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The map label for this gene is purM [H]

Identifier: 50843416

GI number: 50843416

Start: 2131903

End: 2132970

Strand: Reverse

Name: purM [H]

Synonym: PPA1969

Alternate gene names: 50843416

Gene position: 2132970-2131903 (Counterclockwise)

Preceding gene: 50843417

Following gene: 50843415

Centisome position: 83.31

GC content: 62.08

Gene sequence:

>1068_bases
GTGAGCAACGAGTCCGCCTACGCCCGTGCCGGAGTCGACATTGAGGCTGGTGAGCGCGCCGTTGACCTGATGAAGGCCCA
CGTGGCCGCCACCCGTCGTCCAGAGGTCCTTGGCGGCTTGGGCGGCTTCGCTGGCTTTTTCGACGCTTCGGTCCTGGGCC
AGTACCGTCACCCGGTGCTGGCTACCTCGACTGATGGGGTTGGCACCAAGGTGGCCATTGCCCAGGCCATGGACATTCAC
GACACCATTGGTTTTGACCTCGTCGGCATGCTCGTCGACGATCTCGTCGTGGTGGGTGCTGAGCCGTGGTTCGTCACCGA
CTACATTGCATGCGGCCACGTCGACCCCGACCGGATTGCCGCTGTTGTCAAGGGCATCGCCGCAGCGTGTACTCAAGCCG
GCTGTTCCCTGTTGGGCGGCGAGACAGCTGAGCATCCGGGTCTGCTAACCGACGACGAGTACGACGTCGCAGGCGCTACT
ACGGGCGCCGTCGAGTATGACGACATTCTTGGCCCGCAGCGCGTGCAGGAGGGCGACGCTTTGTTGGCGGTGGCTTCCTC
GGGGCTGCACTCGAACGGTTACTCACTGGTCCGTAAGGTGCTGCTGGCTGACGCTGGTTGGGCTTTGAACCGTCATGTCG
ATGAGTTGGGTCGCACCCTTGGCGAAGAGCTGTTGGAGCCGACGACGGTTTATGCAGCTGATCTGCTGGCCCTTATCCGC
CAGATCGAGGTGCACGCTATGAGTCACGTCACCGGCGGGGGATTAGCTAACAACCTGGCCCGTGTCCTGCCTGATGATCT
CGTTGCTACGGTCGACCGGTCCACGTGGACACCAGCGCCGATCTTCAACCTCGTCCAGCAGGTGGGCAACGTCTCACAGC
CTGACATCGAAGCGACCCTCAATATGGGAGTCGGGATGGTCGTCGTCATGCCAGACGCGAACATCTCTGCAGCTATCGAT
CTGCTTGCCGAGCGTGGTCTTTCCGCTTGGCAGTGCGGTCATGTTTCCCATCGTGACGCGACGAATGAGCTGGGGGCGGT
GCTGGTTTCGAGCCATCCTTGCTGCTAG

Upstream 100 bases:

>100_bases
GCCGGGCTTGTTTTGACGGCGTTTATCCCGTACCGGTGCCTGTCTCGGCGCGAGCCGTGCTAGCCGACGCCACCCACACC
AACCCGAACCAGGAGCAGCA

Downstream 100 bases:

>100_bases
GCCGTTCGCCTGGAAACACAATTTGCGGTGGCCCACTTTGGTACGTGGGTCATCGCTCGGGTAGCCTGTGCACCACGATA
GTTGATGATTTTGGGCGGCA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSNESAYARAGVDIEAGERAVDLMKAHVAATRRPEVLGGLGGFAGFFDASVLGQYRHPVLATSTDGVGTKVAIAQAMDIH
DTIGFDLVGMLVDDLVVVGAEPWFVTDYIACGHVDPDRIAAVVKGIAAACTQAGCSLLGGETAEHPGLLTDDEYDVAGAT
TGAVEYDDILGPQRVQEGDALLAVASSGLHSNGYSLVRKVLLADAGWALNRHVDELGRTLGEELLEPTTVYAADLLALIR
QIEVHAMSHVTGGGLANNLARVLPDDLVATVDRSTWTPAPIFNLVQQVGNVSQPDIEATLNMGVGMVVVMPDANISAAID
LLAERGLSAWQCGHVSHRDATNELGAVLVSSHPCC

Sequences:

>Translated_355_residues
MSNESAYARAGVDIEAGERAVDLMKAHVAATRRPEVLGGLGGFAGFFDASVLGQYRHPVLATSTDGVGTKVAIAQAMDIH
DTIGFDLVGMLVDDLVVVGAEPWFVTDYIACGHVDPDRIAAVVKGIAAACTQAGCSLLGGETAEHPGLLTDDEYDVAGAT
TGAVEYDDILGPQRVQEGDALLAVASSGLHSNGYSLVRKVLLADAGWALNRHVDELGRTLGEELLEPTTVYAADLLALIR
QIEVHAMSHVTGGGLANNLARVLPDDLVATVDRSTWTPAPIFNLVQQVGNVSQPDIEATLNMGVGMVVVMPDANISAAID
LLAERGLSAWQCGHVSHRDATNELGAVLVSSHPCC
>Mature_354_residues
SNESAYARAGVDIEAGERAVDLMKAHVAATRRPEVLGGLGGFAGFFDASVLGQYRHPVLATSTDGVGTKVAIAQAMDIHD
TIGFDLVGMLVDDLVVVGAEPWFVTDYIACGHVDPDRIAAVVKGIAAACTQAGCSLLGGETAEHPGLLTDDEYDVAGATT
GAVEYDDILGPQRVQEGDALLAVASSGLHSNGYSLVRKVLLADAGWALNRHVDELGRTLGEELLEPTTVYAADLLALIRQ
IEVHAMSHVTGGGLANNLARVLPDDLVATVDRSTWTPAPIFNLVQQVGNVSQPDIEATLNMGVGMVVVMPDANISAAIDL
LAERGLSAWQCGHVSHRDATNELGAVLVSSHPCC

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=335, Percent_Identity=44.7761194029851, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI209869995, Length=335, Percent_Identity=44.7761194029851, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI209869993, Length=335, Percent_Identity=44.7761194029851, Blast_Score=268, Evalue=6e-72,
Organism=Escherichia coli, GI1788845, Length=339, Percent_Identity=46.6076696165192, Blast_Score=307, Evalue=8e-85,
Organism=Caenorhabditis elegans, GI17567511, Length=339, Percent_Identity=34.2182890855457, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=45.8579881656805, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24582400, Length=274, Percent_Identity=38.3211678832117, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37064; Mature: 36933

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNESAYARAGVDIEAGERAVDLMKAHVAATRRPEVLGGLGGFAGFFDASVLGQYRHPVL
CCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
ATSTDGVGTKVAIAQAMDIHDTIGFDLVGMLVDDLVVVGAEPWFVTDYIACGHVDPDRIA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCCCHHHHH
AVVKGIAAACTQAGCSLLGGETAEHPGLLTDDEYDVAGATTGAVEYDDILGPQRVQEGDA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCE
LLAVASSGLHSNGYSLVRKVLLADAGWALNRHVDELGRTLGEELLEPTTVYAADLLALIR
EEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QIEVHAMSHVTGGGLANNLARVLPDDLVATVDRSTWTPAPIFNLVQQVGNVSQPDIEATL
HHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHH
NMGVGMVVVMPDANISAAIDLLAERGLSAWQCGHVSHRDATNELGAVLVSSHPCC
CCCCEEEEEECCCCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHEEEECCCCCC
>Mature Secondary Structure 
SNESAYARAGVDIEAGERAVDLMKAHVAATRRPEVLGGLGGFAGFFDASVLGQYRHPVL
CCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
ATSTDGVGTKVAIAQAMDIHDTIGFDLVGMLVDDLVVVGAEPWFVTDYIACGHVDPDRIA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCCCHHHHH
AVVKGIAAACTQAGCSLLGGETAEHPGLLTDDEYDVAGATTGAVEYDDILGPQRVQEGDA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCE
LLAVASSGLHSNGYSLVRKVLLADAGWALNRHVDELGRTLGEELLEPTTVYAADLLALIR
EEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QIEVHAMSHVTGGGLANNLARVLPDDLVATVDRSTWTPAPIFNLVQQVGNVSQPDIEATL
HHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHH
NMGVGMVVVMPDANISAAIDLLAERGLSAWQCGHVSHRDATNELGAVLVSSHPCC
CCCCEEEEEECCCCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA