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The map label for this gene is cvrA [H]

Identifier: 50843638

GI number: 50843638

Start: 2384892

End: 2387051

Strand: Reverse

Name: cvrA [H]

Synonym: PPA2203

Alternate gene names: 50843638

Gene position: 2387051-2384892 (Counterclockwise)

Preceding gene: 50843646

Following gene: 50843634

Centisome position: 93.23

GC content: 59.77

Gene sequence:

>2160_bases
ATGGCACTTGTACTGGTACTCGCGGTCGGTGCCCAGTGGCTCGGATGGCGGTTACGCCTTCCCGCGCTGCTGTTCCTCCT
CGTGATCGGCTTCGCCCTCGGACAGTGGGTCACTCCCGATGAGATCTTCGGGAGGAAGCTGCTATTCGATGGTGTCAACC
TTTCAGTAGCGATTATCCTCTTCGAGGGGTCACTTGGACTCAAGCTGCGCGAAGTCCGTGACCTCGGGCGACCGATTTTT
CAGCTGTGCACCGTCACCGCAGGGCTGGCGTGGGTTCTCATCACCGGCGCGGCGATGGCATTGGGGTTTGATGGCCGCGT
TTCCCTGCTGCTGGGCGCGATCCTCATCGTCACCGGCCCAACGGTGATTAACCCGATCCTGCGTCAGTTGCGTCCTACCC
GGCGAGTGAGTGCTCTGTTGAGGTGGGAAGGAATCGTCGTCGATCCGCTCGGCGCCATCCTGGCATTACTGGTGTATCAG
GCCATAACCAGCATCGACGGGTCTTCCATCGGGCAAGGCGTCTTGAACCTGGGGCTCACCCTATTGGTCGGGCTGCTCTT
CGCTGGCCCCATCGGGTGGATCGTCACCGCGATGATGAGACGGCACCTCATCCCGGACTTCCTACAAGGCGTGATTTTTG
TCGGGGTCGCCGTTGGGACGTGTGTTGGCGCTAACGTTATTCGGGAGGAATCGGGCCTGGTCGCCGTTACGATGCTCGGC
ATCTACCTGGCGAACCAGCGCAACCTCGAGCTTGAGCCCGTCATCGAGTTCAAGGAACACCTGCAGGTGCTCCTCGTTGG
CGTCCTGTTCATCATGCTTGCAGGACGCGTGACCCCCTCTCAGATCCTCGACATTCTGTCTGCCGGCCTGATTTTCGTTG
CGCTGCTTGTGCTCGTCATTCGGCCCGCTTCGGTGCTGTTGGGGTTGGTCGGCACCGAGACGACCCGTCAAGAACGCACC
CTGATGTCGTTCATGGCCCCGCGAGGAATCGTGGCGGCGTCGGTGGCGTCGATTTTTGCCATGCAGTTCAGTGAGTCCGC
CGACCACGTGCGGGAGCAGGCGAAGCAGATCGCCGCATCTGATCCGGAACATTCCAAGCGGTTGTTCTCCTTTGCTAACC
AGATCGCTGGTATGGCCAGCCAAGTCGACCGACTCGTACCGCTGGTCTTCCTCGTGATCGTCTGTACTGTCGCTATCTAC
GGTCTGGGTATTGGAAGACTCGCCGAGAAACTCGGGCTGGCCTCTGCGAGTCCGCGTGGAGTGATGTTTGCGGGGTCACC
TGCCTGGACTATCGATACCGCCAAGACCCTACGCGATTTCGATGTGCCGACTCTCATCGTCACCCGACGTGCGTATGACC
TGTACGCGGTACGTAAAGCTGGTCTGAGATGCGAGGCTGCGGATTTTCTATCTGAATATGCCACCGAAGATATGGACCTT
GCCGGAATCGCTTCGATGGTGGCATGCACGCCGGATGACGACACCAATTCAATTGCGTCCGTGCACTATCGGCGTGCGTT
GGGACGGGCGAACGTCTTCCAGCTGGAGCGGATGGATGAGAGAGATGACGGTGACGCCACTACCGGCACGGCGCAGATCC
TCAAAGCAAGGACGGCCTTTGACCCCCCGACTTCGCACTCAGCGATGGACAAGATGTGGCGTAATGGCAAGCGGGTACGA
CGGGTCAAACTGGACGAAAACCGCAACTGGGAAATGTTCCGGGAGGCCATGCCGGACGCTGTGGTGATGTTTGTTGTTAA
GCCTTCTTCGGTGAACGTTGCCACCAACGGGATGAGTGCTCCCAAAGAGGACGACACCATCATTTATCTAGGTGACGAGT
GGAAAGACGCTCCGGAGCCTGTTGCCGCTCAGGAGGAGCAGCCGAGGCGACAGACGATGTCGGTGCCATCTTCAGAAGAG
GCGGTGCGAGATCGCATTGACGCCGACCGCAGAGCGGCTGAAGGGAAGAATAAAGCGGCCGCTAGCGCGACTGCTGGTGA
TCCGGCTGACACCACAGTTGACCATGGTGACAAGGGTGAGAAGCCTGAGCAGACCTCGGAGGCTAGTGGGGGAGTCGAGG
ATCCGGTTCGGCCGCGATTCGATGAGTTGAGCCCGGGAAGGCCGTCGCCGGTTTCTGCGGACTCACCGAGCGAGTGGTGA

Upstream 100 bases:

>100_bases
CTTTCGTCTATATGCCTACGGTGTCCACTCCGTAGTGGATCCCGCGTGGGAAAACCGCCGTTATCCCGGTTAGAGTGCTC
AGGTGGATGCGGCAACATAC

Downstream 100 bases:

>100_bases
GGGACAGCTGAGGACGTTCGTTCCCCTTGGTGCCGTCCCCAGCTCCACTCACACGGCCTGGCGCTTCCGGACAACTCTCT
CCGCCGTCCACACGGTGGCT

Product: putative Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MALVLVLAVGAQWLGWRLRLPALLFLLVIGFALGQWVTPDEIFGRKLLFDGVNLSVAIILFEGSLGLKLREVRDLGRPIF
QLCTVTAGLAWVLITGAAMALGFDGRVSLLLGAILIVTGPTVINPILRQLRPTRRVSALLRWEGIVVDPLGAILALLVYQ
AITSIDGSSIGQGVLNLGLTLLVGLLFAGPIGWIVTAMMRRHLIPDFLQGVIFVGVAVGTCVGANVIREESGLVAVTMLG
IYLANQRNLELEPVIEFKEHLQVLLVGVLFIMLAGRVTPSQILDILSAGLIFVALLVLVIRPASVLLGLVGTETTRQERT
LMSFMAPRGIVAASVASIFAMQFSESADHVREQAKQIAASDPEHSKRLFSFANQIAGMASQVDRLVPLVFLVIVCTVAIY
GLGIGRLAEKLGLASASPRGVMFAGSPAWTIDTAKTLRDFDVPTLIVTRRAYDLYAVRKAGLRCEAADFLSEYATEDMDL
AGIASMVACTPDDDTNSIASVHYRRALGRANVFQLERMDERDDGDATTGTAQILKARTAFDPPTSHSAMDKMWRNGKRVR
RVKLDENRNWEMFREAMPDAVVMFVVKPSSVNVATNGMSAPKEDDTIIYLGDEWKDAPEPVAAQEEQPRRQTMSVPSSEE
AVRDRIDADRRAAEGKNKAAASATAGDPADTTVDHGDKGEKPEQTSEASGGVEDPVRPRFDELSPGRPSPVSADSPSEW

Sequences:

>Translated_719_residues
MALVLVLAVGAQWLGWRLRLPALLFLLVIGFALGQWVTPDEIFGRKLLFDGVNLSVAIILFEGSLGLKLREVRDLGRPIF
QLCTVTAGLAWVLITGAAMALGFDGRVSLLLGAILIVTGPTVINPILRQLRPTRRVSALLRWEGIVVDPLGAILALLVYQ
AITSIDGSSIGQGVLNLGLTLLVGLLFAGPIGWIVTAMMRRHLIPDFLQGVIFVGVAVGTCVGANVIREESGLVAVTMLG
IYLANQRNLELEPVIEFKEHLQVLLVGVLFIMLAGRVTPSQILDILSAGLIFVALLVLVIRPASVLLGLVGTETTRQERT
LMSFMAPRGIVAASVASIFAMQFSESADHVREQAKQIAASDPEHSKRLFSFANQIAGMASQVDRLVPLVFLVIVCTVAIY
GLGIGRLAEKLGLASASPRGVMFAGSPAWTIDTAKTLRDFDVPTLIVTRRAYDLYAVRKAGLRCEAADFLSEYATEDMDL
AGIASMVACTPDDDTNSIASVHYRRALGRANVFQLERMDERDDGDATTGTAQILKARTAFDPPTSHSAMDKMWRNGKRVR
RVKLDENRNWEMFREAMPDAVVMFVVKPSSVNVATNGMSAPKEDDTIIYLGDEWKDAPEPVAAQEEQPRRQTMSVPSSEE
AVRDRIDADRRAAEGKNKAAASATAGDPADTTVDHGDKGEKPEQTSEASGGVEDPVRPRFDELSPGRPSPVSADSPSEW
>Mature_718_residues
ALVLVLAVGAQWLGWRLRLPALLFLLVIGFALGQWVTPDEIFGRKLLFDGVNLSVAIILFEGSLGLKLREVRDLGRPIFQ
LCTVTAGLAWVLITGAAMALGFDGRVSLLLGAILIVTGPTVINPILRQLRPTRRVSALLRWEGIVVDPLGAILALLVYQA
ITSIDGSSIGQGVLNLGLTLLVGLLFAGPIGWIVTAMMRRHLIPDFLQGVIFVGVAVGTCVGANVIREESGLVAVTMLGI
YLANQRNLELEPVIEFKEHLQVLLVGVLFIMLAGRVTPSQILDILSAGLIFVALLVLVIRPASVLLGLVGTETTRQERTL
MSFMAPRGIVAASVASIFAMQFSESADHVREQAKQIAASDPEHSKRLFSFANQIAGMASQVDRLVPLVFLVIVCTVAIYG
LGIGRLAEKLGLASASPRGVMFAGSPAWTIDTAKTLRDFDVPTLIVTRRAYDLYAVRKAGLRCEAADFLSEYATEDMDLA
GIASMVACTPDDDTNSIASVHYRRALGRANVFQLERMDERDDGDATTGTAQILKARTAFDPPTSHSAMDKMWRNGKRVRR
VKLDENRNWEMFREAMPDAVVMFVVKPSSVNVATNGMSAPKEDDTIIYLGDEWKDAPEPVAAQEEQPRRQTMSVPSSEEA
VRDRIDADRRAAEGKNKAAASATAGDPADTTVDHGDKGEKPEQTSEASGGVEDPVRPRFDELSPGRPSPVSADSPSEW

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 77767; Mature: 77636

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVLVLAVGAQWLGWRLRLPALLFLLVIGFALGQWVTPDEIFGRKLLFDGVNLSVAIIL
CCEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHCCCCCEEEEEEE
FEGSLGLKLREVRDLGRPIFQLCTVTAGLAWVLITGAAMALGFDGRVSLLLGAILIVTGP
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCH
TVINPILRQLRPTRRVSALLRWEGIVVDPLGAILALLVYQAITSIDGSSIGQGVLNLGLT
HHHHHHHHHHCHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LLVGLLFAGPIGWIVTAMMRRHLIPDFLQGVIFVGVAVGTCVGANVIREESGLVAVTMLG
HHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHH
IYLANQRNLELEPVIEFKEHLQVLLVGVLFIMLAGRVTPSQILDILSAGLIFVALLVLVI
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RPASVLLGLVGTETTRQERTLMSFMAPRGIVAASVASIFAMQFSESADHVREQAKQIAAS
HHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPEHSKRLFSFANQIAGMASQVDRLVPLVFLVIVCTVAIYGLGIGRLAEKLGLASASPRG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
VMFAGSPAWTIDTAKTLRDFDVPTLIVTRRAYDLYAVRKAGLRCEAADFLSEYATEDMDL
EEEECCCCEEEHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCH
AGIASMVACTPDDDTNSIASVHYRRALGRANVFQLERMDERDDGDATTGTAQILKARTAF
HHHHHHHEECCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
DPPTSHSAMDKMWRNGKRVRRVKLDENRNWEMFREAMPDAVVMFVVKPSSVNVATNGMSA
CCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCEEEECCCCC
PKEDDTIIYLGDEWKDAPEPVAAQEEQPRRQTMSVPSSEEAVRDRIDADRRAAEGKNKAA
CCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHC
ASATAGDPADTTVDHGDKGEKPEQTSEASGGVEDPVRPRFDELSPGRPSPVSADSPSEW
CCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALVLVLAVGAQWLGWRLRLPALLFLLVIGFALGQWVTPDEIFGRKLLFDGVNLSVAIIL
CEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHCCCCCEEEEEEE
FEGSLGLKLREVRDLGRPIFQLCTVTAGLAWVLITGAAMALGFDGRVSLLLGAILIVTGP
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCH
TVINPILRQLRPTRRVSALLRWEGIVVDPLGAILALLVYQAITSIDGSSIGQGVLNLGLT
HHHHHHHHHHCHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LLVGLLFAGPIGWIVTAMMRRHLIPDFLQGVIFVGVAVGTCVGANVIREESGLVAVTMLG
HHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHH
IYLANQRNLELEPVIEFKEHLQVLLVGVLFIMLAGRVTPSQILDILSAGLIFVALLVLVI
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RPASVLLGLVGTETTRQERTLMSFMAPRGIVAASVASIFAMQFSESADHVREQAKQIAAS
HHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPEHSKRLFSFANQIAGMASQVDRLVPLVFLVIVCTVAIYGLGIGRLAEKLGLASASPRG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
VMFAGSPAWTIDTAKTLRDFDVPTLIVTRRAYDLYAVRKAGLRCEAADFLSEYATEDMDL
EEEECCCCEEEHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCH
AGIASMVACTPDDDTNSIASVHYRRALGRANVFQLERMDERDDGDATTGTAQILKARTAF
HHHHHHHEECCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
DPPTSHSAMDKMWRNGKRVRRVKLDENRNWEMFREAMPDAVVMFVVKPSSVNVATNGMSA
CCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCEEEECCCCC
PKEDDTIIYLGDEWKDAPEPVAAQEEQPRRQTMSVPSSEEAVRDRIDADRRAAEGKNKAA
CCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHC
ASATAGDPADTTVDHGDKGEKPEQTSEASGGVEDPVRPRFDELSPGRPSPVSADSPSEW
CCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]