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The map label for this gene is mutX [H]

Identifier: 50843241

GI number: 50843241

Start: 1945114

End: 1945605

Strand: Reverse

Name: mutX [H]

Synonym: PPA1781

Alternate gene names: 50843241

Gene position: 1945605-1945114 (Counterclockwise)

Preceding gene: 50843242

Following gene: 50843240

Centisome position: 75.99

GC content: 59.96

Gene sequence:

>492_bases
ATGATGACCCCGATCCTCACCACCCTTGGTTTCGTCATGCACCCCGACGGCGAACGTGTCCTCATGGTGCACCGCATCGC
CCGTCCTGGGGATGAGCAGCTCGGTAAGTACAACGGGCTGGGTGGCAAAGTCGAGCCGGGGGAGGATGTTGTCGCCGGTA
TGAAGCGCGAATTGCGCGAAGAGGCTCGCATTGAGGTCGATGCCATGAGGCTGCGTGGCACTGTCTCTTGGCCTGGGTTC
GGCAGACACGGTGAAGACCATTTCGGATTTATCTTCCTCGTCGACTCGTGGCATCCCATTGCCGACGCCATCCCTGACGC
CAATGAAGAGGGGCCACTGACCTGGGAGCGCGTCGATTCGCTCGACGAGTTACCGATGTGGGAGGGGGACCGCTACTTTC
TGCCGCTGGTTTTTGATCCTGATGTTCCGCAGTTCCACGGCTGTCTGCCCTATCACGATGGTCGACCGACCGGGTGGTCA
TACTCGGTGTAA

Upstream 100 bases:

>100_bases
TGTGAACGTGCGACCCGCTGGAGTTCGCCTACGAGATCGTGCCGCATGCCTTCGAAAGTGGACATGATCTGATCTTGCTG
CCGGGTGGGAGGATTAGCCC

Downstream 100 bases:

>100_bases
ACCTTTGACGCTGGGGGCTTCGTGGATGCGCGGCGTCATGCTTGCACCGAGGCTTAGGTAAAGCTAACCTTAAGCCCGCT
TTGTATTGGCGCTGTACGCC

Product: putative 7,8-dihydro-8-oxoguanine-triphosphatase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MMTPILTTLGFVMHPDGERVLMVHRIARPGDEQLGKYNGLGGKVEPGEDVVAGMKRELREEARIEVDAMRLRGTVSWPGF
GRHGEDHFGFIFLVDSWHPIADAIPDANEEGPLTWERVDSLDELPMWEGDRYFLPLVFDPDVPQFHGCLPYHDGRPTGWS
YSV

Sequences:

>Translated_163_residues
MMTPILTTLGFVMHPDGERVLMVHRIARPGDEQLGKYNGLGGKVEPGEDVVAGMKRELREEARIEVDAMRLRGTVSWPGF
GRHGEDHFGFIFLVDSWHPIADAIPDANEEGPLTWERVDSLDELPMWEGDRYFLPLVFDPDVPQFHGCLPYHDGRPTGWS
YSV
>Mature_163_residues
MMTPILTTLGFVMHPDGERVLMVHRIARPGDEQLGKYNGLGGKVEPGEDVVAGMKRELREEARIEVDAMRLRGTVSWPGF
GRHGEDHFGFIFLVDSWHPIADAIPDANEEGPLTWERVDSLDELPMWEGDRYFLPLVFDPDVPQFHGCLPYHDGRPTGWS
YSV

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 18458; Mature: 18458

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTPILTTLGFVMHPDGERVLMVHRIARPGDEQLGKYNGLGGKVEPGEDVVAGMKRELRE
CCCHHHHHCCEEECCCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
EARIEVDAMRLRGTVSWPGFGRHGEDHFGFIFLVDSWHPIADAIPDANEEGPLTWERVDS
HHCCEEEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCHHHHCC
LDELPMWEGDRYFLPLVFDPDVPQFHGCLPYHDGRPTGWSYSV
HHCCCCCCCCEEEEEEEECCCCCHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMTPILTTLGFVMHPDGERVLMVHRIARPGDEQLGKYNGLGGKVEPGEDVVAGMKRELRE
CCCHHHHHCCEEECCCCCEEEEEEECCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
EARIEVDAMRLRGTVSWPGFGRHGEDHFGFIFLVDSWHPIADAIPDANEEGPLTWERVDS
HHCCEEEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCHHHHCC
LDELPMWEGDRYFLPLVFDPDVPQFHGCLPYHDGRPTGWSYSV
HHCCCCCCCCEEEEEEEECCCCCHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]