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The map label for this gene is typA [H]

Identifier: 50843449

GI number: 50843449

Start: 2175111

End: 2176973

Strand: Direct

Name: typA [H]

Synonym: PPA2003

Alternate gene names: 50843449

Gene position: 2175111-2176973 (Clockwise)

Preceding gene: 50843443

Following gene: 50843450

Centisome position: 84.96

GC content: 61.3

Gene sequence:

>1863_bases
ATGCCCGTACGCAAGGATCTGCGCAACATTGCCATCGTGGCCCACGTTGACCACGGAAAGACCACTTTGGTCGACGCTAT
GTTGTGGCAGTCGGGAGCCTTCCGCGAGGGTGCCGAAGTCGAGAAACGCGTTATGGACTCGATGGATCTTGAGCGCGAGA
AGGGGATCACGATCCTCGCCAAGAACACCGCCGTCAAGCACGTCATGAGTGACGGCGAGGAAATCACCCTCAACATTATC
GACACCCCCGGCCACGCCGACTTTGGCGGCGAGGTGGAACGCGGCCTAGAGATGGTCGATGGCGTCATTCTGCTCGTCGA
CGCCTCCGAGGGGCCACTGCCGCAGACCCGCTTCGTGCTGCGCAAAGCACTAGCCAAGAAGCTGCCTCTCATCTTGGTGC
TCAACAAGGTTGACCGTTCCGACGCCCGTATCGACGAGGTTGTCGAAGAAACCTACGACCTCTTCATGGACCTTTCCGAC
GACGACGATGCCTCCCTGCTTGACGTCCCGGTGGTCTATGCCTCCGCGAAAGCCGGACGCGCATCCCTCAACAAACCCGG
GGATGGCGAGTTACCCGATTCCCCCGACCTACAGCCGCTGTTCGATTGCATCCTCGAGAACATCCCAGCCCCCACCTACG
ACGAGGGCGGGGTGCTACAGGCTCACGTCACCAACCTCGACGCCTCCCCCTATCTTGGCCGTCTAGCCCTGTGCCGTGTC
GTCTCCGGTGAACTCACCAAGGGACAGACGGTGGCCTGGTGCAAGCGCGACGGCTCGGTCCAAAACGTCAAGCTCTCCGA
ACTACTCATGACCGAGGCCCTGGAACGCGTCCCCGCTGAGAAAGCTGGCCCCGGTGACATCGTCGCTATCGCTGGTATCC
CCGAGATCACCATCGGCGAGACCCTCTCAGATCCCGAGAACCCGGTCCCTTTGCCGCTCATCCACGTCGATGAACCGTCG
ATGTCGATGACGATCGGTATCAATACCTCACCGCTGTCAGGTCGGTCCGGTGACAAGCTCACCGCTCGTCTTCTCAAGGC
TCGTCTCGATCAAGAACTCATCGGAAACGTGTCGATCAAAGTGGCTGACACCGACCGCCCCGACATGTGGGAAGTGCAAG
GCCGCGGCGAATTGCAGCTGGCCGTCCTCGTCGAGCAGATGCGCCGCGAGGGATTCGAACTCACCGTTGGCAAACCGCAG
GTCGTCACCAAAACCATTGACGGCAAGCTGCACGAACCTTTCGAGCGCGTCACCATTGATGCCCCAGAAGAGTTCATGGG
CCCCGTCACCCAGATGATGGGCCTACGCAAGGGCCAGATGATGCACATGGTCAACCACGGCTCCGGCTGGGTGCGCATGG
AGTTCGTCGTCCCAGCCCGTGGCCTTATCGGCTTCCGCACCGAGTTCCTCACCCAGACCCGCGGTCAGGGCATCATGAAC
CAGATCTTCGAGAACTTCCAGCCCTGGGTAGGCGAATTGCGCACCCGTCAGAGTGGCTCGATGGTCGCCGACCGTCAGGG
GGTCGTCACCTCCTACGCCTTGTTCAACTTGCAGGAGCGCGGCACGATGTTCGTCTCGCCGGGCGAGGACACCTACGAGG
GCATGGTCGTCGGCGAAAACTCGCGCCCCGACGACATGGACGTCAACCCCACCAAAGAAAAGCACCTCACCAACGTGCGC
TCTTCCACCGGCGACGAGTTGGAGCGCCTGATCCCGGCGACGAAACTCTCGATGGAGCAGCAGCTTGAGTTCTGCCGCGA
AGACGAGTGCCTGGAGGTCACCCCAGACGTTGTGCGCATCCGCAAGACCGAACTCAATGCCCACGAGCGGGCCAAAGCCC
GCACCCGCGCAAAACATAGCTGA

Upstream 100 bases:

>100_bases
CCCTGCCCTGACCTACACTTCACTGTGGTGTGTTTGCACCCACCAACCACCCGCGGCCCCGTCGCGGTATCTCCATCCTC
GATCTGAACCGGAGTTCTGC

Downstream 100 bases:

>100_bases
TAGACGCCTCAGTGCTGCAGCTCCCCCTAACTAGGGGTGCTGCAGCATCATCGTCATATCCGGCGAAACACCCTGCCACC
GCGGGCCCGGGGGGAGAGAG

Product: GTPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MPVRKDLRNIAIVAHVDHGKTTLVDAMLWQSGAFREGAEVEKRVMDSMDLEREKGITILAKNTAVKHVMSDGEEITLNII
DTPGHADFGGEVERGLEMVDGVILLVDASEGPLPQTRFVLRKALAKKLPLILVLNKVDRSDARIDEVVEETYDLFMDLSD
DDDASLLDVPVVYASAKAGRASLNKPGDGELPDSPDLQPLFDCILENIPAPTYDEGGVLQAHVTNLDASPYLGRLALCRV
VSGELTKGQTVAWCKRDGSVQNVKLSELLMTEALERVPAEKAGPGDIVAIAGIPEITIGETLSDPENPVPLPLIHVDEPS
MSMTIGINTSPLSGRSGDKLTARLLKARLDQELIGNVSIKVADTDRPDMWEVQGRGELQLAVLVEQMRREGFELTVGKPQ
VVTKTIDGKLHEPFERVTIDAPEEFMGPVTQMMGLRKGQMMHMVNHGSGWVRMEFVVPARGLIGFRTEFLTQTRGQGIMN
QIFENFQPWVGELRTRQSGSMVADRQGVVTSYALFNLQERGTMFVSPGEDTYEGMVVGENSRPDDMDVNPTKEKHLTNVR
SSTGDELERLIPATKLSMEQQLEFCREDECLEVTPDVVRIRKTELNAHERAKARTRAKHS

Sequences:

>Translated_620_residues
MPVRKDLRNIAIVAHVDHGKTTLVDAMLWQSGAFREGAEVEKRVMDSMDLEREKGITILAKNTAVKHVMSDGEEITLNII
DTPGHADFGGEVERGLEMVDGVILLVDASEGPLPQTRFVLRKALAKKLPLILVLNKVDRSDARIDEVVEETYDLFMDLSD
DDDASLLDVPVVYASAKAGRASLNKPGDGELPDSPDLQPLFDCILENIPAPTYDEGGVLQAHVTNLDASPYLGRLALCRV
VSGELTKGQTVAWCKRDGSVQNVKLSELLMTEALERVPAEKAGPGDIVAIAGIPEITIGETLSDPENPVPLPLIHVDEPS
MSMTIGINTSPLSGRSGDKLTARLLKARLDQELIGNVSIKVADTDRPDMWEVQGRGELQLAVLVEQMRREGFELTVGKPQ
VVTKTIDGKLHEPFERVTIDAPEEFMGPVTQMMGLRKGQMMHMVNHGSGWVRMEFVVPARGLIGFRTEFLTQTRGQGIMN
QIFENFQPWVGELRTRQSGSMVADRQGVVTSYALFNLQERGTMFVSPGEDTYEGMVVGENSRPDDMDVNPTKEKHLTNVR
SSTGDELERLIPATKLSMEQQLEFCREDECLEVTPDVVRIRKTELNAHERAKARTRAKHS
>Mature_619_residues
PVRKDLRNIAIVAHVDHGKTTLVDAMLWQSGAFREGAEVEKRVMDSMDLEREKGITILAKNTAVKHVMSDGEEITLNIID
TPGHADFGGEVERGLEMVDGVILLVDASEGPLPQTRFVLRKALAKKLPLILVLNKVDRSDARIDEVVEETYDLFMDLSDD
DDASLLDVPVVYASAKAGRASLNKPGDGELPDSPDLQPLFDCILENIPAPTYDEGGVLQAHVTNLDASPYLGRLALCRVV
SGELTKGQTVAWCKRDGSVQNVKLSELLMTEALERVPAEKAGPGDIVAIAGIPEITIGETLSDPENPVPLPLIHVDEPSM
SMTIGINTSPLSGRSGDKLTARLLKARLDQELIGNVSIKVADTDRPDMWEVQGRGELQLAVLVEQMRREGFELTVGKPQV
VTKTIDGKLHEPFERVTIDAPEEFMGPVTQMMGLRKGQMMHMVNHGSGWVRMEFVVPARGLIGFRTEFLTQTRGQGIMNQ
IFENFQPWVGELRTRQSGSMVADRQGVVTSYALFNLQERGTMFVSPGEDTYEGMVVGENSRPDDMDVNPTKEKHLTNVRS
STGDELERLIPATKLSMEQQLEFCREDECLEVTPDVVRIRKTELNAHERAKARTRAKHS

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=504, Percent_Identity=27.1825396825397, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI94966754, Length=160, Percent_Identity=38.75, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI4503483, Length=172, Percent_Identity=33.1395348837209, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI18390331, Length=138, Percent_Identity=42.7536231884058, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI25306287, Length=150, Percent_Identity=42.6666666666667, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI19923640, Length=150, Percent_Identity=42.6666666666667, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI25306283, Length=150, Percent_Identity=42, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=36.0294117647059, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=36.0294117647059, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI310132016, Length=113, Percent_Identity=41.5929203539823, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI310110807, Length=113, Percent_Identity=41.5929203539823, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI310123363, Length=113, Percent_Identity=41.5929203539823, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI94966752, Length=123, Percent_Identity=34.1463414634146, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI34147630, Length=283, Percent_Identity=30.0353356890459, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI53729339, Length=200, Percent_Identity=28.5, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI53729337, Length=200, Percent_Identity=28.5, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI48994988, Length=615, Percent_Identity=46.6666666666667, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI1788922, Length=515, Percent_Identity=28.3495145631068, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=41.8918918918919, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790412, Length=131, Percent_Identity=38.1679389312977, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789737, Length=131, Percent_Identity=38.1679389312977, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790835, Length=138, Percent_Identity=29.7101449275362, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17557151, Length=302, Percent_Identity=31.4569536423841, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17556745, Length=145, Percent_Identity=41.3793103448276, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533571, Length=141, Percent_Identity=41.8439716312057, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=186, Percent_Identity=31.7204301075269, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=34.3283582089552, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=146, Percent_Identity=35.6164383561644, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988811, Length=146, Percent_Identity=35.6164383561644, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=150, Percent_Identity=38, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323320, Length=489, Percent_Identity=26.7893660531697, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324707, Length=161, Percent_Identity=36.6459627329193, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=161, Percent_Identity=36.6459627329193, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=212, Percent_Identity=35.377358490566, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322359, Length=157, Percent_Identity=35.6687898089172, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=155, Percent_Identity=39.3548387096774, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324761, Length=247, Percent_Identity=31.1740890688259, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI78706572, Length=500, Percent_Identity=26.6, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24585709, Length=172, Percent_Identity=34.3023255813954, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585711, Length=172, Percent_Identity=34.3023255813954, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585713, Length=172, Percent_Identity=34.3023255813954, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574573, Length=142, Percent_Identity=40.8450704225352, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24582462, Length=236, Percent_Identity=31.7796610169492, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI21357743, Length=191, Percent_Identity=35.0785340314136, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI221458488, Length=149, Percent_Identity=41.6107382550336, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363316, Length=173, Percent_Identity=35.8381502890173, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17864358, Length=173, Percent_Identity=35.8381502890173, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19921738, Length=281, Percent_Identity=29.5373665480427, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28572034, Length=244, Percent_Identity=26.2295081967213, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 68471; Mature: 68340

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVRKDLRNIAIVAHVDHGKTTLVDAMLWQSGAFREGAEVEKRVMDSMDLEREKGITILA
CCCHHHHCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHCCCEEEE
KNTAVKHVMSDGEEITLNIIDTPGHADFGGEVERGLEMVDGVILLVDASEGPLPQTRFVL
CCHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHH
RKALAKKLPLILVLNKVDRSDARIDEVVEETYDLFMDLSDDDDASLLDVPVVYASAKAGR
HHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEEEECCCCCC
ASLNKPGDGELPDSPDLQPLFDCILENIPAPTYDEGGVLQAHVTNLDASPYLGRLALCRV
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
VSGELTKGQTVAWCKRDGSVQNVKLSELLMTEALERVPAEKAGPGDIVAIAGIPEITIGE
HCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEECCC
TLSDPENPVPLPLIHVDEPSMSMTIGINTSPLSGRSGDKLTARLLKARLDQELIGNVSIK
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCHHHHCCEEEE
VADTDRPDMWEVQGRGELQLAVLVEQMRREGFELTVGKPQVVTKTIDGKLHEPFERVTID
EECCCCCCEEEECCCCCCHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCHHHEECC
APEEFMGPVTQMMGLRKGQMMHMVNHGSGWVRMEFVVPARGLIGFRTEFLTQTRGQGIMN
CCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHH
QIFENFQPWVGELRTRQSGSMVADRQGVVTSYALFNLQERGTMFVSPGEDTYEGMVVGEN
HHHHHHHHHHHHHHCCCCCCEEECCCCCEEHHHHEEECCCCEEEECCCCCCCCCEEEECC
SRPDDMDVNPTKEKHLTNVRSSTGDELERLIPATKLSMEQQLEFCREDECLEVTPDVVRI
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCHHHHCHHHHHHHHCCCCCEECCCHHHHH
RKTELNAHERAKARTRAKHS
HHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
PVRKDLRNIAIVAHVDHGKTTLVDAMLWQSGAFREGAEVEKRVMDSMDLEREKGITILA
CCHHHHCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHCCCEEEE
KNTAVKHVMSDGEEITLNIIDTPGHADFGGEVERGLEMVDGVILLVDASEGPLPQTRFVL
CCHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHH
RKALAKKLPLILVLNKVDRSDARIDEVVEETYDLFMDLSDDDDASLLDVPVVYASAKAGR
HHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEEEEEEECCCCCC
ASLNKPGDGELPDSPDLQPLFDCILENIPAPTYDEGGVLQAHVTNLDASPYLGRLALCRV
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
VSGELTKGQTVAWCKRDGSVQNVKLSELLMTEALERVPAEKAGPGDIVAIAGIPEITIGE
HCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEECCC
TLSDPENPVPLPLIHVDEPSMSMTIGINTSPLSGRSGDKLTARLLKARLDQELIGNVSIK
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCHHHHCCEEEE
VADTDRPDMWEVQGRGELQLAVLVEQMRREGFELTVGKPQVVTKTIDGKLHEPFERVTID
EECCCCCCEEEECCCCCCHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCHHHEECC
APEEFMGPVTQMMGLRKGQMMHMVNHGSGWVRMEFVVPARGLIGFRTEFLTQTRGQGIMN
CCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHH
QIFENFQPWVGELRTRQSGSMVADRQGVVTSYALFNLQERGTMFVSPGEDTYEGMVVGEN
HHHHHHHHHHHHHHCCCCCCEEECCCCCEEHHHHEEECCCCEEEECCCCCCCCCEEEECC
SRPDDMDVNPTKEKHLTNVRSSTGDELERLIPATKLSMEQQLEFCREDECLEVTPDVVRI
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCHHHHCHHHHHHHHCCCCCEECCCHHHHH
RKTELNAHERAKARTRAKHS
HHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]