| Definition | Propionibacterium acnes KPA171202, complete genome. |
|---|---|
| Accession | NC_006085 |
| Length | 2,560,265 |
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The map label for this gene is yqhE [C]
Identifier: 50843567
GI number: 50843567
Start: 2305576
End: 2306397
Strand: Direct
Name: yqhE [C]
Synonym: PPA2129
Alternate gene names: 50843567
Gene position: 2305576-2306397 (Clockwise)
Preceding gene: 50843565
Following gene: 50843570
Centisome position: 90.05
GC content: 60.46
Gene sequence:
>822_bases ATGAGCGTTCCATCTATCACTCTCAACGACGGAGTTGCCATCCCCCAGCTCGGCTTCGGCACTTGGAAGGTTCCTGCCAA CGAGGCCGAGAAGGCCGTCAGCGCCGCCCTGGAGGCAGGTTTCCGCCATATCGACACCGCAGCCATCTACGGCAACGAGG AGGGTGTGGGCCGTGCACTCGCCGACTCCGGCCTGGATCGCAAGGACCTTTTCGTCACCACCAAGCTGTGGAATAGCTCC CATCATGCCGACGATGCTCGCAAGGCCATCGAGACCAGTCTGACCAAGCTGGGCCTCGACCACGTCGACCTCTACCTCAT CCATTGGCCAGCCCCGGTCAAGTACGGCGATGCGTACATCGAGGCGTGGAACGCCCTGCAGGACTTCAAGTCTGAAGGCC TGACGCGTTCCATTGGTGTGTCGAATTTCAAGACCGAGCATCTGGACGCCATCGAGGGGGCCACTCCGAGCGTCGACCAA ATCGAGATGCATCCCTCGTTCAACCAGGCGACCTTCCGCGCAGAGCTGGCCGAGCGCGGCATTAACCCGGAGGCCTGGAG CCCGCTGGGCCAGTCGAAGGACCTCGACAATCCCGTCCTCACCGATATTTCCAAGGCGACTGGAAAGACGCCTGCCCAGG TGGTCATTCGCTGGCACCTGCAGATCGGCAACGTGGTATTCCCCAAGTCGGTGACACCATCACGAATTGCCGAGAACTTT GATGTGTTCGATTTCGAGCTGTCTGACGAGCAGATCGCCGCAATTGATGGCCTGGATCACGGCAACAGGCTCGGTGGTGA CCCTTCTACCGCCGACTTCTGA
Upstream 100 bases:
>100_bases CAGTCGGAGGCGCCACAGGCCCCGTAGTGACGTTTTTGGAACAAACACCGCTGCAAAGACGTTTGCCTTAACGATAACGA TGTTTCGACAGGGAGGATCT
Downstream 100 bases:
>100_bases TTCTGCAACAATAACCGGTCATAGCTTGGCCCCGGCAACGCGGTTGCCGGGGCCAATCGTCTGTCCTTACGAGTTGAGGG CTTCGCGGACCCCGTTATCA
Product: 2,5-diketo-D-gluconic acid reductase A
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 273; Mature: 272
Protein sequence:
>273_residues MSVPSITLNDGVAIPQLGFGTWKVPANEAEKAVSAALEAGFRHIDTAAIYGNEEGVGRALADSGLDRKDLFVTTKLWNSS HHADDARKAIETSLTKLGLDHVDLYLIHWPAPVKYGDAYIEAWNALQDFKSEGLTRSIGVSNFKTEHLDAIEGATPSVDQ IEMHPSFNQATFRAELAERGINPEAWSPLGQSKDLDNPVLTDISKATGKTPAQVVIRWHLQIGNVVFPKSVTPSRIAENF DVFDFELSDEQIAAIDGLDHGNRLGGDPSTADF
Sequences:
>Translated_273_residues MSVPSITLNDGVAIPQLGFGTWKVPANEAEKAVSAALEAGFRHIDTAAIYGNEEGVGRALADSGLDRKDLFVTTKLWNSS HHADDARKAIETSLTKLGLDHVDLYLIHWPAPVKYGDAYIEAWNALQDFKSEGLTRSIGVSNFKTEHLDAIEGATPSVDQ IEMHPSFNQATFRAELAERGINPEAWSPLGQSKDLDNPVLTDISKATGKTPAQVVIRWHLQIGNVVFPKSVTPSRIAENF DVFDFELSDEQIAAIDGLDHGNRLGGDPSTADF >Mature_272_residues SVPSITLNDGVAIPQLGFGTWKVPANEAEKAVSAALEAGFRHIDTAAIYGNEEGVGRALADSGLDRKDLFVTTKLWNSSH HADDARKAIETSLTKLGLDHVDLYLIHWPAPVKYGDAYIEAWNALQDFKSEGLTRSIGVSNFKTEHLDAIEGATPSVDQI EMHPSFNQATFRAELAERGINPEAWSPLGQSKDLDNPVLTDISKATGKTPAQVVIRWHLQIGNVVFPKSVTPSRIAENFD VFDFELSDEQIAAIDGLDHGNRLGGDPSTADF
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=297, Percent_Identity=37.037037037037, Blast_Score=216, Evalue=2e-56, Organism=Homo sapiens, GI5174391, Length=297, Percent_Identity=37.037037037037, Blast_Score=216, Evalue=2e-56, Organism=Homo sapiens, GI5453543, Length=298, Percent_Identity=39.9328859060403, Blast_Score=210, Evalue=1e-54, Organism=Homo sapiens, GI310109920, Length=298, Percent_Identity=39.9328859060403, Blast_Score=209, Evalue=2e-54, Organism=Homo sapiens, GI45446745, Length=298, Percent_Identity=39.9328859060403, Blast_Score=209, Evalue=2e-54, Organism=Homo sapiens, GI4503285, Length=298, Percent_Identity=39.9328859060403, Blast_Score=209, Evalue=2e-54, Organism=Homo sapiens, GI310109922, Length=282, Percent_Identity=41.1347517730496, Blast_Score=207, Evalue=1e-53, Organism=Homo sapiens, GI24497583, Length=296, Percent_Identity=38.8513513513513, Blast_Score=202, Evalue=2e-52, Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=36.1774744027304, Blast_Score=199, Evalue=2e-51, Organism=Homo sapiens, GI24497585, Length=297, Percent_Identity=37.3737373737374, Blast_Score=195, Evalue=4e-50, Organism=Homo sapiens, GI93277124, Length=307, Percent_Identity=33.5504885993485, Blast_Score=181, Evalue=5e-46, Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=35.1170568561873, Blast_Score=174, Evalue=5e-44, Organism=Homo sapiens, GI4502049, Length=296, Percent_Identity=36.4864864864865, Blast_Score=174, Evalue=5e-44, Organism=Homo sapiens, GI291291012, Length=271, Percent_Identity=34.3173431734317, Blast_Score=167, Evalue=6e-42, Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=35.3790613718412, Blast_Score=157, Evalue=7e-39, Organism=Homo sapiens, GI300116271, Length=279, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=6e-35, Organism=Homo sapiens, GI310109926, Length=117, Percent_Identity=51.2820512820513, Blast_Score=118, Evalue=7e-27, Organism=Homo sapiens, GI207028673, Length=117, Percent_Identity=51.2820512820513, Blast_Score=117, Evalue=9e-27, Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=35.7142857142857, Blast_Score=98, Evalue=6e-21, Organism=Escherichia coli, GI87082198, Length=274, Percent_Identity=50.3649635036496, Blast_Score=271, Evalue=3e-74, Organism=Escherichia coli, GI1786400, Length=258, Percent_Identity=35.6589147286822, Blast_Score=157, Evalue=6e-40, Organism=Escherichia coli, GI1788081, Length=283, Percent_Identity=29.3286219081272, Blast_Score=100, Evalue=2e-22, Organism=Escherichia coli, GI1787674, Length=283, Percent_Identity=25.7950530035336, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI87081735, Length=297, Percent_Identity=26.9360269360269, Blast_Score=67, Evalue=2e-12, Organism=Escherichia coli, GI48994888, Length=236, Percent_Identity=25.8474576271186, Blast_Score=64, Evalue=1e-11, Organism=Escherichia coli, GI1788070, Length=215, Percent_Identity=27.906976744186, Blast_Score=62, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17537075, Length=304, Percent_Identity=41.4473684210526, Blast_Score=207, Evalue=3e-54, Organism=Caenorhabditis elegans, GI17537077, Length=296, Percent_Identity=40.2027027027027, Blast_Score=204, Evalue=5e-53, Organism=Caenorhabditis elegans, GI17564128, Length=304, Percent_Identity=37.171052631579, Blast_Score=186, Evalue=2e-47, Organism=Caenorhabditis elegans, GI17561298, Length=275, Percent_Identity=36.3636363636364, Blast_Score=174, Evalue=4e-44, Organism=Caenorhabditis elegans, GI71998625, Length=268, Percent_Identity=33.5820895522388, Blast_Score=164, Evalue=6e-41, Organism=Caenorhabditis elegans, GI17537079, Length=299, Percent_Identity=31.438127090301, Blast_Score=162, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17566692, Length=306, Percent_Identity=31.3725490196078, Blast_Score=159, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17538386, Length=270, Percent_Identity=34.0740740740741, Blast_Score=153, Evalue=8e-38, Organism=Caenorhabditis elegans, GI17550248, Length=294, Percent_Identity=33.3333333333333, Blast_Score=152, Evalue=1e-37, Organism=Caenorhabditis elegans, GI17552492, Length=276, Percent_Identity=31.1594202898551, Blast_Score=149, Evalue=1e-36, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=31.25, Blast_Score=148, Evalue=3e-36, Organism=Caenorhabditis elegans, GI17562292, Length=275, Percent_Identity=30.1818181818182, Blast_Score=125, Evalue=2e-29, Organism=Saccharomyces cerevisiae, GI6324694, Length=288, Percent_Identity=41.3194444444444, Blast_Score=213, Evalue=4e-56, Organism=Saccharomyces cerevisiae, GI6320576, Length=295, Percent_Identity=38.9830508474576, Blast_Score=206, Evalue=4e-54, Organism=Saccharomyces cerevisiae, GI6322556, Length=264, Percent_Identity=36.3636363636364, Blast_Score=177, Evalue=2e-45, Organism=Saccharomyces cerevisiae, GI6321896, Length=314, Percent_Identity=31.8471337579618, Blast_Score=150, Evalue=2e-37, Organism=Saccharomyces cerevisiae, GI6319625, Length=279, Percent_Identity=34.4086021505376, Blast_Score=135, Evalue=6e-33, Organism=Saccharomyces cerevisiae, GI6320079, Length=284, Percent_Identity=32.3943661971831, Blast_Score=114, Evalue=2e-26, Organism=Drosophila melanogaster, GI24663317, Length=293, Percent_Identity=36.1774744027304, Blast_Score=200, Evalue=7e-52, Organism=Drosophila melanogaster, GI24657054, Length=289, Percent_Identity=39.1003460207612, Blast_Score=196, Evalue=1e-50, Organism=Drosophila melanogaster, GI24662789, Length=300, Percent_Identity=35.6666666666667, Blast_Score=189, Evalue=1e-48, Organism=Drosophila melanogaster, GI20129731, Length=287, Percent_Identity=37.6306620209059, Blast_Score=189, Evalue=1e-48, Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=36, Blast_Score=183, Evalue=8e-47, Organism=Drosophila melanogaster, GI21356425, Length=295, Percent_Identity=35.5932203389831, Blast_Score=183, Evalue=9e-47, Organism=Drosophila melanogaster, GI45553081, Length=293, Percent_Identity=34.4709897610922, Blast_Score=181, Evalue=5e-46, Organism=Drosophila melanogaster, GI24662781, Length=297, Percent_Identity=38.047138047138, Blast_Score=178, Evalue=3e-45, Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=33.75, Blast_Score=176, Evalue=2e-44, Organism=Drosophila melanogaster, GI24662785, Length=294, Percent_Identity=37.7551020408163, Blast_Score=170, Evalue=8e-43, Organism=Drosophila melanogaster, GI281366140, Length=257, Percent_Identity=33.0739299610895, Blast_Score=148, Evalue=4e-36,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 29689; Mature: 29558
Theoretical pI: Translated: 4.59; Mature: 4.59
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 0.7 %Met (Translated Protein) 0.7 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 0.4 %Met (Mature Protein) 0.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSVPSITLNDGVAIPQLGFGTWKVPANEAEKAVSAALEAGFRHIDTAAIYGNEEGVGRAL CCCCCEECCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHH ADSGLDRKDLFVTTKLWNSSHHADDARKAIETSLTKLGLDHVDLYLIHWPAPVKYGDAYI HHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHH EAWNALQDFKSEGLTRSIGVSNFKTEHLDAIEGATPSVDQIEMHPSFNQATFRAELAERG HHHHHHHHHHHCCCEEECCCCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCC INPEAWSPLGQSKDLDNPVLTDISKATGKTPAQVVIRWHLQIGNVVFPKSVTPSRIAENF CCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHEEEEEEEEECCEECCCCCCHHHHHCCC DVFDFELSDEQIAAIDGLDHGNRLGGDPSTADF CEEEEEECCCEEEEECCCCCCCCCCCCCCCCCC >Mature Secondary Structure SVPSITLNDGVAIPQLGFGTWKVPANEAEKAVSAALEAGFRHIDTAAIYGNEEGVGRAL CCCCEECCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHH ADSGLDRKDLFVTTKLWNSSHHADDARKAIETSLTKLGLDHVDLYLIHWPAPVKYGDAYI HHCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHH EAWNALQDFKSEGLTRSIGVSNFKTEHLDAIEGATPSVDQIEMHPSFNQATFRAELAERG HHHHHHHHHHHCCCEEECCCCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCC INPEAWSPLGQSKDLDNPVLTDISKATGKTPAQVVIRWHLQIGNVVFPKSVTPSRIAENF CCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHEEEEEEEEECCEECCCCCCHHHHHCCC DVFDFELSDEQIAAIDGLDHGNRLGGDPSTADF CEEEEEECCCEEEEECCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA