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The map label for this gene is coaA

Identifier: 50843257

GI number: 50843257

Start: 1963291

End: 1964274

Strand: Direct

Name: coaA

Synonym: PPA1799

Alternate gene names: 50843257

Gene position: 1963291-1964274 (Clockwise)

Preceding gene: 50843256

Following gene: 50843263

Centisome position: 76.68

GC content: 60.98

Gene sequence:

>984_bases
ATGAACTTGACCCCCACCACTCCCGTTGACGACGACAACACCGAACCGGGGCCGTTCATCGAATTATCGCGAGAATCGTG
GGCCGTACTTTCGGACTCGACCGAGATCGATATCGACGAGGCCACCCTGGACCACATCCGTGGTCTCGGCGACCCCACCA
GTCACCGCGACGTCGTCGAGGTGTACCGCCCGTTGACCCAACTCATCCACCTGTACTGCATGCACACGGGCGCCCTCTTC
GACGCCTCCAATAACTTCCTGCAACTCACCCGCCACGGCATGAAGCGCACCCCCTTTGTCATCGGGATCGCCGGGTCGGT
GGCCGTTGGCAAGTCGACCGTGGCTCGTCTGCTACGGGAGCTCCTGGGACGTTCCCCGCGCCGTCCGGTCGTGGACCTCG
TGACGACCGACGGATTCCTCTACCCTAACCGGGTACTCGAGGAACGCGAGCTGCTTTCCCGCAAGGGGTTCCCTGAATCC
TACGACCGCAAGGCCTTGCTGAGGTTCGTCGTCGATGTCAAGTCCGGGATGCCTGAAGTCACCGCACCGGTTTACTCTCA
CGTCACCTACGACATCGTGCCCAACCAGCAACTCGTCGTCCGGCAACCCGACATCCTCATTATTGAGGGGCTTAACGTTC
TACAGCCACCACGACGGCGCAGCAGTGGGACAATGGGACTGGCCCTGAGCGACTTCTTCGACTTCTCGGTATACGTCGAT
GCTGAGGAGGCCGACATCATCCGGTGGTACATCAACCGGTTCCTCACCCTGCGGCAAACCGCGTTCACCGACCCCCACTC
GTTCTTCGGTGAGTACGCACGAATGCCCGACAACGAAGCCATCACCATCGCTAAGGAGATTTGGGACACCATCAACGGCC
CGAACCTGGTGCAGAACGTGCTGCCCACCCGCGGCCGGGCTACCGCGATCCTGCATAAGGGTCCCGACCACGAGGTCCGC
AATGTGTGGATCAGGAAAGTTTGA

Upstream 100 bases:

>100_bases
TCGACGCTACTCGGAAATGTGCCCATCAACGTCGCATTAACCACGTCCCCAACGTCGCGGTGAAGTACAGTCACTACGAC
CAACCATTCGGAGGCGCCCG

Downstream 100 bases:

>100_bases
GTCGGTGCTGTCTCCTCGGGCCTGACCTTCAGAGGCTCTACCGGTCACATGACATGCCAGGGGAACGGATCCGCGATTCG
CGACGCCGACAAGGCCTGGT

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MNLTPTTPVDDDNTEPGPFIELSRESWAVLSDSTEIDIDEATLDHIRGLGDPTSHRDVVEVYRPLTQLIHLYCMHTGALF
DASNNFLQLTRHGMKRTPFVIGIAGSVAVGKSTVARLLRELLGRSPRRPVVDLVTTDGFLYPNRVLEERELLSRKGFPES
YDRKALLRFVVDVKSGMPEVTAPVYSHVTYDIVPNQQLVVRQPDILIIEGLNVLQPPRRRSSGTMGLALSDFFDFSVYVD
AEEADIIRWYINRFLTLRQTAFTDPHSFFGEYARMPDNEAITIAKEIWDTINGPNLVQNVLPTRGRATAILHKGPDHEVR
NVWIRKV

Sequences:

>Translated_327_residues
MNLTPTTPVDDDNTEPGPFIELSRESWAVLSDSTEIDIDEATLDHIRGLGDPTSHRDVVEVYRPLTQLIHLYCMHTGALF
DASNNFLQLTRHGMKRTPFVIGIAGSVAVGKSTVARLLRELLGRSPRRPVVDLVTTDGFLYPNRVLEERELLSRKGFPES
YDRKALLRFVVDVKSGMPEVTAPVYSHVTYDIVPNQQLVVRQPDILIIEGLNVLQPPRRRSSGTMGLALSDFFDFSVYVD
AEEADIIRWYINRFLTLRQTAFTDPHSFFGEYARMPDNEAITIAKEIWDTINGPNLVQNVLPTRGRATAILHKGPDHEVR
NVWIRKV
>Mature_327_residues
MNLTPTTPVDDDNTEPGPFIELSRESWAVLSDSTEIDIDEATLDHIRGLGDPTSHRDVVEVYRPLTQLIHLYCMHTGALF
DASNNFLQLTRHGMKRTPFVIGIAGSVAVGKSTVARLLRELLGRSPRRPVVDLVTTDGFLYPNRVLEERELLSRKGFPES
YDRKALLRFVVDVKSGMPEVTAPVYSHVTYDIVPNQQLVVRQPDILIIEGLNVLQPPRRRSSGTMGLALSDFFDFSVYVD
AEEADIIRWYINRFLTLRQTAFTDPHSFFGEYARMPDNEAITIAKEIWDTINGPNLVQNVLPTRGRATAILHKGPDHEVR
NVWIRKV

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Escherichia coli, GI1790409, Length=312, Percent_Identity=47.7564102564103, Blast_Score=292, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_PROAC (Q6A6T7)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056484.1
- HSSP:   P0A6I3
- ProteinModelPortal:   Q6A6T7
- SMR:   Q6A6T7
- GeneID:   2932083
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1799
- NMPDR:   fig|267747.1.peg.1761
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- ProtClustDB:   PRK05439
- BioCyc:   PACN267747:PPA1799-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 37005; Mature: 37005

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTPTTPVDDDNTEPGPFIELSRESWAVLSDSTEIDIDEATLDHIRGLGDPTSHRDVVE
CCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHH
VYRPLTQLIHLYCMHTGALFDASNNFLQLTRHGMKRTPFVIGIAGSVAVGKSTVARLLRE
HHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCCCCCCEEEEECCCHHHCHHHHHHHHHH
LLGRSPRRPVVDLVTTDGFLYPNRVLEERELLSRKGFPESYDRKALLRFVVDVKSGMPEV
HHCCCCCCCEEEEEECCCEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCH
TAPVYSHVTYDIVPNQQLVVRQPDILIIEGLNVLQPPRRRSSGTMGLALSDFFDFSVYVD
HHHHHHCEEEEECCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCEEEHHHCCCEEEEEE
AEEADIIRWYINRFLTLRQTAFTDPHSFFGEYARMPDNEAITIAKEIWDTINGPNLVQNV
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEHHHHHHHCCCHHHHHHH
LPTRGRATAILHKGPDHEVRNVWIRKV
CCCCCCEEEEEECCCCCHHHHEEEECC
>Mature Secondary Structure
MNLTPTTPVDDDNTEPGPFIELSRESWAVLSDSTEIDIDEATLDHIRGLGDPTSHRDVVE
CCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHH
VYRPLTQLIHLYCMHTGALFDASNNFLQLTRHGMKRTPFVIGIAGSVAVGKSTVARLLRE
HHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCCCCCCEEEEECCCHHHCHHHHHHHHHH
LLGRSPRRPVVDLVTTDGFLYPNRVLEERELLSRKGFPESYDRKALLRFVVDVKSGMPEV
HHCCCCCCCEEEEEECCCEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCH
TAPVYSHVTYDIVPNQQLVVRQPDILIIEGLNVLQPPRRRSSGTMGLALSDFFDFSVYVD
HHHHHHCEEEEECCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCEEEHHHCCCEEEEEE
AEEADIIRWYINRFLTLRQTAFTDPHSFFGEYARMPDNEAITIAKEIWDTINGPNLVQNV
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEHHHHHHHCCCHHHHHHH
LPTRGRATAILHKGPDHEVRNVWIRKV
CCCCCCEEEEEECCCCCHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA