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The map label for this gene is ldh2 [H]

Identifier: 50843401

GI number: 50843401

Start: 2112772

End: 2113737

Strand: Direct

Name: ldh2 [H]

Synonym: PPA1952

Alternate gene names: 50843401

Gene position: 2112772-2113737 (Clockwise)

Preceding gene: 50843398

Following gene: 50843402

Centisome position: 82.52

GC content: 61.08

Gene sequence:

>966_bases
ATGCCCATCAAGCCACATAAGCTCGGGATTATCGGGGTCGGCCGAGTCGGGGATGCAGTGCTGTCCGACGCCATGATGAG
TGGACTCTTCGGTGAGATTTGCGTCATCGACGTCAATGAGAAGTTGGCCGCCGGTCAGGCCCTCGATCAGCATCACGCCA
CCGCACTGCCCAACGTCACCAATGTCGCCGTGTACGCCGGTGACTACGACGACCTGTCTAATGCCGACGTCATCATCATG
ACTGCCGGCCCGTCTATCGACGCGTCCAACGGCCCGGCAACCGGCGCTGCACGGCGTGAATTGGCCGCCACTAACGGCAA
GATCATCCGCTCCACCATGACGCAGATCACCAGCCGCAACCACGACGCAGCCATCATCATTTGCTCCAACCCTCTTGATG
CCTTGGTCCATATCGCTAGCACCGAGTTCGATCACCCGCAGGGGTTGGTGCTCGGCACCGGAACGATCCTTGATTCGGCC
CGCATGTGTCGCGTGGTCGCCGACCATCTCGGCGTCGATCCAGACTATGTGCGTGGCTACATGATCGGCGAGCATGGCCC
GTCCGGGTTCCCGATGTTCACTGGAGTCAATGTCGGCGGCGTCGGATTCGACGGGCTGGCCAAGCTCTTCGATGCAGACC
CGATGGACCGCGACGAGCTGACCACGCGCATTAACGATGCCGGTACTGCCGTATTCAATTTGAAAGGCTGGACGAGCGCT
GGCATCGGCCAATCGGCCATCACCATTGCGCGCTCTATCCTCCTCAATGAACACGCCGTCTACCCGGTTTGTACCACCTT
GCACGGCCAATACGGTCACGACGGCGACGTGTCTATGGGCGTGCCGTGCGTTATCGGCGCCACGGGTGTCGAACGCATCC
TCGAGGTGCCGCTGGATGACTGGGAGCAAGAGCACCTGGCCAGCACCATCAAGGCCATCCAAGAGACCGTCGAGGCGGCT
TCCTGA

Upstream 100 bases:

>100_bases
TATGGCGGAGGGGCGTCACGAAGTTGAAACCTGCCTGGTGAATGATGGAGATGTAAGCATGTACTGCGAAGGTACTTCGT
GACGACTGCAGGAGGTTTCT

Downstream 100 bases:

>100_bases
GCGCGCTTCGACGAAGCTCGTAGGATTGAGCTATGGAACTCCCCTCGTGGCTCGGTATCCCTACCCTCGCATTCGGATTG
GGGAGCCGAACCCCCCAGCA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 2 [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MPIKPHKLGIIGVGRVGDAVLSDAMMSGLFGEICVIDVNEKLAAGQALDQHHATALPNVTNVAVYAGDYDDLSNADVIIM
TAGPSIDASNGPATGAARRELAATNGKIIRSTMTQITSRNHDAAIIICSNPLDALVHIASTEFDHPQGLVLGTGTILDSA
RMCRVVADHLGVDPDYVRGYMIGEHGPSGFPMFTGVNVGGVGFDGLAKLFDADPMDRDELTTRINDAGTAVFNLKGWTSA
GIGQSAITIARSILLNEHAVYPVCTTLHGQYGHDGDVSMGVPCVIGATGVERILEVPLDDWEQEHLASTIKAIQETVEAA
S

Sequences:

>Translated_321_residues
MPIKPHKLGIIGVGRVGDAVLSDAMMSGLFGEICVIDVNEKLAAGQALDQHHATALPNVTNVAVYAGDYDDLSNADVIIM
TAGPSIDASNGPATGAARRELAATNGKIIRSTMTQITSRNHDAAIIICSNPLDALVHIASTEFDHPQGLVLGTGTILDSA
RMCRVVADHLGVDPDYVRGYMIGEHGPSGFPMFTGVNVGGVGFDGLAKLFDADPMDRDELTTRINDAGTAVFNLKGWTSA
GIGQSAITIARSILLNEHAVYPVCTTLHGQYGHDGDVSMGVPCVIGATGVERILEVPLDDWEQEHLASTIKAIQETVEAA
S
>Mature_320_residues
PIKPHKLGIIGVGRVGDAVLSDAMMSGLFGEICVIDVNEKLAAGQALDQHHATALPNVTNVAVYAGDYDDLSNADVIIMT
AGPSIDASNGPATGAARRELAATNGKIIRSTMTQITSRNHDAAIIICSNPLDALVHIASTEFDHPQGLVLGTGTILDSAR
MCRVVADHLGVDPDYVRGYMIGEHGPSGFPMFTGVNVGGVGFDGLAKLFDADPMDRDELTTRINDAGTAVFNLKGWTSAG
IGQSAITIARSILLNEHAVYPVCTTLHGQYGHDGDVSMGVPCVIGATGVERILEVPLDDWEQEHLASTIKAIQETVEAAS

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI15082234, Length=316, Percent_Identity=29.746835443038, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI5031857, Length=318, Percent_Identity=31.4465408805031, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI260099723, Length=318, Percent_Identity=31.4465408805031, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI47059044, Length=321, Percent_Identity=30.8411214953271, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI221136809, Length=321, Percent_Identity=30.8411214953271, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI9257228, Length=315, Percent_Identity=32.0634920634921, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI4504973, Length=315, Percent_Identity=32.0634920634921, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI291575128, Length=318, Percent_Identity=29.874213836478, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4557032, Length=318, Percent_Identity=29.874213836478, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI207028494, Length=197, Percent_Identity=35.0253807106599, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI260099727, Length=201, Percent_Identity=30.8457711442786, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI260099725, Length=201, Percent_Identity=30.8457711442786, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI103472011, Length=317, Percent_Identity=19.5583596214511, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17535107, Length=295, Percent_Identity=28.8135593220339, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17136226, Length=314, Percent_Identity=31.5286624203822, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45550422, Length=313, Percent_Identity=28.4345047923323, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 33664; Mature: 33533

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKPHKLGIIGVGRVGDAVLSDAMMSGLFGEICVIDVNEKLAAGQALDQHHATALPNVT
CCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCHHHHCHHHHHHHHHCCCCCC
NVAVYAGDYDDLSNADVIIMTAGPSIDASNGPATGAARRELAATNGKIIRSTMTQITSRN
EEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCC
HDAAIIICSNPLDALVHIASTEFDHPQGLVLGTGTILDSARMCRVVADHLGVDPDYVRGY
CCEEEEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCHHHHEEE
MIGEHGPSGFPMFTGVNVGGVGFDGLAKLFDADPMDRDELTTRINDAGTAVFNLKGWTSA
EEECCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCC
GIGQSAITIARSILLNEHAVYPVCTTLHGQYGHDGDVSMGVPCVIGATGVERILEVPLDD
CCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCC
WEQEHLASTIKAIQETVEAAS
CHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PIKPHKLGIIGVGRVGDAVLSDAMMSGLFGEICVIDVNEKLAAGQALDQHHATALPNVT
CCCCCEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCHHHHCHHHHHHHHHCCCCCC
NVAVYAGDYDDLSNADVIIMTAGPSIDASNGPATGAARRELAATNGKIIRSTMTQITSRN
EEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCC
HDAAIIICSNPLDALVHIASTEFDHPQGLVLGTGTILDSARMCRVVADHLGVDPDYVRGY
CCEEEEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCHHHHEEE
MIGEHGPSGFPMFTGVNVGGVGFDGLAKLFDADPMDRDELTTRINDAGTAVFNLKGWTSA
EEECCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCC
GIGQSAITIARSILLNEHAVYPVCTTLHGQYGHDGDVSMGVPCVIGATGVERILEVPLDD
CCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCC
WEQEHLASTIKAIQETVEAAS
CHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]