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The map label for this gene is groEL

Identifier: 50843232

GI number: 50843232

Start: 1936034

End: 1937629

Strand: Reverse

Name: groEL

Synonym: PPA1772

Alternate gene names: 50843232

Gene position: 1937629-1936034 (Counterclockwise)

Preceding gene: 50843233

Following gene: 50843231

Centisome position: 75.68

GC content: 62.16

Gene sequence:

>1596_bases
ATGGCAGCTAAGCAACTTCAGTTTGATGAGGAGGCCCGTCGCTCCCTCGAGCGCGGTGTCGACACTCTCGCCGACACCGT
CAAGGTGACCCTCGGTCCTAAGGGCCGTTATGTTGTCCTCGACAAAAAGTGGGGAGCCCCGACCATCACCAACGACGGTG
TGACCGTCGCCAAGGAGGTCGACCTCACTGATCCGTATGAGAATCTTGGCGCCCAGCTCGCCAAGGAGGTCGCCACTAAG
ACCAACGACGTGGCCGGTGATGGAACCACCACCGCTACCGTGCTAGCCCAGGCTCTCGTCCACGAGGGGCTGCGCGCTGT
GGCCTCTGGGGCAAACCCGGTCGGCCTCAAGCGCGGTATCGAGAAGGCTGTCGACGCCGTTGTGGAGGAGCTCCGCTCTA
TCTCGCGCGCCATCGACACCACCTCGGACATGGCCAGCGTTGCCACCATCTCCAGCCGTGACGAGACCATCGGCGCCCTC
ATCGCTGAGGCCTTCGACAAGGTTGGTAAGGACGGGGTTATCACCGTCGACGAGTCGCAGACCTTCGGCACTGAGCTTGA
CTTCACCGAGGGCATGCAGTTCGACAAGGGTTACCTGTCGCCCTACATGGTCACCGACCAGGATCGCATGGAGGCTGTGA
TCGAGGATCCTTACATCCTCATTCACTCCGGCAAGATCTCGTCGATGAACGACCTGCTCCCCTTGCTGGAGAAGGTTATT
GCCGCCCACGGCAGCCTGTTTATCGTGGCCGAGGACGTTGACGGGGAGGCTCTGAGCACCCTCGTCGTCAATAAGATCCG
CGGTACCTTCAGCTCGGTGGCTGTCAAGGCTCCGGCGTTCGGTGACCGCCGCAAGGCAATGCTGCAGGACATCGCCACCC
TCACCGGTGGTCAGGTCGTCGCTCCCGAGGTTGGGCTCAAGCTCGACCAGGTGGGCCTCGAGGTTCTGGGCCGTGCCAAG
AAGGTGGTCGTTACCAAGGACAACACCACCATCGTTGACGGCGCCGGTGATAAGGCCGATGTCGAGGGTCGCGTCATTCA
GCTGCGTGCTGAGTACGACAACTCGGACTCCGAGTGGGACCGCGAGAAACTCCAGGAACGTATCGCCAAGCTCGCTGGTG
GTGTGTGCGTCATTCGTGTGGGTGCGGCCACGGAGGTCGAGCTCAACGAGAAGAAGCACCGCATCGAGGACGCTGTTTCC
GCGACTCGTGCAGCCATTGAGGAGGGTATCGTCGCCGGCGGCGGCTCTGCCCTTATCCACGCTGCCCATGTGCTCGACGG
GGATCTCCACCTCGAGGGTGACGAGAAGGCCGGCGTGCAGATTGTCGCTAAAGCCGTTCGTGAGCCGCTGCGCTGGATTG
CCGAGAACGGTGGCGAGCCCGGCTACGTGATCGTCTCCAAGGTTGCCGAGATGGAGCCCGGACACGGCTACAACGGCAAG
ACCGGACAGTACGTGGACCTCATCGCTGACGGCGTCATTGATCCCCTCAAGGTGACCCGTTCGGCCCTGGCCAATGCTGC
TTCTATCGCCTCGCTGCTCCTGACGACAGAGACCCTCGTCGTCGACAAGCCCGAGGAGGACAACGAGGACAAGTGA

Upstream 100 bases:

>100_bases
CCAAGTACGGCGGCACCGAGGTCAAGTACGACGGTCAGGAGTACTTGCTCCTCAACGCCCGTGACATCCTCGCCGTCGTC
GAGAAGTGAGGCGCTGATAC

Downstream 100 bases:

>100_bases
CCTCGTCGCGTCGGGGGCCCCGGACCGTTGTGGTTCGGGGCCCTCGCCATATCTGGGCTGATGTTTGTCACAAAGAAACG
GAAGTATTGAGCGGATTAAC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MAAKQLQFDEEARRSLERGVDTLADTVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAKEVDLTDPYENLGAQLAKEVATK
TNDVAGDGTTTATVLAQALVHEGLRAVASGANPVGLKRGIEKAVDAVVEELRSISRAIDTTSDMASVATISSRDETIGAL
IAEAFDKVGKDGVITVDESQTFGTELDFTEGMQFDKGYLSPYMVTDQDRMEAVIEDPYILIHSGKISSMNDLLPLLEKVI
AAHGSLFIVAEDVDGEALSTLVVNKIRGTFSSVAVKAPAFGDRRKAMLQDIATLTGGQVVAPEVGLKLDQVGLEVLGRAK
KVVVTKDNTTIVDGAGDKADVEGRVIQLRAEYDNSDSEWDREKLQERIAKLAGGVCVIRVGAATEVELNEKKHRIEDAVS
ATRAAIEEGIVAGGGSALIHAAHVLDGDLHLEGDEKAGVQIVAKAVREPLRWIAENGGEPGYVIVSKVAEMEPGHGYNGK
TGQYVDLIADGVIDPLKVTRSALANAASIASLLLTTETLVVDKPEEDNEDK

Sequences:

>Translated_531_residues
MAAKQLQFDEEARRSLERGVDTLADTVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAKEVDLTDPYENLGAQLAKEVATK
TNDVAGDGTTTATVLAQALVHEGLRAVASGANPVGLKRGIEKAVDAVVEELRSISRAIDTTSDMASVATISSRDETIGAL
IAEAFDKVGKDGVITVDESQTFGTELDFTEGMQFDKGYLSPYMVTDQDRMEAVIEDPYILIHSGKISSMNDLLPLLEKVI
AAHGSLFIVAEDVDGEALSTLVVNKIRGTFSSVAVKAPAFGDRRKAMLQDIATLTGGQVVAPEVGLKLDQVGLEVLGRAK
KVVVTKDNTTIVDGAGDKADVEGRVIQLRAEYDNSDSEWDREKLQERIAKLAGGVCVIRVGAATEVELNEKKHRIEDAVS
ATRAAIEEGIVAGGGSALIHAAHVLDGDLHLEGDEKAGVQIVAKAVREPLRWIAENGGEPGYVIVSKVAEMEPGHGYNGK
TGQYVDLIADGVIDPLKVTRSALANAASIASLLLTTETLVVDKPEEDNEDK
>Mature_530_residues
AAKQLQFDEEARRSLERGVDTLADTVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAKEVDLTDPYENLGAQLAKEVATKT
NDVAGDGTTTATVLAQALVHEGLRAVASGANPVGLKRGIEKAVDAVVEELRSISRAIDTTSDMASVATISSRDETIGALI
AEAFDKVGKDGVITVDESQTFGTELDFTEGMQFDKGYLSPYMVTDQDRMEAVIEDPYILIHSGKISSMNDLLPLLEKVIA
AHGSLFIVAEDVDGEALSTLVVNKIRGTFSSVAVKAPAFGDRRKAMLQDIATLTGGQVVAPEVGLKLDQVGLEVLGRAKK
VVVTKDNTTIVDGAGDKADVEGRVIQLRAEYDNSDSEWDREKLQERIAKLAGGVCVIRVGAATEVELNEKKHRIEDAVSA
TRAAIEEGIVAGGGSALIHAAHVLDGDLHLEGDEKAGVQIVAKAVREPLRWIAENGGEPGYVIVSKVAEMEPGHGYNGKT
GQYVDLIADGVIDPLKVTRSALANAASIASLLLTTETLVVDKPEEDNEDK

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=46.6918714555766, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=46.6918714555766, Blast_Score=481, Evalue=1e-136,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=56.9548872180451, Blast_Score=588, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=44.6969696969697, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=43.3333333333333, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=48.8549618320611, Blast_Score=492, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322524, Length=140, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322350, Length=535, Percent_Identity=23.3644859813084, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=47.8178368121442, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=47.8178368121442, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=45.3510436432638, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=45.3510436432638, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=45.3510436432638, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17864606, Length=531, Percent_Identity=41.0546139359699, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24584129, Length=529, Percent_Identity=34.0264650283554, Blast_Score=277, Evalue=2e-74,
Organism=Drosophila melanogaster, GI19921262, Length=529, Percent_Identity=34.0264650283554, Blast_Score=277, Evalue=2e-74,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_PROAC (Q6A6W2)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056459.1
- ProteinModelPortal:   Q6A6W2
- SMR:   Q6A6W2
- GeneID:   2930931
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1772
- NMPDR:   fig|267747.1.peg.1736
- HOGENOM:   HBG625289
- OMA:   LEKEQYA
- ProtClustDB:   PRK12849
- BioCyc:   PACN267747:PPA1772-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56429; Mature: 56298

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKQLQFDEEARRSLERGVDTLADTVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAKEV
CCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEC
DLTDPYENLGAQLAKEVATKTNDVAGDGTTTATVLAQALVHEGLRAVASGANPVGLKRGI
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EKAVDAVVEELRSISRAIDTTSDMASVATISSRDETIGALIAEAFDKVGKDGVITVDESQ
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
TFGTELDFTEGMQFDKGYLSPYMVTDQDRMEAVIEDPYILIHSGKISSMNDLLPLLEKVI
CCCCCCCHHCCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHH
AAHGSLFIVAEDVDGEALSTLVVNKIRGTFSSVAVKAPAFGDRRKAMLQDIATLTGGQVV
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCEEE
APEVGLKLDQVGLEVLGRAKKVVVTKDNTTIVDGAGDKADVEGRVIQLRAEYDNSDSEWD
CHHHCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCEEEEEEECCCCCCCHHH
REKLQERIAKLAGGVCVIRVGAATEVELNEKKHRIEDAVSATRAAIEEGIVAGGGSALIH
HHHHHHHHHHHHCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AAHVLDGDLHLEGDEKAGVQIVAKAVREPLRWIAENGGEPGYVIVSKVAEMEPGHGYNGK
HHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCC
TGQYVDLIADGVIDPLKVTRSALANAASIASLLLTTETLVVDKPEEDNEDK
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC
>Mature Secondary Structure 
AAKQLQFDEEARRSLERGVDTLADTVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAKEV
CCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEC
DLTDPYENLGAQLAKEVATKTNDVAGDGTTTATVLAQALVHEGLRAVASGANPVGLKRGI
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EKAVDAVVEELRSISRAIDTTSDMASVATISSRDETIGALIAEAFDKVGKDGVITVDESQ
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
TFGTELDFTEGMQFDKGYLSPYMVTDQDRMEAVIEDPYILIHSGKISSMNDLLPLLEKVI
CCCCCCCHHCCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHH
AAHGSLFIVAEDVDGEALSTLVVNKIRGTFSSVAVKAPAFGDRRKAMLQDIATLTGGQVV
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCEEE
APEVGLKLDQVGLEVLGRAKKVVVTKDNTTIVDGAGDKADVEGRVIQLRAEYDNSDSEWD
CHHHCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCEEEEEEECCCCCCCHHH
REKLQERIAKLAGGVCVIRVGAATEVELNEKKHRIEDAVSATRAAIEEGIVAGGGSALIH
HHHHHHHHHHHHCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AAHVLDGDLHLEGDEKAGVQIVAKAVREPLRWIAENGGEPGYVIVSKVAEMEPGHGYNGK
HHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCC
TGQYVDLIADGVIDPLKVTRSALANAASIASLLLTTETLVVDKPEEDNEDK
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA