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The map label for this gene is nuoH

Identifier: 50843379

GI number: 50843379

Start: 2088769

End: 2090091

Strand: Reverse

Name: nuoH

Synonym: PPA1929

Alternate gene names: 50843379

Gene position: 2090091-2088769 (Counterclockwise)

Preceding gene: 50843380

Following gene: 50843378

Centisome position: 81.64

GC content: 60.24

Gene sequence:

>1323_bases
ATGAGTCCCCTCGAGGCCACCATCGACCCGGTGTGGCTCATCATCGTCAAGGTCGTCATCCTCTTCGTGATCCTGCTGGC
CTGGACCATCTTCAACGTGTGGTTCGAGCGCCGTGTGTTGGCCAAGATGCAGAACCGCATCGGCCCGATCATGAACTCGG
CGTGGGCTGGTGGCGTGTTTCAGGCTGTTGGTGACGGCCTGAAGCTCATCTTCAAGGAGATGCTCACCCCGAAGGGTGCC
GATAAGATCGTCTTCAACCTGGCGCCGGTCATAGCGGGCATCGCCTGCTTCGCGTCCTGGTCCGTCATCCCTCTTGGTGG
TCAAGTGTCGATGTTCGGTCACACCACCAGGCTCCAGATCACTGACGTGCCGGTTGCCGTGCTGTTTATCCTTGCGGTGG
CGTCCATCGGCATCTACGGCGTGGTGTTGGCCGGCTGGTCGTCGGCGGGCACGTACTCCTTGCTCGGCTCGCTGCGCTCC
AGTGCTCAGATGATCTCCTACGAGGTCGCGATGGGCCTGTCTCTGGTGACGGTGTTCATCTTCTCCGGCTCGATGTCGAC
GTCGCAGATCGTCGAGTCCCAGGCAAATCACCTGGTCGTCGGCGGGTTCGATACCCATATCGCCGGGCATTACTGGTTGC
TGTTGATCCCGAGCTTCGTCATCTACGTCATCACGATGTTTGGTGAGTCGAACCGCCTGCCCTTCGACCTACCGGAGTGT
GAGTCGGAGCTCGTCAGCGGTTACATCACCGAGTATTCAGGTTTCCCCTATGGCATGTACTTCCTGGCGGAGTACATCAA
CATGGCGACCCTGTCGGCGGTCTGTACCACGTTGTTCTTGGGCGGCTACCGCGCTCCGTGGCCGCTGAATTACTTCGGCG
TCATCGATTCGGGCTGGTGGGGTCTGTTGTGGTTCTTCCTCAAGACCCAGCTCGTCATCTTCTTCTTCGTGTGGGTGCGT
GCCGCGATCCCGAGGTTCCGTTATGACCACTTCATGGATCTGGGTTGGAAGGTCCTCATCCCGGTGTCGCTGGGGTGGGT
CCTGCTGGTCGCTGCCTGGCGCACCGTCATCAATCAAGGATGGGGTCGAAACCCGGTCTTTTTGGTGGTCGTCGGCGTCA
TCCTCGTCGCTCTCATCGTGTGGGCGTTCATGGGTGGTAAGACCGATTCCACGGCCGATGAGGCTCCTGACGAACCCTTC
GACGCTTTCGCCGGTGGCTATCCGGTACCGCCATTGCCACATCAGGTGCAGGCCCCATTGGCTGGGGCTGCAACGGCCAC
CACGGTGGCTCGACGAGACCACGACGAGAACGGAGGTCTGTGA

Upstream 100 bases:

>100_bases
CGACCGCCCCTCAGAGCCGCACCACCGTCCCCGACGCTCCCGGAACCGTCGTCTCGCTGAGCGCCGTTGAAACCGAAACT
TCCCGAGAGGCAGGTGTGGC

Downstream 100 bases:

>100_bases
TGGGAGCCTGGTCCGGATTCGGGATCACCTTCGAGACGATGTTCCGCAAGTCCTTCACCCAGGGATACCCGGAGAAGGGC
AAGGAAAAGCCGATGCCGCC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSPLEATIDPVWLIIVKVVILFVILLAWTIFNVWFERRVLAKMQNRIGPIMNSAWAGGVFQAVGDGLKLIFKEMLTPKGA
DKIVFNLAPVIAGIACFASWSVIPLGGQVSMFGHTTRLQITDVPVAVLFILAVASIGIYGVVLAGWSSAGTYSLLGSLRS
SAQMISYEVAMGLSLVTVFIFSGSMSTSQIVESQANHLVVGGFDTHIAGHYWLLLIPSFVIYVITMFGESNRLPFDLPEC
ESELVSGYITEYSGFPYGMYFLAEYINMATLSAVCTTLFLGGYRAPWPLNYFGVIDSGWWGLLWFFLKTQLVIFFFVWVR
AAIPRFRYDHFMDLGWKVLIPVSLGWVLLVAAWRTVINQGWGRNPVFLVVVGVILVALIVWAFMGGKTDSTADEAPDEPF
DAFAGGYPVPPLPHQVQAPLAGAATATTVARRDHDENGGL

Sequences:

>Translated_440_residues
MSPLEATIDPVWLIIVKVVILFVILLAWTIFNVWFERRVLAKMQNRIGPIMNSAWAGGVFQAVGDGLKLIFKEMLTPKGA
DKIVFNLAPVIAGIACFASWSVIPLGGQVSMFGHTTRLQITDVPVAVLFILAVASIGIYGVVLAGWSSAGTYSLLGSLRS
SAQMISYEVAMGLSLVTVFIFSGSMSTSQIVESQANHLVVGGFDTHIAGHYWLLLIPSFVIYVITMFGESNRLPFDLPEC
ESELVSGYITEYSGFPYGMYFLAEYINMATLSAVCTTLFLGGYRAPWPLNYFGVIDSGWWGLLWFFLKTQLVIFFFVWVR
AAIPRFRYDHFMDLGWKVLIPVSLGWVLLVAAWRTVINQGWGRNPVFLVVVGVILVALIVWAFMGGKTDSTADEAPDEPF
DAFAGGYPVPPLPHQVQAPLAGAATATTVARRDHDENGGL
>Mature_439_residues
SPLEATIDPVWLIIVKVVILFVILLAWTIFNVWFERRVLAKMQNRIGPIMNSAWAGGVFQAVGDGLKLIFKEMLTPKGAD
KIVFNLAPVIAGIACFASWSVIPLGGQVSMFGHTTRLQITDVPVAVLFILAVASIGIYGVVLAGWSSAGTYSLLGSLRSS
AQMISYEVAMGLSLVTVFIFSGSMSTSQIVESQANHLVVGGFDTHIAGHYWLLLIPSFVIYVITMFGESNRLPFDLPECE
SELVSGYITEYSGFPYGMYFLAEYINMATLSAVCTTLFLGGYRAPWPLNYFGVIDSGWWGLLWFFLKTQLVIFFFVWVRA
AIPRFRYDHFMDLGWKVLIPVSLGWVLLVAAWRTVINQGWGRNPVFLVVVGVILVALIVWAFMGGKTDSTADEAPDEPFD
AFAGGYPVPPLPHQVQAPLAGAATATTVARRDHDENGGL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=314, Percent_Identity=34.0764331210191, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1788618, Length=356, Percent_Identity=37.0786516853933, Blast_Score=218, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_PROAC (Q6A6G5)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056606.1
- GeneID:   2931977
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1929
- NMPDR:   fig|267747.1.peg.1883
- HOGENOM:   HBG727670
- OMA:   QLMNLGW
- ProtClustDB:   PRK06076
- BioCyc:   PACN267747:PPA1929-MONOMER
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 48287; Mature: 48156

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1442b5cc)-; HASH(0x13be80a4)-; HASH(0x147a9794)-; HASH(0x14799ab4)-; HASH(0x147b41a0)-; HASH(0x147ac47c)-; HASH(0x147a9908)-; HASH(0x12882350)-; HASH(0x147af66c)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLEATIDPVWLIIVKVVILFVILLAWTIFNVWFERRVLAKMQNRIGPIMNSAWAGGVF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
QAVGDGLKLIFKEMLTPKGADKIVFNLAPVIAGIACFASWSVIPLGGQVSMFGHTTRLQI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCEEEEE
TDVPVAVLFILAVASIGIYGVVLAGWSSAGTYSLLGSLRSSAQMISYEVAMGLSLVTVFI
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSGSMSTSQIVESQANHLVVGGFDTHIAGHYWLLLIPSFVIYVITMFGESNRLPFDLPEC
HCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
ESELVSGYITEYSGFPYGMYFLAEYINMATLSAVCTTLFLGGYRAPWPLNYFGVIDSGWW
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHH
GLLWFFLKTQLVIFFFVWVRAAIPRFRYDHFMDLGWKVLIPVSLGWVLLVAAWRTVINQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCC
WGRNPVFLVVVGVILVALIVWAFMGGKTDSTADEAPDEPFDAFAGGYPVPPLPHQVQAPL
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHCCCC
AGAATATTVARRDHDENGGL
CCHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure 
SPLEATIDPVWLIIVKVVILFVILLAWTIFNVWFERRVLAKMQNRIGPIMNSAWAGGVF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
QAVGDGLKLIFKEMLTPKGADKIVFNLAPVIAGIACFASWSVIPLGGQVSMFGHTTRLQI
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCEEEECCCCEEEEE
TDVPVAVLFILAVASIGIYGVVLAGWSSAGTYSLLGSLRSSAQMISYEVAMGLSLVTVFI
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSGSMSTSQIVESQANHLVVGGFDTHIAGHYWLLLIPSFVIYVITMFGESNRLPFDLPEC
HCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
ESELVSGYITEYSGFPYGMYFLAEYINMATLSAVCTTLFLGGYRAPWPLNYFGVIDSGWW
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHH
GLLWFFLKTQLVIFFFVWVRAAIPRFRYDHFMDLGWKVLIPVSLGWVLLVAAWRTVINQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCC
WGRNPVFLVVVGVILVALIVWAFMGGKTDSTADEAPDEPFDAFAGGYPVPPLPHQVQAPL
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHCCCC
AGAATATTVARRDHDENGGL
CCHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA