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The map label for this gene is nikD [C]

Identifier: 50843366

GI number: 50843366

Start: 2075901

End: 2076722

Strand: Direct

Name: nikD [C]

Synonym: PPA1915

Alternate gene names: 50843366

Gene position: 2075901-2076722 (Clockwise)

Preceding gene: 50843365

Following gene: 50843367

Centisome position: 81.08

GC content: 58.88

Gene sequence:

>822_bases
ATGCGTCCATCCGATGATGCCGACCGACTCCCCTCCCCGCGAGGGGGGCCAGTCCTCGCGAGTACATCGAAGTTCGAGGG
TCCGTTTTCTTGTCACGAGCCCGTCATCGAGATCAAGGATTTGGATTTCTACTACTCTGACAAGCCGGTCCTCAACAATG
TCACTCTGGCAATAACCCAAGGATCTTGCCTTGCGCTCATTGGCCCCAACGGATCGGGAAAGTCCACGCTGTGCAAGATC
TTGCAGGGCATCCTCGCTGCCCCGAAGACGGCGACGACCAATGTCCTCGGCTACCCCTGCGGTTCCCGAATCGCGTGCAG
GGCGATCTCCTACTGCGCCGACAACGATCACCTACCGCAATTCCTCACCGGGGCGGAATTCATCTCGTACACCCTGTCTC
TGAGGTCCCCATCGGTTCTCGGGAAACCACGTCTGCGTGGTGCGACCGCTGACATCTTCGAACGTCTGGGAATGGCGGGT
CGCCATGACGATCTTATGGAGAGCTATTCCCACGGCATGCTCAAGAAAACCCAAATCGCAGCTGCGCTCCTTGCCCACTC
CCCCGTGATCATCATCGACGAGTCGCTCAACGGCATCGACATCGAGGCCCAGATGACGATCGAGGACGCCCTTTTCAACC
ACATCCGGCAAGGCGGTACCCAGATCATCTGCAGCCACGATTTCGCCATGCTGGACCGCTGCGCAACCCACGTCGCCATG
CTCGACTATGGGAATATGGTCGAGTTCTCCGCCGTCGACCAATTGCGCGCCCGACATGCCACCATCCGTGACCTCATCGT
TGGGTATATGGGGCTGGGATGA

Upstream 100 bases:

>100_bases
GTATGGCCATCTGGTGCGTCGTCAACCAGCACGGGAAGTTCACCGGCCACTGGAAATGGGTGAAGTACGGCATCTCCATA
TCTATGGAGTGTGCACGCTA

Downstream 100 bases:

>100_bases
CCGAGACTGACACCATCTGGGTAGCCAGTGCGGGAAAGACTTCACCCACGCAAGGCCGAATCACCGTCACACCGGCGCCT
CGAACCCGCCTCCGTGAGAA

Product: ABC transporter, ATP-binding protein

Products: Ni2; [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MRPSDDADRLPSPRGGPVLASTSKFEGPFSCHEPVIEIKDLDFYYSDKPVLNNVTLAITQGSCLALIGPNGSGKSTLCKI
LQGILAAPKTATTNVLGYPCGSRIACRAISYCADNDHLPQFLTGAEFISYTLSLRSPSVLGKPRLRGATADIFERLGMAG
RHDDLMESYSHGMLKKTQIAAALLAHSPVIIIDESLNGIDIEAQMTIEDALFNHIRQGGTQIICSHDFAMLDRCATHVAM
LDYGNMVEFSAVDQLRARHATIRDLIVGYMGLG

Sequences:

>Translated_273_residues
MRPSDDADRLPSPRGGPVLASTSKFEGPFSCHEPVIEIKDLDFYYSDKPVLNNVTLAITQGSCLALIGPNGSGKSTLCKI
LQGILAAPKTATTNVLGYPCGSRIACRAISYCADNDHLPQFLTGAEFISYTLSLRSPSVLGKPRLRGATADIFERLGMAG
RHDDLMESYSHGMLKKTQIAAALLAHSPVIIIDESLNGIDIEAQMTIEDALFNHIRQGGTQIICSHDFAMLDRCATHVAM
LDYGNMVEFSAVDQLRARHATIRDLIVGYMGLG
>Mature_273_residues
MRPSDDADRLPSPRGGPVLASTSKFEGPFSCHEPVIEIKDLDFYYSDKPVLNNVTLAITQGSCLALIGPNGSGKSTLCKI
LQGILAAPKTATTNVLGYPCGSRIACRAISYCADNDHLPQFLTGAEFISYTLSLRSPSVLGKPRLRGATADIFERLGMAG
RHDDLMESYSHGMLKKTQIAAALLAHSPVIIIDESLNGIDIEAQMTIEDALFNHIRQGGTQIICSHDFAMLDRCATHVAM
LDYGNMVEFSAVDQLRARHATIRDLIVGYMGLG

Specific function: Part Of The Binding-Protein-Dependent Transport System For Nickel. Probably Responsible For Energy Coupling To The Transport System. [C]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI31657092, Length=224, Percent_Identity=25.8928571428571, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI21536376, Length=242, Percent_Identity=25.2066115702479, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI105990541, Length=223, Percent_Identity=25.1121076233184, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI150417984, Length=216, Percent_Identity=24.0740740740741, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI45446740, Length=220, Percent_Identity=24.5454545454545, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI47078218, Length=220, Percent_Identity=24.5454545454545, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI116734710, Length=239, Percent_Identity=25.9414225941423, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI27881501, Length=204, Percent_Identity=25.4901960784314, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI30795238, Length=204, Percent_Identity=25.4901960784314, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1789890, Length=246, Percent_Identity=30.0813008130081, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787029, Length=226, Percent_Identity=24.7787610619469, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788225, Length=237, Percent_Identity=25.3164556962025, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787089, Length=227, Percent_Identity=25.1101321585903, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790739, Length=222, Percent_Identity=26.1261261261261, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081709, Length=240, Percent_Identity=22.5, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1786703, Length=193, Percent_Identity=27.4611398963731, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786319, Length=212, Percent_Identity=23.5849056603774, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI87081782, Length=234, Percent_Identity=23.9316239316239, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1789751, Length=227, Percent_Identity=26.8722466960352, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=225, Percent_Identity=28, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71983516, Length=225, Percent_Identity=28, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71983510, Length=225, Percent_Identity=28, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17510237, Length=230, Percent_Identity=25.2173913043478, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324498, Length=215, Percent_Identity=26.046511627907, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28573571, Length=228, Percent_Identity=25.4385964912281, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573573, Length=228, Percent_Identity=25.4385964912281, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24643674, Length=219, Percent_Identity=25.5707762557078, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24666092, Length=222, Percent_Identity=25.2252252252252, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 29527; Mature: 29527

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPSDDADRLPSPRGGPVLASTSKFEGPFSCHEPVIEIKDLDFYYSDKPVLNNVTLAITQ
CCCCCCHHCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEECEEEECCCCCCCCEEEEEEC
GSCLALIGPNGSGKSTLCKILQGILAAPKTATTNVLGYPCGSRIACRAISYCADNDHLPQ
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCHH
FLTGAEFISYTLSLRSPSVLGKPRLRGATADIFERLGMAGRHDDLMESYSHGMLKKTQIA
HHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHH
AALLAHSPVIIIDESLNGIDIEAQMTIEDALFNHIRQGGTQIICSHDFAMLDRCATHVAM
HHHHHCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHH
LDYGNMVEFSAVDQLRARHATIRDLIVGYMGLG
HCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRPSDDADRLPSPRGGPVLASTSKFEGPFSCHEPVIEIKDLDFYYSDKPVLNNVTLAITQ
CCCCCCHHCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEECEEEECCCCCCCCEEEEEEC
GSCLALIGPNGSGKSTLCKILQGILAAPKTATTNVLGYPCGSRIACRAISYCADNDHLPQ
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCHH
FLTGAEFISYTLSLRSPSVLGKPRLRGATADIFERLGMAGRHDDLMESYSHGMLKKTQIA
HHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHH
AALLAHSPVIIIDESLNGIDIEAQMTIEDALFNHIRQGGTQIICSHDFAMLDRCATHVAM
HHHHHCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHH
LDYGNMVEFSAVDQLRARHATIRDLIVGYMGLG
HCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; ATP; H2O [C]

Specific reaction: Ni2+ [Periplasm] + ATP + H2O = Ni2+ [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1670771; 8590279; 8905231 [H]