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The map label for this gene is cysM [C]

Identifier: 50843715

GI number: 50843715

Start: 2469510

End: 2470931

Strand: Direct

Name: cysM [C]

Synonym: PPA2278

Alternate gene names: 50843715

Gene position: 2469510-2470931 (Clockwise)

Preceding gene: 50843714

Following gene: 50843716

Centisome position: 96.46

GC content: 62.8

Gene sequence:

>1422_bases
ATGAGCAACTCATATGACGACGTCATGGCCCGCCGCAGCGACATCATGCGGCGCGCCCTCGCCCTGGACTATGACAGTTT
TCAACACGGTGACCTCATCTTCGATTACGACGCCCTGATGTCCTCCACTAGCTACAGCCTCGATGACGTCGCACGCATCC
AGGCCGAGACCAAAGTTGGCGACACCCCGCTGTACGAGTTGCACCGTCTCACCGAAGCCGTCCGTGAGATCGCCGGCCCT
GGAAAGGGCGCCCGGATTCTCCTCAAGGACGAGGCTGCTAATGCGTCGGGCAGCTTCAAAGCTCGTCGTGCCTCCCTGAG
CGCCCATGAGGCCCAAGCCAAGGGGTTCGCCGGCATGGTAACGGCAACCAGTGGAAACTACGGCGCTGGCGTCGCCTCCC
AAGCCGCTCAGCGCGGGCTGGCCTGCATCGTCATCCAAGAAATCTACGACTCCCAACACGTCGGCCAACCCGAGATTGTC
GAAAAATCCCGAGCCTGCGAGGCCTACGGCGCAGAAGTGATCAAGCTGACGGTTGGACCGGAACTTTTCTACGTGCTGCT
GCGCACCCTGGAGGACACCGGATACTTCAACGCCAGCCTTTACACCCCCTACGGCATCGCCGGTATCGAAACTCTCGGCG
CCGAGATCGGCCGCGAGGTGCAGCAACGCTACGGACGCCAGCCCGACGCCGTCGTCGTTACTCACGCCGGTGGCGGAAAC
ATCACCGGGACCACCCGCGGCCTGCGCAAGATGGGCTGCGACCAGACCCAGGTCATCGCCGTATCGGTGGATCTCACCGG
GCTGCACATGGCCTCCGACCACGACTTCAACAACAAGTCGTTTACGACCGGCCACACCGGCTTCGGCGTGCCTTTCGCAA
CCTGGCCGGACCGCGTCGACGTCCCGCGCAATGCCGCACGTCCGCTACGTTACATGGACGGCTACCAGCTAGTGTCCCAG
GGCGAGGTCTTCTACATGACCGAGCTTCTCACCAAGATCGAAGGCCTAGAGCGCGGACCGGCCGGCAACACCAGCTTGAC
GGCCGCGGTTGCCATGGCTCGTCAGATGGATCGCGACCAGATCGTTGTCGTCCAAGAGACCGAGTACACCGGCGCTGGAA
AACACCACAACAGCCAGCTGTCATTCGCACGGTCGCGCGGCATCGAGGTTCGGCGCGGGGATCCAGCCGGCAACGTCCCG
GGCAAAGCGATCGTCATTCCTGAACGCCTCGATCAAGTGAGCGTCCACCCACTCGACCTCGACAAGCTGCGTCACAGCTA
CTTGCGCCACGCCAGTCAGATCGTGGCACCAGAGCAATGGGGAGACGCCGAGTTGGAGTTCCTGGCGGCTGAGACCAACA
CCACCACTGACGACGTCCGCCTGATCGGCACTGAGCTGGCGACGCGCACGAAAGGAGCATGA

Upstream 100 bases:

>100_bases
ATCCCAGTTACAGCCACAGCTTCGGCAACACCGTGCCCGAGCTACTGACCATCGGCACCACGCACGAACCCATCACATTT
CACGGGCAGGAGGACCAGTC

Downstream 100 bases:

>100_bases
TGTCCAACCCGGATCAGGAGCGCGTCGAACGCTACGAAGCTCTGCGCACCGAACTCGCCGATCTCGACGACGCCGCCCTC
AAGGAACGCTTCTGGCAATT

Product: putative threonine synthase / cystathionine beta-synthase

Products: cystathionine; H2O

Alternate protein names: Threonine Synthase; Cystathionine Beta-Synthase; Cysteine Synthase; 2-Amino-4-Ketopentanoate Thiolase Beta Subunit; Pyridoxal-5-Phosphate-Dependent Beta Subunit; Pyridoxal-Phosphate Dependent; Threonine Synthase / Cystathionine Beta-Synthase

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSNSYDDVMARRSDIMRRALALDYDSFQHGDLIFDYDALMSSTSYSLDDVARIQAETKVGDTPLYELHRLTEAVREIAGP
GKGARILLKDEAANASGSFKARRASLSAHEAQAKGFAGMVTATSGNYGAGVASQAAQRGLACIVIQEIYDSQHVGQPEIV
EKSRACEAYGAEVIKLTVGPELFYVLLRTLEDTGYFNASLYTPYGIAGIETLGAEIGREVQQRYGRQPDAVVVTHAGGGN
ITGTTRGLRKMGCDQTQVIAVSVDLTGLHMASDHDFNNKSFTTGHTGFGVPFATWPDRVDVPRNAARPLRYMDGYQLVSQ
GEVFYMTELLTKIEGLERGPAGNTSLTAAVAMARQMDRDQIVVVQETEYTGAGKHHNSQLSFARSRGIEVRRGDPAGNVP
GKAIVIPERLDQVSVHPLDLDKLRHSYLRHASQIVAPEQWGDAELEFLAAETNTTTDDVRLIGTELATRTKGA

Sequences:

>Translated_473_residues
MSNSYDDVMARRSDIMRRALALDYDSFQHGDLIFDYDALMSSTSYSLDDVARIQAETKVGDTPLYELHRLTEAVREIAGP
GKGARILLKDEAANASGSFKARRASLSAHEAQAKGFAGMVTATSGNYGAGVASQAAQRGLACIVIQEIYDSQHVGQPEIV
EKSRACEAYGAEVIKLTVGPELFYVLLRTLEDTGYFNASLYTPYGIAGIETLGAEIGREVQQRYGRQPDAVVVTHAGGGN
ITGTTRGLRKMGCDQTQVIAVSVDLTGLHMASDHDFNNKSFTTGHTGFGVPFATWPDRVDVPRNAARPLRYMDGYQLVSQ
GEVFYMTELLTKIEGLERGPAGNTSLTAAVAMARQMDRDQIVVVQETEYTGAGKHHNSQLSFARSRGIEVRRGDPAGNVP
GKAIVIPERLDQVSVHPLDLDKLRHSYLRHASQIVAPEQWGDAELEFLAAETNTTTDDVRLIGTELATRTKGA
>Mature_472_residues
SNSYDDVMARRSDIMRRALALDYDSFQHGDLIFDYDALMSSTSYSLDDVARIQAETKVGDTPLYELHRLTEAVREIAGPG
KGARILLKDEAANASGSFKARRASLSAHEAQAKGFAGMVTATSGNYGAGVASQAAQRGLACIVIQEIYDSQHVGQPEIVE
KSRACEAYGAEVIKLTVGPELFYVLLRTLEDTGYFNASLYTPYGIAGIETLGAEIGREVQQRYGRQPDAVVVTHAGGGNI
TGTTRGLRKMGCDQTQVIAVSVDLTGLHMASDHDFNNKSFTTGHTGFGVPFATWPDRVDVPRNAARPLRYMDGYQLVSQG
EVFYMTELLTKIEGLERGPAGNTSLTAAVAMARQMDRDQIVVVQETEYTGAGKHHNSQLSFARSRGIEVRRGDPAGNVPG
KAIVIPERLDQVSVHPLDLDKLRHSYLRHASQIVAPEQWGDAELEFLAAETNTTTDDVRLIGTELATRTKGA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.22

Molecular weight: Translated: 51405; Mature: 51274

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSYDDVMARRSDIMRRALALDYDSFQHGDLIFDYDALMSSTSYSLDDVARIQAETKVG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHCCCC
DTPLYELHRLTEAVREIAGPGKGARILLKDEAANASGSFKARRASLSAHEAQAKGFAGMV
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
TATSGNYGAGVASQAAQRGLACIVIQEIYDSQHVGQPEIVEKSRACEAYGAEVIKLTVGP
EECCCCCCCCHHHHHHHCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECH
ELFYVLLRTLEDTGYFNASLYTPYGIAGIETLGAEIGREVQQRYGRQPDAVVVTHAGGGN
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
ITGTTRGLRKMGCDQTQVIAVSVDLTGLHMASDHDFNNKSFTTGHTGFGVPFATWPDRVD
CCCCHHHHHHHCCCCEEEEEEEEEEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCC
VPRNAARPLRYMDGYQLVSQGEVFYMTELLTKIEGLERGPAGNTSLTAAVAMARQMDRDQ
CCCCCCCCHHHHCCHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
IVVVQETEYTGAGKHHNSQLSFARSRGIEVRRGDPAGNVPGKAIVIPERLDQVSVHPLDL
EEEEEECCCCCCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCH
DKLRHSYLRHASQIVAPEQWGDAELEFLAAETNTTTDDVRLIGTELATRTKGA
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHEEHHHHHHHHCCCC
>Mature Secondary Structure 
SNSYDDVMARRSDIMRRALALDYDSFQHGDLIFDYDALMSSTSYSLDDVARIQAETKVG
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHCCCC
DTPLYELHRLTEAVREIAGPGKGARILLKDEAANASGSFKARRASLSAHEAQAKGFAGMV
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
TATSGNYGAGVASQAAQRGLACIVIQEIYDSQHVGQPEIVEKSRACEAYGAEVIKLTVGP
EECCCCCCCCHHHHHHHCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECH
ELFYVLLRTLEDTGYFNASLYTPYGIAGIETLGAEIGREVQQRYGRQPDAVVVTHAGGGN
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
ITGTTRGLRKMGCDQTQVIAVSVDLTGLHMASDHDFNNKSFTTGHTGFGVPFATWPDRVD
CCCCHHHHHHHCCCCEEEEEEEEEEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCC
VPRNAARPLRYMDGYQLVSQGEVFYMTELLTKIEGLERGPAGNTSLTAAVAMARQMDRDQ
CCCCCCCCHHHHCCHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
IVVVQETEYTGAGKHHNSQLSFARSRGIEVRRGDPAGNVPGKAIVIPERLDQVSVHPLDL
EEEEEECCCCCCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCH
DKLRHSYLRHASQIVAPEQWGDAELEFLAAETNTTTDDVRLIGTELATRTKGA
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-serine; L-homocysteine

Specific reaction: L-serine + L-homocysteine = cystathionine + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA