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The map label for this gene is pbpG [H]

Identifier: 50843587

GI number: 50843587

Start: 2331304

End: 2333847

Strand: Direct

Name: pbpG [H]

Synonym: PPA2149

Alternate gene names: 50843587

Gene position: 2331304-2333847 (Clockwise)

Preceding gene: 50843584

Following gene: 50843588

Centisome position: 91.06

GC content: 59.08

Gene sequence:

>2544_bases
ATGTCTGAAGCCTCACGTATTCTTGGGTACATGCGCTCAGACAGGCACGGCAAGCTCTACCCCCTGGCCATGTTCGGAAT
CGTAAGTATCCTGACCGGACTGCTAATGGCTGGATTCGTTGTGCCCCTGGCGGCTTTAACCGGCGGAACGGCCAAGATGG
TTGCCAGTAGCATGGAGGACCTACCTCCCGAATTGATGAGCACACCGCAGGCTCAAAAGTCCCACATTCTGATGGCCGAT
GGATCGGTACTAGCCACCTTCTACGACGAGAACCGCGAATACGTTCCGTTGTCAAAGATCTCCAAGCAGATGCAAACGGC
CCAGGTCGCTATCGAGGACAACCGATTCTTCTCCCATGGTGCGATCGACCTCAAAGGCACCGCTCGCGCCCTAGCGACAA
ACATCGCCGGATCAGCCCGGCAGGGCGGATCAACTCTGACCCAGCAGTACGTCAAGCAGATCCGTATCGAGGCTGCCGTA
GCTGCGGGCAATGAGGAGGGCGTGCAAGCCGCCCAGGAGCCGACGATCACCCGAAAGATACAAGAGTTGCGCTATGCGGT
GGCTATGGAGAAGAAGCTCTCTAAGAAACAGATCCTGGAGCGCTACCTCAATATCGCCTATTTCGGTGACGGTGCCTACG
GCGTCGAGTCTGCAGCTCATCACTACTTTGGGACCACAGCCGCCAACCTTGACCTCGCCCAGTCGGCGATGCTAGCTGGC
CTGGTACAGAACCCGGTCGCCTACGACCCAGTAAACCACCCAGAGGCAGCCATGAACCGCCGCAATATCGTGCTGGCACG
TATGGCCCAACTTAACCTCATCAGCGCTGACCAAGCTCGGAAGGCCGAGGCGACCGTCTTCGACAAGTCGAAGGTCTTTT
ATCCGAAAAACGGCTGCATCTCATCGAAGTACCCGTTCATCTGCGACTACGCGTATCGCAGCTTGTTGCAGATGCCGAGT
CTGGGCAAGAACCCCGAGGAGCGGGCCAAGATGGTCAAGCGTGGTGGATTGACAATCCAGACGAGTATTGACCCAAAGGT
TCAGGATGCCGCCCAGAACGCCGTCTCGAACGTCGTCGGGCCCAAGGACCCAGTTCTTGCCGGAACAGCCATCGTCCAGC
CGGGCACCGGCTTGCTCATGGCGATGGCACAGTCTCGTCCCATCATGGGCGACAAGCCCGGGCAAACCTACTACAACTAC
ATGGCACCGGCCTCAATGGGCGGAGCCACTGGTTTCCAGGCAGGGTCGACTTTCAAGGCCTTCACGACGGCTGCGGCCAT
TGCCAAGGGCATACCCATGAGCAAGCATTACACCGCATCCTCTCCCATGGACTTCACCGGCGAAAAGTTCACCAGCTGTA
AGGGCACCTTTAAGTCGGGGCCGTTCCGGGTGCGCAACTCAACCGGACACTCGTGGAACATCGGCTTGCGTGAGGCGGCC
GCGTGGTCGGTTAACACCTACTTTGTCCAGCTAGAGCAGGACGTCGGTATGTGCGGGGTCACCAAAATGGCTCAGGACAG
TGGCGTGAAACTCTCTAGCGGTAAGGACATCGTCAAGACCTTCCAGAAGGTGCCATCGTTTACCCTCGGTACTGCTTATG
TGTCCCCACTGTCCATGGCTTCGTCCTATGCGTCCTTCGCCTCACGTGGCATTCAGTGCGACCCCATTATTCTCACGTCG
GTTAAGAATCGCGATGGTTCACCTCTTAAGGTCCCGACCGGCAATTGCAAGCGAGTCATGCCGCAGAAGGTTGCTGACGG
CGTTAACTCGGTGCTTTCAGGTGTCATGGACGCCACGGGTATGCCCGCGAGGATTCCAGGTGGTTATCCGCAGGCCGGCA
AGACAGGTACCACCGACGCCCATGAGGCTGCCTGGTTCGACGGGTATACCCCGCAGGCTGCCGGTGTAGCGATGATCGCT
GCCGATGGTGGAAACTCCTACTTCCGTGGCGATAAGTCCCGCTCGATCAAGGGCATCCGGACCTCTACCGGGGTCTACCT
CAACGGTTCTGGTGGTAGCGACGCCGGCAAGATCTACCGTGCGGCGATGGCCGGCGCCCTCCAAGGCAAGCCCAAGACAG
AGTTCGTAGCTCCCACCGACGAGGTGCGCTACGGCAAGCTCATCAAGATTCCCAGCACTGACGGGATGACCTATCCCCAG
GCCAAAGCTGCCATTCTTAAGGCGGGATTCCGCACCAAAGTGTGGCATGTATGGGACGACTCAGAGCCCGGTACCTACCT
CGGCACGGATCCCGAGGGGTCAGCCCACGCCGGAGCCGCCGTCACCCTCAAAATATCGAAGGGCCCGAAGCCAGCCCCTA
AACCGACCTACGCTCCTCCGCAGCCGCCACAAAACCAGCCAAACAACCCCGGCAATGAGCAGCCCGGTGGCCAGCAGAAC
AACCCACCCGGCGATAATACCGCGGGTAATAATGGCGGCACCGAGGGTAATAATGGCGGCACCGAGGGTAATAATGGCGG
CGATTACGGGGGTAACACCGGAGGTGGTCAACAGAACCCGCCCGGAACGACGGGACCTCGCTGA

Upstream 100 bases:

>100_bases
GTGACGCCGTGACGCAAAGGCTGTCAGGCGCGATTGCCACGATAGTAGGAACAGGGAGTAAACCCAGGAAAGACTTGCCG
CTGACCCAGGTAACTCGGGT

Downstream 100 bases:

>100_bases
CATGAGAGCCGCCATGAAGACGGGCTTCACAGCGGTCGCTAGCGTTATTGGGGTCGGCGTTGCAGGTCTGGCCTACGGTG
TAATCGAAGCGCATCGATTT

Product: penicillin-binding protein (transglycosylase/transpeptidase)

Products: NA

Alternate protein names: PBP-2D; PBP2d [H]

Number of amino acids: Translated: 847; Mature: 846

Protein sequence:

>847_residues
MSEASRILGYMRSDRHGKLYPLAMFGIVSILTGLLMAGFVVPLAALTGGTAKMVASSMEDLPPELMSTPQAQKSHILMAD
GSVLATFYDENREYVPLSKISKQMQTAQVAIEDNRFFSHGAIDLKGTARALATNIAGSARQGGSTLTQQYVKQIRIEAAV
AAGNEEGVQAAQEPTITRKIQELRYAVAMEKKLSKKQILERYLNIAYFGDGAYGVESAAHHYFGTTAANLDLAQSAMLAG
LVQNPVAYDPVNHPEAAMNRRNIVLARMAQLNLISADQARKAEATVFDKSKVFYPKNGCISSKYPFICDYAYRSLLQMPS
LGKNPEERAKMVKRGGLTIQTSIDPKVQDAAQNAVSNVVGPKDPVLAGTAIVQPGTGLLMAMAQSRPIMGDKPGQTYYNY
MAPASMGGATGFQAGSTFKAFTTAAAIAKGIPMSKHYTASSPMDFTGEKFTSCKGTFKSGPFRVRNSTGHSWNIGLREAA
AWSVNTYFVQLEQDVGMCGVTKMAQDSGVKLSSGKDIVKTFQKVPSFTLGTAYVSPLSMASSYASFASRGIQCDPIILTS
VKNRDGSPLKVPTGNCKRVMPQKVADGVNSVLSGVMDATGMPARIPGGYPQAGKTGTTDAHEAAWFDGYTPQAAGVAMIA
ADGGNSYFRGDKSRSIKGIRTSTGVYLNGSGGSDAGKIYRAAMAGALQGKPKTEFVAPTDEVRYGKLIKIPSTDGMTYPQ
AKAAILKAGFRTKVWHVWDDSEPGTYLGTDPEGSAHAGAAVTLKISKGPKPAPKPTYAPPQPPQNQPNNPGNEQPGGQQN
NPPGDNTAGNNGGTEGNNGGTEGNNGGDYGGNTGGGQQNPPGTTGPR

Sequences:

>Translated_847_residues
MSEASRILGYMRSDRHGKLYPLAMFGIVSILTGLLMAGFVVPLAALTGGTAKMVASSMEDLPPELMSTPQAQKSHILMAD
GSVLATFYDENREYVPLSKISKQMQTAQVAIEDNRFFSHGAIDLKGTARALATNIAGSARQGGSTLTQQYVKQIRIEAAV
AAGNEEGVQAAQEPTITRKIQELRYAVAMEKKLSKKQILERYLNIAYFGDGAYGVESAAHHYFGTTAANLDLAQSAMLAG
LVQNPVAYDPVNHPEAAMNRRNIVLARMAQLNLISADQARKAEATVFDKSKVFYPKNGCISSKYPFICDYAYRSLLQMPS
LGKNPEERAKMVKRGGLTIQTSIDPKVQDAAQNAVSNVVGPKDPVLAGTAIVQPGTGLLMAMAQSRPIMGDKPGQTYYNY
MAPASMGGATGFQAGSTFKAFTTAAAIAKGIPMSKHYTASSPMDFTGEKFTSCKGTFKSGPFRVRNSTGHSWNIGLREAA
AWSVNTYFVQLEQDVGMCGVTKMAQDSGVKLSSGKDIVKTFQKVPSFTLGTAYVSPLSMASSYASFASRGIQCDPIILTS
VKNRDGSPLKVPTGNCKRVMPQKVADGVNSVLSGVMDATGMPARIPGGYPQAGKTGTTDAHEAAWFDGYTPQAAGVAMIA
ADGGNSYFRGDKSRSIKGIRTSTGVYLNGSGGSDAGKIYRAAMAGALQGKPKTEFVAPTDEVRYGKLIKIPSTDGMTYPQ
AKAAILKAGFRTKVWHVWDDSEPGTYLGTDPEGSAHAGAAVTLKISKGPKPAPKPTYAPPQPPQNQPNNPGNEQPGGQQN
NPPGDNTAGNNGGTEGNNGGTEGNNGGDYGGNTGGGQQNPPGTTGPR
>Mature_846_residues
SEASRILGYMRSDRHGKLYPLAMFGIVSILTGLLMAGFVVPLAALTGGTAKMVASSMEDLPPELMSTPQAQKSHILMADG
SVLATFYDENREYVPLSKISKQMQTAQVAIEDNRFFSHGAIDLKGTARALATNIAGSARQGGSTLTQQYVKQIRIEAAVA
AGNEEGVQAAQEPTITRKIQELRYAVAMEKKLSKKQILERYLNIAYFGDGAYGVESAAHHYFGTTAANLDLAQSAMLAGL
VQNPVAYDPVNHPEAAMNRRNIVLARMAQLNLISADQARKAEATVFDKSKVFYPKNGCISSKYPFICDYAYRSLLQMPSL
GKNPEERAKMVKRGGLTIQTSIDPKVQDAAQNAVSNVVGPKDPVLAGTAIVQPGTGLLMAMAQSRPIMGDKPGQTYYNYM
APASMGGATGFQAGSTFKAFTTAAAIAKGIPMSKHYTASSPMDFTGEKFTSCKGTFKSGPFRVRNSTGHSWNIGLREAAA
WSVNTYFVQLEQDVGMCGVTKMAQDSGVKLSSGKDIVKTFQKVPSFTLGTAYVSPLSMASSYASFASRGIQCDPIILTSV
KNRDGSPLKVPTGNCKRVMPQKVADGVNSVLSGVMDATGMPARIPGGYPQAGKTGTTDAHEAAWFDGYTPQAAGVAMIAA
DGGNSYFRGDKSRSIKGIRTSTGVYLNGSGGSDAGKIYRAAMAGALQGKPKTEFVAPTDEVRYGKLIKIPSTDGMTYPQA
KAAILKAGFRTKVWHVWDDSEPGTYLGTDPEGSAHAGAAVTLKISKGPKPAPKPTYAPPQPPQNQPNNPGNEQPGGQQNN
PPGDNTAGNNGGTEGNNGGTEGNNGGDYGGNTGGGQQNPPGTTGPR

Specific function: Involved in the polymerization and cross-linking of spore peptidoglycan. May be required for synthesis of the spore germ cell wall, the first layer of peptidoglycan synthesized on the surface of the inner forespore membrane [H]

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=297, Percent_Identity=34.006734006734, Blast_Score=136, Evalue=6e-33,
Organism=Escherichia coli, GI1786343, Length=580, Percent_Identity=26.3793103448276, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1788867, Length=212, Percent_Identity=32.0754716981132, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1789601, Length=188, Percent_Identity=32.4468085106383, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.- [C]

Molecular weight: Translated: 89442; Mature: 89311

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEASRILGYMRSDRHGKLYPLAMFGIVSILTGLLMAGFVVPLAALTGGTAKMVASSMED
CCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LPPELMSTPQAQKSHILMADGSVLATFYDENREYVPLSKISKQMQTAQVAIEDNRFFSHG
CCHHHHCCCCHHHCEEEEECCCEEEEEECCCCCEECHHHHHHHHHHHEEEEECCEEEECC
AIDLKGTARALATNIAGSARQGGSTLTQQYVKQIRIEAAVAAGNEEGVQAAQEPTITRKI
CEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCHHHHHH
QELRYAVAMEKKLSKKQILERYLNIAYFGDGAYGVESAAHHYFGTTAANLDLAQSAMLAG
HHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
LVQNPVAYDPVNHPEAAMNRRNIVLARMAQLNLISADQARKAEATVFDKSKVFYPKNGCI
HHHCCCCCCCCCCCHHHHCCCCEEEEHHHHHHEECCCCCCCCHHEEEECCEEEECCCCCC
SSKYPFICDYAYRSLLQMPSLGKNPEERAKMVKRGGLTIQTSIDPKVQDAAQNAVSNVVG
CCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCC
PKDPVLAGTAIVQPGTGLLMAMAQSRPIMGDKPGQTYYNYMAPASMGGATGFQAGSTFKA
CCCCCEECEEEECCCCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHH
FTTAAAIAKGIPMSKHYTASSPMDFTGEKFTSCKGTFKSGPFRVRNSTGHSWNIGLREAA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEECCCCCEEECCHHHHH
AWSVNTYFVQLEQDVGMCGVTKMAQDSGVKLSSGKDIVKTFQKVPSFTLGTAYVSPLSMA
EEEEEEEEEEECCCCCCCCCHHHHHCCCCEECCCHHHHHHHHHCCCCEEHHHHHHHHHHH
SSYASFASRGIQCDPIILTSVKNRDGSPLKVPTGNCKRVMPQKVADGVNSVLSGVMDATG
HHHHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
MPARIPGGYPQAGKTGTTDAHEAAWFDGYTPQAAGVAMIAADGGNSYFRGDKSRSIKGIR
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEE
TSTGVYLNGSGGSDAGKIYRAAMAGALQGKPKTEFVAPTDEVRYGKLIKIPSTDGMTYPQ
ECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCEEEECCCCCCCCCH
AKAAILKAGFRTKVWHVWDDSEPGTYLGTDPEGSAHAGAAVTLKISKGPKPAPKPTYAPP
HHHHHHHCCCCCEEEEEECCCCCCCEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC
QPPQNQPNNPGNEQPGGQQNNPPGDNTAGNNGGTEGNNGGTEGNNGGDYGGNTGGGQQNP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGTTGPR
CCCCCCC
>Mature Secondary Structure 
SEASRILGYMRSDRHGKLYPLAMFGIVSILTGLLMAGFVVPLAALTGGTAKMVASSMED
CHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LPPELMSTPQAQKSHILMADGSVLATFYDENREYVPLSKISKQMQTAQVAIEDNRFFSHG
CCHHHHCCCCHHHCEEEEECCCEEEEEECCCCCEECHHHHHHHHHHHEEEEECCEEEECC
AIDLKGTARALATNIAGSARQGGSTLTQQYVKQIRIEAAVAAGNEEGVQAAQEPTITRKI
CEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCHHHHHH
QELRYAVAMEKKLSKKQILERYLNIAYFGDGAYGVESAAHHYFGTTAANLDLAQSAMLAG
HHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
LVQNPVAYDPVNHPEAAMNRRNIVLARMAQLNLISADQARKAEATVFDKSKVFYPKNGCI
HHHCCCCCCCCCCCHHHHCCCCEEEEHHHHHHEECCCCCCCCHHEEEECCEEEECCCCCC
SSKYPFICDYAYRSLLQMPSLGKNPEERAKMVKRGGLTIQTSIDPKVQDAAQNAVSNVVG
CCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCC
PKDPVLAGTAIVQPGTGLLMAMAQSRPIMGDKPGQTYYNYMAPASMGGATGFQAGSTFKA
CCCCCEECEEEECCCCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHH
FTTAAAIAKGIPMSKHYTASSPMDFTGEKFTSCKGTFKSGPFRVRNSTGHSWNIGLREAA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEECCCCCEEECCHHHHH
AWSVNTYFVQLEQDVGMCGVTKMAQDSGVKLSSGKDIVKTFQKVPSFTLGTAYVSPLSMA
EEEEEEEEEEECCCCCCCCCHHHHHCCCCEECCCHHHHHHHHHCCCCEEHHHHHHHHHHH
SSYASFASRGIQCDPIILTSVKNRDGSPLKVPTGNCKRVMPQKVADGVNSVLSGVMDATG
HHHHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
MPARIPGGYPQAGKTGTTDAHEAAWFDGYTPQAAGVAMIAADGGNSYFRGDKSRSIKGIR
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEE
TSTGVYLNGSGGSDAGKIYRAAMAGALQGKPKTEFVAPTDEVRYGKLIKIPSTDGMTYPQ
ECCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCEEEECCCCCCCCCH
AKAAILKAGFRTKVWHVWDDSEPGTYLGTDPEGSAHAGAAVTLKISKGPKPAPKPTYAPP
HHHHHHHCCCCCEEEEEECCCCCCCEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC
QPPQNQPNNPGNEQPGGQQNNPPGDNTAGNNGGTEGNNGGTEGNNGGDYGGNTGGGQQNP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGTTGPR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]