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The map label for this gene is appC [H]

Identifier: 50843509

GI number: 50843509

Start: 2245728

End: 2246669

Strand: Direct

Name: appC [H]

Synonym: PPA2065

Alternate gene names: 50843509

Gene position: 2245728-2246669 (Clockwise)

Preceding gene: 50843508

Following gene: 50843510

Centisome position: 87.71

GC content: 60.93

Gene sequence:

>942_bases
ATGAGCACCGAGATCGCTATTCCCGATCCTCAGAGCCGACGTCCCGAATCTGCCCGTCCCATGCGTCCCGGCACAGCGCG
ACGGACCAGCAGACGCACCAGCCTCTTCAAACAGGGGGTGGAGGTGTTCTTCGAGAACCGTTTGGCCGTCGTAGGATTTG
TCACCCTGCTTATCATCGTCGTTCTGTGCTTCATCGGACCGTCGATCTGGCGCACCGATCAGGTCCACACCCAGCTGTCC
AGCGCTTACCTCCCCATCTCCGGCACGCACCCTCTTGGTACGGACGCGGTGGGCTACGACCAGCTCGGACGACTCATGCT
CGGCGGCCAGACATCCATCATCGTCGGCCTGGCAGCTGGCATCCTGGCCACCACCATCGGAACGATTTGGGGCGCCACAG
CCGGATTCGTCGGAGGATGGTTAGACGCTGCGATGATGCGAATCGTTGACTCACTCATGGCTATCCCGGCCTTGTTCCTC
TTCATGCTCATCGCCACGCTCGTCACACCGACCGTGCCCTTGTTGGTACTCATCATTGGCGCATTTGCTTGGCTCAACCC
AGCTCGGCTCATCCGCGGTGAGTCGCTGGCTCTGCGCAGCCGGGAATACATCGTCGCTATGCGTGGCATGGGCGGTAGCT
CTCTGCGCGCCGTACGCACTCACGTTGTGCGTAATGCCATCGGCACCGTCATCGTCAATGCAACCTTCCAGGTGGCAGAC
GCCATCCTCTACGTCGCGTACCTGTCATTTCTCGGCCTCGGGGTTCCCCCACCAGCGGCCAATTGGGGCGGCATGCTTTC
CGACGGGCTCGCCGAGGTCTACTCGGGTCACTGGTGGCTGTTATACCCGCCCGGGGTACTCATCATCATTCTGGTTGTCG
CGTTTAACTTCGTCGGTGACGGATTACGGGACGCCTTCGAGGTTCGGCTGAGGAGTAGATGA

Upstream 100 bases:

>100_bases
TCACCATCATCATCTCAATGGCCACCGTGCTCGGCGCCCTCATCGCAGACATCCTCTATGCCGTCGTCGATCCGCGGATT
CGTTACGGAGGAGCAGACCG

Downstream 100 bases:

>100_bases
CATGAGCATGTCACAGCCCGAAGACATCTTGCTGCGTCTGCAAGATCTGGAGGTCACTATTGACGTGCGCGGTGGCAGGG
TCGCGCCTTTGCGGGGCTGC

Product: dipeptide transport system permease protein DppC

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSTEIAIPDPQSRRPESARPMRPGTARRTSRRTSLFKQGVEVFFENRLAVVGFVTLLIIVVLCFIGPSIWRTDQVHTQLS
SAYLPISGTHPLGTDAVGYDQLGRLMLGGQTSIIVGLAAGILATTIGTIWGATAGFVGGWLDAAMMRIVDSLMAIPALFL
FMLIATLVTPTVPLLVLIIGAFAWLNPARLIRGESLALRSREYIVAMRGMGGSSLRAVRTHVVRNAIGTVIVNATFQVAD
AILYVAYLSFLGLGVPPPAANWGGMLSDGLAEVYSGHWWLLYPPGVLIIILVVAFNFVGDGLRDAFEVRLRSR

Sequences:

>Translated_313_residues
MSTEIAIPDPQSRRPESARPMRPGTARRTSRRTSLFKQGVEVFFENRLAVVGFVTLLIIVVLCFIGPSIWRTDQVHTQLS
SAYLPISGTHPLGTDAVGYDQLGRLMLGGQTSIIVGLAAGILATTIGTIWGATAGFVGGWLDAAMMRIVDSLMAIPALFL
FMLIATLVTPTVPLLVLIIGAFAWLNPARLIRGESLALRSREYIVAMRGMGGSSLRAVRTHVVRNAIGTVIVNATFQVAD
AILYVAYLSFLGLGVPPPAANWGGMLSDGLAEVYSGHWWLLYPPGVLIIILVVAFNFVGDGLRDAFEVRLRSR
>Mature_312_residues
STEIAIPDPQSRRPESARPMRPGTARRTSRRTSLFKQGVEVFFENRLAVVGFVTLLIIVVLCFIGPSIWRTDQVHTQLSS
AYLPISGTHPLGTDAVGYDQLGRLMLGGQTSIIVGLAAGILATTIGTIWGATAGFVGGWLDAAMMRIVDSLMAIPALFLF
MLIATLVTPTVPLLVLIIGAFAWLNPARLIRGESLALRSREYIVAMRGMGGSSLRAVRTHVVRNAIGTVIVNATFQVADA
ILYVAYLSFLGLGVPPPAANWGGMLSDGLAEVYSGHWWLLYPPGVLIIILVVAFNFVGDGLRDAFEVRLRSR

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787498, Length=280, Percent_Identity=36.7857142857143, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1787760, Length=262, Percent_Identity=34.3511450381679, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1787054, Length=262, Percent_Identity=32.0610687022901, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789964, Length=226, Percent_Identity=38.4955752212389, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789889, Length=235, Percent_Identity=35.3191489361702, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788505, Length=223, Percent_Identity=30.0448430493274, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787549, Length=310, Percent_Identity=30.3225806451613, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33774; Mature: 33643

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEIAIPDPQSRRPESARPMRPGTARRTSRRTSLFKQGVEVFFENRLAVVGFVTLLIIV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VLCFIGPSIWRTDQVHTQLSSAYLPISGTHPLGTDAVGYDQLGRLMLGGQTSIIVGLAAG
HHHHHCCCHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
ILATTIGTIWGATAGFVGGWLDAAMMRIVDSLMAIPALFLFMLIATLVTPTVPLLVLIIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AFAWLNPARLIRGESLALRSREYIVAMRGMGGSSLRAVRTHVVRNAIGTVIVNATFQVAD
HHHHCCHHHHHCCCHHHHHCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AILYVAYLSFLGLGVPPPAANWGGMLSDGLAEVYSGHWWLLYPPGVLIIILVVAFNFVGD
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCH
GLRDAFEVRLRSR
HHHHHHHHHHCCC
>Mature Secondary Structure 
STEIAIPDPQSRRPESARPMRPGTARRTSRRTSLFKQGVEVFFENRLAVVGFVTLLIIV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VLCFIGPSIWRTDQVHTQLSSAYLPISGTHPLGTDAVGYDQLGRLMLGGQTSIIVGLAAG
HHHHHCCCHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
ILATTIGTIWGATAGFVGGWLDAAMMRIVDSLMAIPALFLFMLIATLVTPTVPLLVLIIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AFAWLNPARLIRGESLALRSREYIVAMRGMGGSSLRAVRTHVVRNAIGTVIVNATFQVAD
HHHHCCHHHHHCCCHHHHHCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AILYVAYLSFLGLGVPPPAANWGGMLSDGLAEVYSGHWWLLYPPGVLIIILVVAFNFVGD
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCH
GLRDAFEVRLRSR
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]