Click here to switch to the map view.

The map label for this gene is purH

Identifier: 50843207

GI number: 50843207

Start: 1907975

End: 1909525

Strand: Reverse

Name: purH

Synonym: PPA1747

Alternate gene names: 50843207

Gene position: 1909525-1907975 (Counterclockwise)

Preceding gene: 50843208

Following gene: 50843204

Centisome position: 74.58

GC content: 64.15

Gene sequence:

>1551_bases
GTGAGCGAACGTCAACCCATCCGTCGGGCCCTCGTCTCCGTCTACGACAAGTCTGGTCTTGACCAGTTGGCCAAGGCCCT
TATTGACGCGCAGGTCGAGGTGGTCTCGACGGGGTCAACCGCTAAAGAGCTGGCCTCTCATGGGGTGACGGTGACTGAGG
TTAGTGAGATTACGGGGTTCCCGGAGTGCCTCGACGGACGTGTCAAGACCCTGCACCCGAAGGTGCACGCCGGGATCCTC
GCCGACCGCCGCTTGACGTCCCATCGTGAGCAGCTGACTGCTTTAGAAGTGAAGCCCTTTGACCTCGTCGTGTGCAATCT
GTACCCCTTCGCCGAGACCGTAGCGCAAGGGGGAGATTTCGATGAGTGCATTGAGAAGATCGACATCGGTGGCCCGTCGA
TGGTGCGTGCCGCTGCTAAGAATCACGCCAATGTGGCGGTCCTGACCAACCCGGACCAGTACGAAGACCTTGCCCGGGCC
CTGTCCGAAGGCGGGTACACCATGGAGGAGCGTCGCGTGCTGGCGGCCCGTGCCTTCGCCCACACCGCTGCCTATGACGT
CGCGGTGGCCACCTGGTTCGGCAGTCGTGATGGGGTGGCCGTTGACGGCGTTCCCACCTTCGTCGGTACGACCGGGGAGC
TGTCCCACCCGTTGCGCTATGGCGAGAACTCCCACCAGGCCGCAGCCGTATACCGTAGCTCCGGCGAGCCCGGCCTGGCC
GGAGCCCGCCAACTCCATGGCAAGGCCATGAGCTACAACAACTATGTCGACACCAACTCGGCGCGGCGGGCGGCCTTCGA
CTTCGAGGCCCCCTGCGTGGCCGTCATCAAGCACTCGAATCCGTGCGGCATCGCTACCGGCTCCGACATTGCCGAAGCCC
ATCGCAAGGCTCACGCCTGTGACTCTCTGAGCGCTTTCGGTGGCGTTATCGCCACCAATCGCCCGGTCAGCGTGGAGATG
GCCGAGCAGGTTGCCGAGATCTTCACCGAGGTCGTCGTCGCTCCCGGCTATGAGGATGGTGCGGTCGAGATCCTGTCTCG
CAAGAAGAACATCCGGCTGTTGGAGTGCCCTGCCCCGCACCTGGCCGGTTGGGAGCTGCGTCAGATCGACGGTGGCCTGC
TGGCCATGGAGACCGACCTCTTCCAGGCCGACGGCGACGATCCGGCCAACTGGACTCTGGCGGCAGGTGACCCGGTTGAT
GATGTCACCTTGGCCGACCTGTCCTTCGCCTGGCGGGCATGCCGTTCGGTGAGGTCCAACGCCATTTTGCTGGCCCACGA
CGGCGCCTCAGTGGGTGTCGGTATGGGGCAAGTGAACCGGGTCGACTCCTGCAGGCTCGCCGTGGAGCGGGCCGGAGATC
GTGCCGCCGGATCGGTCGCCGCTTCCGACGCTTTTTTCCCATTTGCCGACGGTCCCCAGGTGCTCATTGACGCCCATATC
GCTGCGATCGTCGAGCCGGGTGGTTCCATTCGTGACGACCAGACGATCGAGGTCTGCCGTACGGCCGGCGTCCCACTCTA
CTTTACCGGGACTCGCCACTTCTTCCACTGA

Upstream 100 bases:

>100_bases
TGAAGGAACGCGAAATGCTTGTCACGGTGGTCACAGAACTTGCCGGGGTGCGTCCCGGCATGGAAGAACTCGGCACCGAA
TCGTCTCGAAAGGATCCCCA

Downstream 100 bases:

>100_bases
TTCCGCGCTCCTCATAGAGGTTTCTTGGAACACGTCAGGGGGTCCGATGGTTCGGACCCCCTGACGGTTCTGAGGGGTCA
GTCAAGCTCGGCGATGTAGT

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSERQPIRRALVSVYDKSGLDQLAKALIDAQVEVVSTGSTAKELASHGVTVTEVSEITGFPECLDGRVKTLHPKVHAGIL
ADRRLTSHREQLTALEVKPFDLVVCNLYPFAETVAQGGDFDECIEKIDIGGPSMVRAAAKNHANVAVLTNPDQYEDLARA
LSEGGYTMEERRVLAARAFAHTAAYDVAVATWFGSRDGVAVDGVPTFVGTTGELSHPLRYGENSHQAAAVYRSSGEPGLA
GARQLHGKAMSYNNYVDTNSARRAAFDFEAPCVAVIKHSNPCGIATGSDIAEAHRKAHACDSLSAFGGVIATNRPVSVEM
AEQVAEIFTEVVVAPGYEDGAVEILSRKKNIRLLECPAPHLAGWELRQIDGGLLAMETDLFQADGDDPANWTLAAGDPVD
DVTLADLSFAWRACRSVRSNAILLAHDGASVGVGMGQVNRVDSCRLAVERAGDRAAGSVAASDAFFPFADGPQVLIDAHI
AAIVEPGGSIRDDQTIEVCRTAGVPLYFTGTRHFFH

Sequences:

>Translated_516_residues
MSERQPIRRALVSVYDKSGLDQLAKALIDAQVEVVSTGSTAKELASHGVTVTEVSEITGFPECLDGRVKTLHPKVHAGIL
ADRRLTSHREQLTALEVKPFDLVVCNLYPFAETVAQGGDFDECIEKIDIGGPSMVRAAAKNHANVAVLTNPDQYEDLARA
LSEGGYTMEERRVLAARAFAHTAAYDVAVATWFGSRDGVAVDGVPTFVGTTGELSHPLRYGENSHQAAAVYRSSGEPGLA
GARQLHGKAMSYNNYVDTNSARRAAFDFEAPCVAVIKHSNPCGIATGSDIAEAHRKAHACDSLSAFGGVIATNRPVSVEM
AEQVAEIFTEVVVAPGYEDGAVEILSRKKNIRLLECPAPHLAGWELRQIDGGLLAMETDLFQADGDDPANWTLAAGDPVD
DVTLADLSFAWRACRSVRSNAILLAHDGASVGVGMGQVNRVDSCRLAVERAGDRAAGSVAASDAFFPFADGPQVLIDAHI
AAIVEPGGSIRDDQTIEVCRTAGVPLYFTGTRHFFH
>Mature_515_residues
SERQPIRRALVSVYDKSGLDQLAKALIDAQVEVVSTGSTAKELASHGVTVTEVSEITGFPECLDGRVKTLHPKVHAGILA
DRRLTSHREQLTALEVKPFDLVVCNLYPFAETVAQGGDFDECIEKIDIGGPSMVRAAAKNHANVAVLTNPDQYEDLARAL
SEGGYTMEERRVLAARAFAHTAAYDVAVATWFGSRDGVAVDGVPTFVGTTGELSHPLRYGENSHQAAAVYRSSGEPGLAG
ARQLHGKAMSYNNYVDTNSARRAAFDFEAPCVAVIKHSNPCGIATGSDIAEAHRKAHACDSLSAFGGVIATNRPVSVEMA
EQVAEIFTEVVVAPGYEDGAVEILSRKKNIRLLECPAPHLAGWELRQIDGGLLAMETDLFQADGDDPANWTLAAGDPVDD
VTLADLSFAWRACRSVRSNAILLAHDGASVGVGMGQVNRVDSCRLAVERAGDRAAGSVAASDAFFPFADGPQVLIDAHIA
AIVEPGGSIRDDQTIEVCRTAGVPLYFTGTRHFFH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=480, Percent_Identity=34.5833333333333, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1790439, Length=541, Percent_Identity=41.2199630314233, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71985564, Length=475, Percent_Identity=32.4210526315789, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71985574, Length=307, Percent_Identity=25.0814332247557, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323056, Length=483, Percent_Identity=34.1614906832298, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6323768, Length=479, Percent_Identity=34.8643006263048, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24649832, Length=478, Percent_Identity=35.5648535564854, Blast_Score=218, Evalue=7e-57,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_PROAC (Q6A6Y8)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056434.1
- HSSP:   P31335
- ProteinModelPortal:   Q6A6Y8
- GeneID:   2932978
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1747
- NMPDR:   fig|267747.1.peg.1711
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- ProtClustDB:   PRK00881
- BioCyc:   PACN267747:PPA1747-MONOMER
- BRENDA:   2.1.2.3
- BRENDA:   3.5.4.10
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 54992; Mature: 54861

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERQPIRRALVSVYDKSGLDQLAKALIDAQVEVVSTGSTAKELASHGVTVTEVSEITGF
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHCCCEEEEHHHHCCC
PECLDGRVKTLHPKVHAGILADRRLTSHREQLTALEVKPFDLVVCNLYPFAETVAQGGDF
HHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCHHHHHHHCCCCH
DECIEKIDIGGPSMVRAAAKNHANVAVLTNPDQYEDLARALSEGGYTMEERRVLAARAFA
HHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
HTAAYDVAVATWFGSRDGVAVDGVPTFVGTTGELSHPLRYGENSHQAAAVYRSSGEPGLA
HHHHHHEEEEEEECCCCCEEECCCCCEECCCCCCCCCHHCCCCCCCEEEEEECCCCCCCC
GARQLHGKAMSYNNYVDTNSARRAAFDFEAPCVAVIKHSNPCGIATGSDIAEAHRKAHAC
HHHHHCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
DSLSAFGGVIATNRPVSVEMAEQVAEIFTEVVVAPGYEDGAVEILSRKKNIRLLECPAPH
HHHHHHCCEEECCCCCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCCCEEEECCCCC
LAGWELRQIDGGLLAMETDLFQADGDDPANWTLAAGDPVDDVTLADLSFAWRACRSVRSN
CCCCEEEECCCCEEEEEEHHEECCCCCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHCCC
AILLAHDGASVGVGMGQVNRVDSCRLAVERAGDRAAGSVAASDAFFPFADGPQVLIDAHI
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCEEEEEEE
AAIVEPGGSIRDDQTIEVCRTAGVPLYFTGTRHFFH
EEEECCCCCCCCCCHHHHHHHCCCCEEECCCHHCCC
>Mature Secondary Structure 
SERQPIRRALVSVYDKSGLDQLAKALIDAQVEVVSTGSTAKELASHGVTVTEVSEITGF
CCCHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHCCCEEEEHHHHCCC
PECLDGRVKTLHPKVHAGILADRRLTSHREQLTALEVKPFDLVVCNLYPFAETVAQGGDF
HHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCHHHHHHHCCCCH
DECIEKIDIGGPSMVRAAAKNHANVAVLTNPDQYEDLARALSEGGYTMEERRVLAARAFA
HHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
HTAAYDVAVATWFGSRDGVAVDGVPTFVGTTGELSHPLRYGENSHQAAAVYRSSGEPGLA
HHHHHHEEEEEEECCCCCEEECCCCCEECCCCCCCCCHHCCCCCCCEEEEEECCCCCCCC
GARQLHGKAMSYNNYVDTNSARRAAFDFEAPCVAVIKHSNPCGIATGSDIAEAHRKAHAC
HHHHHCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
DSLSAFGGVIATNRPVSVEMAEQVAEIFTEVVVAPGYEDGAVEILSRKKNIRLLECPAPH
HHHHHHCCEEECCCCCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCCCEEEECCCCC
LAGWELRQIDGGLLAMETDLFQADGDDPANWTLAAGDPVDDVTLADLSFAWRACRSVRSN
CCCCEEEECCCCEEEEEEHHEECCCCCCCCEEEECCCCCCCEEHHHHHHHHHHHHHHCCC
AILLAHDGASVGVGMGQVNRVDSCRLAVERAGDRAAGSVAASDAFFPFADGPQVLIDAHI
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCEEEEEEE
AAIVEPGGSIRDDQTIEVCRTAGVPLYFTGTRHFFH
EEEECCCCCCCCCCHHHHHHHCCCCEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA