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The map label for this gene is menA [H]

Identifier: 50843394

GI number: 50843394

Start: 2106470

End: 2107348

Strand: Reverse

Name: menA [H]

Synonym: PPA1945

Alternate gene names: 50843394

Gene position: 2107348-2106470 (Counterclockwise)

Preceding gene: 50843399

Following gene: 50843391

Centisome position: 82.31

GC content: 62.23

Gene sequence:

>879_bases
ATGGCTGCAGCAGCCGAATGGCTTGAGGGGGCTCGTCCCCGCACCCTTCCTACCGCGATCGCGCCGGTGTTGGCTGGTAC
CGCGATCGCTATCACCGACGGTGGTGCGCGCTGGGGGTTGGCTGCGCTGTGCCTTGTGGTGGCTCTCGGACTGGTTATCG
GGGTGAACTTCGCCAATGACTACTCCGACGGTGTCCGTGGCTCTGACGGTGAAGATCGAGTCGGTCCGCTGCGGTTAGTC
GGGTCAGGGTTGGCCGAACCCTCCCACGTCAGAGTTGCGGCCTTCGCGTGCTTCGCGGTCTCGGCAGTGGCCGGACTGGT
CATCACGATCATGACCGGGCATTGGTGGTTTATCGCCGTGGGGGTCGTCTGTATTCTCGCTGCCTGGTTCTATACTGGGG
GCTCCCACCCTTACGGTTATGCGGGGTTGGGAGAAATCTTCGTCTTCATCTTCTTCGGGTTGGTTGCTGTCGGCGGCACG
ATCTATGTGCAGACTGACCACGTTGGCGCGGCTGGCTGGGTGACGGCTTGTCTCATCGGCGCGACGGCGTGCGGGGTACT
GACGGCCAATAACCTGCGCGACATCGACGGTGACCGCGTCAGCGGCAAGCACACCCTTGCGACCAAGCTCGGGCACCAGG
GGACGCGGATCTTCTACCTTGTCTTGGTGACGCTAGCCTGCGTCGGCGTGGTTGTTGTTGCCGCCTTGACGACGTGGTGG
GTTCTGCTCGGCCTGTTCGCGATTGTCCTACTCATCTCTCCAATACGGGCGATGGTCGCTAAGACCACTGGAATGGCGCT
GGTGCCGGCATTGAAGAACACCGGACTGGCTGAGTTAGTGTGCTCGATCGGTCTGTTCGTCGGCGCCCTTGTCGGTTAG

Upstream 100 bases:

>100_bases
GATATGGTCGGCAGTGGTGTGTGCTCCGAAAAGATCTTCGGTTCGGTGCCCGTCTGACGCATACAATCCGCGTCTTTACC
ACTGATTCAGGGAGTTGTCC

Downstream 100 bases:

>100_bases
GTCGTCCTGGGTCCCGGTGGGGATTAAGGCCTCGCGGGAGTACTTATCGCGAAGCCAATGGCGAACGGCCAGAGTGGCCC
GCACATCATCCTCGTTGTAC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MAAAAEWLEGARPRTLPTAIAPVLAGTAIAITDGGARWGLAALCLVVALGLVIGVNFANDYSDGVRGSDGEDRVGPLRLV
GSGLAEPSHVRVAAFACFAVSAVAGLVITIMTGHWWFIAVGVVCILAAWFYTGGSHPYGYAGLGEIFVFIFFGLVAVGGT
IYVQTDHVGAAGWVTACLIGATACGVLTANNLRDIDGDRVSGKHTLATKLGHQGTRIFYLVLVTLACVGVVVVAALTTWW
VLLGLFAIVLLISPIRAMVAKTTGMALVPALKNTGLAELVCSIGLFVGALVG

Sequences:

>Translated_292_residues
MAAAAEWLEGARPRTLPTAIAPVLAGTAIAITDGGARWGLAALCLVVALGLVIGVNFANDYSDGVRGSDGEDRVGPLRLV
GSGLAEPSHVRVAAFACFAVSAVAGLVITIMTGHWWFIAVGVVCILAAWFYTGGSHPYGYAGLGEIFVFIFFGLVAVGGT
IYVQTDHVGAAGWVTACLIGATACGVLTANNLRDIDGDRVSGKHTLATKLGHQGTRIFYLVLVTLACVGVVVVAALTTWW
VLLGLFAIVLLISPIRAMVAKTTGMALVPALKNTGLAELVCSIGLFVGALVG
>Mature_291_residues
AAAAEWLEGARPRTLPTAIAPVLAGTAIAITDGGARWGLAALCLVVALGLVIGVNFANDYSDGVRGSDGEDRVGPLRLVG
SGLAEPSHVRVAAFACFAVSAVAGLVITIMTGHWWFIAVGVVCILAAWFYTGGSHPYGYAGLGEIFVFIFFGLVAVGGTI
YVQTDHVGAAGWVTACLIGATACGVLTANNLRDIDGDRVSGKHTLATKLGHQGTRIFYLVLVTLACVGVVVVAALTTWWV
LLGLFAIVLLISPIRAMVAKTTGMALVPALKNTGLAELVCSIGLFVGALVG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=298, Percent_Identity=36.5771812080537, Blast_Score=164, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 29992; Mature: 29860

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAAEWLEGARPRTLPTAIAPVLAGTAIAITDGGARWGLAALCLVVALGLVIGVNFAND
CCCHHHHHCCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCC
YSDGVRGSDGEDRVGPLRLVGSGLAEPSHVRVAAFACFAVSAVAGLVITIMTGHWWFIAV
CCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
GVVCILAAWFYTGGSHPYGYAGLGEIFVFIFFGLVAVGGTIYVQTDHVGAAGWVTACLIG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHH
ATACGVLTANNLRDIDGDRVSGKHTLATKLGHQGTRIFYLVLVTLACVGVVVVAALTTWW
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLLGLFAIVLLISPIRAMVAKTTGMALVPALKNTGLAELVCSIGLFVGALVG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AAAAEWLEGARPRTLPTAIAPVLAGTAIAITDGGARWGLAALCLVVALGLVIGVNFAND
CCHHHHHCCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCC
YSDGVRGSDGEDRVGPLRLVGSGLAEPSHVRVAAFACFAVSAVAGLVITIMTGHWWFIAV
CCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
GVVCILAAWFYTGGSHPYGYAGLGEIFVFIFFGLVAVGGTIYVQTDHVGAAGWVTACLIG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHH
ATACGVLTANNLRDIDGDRVSGKHTLATKLGHQGTRIFYLVLVTLACVGVVVVAALTTWW
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLLGLFAIVLLISPIRAMVAKTTGMALVPALKNTGLAELVCSIGLFVGALVG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]