaspartate mutase

Products: L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTVLTTLEIGSTITKANAFRMESGLLHHIGQGFAPTSVAAGDVRIGADAAIAQMREQCASPPAAGEIFVNSSAAGGLRMS
VHGLTRSMTARAAREAALGAGAIVTMTTVGAMDEFDLEDLQENRPSIILLAGGVDDGEKRIVVENAKVIASAQLGVPVVY
AGNSRVRRRVEHIFVDAGQPLTCVDNVFPDVDVLRVEPVRAVIHDVFNDHITAAPGMHGLVELTNHEILPTPGAVLLATE
LFADAVGDAVVVDVGGATTDVHSVTDGSSEWSARVIDPEPRTKRTVEGDLGVFVNARRVAAMTDEGEDEERLEWLRAIPS
DEREAEVTRWLAREAVEAGVGRHAGTVTEIFTPTGKTQVVRGKDLSAVRWVVGTGGALTRVPGGADILRRICTGAGAQLL
PSPEATIVIDRDYRFSALGTVAQCYPDEVRRTFAAWIESLTGNTKLPSDEGVGVNDDAAPPDVTKNDTPHGLESTS

Sequences:

>Translated_476_residues
MTVLTTLEIGSTITKANAFRMESGLLHHIGQGFAPTSVAAGDVRIGADAAIAQMREQCASPPAAGEIFVNSSAAGGLRMS
VHGLTRSMTARAAREAALGAGAIVTMTTVGAMDEFDLEDLQENRPSIILLAGGVDDGEKRIVVENAKVIASAQLGVPVVY
AGNSRVRRRVEHIFVDAGQPLTCVDNVFPDVDVLRVEPVRAVIHDVFNDHITAAPGMHGLVELTNHEILPTPGAVLLATE
LFADAVGDAVVVDVGGATTDVHSVTDGSSEWSARVIDPEPRTKRTVEGDLGVFVNARRVAAMTDEGEDEERLEWLRAIPS
DEREAEVTRWLAREAVEAGVGRHAGTVTEIFTPTGKTQVVRGKDLSAVRWVVGTGGALTRVPGGADILRRICTGAGAQLL
PSPEATIVIDRDYRFSALGTVAQCYPDEVRRTFAAWIESLTGNTKLPSDEGVGVNDDAAPPDVTKNDTPHGLESTS
>Mature_475_residues
TVLTTLEIGSTITKANAFRMESGLLHHIGQGFAPTSVAAGDVRIGADAAIAQMREQCASPPAAGEIFVNSSAAGGLRMSV
HGLTRSMTARAAREAALGAGAIVTMTTVGAMDEFDLEDLQENRPSIILLAGGVDDGEKRIVVENAKVIASAQLGVPVVYA
GNSRVRRRVEHIFVDAGQPLTCVDNVFPDVDVLRVEPVRAVIHDVFNDHITAAPGMHGLVELTNHEILPTPGAVLLATEL
FADAVGDAVVVDVGGATTDVHSVTDGSSEWSARVIDPEPRTKRTVEGDLGVFVNARRVAAMTDEGEDEERLEWLRAIPSD
EREAEVTRWLAREAVEAGVGRHAGTVTEIFTPTGKTQVVRGKDLSAVRWVVGTGGALTRVPGGADILRRICTGAGAQLLP
SPEATIVIDRDYRFSALGTVAQCYPDEVRRTFAAWIESLTGNTKLPSDEGVGVNDDAAPPDVTKNDTPHGLESTS

Specific function: May play a role in glutamate fermentation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006230
- InterPro:   IPR002821 [H]

Pfam domain/function: PF01968 Hydantoinase_A [H]

EC number: 5.4.99.1

Molecular weight: Translated: 50296; Mature: 50165

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLTTLEIGSTITKANAFRMESGLLHHIGQGFAPTSVAAGDVRIGADAAIAQMREQCAS
CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHCC
PPAAGEIFVNSSAAGGLRMSVHGLTRSMTARAAREAALGAGAIVTMTTVGAMDEFDLEDL
CCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHH
QENRPSIILLAGGVDDGEKRIVVENAKVIASAQLGVPVVYAGNSRVRRRVEHIFVDAGQP
HCCCCCEEEEECCCCCCCCEEEEECCEEEEEECCCCEEEECCCHHHHHHHHHHEECCCCC
LTCVDNVFPDVDVLRVEPVRAVIHDVFNDHITAAPGMHGLVELTNHEILPTPGAVLLATE
CCHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCEEEECCCEECCCCCHHHHHHH
LFADAVGDAVVVDVGGATTDVHSVTDGSSEWSARVIDPEPRTKRTVEGDLGVFVNARRVA
HHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCEEEECEEEE
AMTDEGEDEERLEWLRAIPSDEREAEVTRWLAREAVEAGVGRHAGTVTEIFTPTGKTQVV
EECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEE
RGKDLSAVRWVVGTGGALTRVPGGADILRRICTGAGAQLLPSPEATIVIDRDYRFSALGT
ECCCCCEEEEEEECCCCEEECCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHH
VAQCYPDEVRRTFAAWIESLTGNTKLPSDEGVGVNDDAAPPDVTKNDTPHGLESTS
HHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TVLTTLEIGSTITKANAFRMESGLLHHIGQGFAPTSVAAGDVRIGADAAIAQMREQCAS
EEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHCC
PPAAGEIFVNSSAAGGLRMSVHGLTRSMTARAAREAALGAGAIVTMTTVGAMDEFDLEDL
CCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHH
QENRPSIILLAGGVDDGEKRIVVENAKVIASAQLGVPVVYAGNSRVRRRVEHIFVDAGQP
HCCCCCEEEEECCCCCCCCEEEEECCEEEEEECCCCEEEECCCHHHHHHHHHHEECCCCC
LTCVDNVFPDVDVLRVEPVRAVIHDVFNDHITAAPGMHGLVELTNHEILPTPGAVLLATE
CCHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCEEEECCCEECCCCCHHHHHHH
LFADAVGDAVVVDVGGATTDVHSVTDGSSEWSARVIDPEPRTKRTVEGDLGVFVNARRVA
HHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEECCCCCEEEECEEEE
AMTDEGEDEERLEWLRAIPSDEREAEVTRWLAREAVEAGVGRHAGTVTEIFTPTGKTQVV
EECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEE
RGKDLSAVRWVVGTGGALTRVPGGADILRRICTGAGAQLLPSPEATIVIDRDYRFSALGT
ECCCCCEEEEEEECCCCEEECCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHH
VAQCYPDEVRRTFAAWIESLTGNTKLPSDEGVGVNDDAAPPDVTKNDTPHGLESTS
HHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-threo-3-methylaspartate

Specific reaction: L-threo-3-methylaspartate = L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8428631 [H]