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The map label for this gene is glmS [H]

Identifier: 50843255

GI number: 50843255

Start: 1958978

End: 1960891

Strand: Reverse

Name: glmS [H]

Synonym: PPA1794

Alternate gene names: 50843255

Gene position: 1960891-1958978 (Counterclockwise)

Preceding gene: 50843258

Following gene: 50843254

Centisome position: 76.59

GC content: 60.5

Gene sequence:

>1914_bases
ATGTTGTTCAAACGTGCAGGCGTTTCAAGTCGCGGAGCCGCTCATGATTCATGTACGTTTCTTGCCATGTGCGGAATTGT
TGGTTACTCGGGCCATCGGCAGGCTGAACGCGTCATCATCGACGGGCTCCGGCGTCTTGAGTATCGAGGATATGACTCGG
CCGGTTTGGCGGTCGTGGCGGACGGAAACTTGTACCGAGCCAAGAAGTCGGGCAAGCTAACTCATCTCGAGGAGGAGCTG
GCAGTCCATCCGCTCCCAGAGTCCACTCAAGGTATCGGTCACACTCGGTGGGCCACCCACGGCGCTCCCACTGATGAGAA
CGCCCACCCCCACATTTCCTTCGACGGACGCGTCGCAGTCGTTCACAACGGCATTATCGAGAACTTCGCCGTGCTGCGCG
CTGAGCTTGAGAGCGAGGGCATCACTTTTTCGTCGGAGACTGACACCGAGACTGCCGCTCACATGCTCGCCTTGGAGATG
CAGCGAAGGTCCTCGCTGACAGAGGCCATGGGGGCGGTGGCGTCACGACTCGAAGGAGCTTTCACACTGGTGGCCGTCAG
CCCGGACGCCCCCGACACAGTGGTGGCCGCTCGTCGCAACTCTCCACTCGTCGTCGGGCTAGGGCAGGGGGAGAATTTCC
TAGCCTCCGATGTCGCAGCGTTTATCGAGCACACCCGCGAGGCTCTCGAACTGGGCCAGGACCAGGTTGTTGTGCTCACC
CCCGATGAGGTCACCGTCACCGACTTCGAGGGCAACCTCAGCCAGGCCCGCCCCTATCACGTCGACTGGGACCTGTCAGC
AGCTGAGAAGCAGGGCCACGACTGGTTCATGCGCAAGGAGATCTTCGAGCAGCCACGTGCGGTGGCCGACACGTTATTGG
GTCGTTGGTCCGACCGTGGTGATCTAGTCCTTGACGAAGTGCATATCTCGCCGGAGGAGTTGCGCCGCATCAACAAGATT
GTGGTCGTCGCATGCGGGTCAGCGTATTACGCCGGCATGGTTGCCAAGTACGCCATCGAGCACTGGACGAGGGTCGCGTG
CGAGGTCGATCTGGCCAGTGAATTCCGCTACCGCGACCCGATCATCGACCCAATGACGCTCGTCGTGACGGTTTCCCAGT
CTGGTGAGACGGCCGATACTCTCATGGCCATCCGACATGCTCGCGAGCAGCATGCCAAGGTCATCGCGATCTGCAACACC
AACGGCGCGACGATTCCCCGCGAGTCCGATGCCGTTATCTACACCCACGCTGGCCCCGAGATTGGCGTGGCCTCAACCAA
GGGGTTCCTCACCCAGGTCGTCGCTTGCTATCTGCTGGGCCTCTACCTGGCTCAGGTGCGTGGTATGAAGTACGGAGACG
AAATCCGCGGCGTCATGTCTGAGCTCGACCAGATGCCTGGCAAGATTCAGGAAGTTCTCGACGAGATCGAACCGGTTTAT
GAGTTGGCTCGTGTGATGGCGAAAGAAGAGGAAGCGGTGTTCTTCCTTGGGCGCCACGTCGGTTATCCAGTGGCCCTTGA
GGGTGCTCTCAAGCTCAAGGAGATCGCCTATATGCATGCCGAGGGGTTTGCTGCTGGCGAGCTCAAGCACGGCCCCATAG
CCGTCATCGAGGAGGGCACCCCGGTCTTCGTCGTTGTGCCACCGAAGGGGCGAGATCAGCTTCATGACAAGGTAGTCTCT
AACATCCAGGAGATCCGTGCCCGTGGCGCTAGGACGATCGTGCTTGCCGAGCGAGGGGACGACGACGTCAAACCGTACGC
TGACACCTTCGTCGGGCTTCCGGCTTGCTCGACCCTGCTCCAACCGTTGGTAGCCGCAGTGCCATTGCAGGCTTTCGCCT
GTGAACTGGCCACCGCCAAGGGTCATGACGTTGACCAGCCAAGGAATCTGGCCAAGTCCGTCACGGTGGAGTGA

Upstream 100 bases:

>100_bases
CTTGCGTCGATGCAGGATGTGAGTTTGACGCTATGAATCGTCGGGGTCACGTGAGGCCTCAGATAGCGAAGTAGTGCATA
CGTGCAGATGGTCGTGTGAG

Downstream 100 bases:

>100_bases
GCTCACTCAGACTAGGTGCCCCCGGCGTTGGCCCCGGGGGCACCTTTGGTGATGTGCCGTTCGTACGTCAGGCGGCAGTC
GCCAGGTGCTCGGAACTGAC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MLFKRAGVSSRGAAHDSCTFLAMCGIVGYSGHRQAERVIIDGLRRLEYRGYDSAGLAVVADGNLYRAKKSGKLTHLEEEL
AVHPLPESTQGIGHTRWATHGAPTDENAHPHISFDGRVAVVHNGIIENFAVLRAELESEGITFSSETDTETAAHMLALEM
QRRSSLTEAMGAVASRLEGAFTLVAVSPDAPDTVVAARRNSPLVVGLGQGENFLASDVAAFIEHTREALELGQDQVVVLT
PDEVTVTDFEGNLSQARPYHVDWDLSAAEKQGHDWFMRKEIFEQPRAVADTLLGRWSDRGDLVLDEVHISPEELRRINKI
VVVACGSAYYAGMVAKYAIEHWTRVACEVDLASEFRYRDPIIDPMTLVVTVSQSGETADTLMAIRHAREQHAKVIAICNT
NGATIPRESDAVIYTHAGPEIGVASTKGFLTQVVACYLLGLYLAQVRGMKYGDEIRGVMSELDQMPGKIQEVLDEIEPVY
ELARVMAKEEEAVFFLGRHVGYPVALEGALKLKEIAYMHAEGFAAGELKHGPIAVIEEGTPVFVVVPPKGRDQLHDKVVS
NIQEIRARGARTIVLAERGDDDVKPYADTFVGLPACSTLLQPLVAAVPLQAFACELATAKGHDVDQPRNLAKSVTVE

Sequences:

>Translated_637_residues
MLFKRAGVSSRGAAHDSCTFLAMCGIVGYSGHRQAERVIIDGLRRLEYRGYDSAGLAVVADGNLYRAKKSGKLTHLEEEL
AVHPLPESTQGIGHTRWATHGAPTDENAHPHISFDGRVAVVHNGIIENFAVLRAELESEGITFSSETDTETAAHMLALEM
QRRSSLTEAMGAVASRLEGAFTLVAVSPDAPDTVVAARRNSPLVVGLGQGENFLASDVAAFIEHTREALELGQDQVVVLT
PDEVTVTDFEGNLSQARPYHVDWDLSAAEKQGHDWFMRKEIFEQPRAVADTLLGRWSDRGDLVLDEVHISPEELRRINKI
VVVACGSAYYAGMVAKYAIEHWTRVACEVDLASEFRYRDPIIDPMTLVVTVSQSGETADTLMAIRHAREQHAKVIAICNT
NGATIPRESDAVIYTHAGPEIGVASTKGFLTQVVACYLLGLYLAQVRGMKYGDEIRGVMSELDQMPGKIQEVLDEIEPVY
ELARVMAKEEEAVFFLGRHVGYPVALEGALKLKEIAYMHAEGFAAGELKHGPIAVIEEGTPVFVVVPPKGRDQLHDKVVS
NIQEIRARGARTIVLAERGDDDVKPYADTFVGLPACSTLLQPLVAAVPLQAFACELATAKGHDVDQPRNLAKSVTVE
>Mature_637_residues
MLFKRAGVSSRGAAHDSCTFLAMCGIVGYSGHRQAERVIIDGLRRLEYRGYDSAGLAVVADGNLYRAKKSGKLTHLEEEL
AVHPLPESTQGIGHTRWATHGAPTDENAHPHISFDGRVAVVHNGIIENFAVLRAELESEGITFSSETDTETAAHMLALEM
QRRSSLTEAMGAVASRLEGAFTLVAVSPDAPDTVVAARRNSPLVVGLGQGENFLASDVAAFIEHTREALELGQDQVVVLT
PDEVTVTDFEGNLSQARPYHVDWDLSAAEKQGHDWFMRKEIFEQPRAVADTLLGRWSDRGDLVLDEVHISPEELRRINKI
VVVACGSAYYAGMVAKYAIEHWTRVACEVDLASEFRYRDPIIDPMTLVVTVSQSGETADTLMAIRHAREQHAKVIAICNT
NGATIPRESDAVIYTHAGPEIGVASTKGFLTQVVACYLLGLYLAQVRGMKYGDEIRGVMSELDQMPGKIQEVLDEIEPVY
ELARVMAKEEEAVFFLGRHVGYPVALEGALKLKEIAYMHAEGFAAGELKHGPIAVIEEGTPVFVVVPPKGRDQLHDKVVS
NIQEIRARGARTIVLAERGDDDVKPYADTFVGLPACSTLLQPLVAAVPLQAFACELATAKGHDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=35.4136429608128, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI205277386, Length=694, Percent_Identity=35.1585014409222, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI29570798, Length=199, Percent_Identity=31.6582914572864, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1790167, Length=618, Percent_Identity=44.336569579288, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI87082251, Length=329, Percent_Identity=23.4042553191489, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=27.7456647398844, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=722, Percent_Identity=32.6869806094183, Blast_Score=347, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17532899, Length=729, Percent_Identity=32.2359396433471, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17532897, Length=436, Percent_Identity=35.3211009174312, Blast_Score=261, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6322745, Length=436, Percent_Identity=35.5504587155963, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323731, Length=438, Percent_Identity=28.5388127853881, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=38.6473429951691, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=34.3976777939042, Blast_Score=380, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 69413; Mature: 69413

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFKRAGVSSRGAAHDSCTFLAMCGIVGYSGHRQAERVIIDGLRRLEYRGYDSAGLAVVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEE
DGNLYRAKKSGKLTHLEEELAVHPLPESTQGIGHTRWATHGAPTDENAHPHISFDGRVAV
CCCEEEECCCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEE
VHNGIIENFAVLRAELESEGITFSSETDTETAAHMLALEMQRRSSLTEAMGAVASRLEGA
EECCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
FTLVAVSPDAPDTVVAARRNSPLVVGLGQGENFLASDVAAFIEHTREALELGQDQVVVLT
EEEEEECCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEC
PDEVTVTDFEGNLSQARPYHVDWDLSAAEKQGHDWFMRKEIFEQPRAVADTLLGRWSDRG
CCCEEEEECCCCCCCCCCEEECCCCCHHHHCCCHHHHHHHHHHCHHHHHHHHHHCCCCCC
DLVLDEVHISPEELRRINKIVVVACGSAYYAGMVAKYAIEHWTRVACEVDLASEFRYRDP
CEEEEEECCCHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHHHEEEEHHHHHHCCCC
IIDPMTLVVTVSQSGETADTLMAIRHAREQHAKVIAICNTNGATIPRESDAVIYTHAGPE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEEECCCC
IGVASTKGFLTQVVACYLLGLYLAQVRGMKYGDEIRGVMSELDQMPGKIQEVLDEIEPVY
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ELARVMAKEEEAVFFLGRHVGYPVALEGALKLKEIAYMHAEGFAAGELKHGPIAVIEEGT
HHHHHHHCCCCCEEEEEHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
PVFVVVPPKGRDQLHDKVVSNIQEIRARGARTIVLAERGDDDVKPYADTFVGLPACSTLL
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHCHHHHHHHH
QPLVAAVPLQAFACELATAKGHDVDQPRNLAKSVTVE
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MLFKRAGVSSRGAAHDSCTFLAMCGIVGYSGHRQAERVIIDGLRRLEYRGYDSAGLAVVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEE
DGNLYRAKKSGKLTHLEEELAVHPLPESTQGIGHTRWATHGAPTDENAHPHISFDGRVAV
CCCEEEECCCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEE
VHNGIIENFAVLRAELESEGITFSSETDTETAAHMLALEMQRRSSLTEAMGAVASRLEGA
EECCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
FTLVAVSPDAPDTVVAARRNSPLVVGLGQGENFLASDVAAFIEHTREALELGQDQVVVLT
EEEEEECCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEC
PDEVTVTDFEGNLSQARPYHVDWDLSAAEKQGHDWFMRKEIFEQPRAVADTLLGRWSDRG
CCCEEEEECCCCCCCCCCEEECCCCCHHHHCCCHHHHHHHHHHCHHHHHHHHHHCCCCCC
DLVLDEVHISPEELRRINKIVVVACGSAYYAGMVAKYAIEHWTRVACEVDLASEFRYRDP
CEEEEEECCCHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHHHEEEEHHHHHHCCCC
IIDPMTLVVTVSQSGETADTLMAIRHAREQHAKVIAICNTNGATIPRESDAVIYTHAGPE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEEECCCC
IGVASTKGFLTQVVACYLLGLYLAQVRGMKYGDEIRGVMSELDQMPGKIQEVLDEIEPVY
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ELARVMAKEEEAVFFLGRHVGYPVALEGALKLKEIAYMHAEGFAAGELKHGPIAVIEEGT
HHHHHHHCCCCCEEEEEHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
PVFVVVPPKGRDQLHDKVVSNIQEIRARGARTIVLAERGDDDVKPYADTFVGLPACSTLL
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHCHHHHHHHH
QPLVAAVPLQAFACELATAKGHDVDQPRNLAKSVTVE
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]