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The map label for this gene is fkbP [H]

Identifier: 50843600

GI number: 50843600

Start: 2343229

End: 2343594

Strand: Direct

Name: fkbP [H]

Synonym: PPA2163

Alternate gene names: 50843600

Gene position: 2343229-2343594 (Clockwise)

Preceding gene: 50843599

Following gene: 50843602

Centisome position: 91.52

GC content: 60.93

Gene sequence:

>366_bases
ATGAGCAAGCCCGAAGTGACCCTGCCCGATTCCGCCCCCGACGACCTCGTCGTTGAGGACATCACCATCGGCGACGGCCC
TGAAGCGTCCGCTGGCAACCTCGTCGAAGTGCACTACGTCGGCGTGGCCTTAAGCAATGGTCGTGAGTTCGATTCTTCCT
GGAACCGCGGTGAGCCGCTGACCTTCCAACTAGGGGCTGGCCAGGTGATCCCCGGGTGGGATGAAGGTGTCCAAGGTATG
AAGGTCGGTGGACGACGCAAACTCGTCATCCCCCACCACCTTGCTTACGGTCCGCAAGGAATCTCCGGTGTGATCGCTGG
CGGTGAGACGCTGGTCTTCGTCTGCGACCTTGTCAACGTCATCTGA

Upstream 100 bases:

>100_bases
GGCTGATCGACGTCGAGGACTGAACCCTGGGAGCCTGGGCGGTCCAGCATGACTGCTCAGGCTCATTACCAAAACGCGTC
GATCCCGTAGGGTTGTCGTC

Downstream 100 bases:

>100_bases
CGTGACCCCCGCTCAAGCAGTCTTCGCGCCCGGGCCCTCATAGGGTCCGGGCGTCGCGCGGTAGCTGAGCCCGAAACCGC
GCGGAAAAGCTGTGCCTCCG

Product: FK506-binding protein/peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 121; Mature: 120

Protein sequence:

>121_residues
MSKPEVTLPDSAPDDLVVEDITIGDGPEASAGNLVEVHYVGVALSNGREFDSSWNRGEPLTFQLGAGQVIPGWDEGVQGM
KVGGRRKLVIPHHLAYGPQGISGVIAGGETLVFVCDLVNVI

Sequences:

>Translated_121_residues
MSKPEVTLPDSAPDDLVVEDITIGDGPEASAGNLVEVHYVGVALSNGREFDSSWNRGEPLTFQLGAGQVIPGWDEGVQGM
KVGGRRKLVIPHHLAYGPQGISGVIAGGETLVFVCDLVNVI
>Mature_120_residues
SKPEVTLPDSAPDDLVVEDITIGDGPEASAGNLVEVHYVGVALSNGREFDSSWNRGEPLTFQLGAGQVIPGWDEGVQGMK
VGGRRKLVIPHHLAYGPQGISGVIAGGETLVFVCDLVNVI

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=93, Percent_Identity=47.3118279569892, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI17149844, Length=93, Percent_Identity=47.3118279569892, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI17149842, Length=93, Percent_Identity=47.3118279569892, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI17149836, Length=104, Percent_Identity=45.1923076923077, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI4503725, Length=104, Percent_Identity=45.1923076923077, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI150010552, Length=96, Percent_Identity=39.5833333333333, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI4758380, Length=104, Percent_Identity=41.3461538461538, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI192448443, Length=92, Percent_Identity=40.2173913043478, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI224809329, Length=98, Percent_Identity=44.8979591836735, Blast_Score=73, Evalue=5e-14,
Organism=Homo sapiens, GI224809327, Length=98, Percent_Identity=44.8979591836735, Blast_Score=73, Evalue=5e-14,
Organism=Homo sapiens, GI4758384, Length=98, Percent_Identity=44.8979591836735, Blast_Score=73, Evalue=5e-14,
Organism=Homo sapiens, GI224809331, Length=99, Percent_Identity=44.4444444444444, Blast_Score=72, Evalue=7e-14,
Organism=Homo sapiens, GI8923659, Length=95, Percent_Identity=41.0526315789474, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI33469985, Length=93, Percent_Identity=37.6344086021505, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI7706131, Length=93, Percent_Identity=36.5591397849462, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI219842220, Length=79, Percent_Identity=41.7721518987342, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI206725547, Length=94, Percent_Identity=40.4255319148936, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789745, Length=105, Percent_Identity=46.6666666666667, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI87082390, Length=112, Percent_Identity=39.2857142857143, Blast_Score=68, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71993519, Length=89, Percent_Identity=47.1910112359551, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540882, Length=116, Percent_Identity=40.5172413793103, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17561782, Length=88, Percent_Identity=45.4545454545455, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561778, Length=94, Percent_Identity=40.4255319148936, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=103, Percent_Identity=52.4271844660194, Blast_Score=101, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6323566, Length=105, Percent_Identity=48.5714285714286, Blast_Score=96, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323482, Length=118, Percent_Identity=44.0677966101695, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=107, Percent_Identity=43.9252336448598, Blast_Score=89, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281363946, Length=108, Percent_Identity=47.2222222222222, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17352457, Length=108, Percent_Identity=47.2222222222222, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24647110, Length=101, Percent_Identity=47.5247524752475, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24655568, Length=101, Percent_Identity=45.5445544554455, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356629, Length=67, Percent_Identity=58.2089552238806, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583150, Length=117, Percent_Identity=39.3162393162393, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 12692; Mature: 12561

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPEVTLPDSAPDDLVVEDITIGDGPEASAGNLVEVHYVGVALSNGREFDSSWNRGEPL
CCCCCEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCE
TFQLGAGQVIPGWDEGVQGMKVGGRRKLVIPHHLAYGPQGISGVIAGGETLVFVCDLVNV
EEECCCCCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCEEEEECCCEEEEEEEHHHC
I
C
>Mature Secondary Structure 
SKPEVTLPDSAPDDLVVEDITIGDGPEASAGNLVEVHYVGVALSNGREFDSSWNRGEPL
CCCCEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCE
TFQLGAGQVIPGWDEGVQGMKVGGRRKLVIPHHLAYGPQGISGVIAGGETLVFVCDLVNV
EEECCCCCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCEEEEECCCEEEEEEEHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1381710 [H]