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The map label for this gene is hutU [H]

Identifier: 50843603

GI number: 50843603

Start: 2346204

End: 2347742

Strand: Direct

Name: hutU [H]

Synonym: PPA2166

Alternate gene names: 50843603

Gene position: 2346204-2347742 (Clockwise)

Preceding gene: 50843602

Following gene: 50843604

Centisome position: 91.64

GC content: 61.08

Gene sequence:

>1539_bases
TTGGTCGTCATGAGCGGTCACCCGCTGGGGCTTTTCCCGTCGCGCCCAGAATCCCCGCGTGTCATCATCACCAACTCCCT
CATGGTCGGCCATTTCGACAACCAGAAGGACTGGGAGATCTGTGAGGAGATGGGGGTGGCGAACTATGGACAGATGACCG
CCGGCGGCTGGATGTATATTGGCCCGCAGGGCATCGTCCATGGCACCTTCAACACCATTCTCAACGCCGGAAGAATCCGG
CTGGGAATTCCCGCTGACGGGGATCTCTCCGGGGTGCTTTTTGTCTCGTCAGGTCTCGGTGGCATGTCCGGGGCCCAGCC
CAAGGCCGCCGAGATCGCCCACCCCGTCGGGATCATTGCCGAGGTCGACATGTCGCGCATCCAGACCCGACTGGATCAGG
GTTGGGTGGGTCACGTCTCTGACGACCTTGACGAAGTTTTCGCGCTAGCCAAAAAACACATTGACGAACACACCCCAATC
TCCATCGCCTACCACGGCAACATCGTCGATCTGTTGAAGTACGCCGTCGACAACAACATCAACATCCCGCTGCTATCGGA
CCAGACCTCCTGTCATGCCGCTTATGACGGCGGTTACTGCCCGCAGGGGCTGACCTTCGAGCAGCGCACCGAACTGTTGG
CCCGCGATCGTGACGAATACGCCCGCCGCGTCAACGAATCCTTGCGCACGCACTACGAGCTCATCCGCACCCTCACCGAC
CGCGGCACCTATTTCTTCGATTACGGCAACGCCTTCATGGCCACCGTCTTTGAGTCCGGGGTGACCGAGATCGCCAAGGA
CGGGGACGCCCGCAACGGGTTCATCTGGCCGTCCTACGTTGAGGACATCATGGGCCCGGAACTCTTCGACTACGGCTACG
GGCCGTTCCGGTGGGTGTGCCTGTCCGGCAAGCGCGAGGACCTCATTGCCACCGACCATGCCGCGATGGATTGCATCGAC
CCGAATCGCCGCGGCCAGGATCGCGATAACTACATCTGGATCCGTGACGCCGAGGCTAACAACCTGGTCGTGGGCACCCA
GGCGCGCATCCTCTACCAAGATGCTCAAGGCCGTATGGACATCGCCTTGCGATTCAACAAGATGGTCCGCGATGGCGAGA
TCGGACCGGTCATGCTGGGACGTGATCACCACGATGTCTCCGGGACTGACTCTCCCTTCCGTGAGACCGCCAACATCAAG
GACGGCTCTAACGTCATGGCTGATATGGCTACCCAGTGCTTCGCCGGCAATGCCGCCCGCGGCATGAGTCTGGTGACCCT
ACATAACGGCGGCGGAACCGGCATTGGTAACGCCATCAACGGCGGGTTCGGGCTCGTCCTGGACGGCTCTGAGCGGGTCG
ACAACGTCATTCGCAGTTCTCTGCTGTGGGATGTCATGTGCGGGGTGGCGCGACGCGGCTGGGCCCGCAACGCTCACTCC
ATCGAGACGGCCACCGAGTTCAACCACGAGCACAACGACGCCCAAATCACCCTGCCCTACCTGGTAGATGACGCCCTTAT
TGACGGATTGGTGAAGTGA

Upstream 100 bases:

>100_bases
CGAACTCGTCACCTATGGCGAGACCGGTAGCGTCTGCCAGAATTAGCTGCAGTACCGGCTCATCAAGAAATACCTCTCCC
AGCTCACCGAGGACACCACC

Downstream 100 bases:

>100_bases
TGACGACCTGGACTGCTGCCAGTCTGCTGGCTGAAATCGCCGCGATTGGACGCAACGAGGACGGCTCTTATTCGCGGTTT
TGCCTACGTCCCGAGGAGGT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MVVMSGHPLGLFPSRPESPRVIITNSLMVGHFDNQKDWEICEEMGVANYGQMTAGGWMYIGPQGIVHGTFNTILNAGRIR
LGIPADGDLSGVLFVSSGLGGMSGAQPKAAEIAHPVGIIAEVDMSRIQTRLDQGWVGHVSDDLDEVFALAKKHIDEHTPI
SIAYHGNIVDLLKYAVDNNINIPLLSDQTSCHAAYDGGYCPQGLTFEQRTELLARDRDEYARRVNESLRTHYELIRTLTD
RGTYFFDYGNAFMATVFESGVTEIAKDGDARNGFIWPSYVEDIMGPELFDYGYGPFRWVCLSGKREDLIATDHAAMDCID
PNRRGQDRDNYIWIRDAEANNLVVGTQARILYQDAQGRMDIALRFNKMVRDGEIGPVMLGRDHHDVSGTDSPFRETANIK
DGSNVMADMATQCFAGNAARGMSLVTLHNGGGTGIGNAINGGFGLVLDGSERVDNVIRSSLLWDVMCGVARRGWARNAHS
IETATEFNHEHNDAQITLPYLVDDALIDGLVK

Sequences:

>Translated_512_residues
MVVMSGHPLGLFPSRPESPRVIITNSLMVGHFDNQKDWEICEEMGVANYGQMTAGGWMYIGPQGIVHGTFNTILNAGRIR
LGIPADGDLSGVLFVSSGLGGMSGAQPKAAEIAHPVGIIAEVDMSRIQTRLDQGWVGHVSDDLDEVFALAKKHIDEHTPI
SIAYHGNIVDLLKYAVDNNINIPLLSDQTSCHAAYDGGYCPQGLTFEQRTELLARDRDEYARRVNESLRTHYELIRTLTD
RGTYFFDYGNAFMATVFESGVTEIAKDGDARNGFIWPSYVEDIMGPELFDYGYGPFRWVCLSGKREDLIATDHAAMDCID
PNRRGQDRDNYIWIRDAEANNLVVGTQARILYQDAQGRMDIALRFNKMVRDGEIGPVMLGRDHHDVSGTDSPFRETANIK
DGSNVMADMATQCFAGNAARGMSLVTLHNGGGTGIGNAINGGFGLVLDGSERVDNVIRSSLLWDVMCGVARRGWARNAHS
IETATEFNHEHNDAQITLPYLVDDALIDGLVK
>Mature_512_residues
MVVMSGHPLGLFPSRPESPRVIITNSLMVGHFDNQKDWEICEEMGVANYGQMTAGGWMYIGPQGIVHGTFNTILNAGRIR
LGIPADGDLSGVLFVSSGLGGMSGAQPKAAEIAHPVGIIAEVDMSRIQTRLDQGWVGHVSDDLDEVFALAKKHIDEHTPI
SIAYHGNIVDLLKYAVDNNINIPLLSDQTSCHAAYDGGYCPQGLTFEQRTELLARDRDEYARRVNESLRTHYELIRTLTD
RGTYFFDYGNAFMATVFESGVTEIAKDGDARNGFIWPSYVEDIMGPELFDYGYGPFRWVCLSGKREDLIATDHAAMDCID
PNRRGQDRDNYIWIRDAEANNLVVGTQARILYQDAQGRMDIALRFNKMVRDGEIGPVMLGRDHHDVSGTDSPFRETANIK
DGSNVMADMATQCFAGNAARGMSLVTLHNGGGTGIGNAINGGFGLVLDGSERVDNVIRSSLLWDVMCGVARRGWARNAHS
IETATEFNHEHNDAQITLPYLVDDALIDGLVK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=518, Percent_Identity=46.7181467181467, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI260306182, Length=578, Percent_Identity=41.8685121107266, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71997891, Length=520, Percent_Identity=46.1538461538462, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 56291; Mature: 56291

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVMSGHPLGLFPSRPESPRVIITNSLMVGHFDNQKDWEICEEMGVANYGQMTAGGWMYI
CEEECCCCCCCCCCCCCCCEEEEECCEEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEE
GPQGIVHGTFNTILNAGRIRLGIPADGDLSGVLFVSSGLGGMSGAQPKAAEIAHPVGIIA
CCCCEEEECHHHHHCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCEEE
EVDMSRIQTRLDQGWVGHVSDDLDEVFALAKKHIDEHTPISIAYHGNIVDLLKYAVDNNI
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCC
NIPLLSDQTSCHAAYDGGYCPQGLTFEQRTELLARDRDEYARRVNESLRTHYELIRTLTD
CEEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
RGTYFFDYGNAFMATVFESGVTEIAKDGDARNGFIWPSYVEDIMGPELFDYGYGPFRWVC
CCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHCCCCCEEEEE
LSGKREDLIATDHAAMDCIDPNRRGQDRDNYIWIRDAEANNLVVGTQARILYQDAQGRMD
ECCCCCCEEECCCCHHCCCCCCCCCCCCCCEEEEEECCCCCEEEECCEEEEEECCCCCEE
IALRFNKMVRDGEIGPVMLGRDHHDVSGTDSPFRETANIKDGSNVMADMATQCFAGNAAR
EEEEEHHHHCCCCCCCEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCC
GMSLVTLHNGGGTGIGNAINGGFGLVLDGSERVDNVIRSSLLWDVMCGVARRGWARNAHS
CEEEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IETATEFNHEHNDAQITLPYLVDDALIDGLVK
CHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVMSGHPLGLFPSRPESPRVIITNSLMVGHFDNQKDWEICEEMGVANYGQMTAGGWMYI
CEEECCCCCCCCCCCCCCCEEEEECCEEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEE
GPQGIVHGTFNTILNAGRIRLGIPADGDLSGVLFVSSGLGGMSGAQPKAAEIAHPVGIIA
CCCCEEEECHHHHHCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCEEE
EVDMSRIQTRLDQGWVGHVSDDLDEVFALAKKHIDEHTPISIAYHGNIVDLLKYAVDNNI
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCC
NIPLLSDQTSCHAAYDGGYCPQGLTFEQRTELLARDRDEYARRVNESLRTHYELIRTLTD
CEEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
RGTYFFDYGNAFMATVFESGVTEIAKDGDARNGFIWPSYVEDIMGPELFDYGYGPFRWVC
CCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHCCCCCEEEEE
LSGKREDLIATDHAAMDCIDPNRRGQDRDNYIWIRDAEANNLVVGTQARILYQDAQGRMD
ECCCCCCEEECCCCHHCCCCCCCCCCCCCCEEEEEECCCCCEEEECCEEEEEECCCCCEE
IALRFNKMVRDGEIGPVMLGRDHHDVSGTDSPFRETANIKDGSNVMADMATQCFAGNAAR
EEEEEHHHHCCCCCCCEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCC
GMSLVTLHNGGGTGIGNAINGGFGLVLDGSERVDNVIRSSLLWDVMCGVARRGWARNAHS
CEEEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IETATEFNHEHNDAQITLPYLVDDALIDGLVK
CHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA