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The map label for this gene is manC [H]

Identifier: 50843158

GI number: 50843158

Start: 1848521

End: 1849597

Strand: Reverse

Name: manC [H]

Synonym: PPA1696

Alternate gene names: 50843158

Gene position: 1849597-1848521 (Counterclockwise)

Preceding gene: 50843160

Following gene: 50843157

Centisome position: 72.24

GC content: 59.15

Gene sequence:

>1077_bases
ATGCAGCACATCCTCATCCTGGCCGGAGGATCCGGTACTCGCCTGTGGCCGTTGTCTCACCAGGGAGAGCCCAAGCAATT
ATTGGAACTTATTGACGGGGTCAGTTTGCTTCGGATGGCCTACGAACGAGTCGCTGGGCTGGTGCCCGACGCCAACATTT
TGGTGTGCACGGGTTCCTCGTATGCCGATACCGTCGCCAAGCTGTTGCCAGAAGTTCCCGCCGAGAATATTCTGGGCGAG
CCGGTGGGGCGTGACTCCCTCAGCGCCGTGGCATGGCCGGCGGGAATTATCGCCGACCGCGACCCCGATGGCGTCATGGC
TGTCGTCACAGCTGACCACATTATTCGTCCTGTCGATGATTTTCGGGCCGCCCTCCAGCACGGTTTTGATCTCGCCAATA
CTGACCCCACCGCTTTAGTGACTTTCGGTGTTGTCCCCACCGAGCCCAATACCGGATTCGGATACCTGCATCGGGGTGGC
CGGCTAAGGCCTGGTTCGCGTGCTCACCAGGTACTGGAATTCGTTGAAAAGCCCAGCGCTGAGGTGGCTCGTCAGTATCT
GGATTCCGGTGAGTACTGGTGGAATTCCGGCATGTTTGTGTGGCGGGCTGCGACCCTATTGGACTGCTTATCTCAACTCA
AGCCCCAGACCCGTCATCACGTCGACGAGTTGGTCGCGGATCCGTCCCGACTAGCTGAGGTTTACCCGTGCATGGAGAAA
GTCTCGGTCGACATCGCGGTCATGGAACCGGCATCTCACGGCGGATGTGGTGTTCATGTTGCAGCTATTCCGTTGGAGAT
CCAGTGGTACGACGTCGGCTCTTACGAGGCGCTGGCCCCCCACTTACCTAGTGATGGGATGGGCAACAACGTGAGCGGTT
TGACGGTATCGGTTGACTCAGCCGGAAACTTGTTGATCAATGACCGTCCTGACGCTGTCTTAGCCGTCGCAGGCTTGCAT
GACATGGCCGTCGTGAGCACTGATCGCGCCACCCTGGTGGTGCCGATGTCTCAATCGCAGCAGGTTAAGGCTGTGGTGGC
CGAGGTTGCTGCCCGGGTGGGAGCGCGATACGCGTGA

Upstream 100 bases:

>100_bases
AGTTGGCCGAGTAAGGGAAACCATGGCACCCATTGTGAAGGATAAGACGCTGTGGTGCGTCTAACGCGGTTGCGTTGTCG
CGGCCGGATACTCTGTAGAC

Downstream 100 bases:

>100_bases
GCAACGCCCGAGAAATTCGTGAGCCACTTGCGTGGACAGTCATCGTTGTCAGCGTTGGTTTCCTTGTCGCTTTTGTTGTG
CGTGTGGTCAAGATGCTAAC

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MQHILILAGGSGTRLWPLSHQGEPKQLLELIDGVSLLRMAYERVAGLVPDANILVCTGSSYADTVAKLLPEVPAENILGE
PVGRDSLSAVAWPAGIIADRDPDGVMAVVTADHIIRPVDDFRAALQHGFDLANTDPTALVTFGVVPTEPNTGFGYLHRGG
RLRPGSRAHQVLEFVEKPSAEVARQYLDSGEYWWNSGMFVWRAATLLDCLSQLKPQTRHHVDELVADPSRLAEVYPCMEK
VSVDIAVMEPASHGGCGVHVAAIPLEIQWYDVGSYEALAPHLPSDGMGNNVSGLTVSVDSAGNLLINDRPDAVLAVAGLH
DMAVVSTDRATLVVPMSQSQQVKAVVAEVAARVGARYA

Sequences:

>Translated_358_residues
MQHILILAGGSGTRLWPLSHQGEPKQLLELIDGVSLLRMAYERVAGLVPDANILVCTGSSYADTVAKLLPEVPAENILGE
PVGRDSLSAVAWPAGIIADRDPDGVMAVVTADHIIRPVDDFRAALQHGFDLANTDPTALVTFGVVPTEPNTGFGYLHRGG
RLRPGSRAHQVLEFVEKPSAEVARQYLDSGEYWWNSGMFVWRAATLLDCLSQLKPQTRHHVDELVADPSRLAEVYPCMEK
VSVDIAVMEPASHGGCGVHVAAIPLEIQWYDVGSYEALAPHLPSDGMGNNVSGLTVSVDSAGNLLINDRPDAVLAVAGLH
DMAVVSTDRATLVVPMSQSQQVKAVVAEVAARVGARYA
>Mature_358_residues
MQHILILAGGSGTRLWPLSHQGEPKQLLELIDGVSLLRMAYERVAGLVPDANILVCTGSSYADTVAKLLPEVPAENILGE
PVGRDSLSAVAWPAGIIADRDPDGVMAVVTADHIIRPVDDFRAALQHGFDLANTDPTALVTFGVVPTEPNTGFGYLHRGG
RLRPGSRAHQVLEFVEKPSAEVARQYLDSGEYWWNSGMFVWRAATLLDCLSQLKPQTRHHVDELVADPSRLAEVYPCMEK
VSVDIAVMEPASHGGCGVHVAAIPLEIQWYDVGSYEALAPHLPSDGMGNNVSGLTVSVDSAGNLLINDRPDAVLAVAGLH
DMAVVSTDRATLVVPMSQSQQVKAVVAEVAARVGARYA

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=362, Percent_Identity=33.9779005524862, Blast_Score=172, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 38284; Mature: 38284

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHILILAGGSGTRLWPLSHQGEPKQLLELIDGVSLLRMAYERVAGLVPDANILVCTGSS
CCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCH
YADTVAKLLPEVPAENILGEPVGRDSLSAVAWPAGIIADRDPDGVMAVVTADHIIRPVDD
HHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHCCCCEECCCCCCCEEEEEEHHHHHCCHHH
FRAALQHGFDLANTDPTALVTFGVVPTEPNTGFGYLHRGGRLRPGSRAHQVLEFVEKPSA
HHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCH
EVARQYLDSGEYWWNSGMFVWRAATLLDCLSQLKPQTRHHVDELVADPSRLAEVYPCMEK
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHH
VSVDIAVMEPASHGGCGVHVAAIPLEIQWYDVGSYEALAPHLPSDGMGNNVSGLTVSVDS
HEEEEEEECCCCCCCCEEEEEEEEEEEEEEECCCCHHHCCCCCCCCCCCCCCEEEEEECC
AGNLLINDRPDAVLAVAGLHDMAVVSTDRATLVVPMSQSQQVKAVVAEVAARVGARYA
CCCEEEECCCCEEEEEECCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQHILILAGGSGTRLWPLSHQGEPKQLLELIDGVSLLRMAYERVAGLVPDANILVCTGSS
CCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCH
YADTVAKLLPEVPAENILGEPVGRDSLSAVAWPAGIIADRDPDGVMAVVTADHIIRPVDD
HHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHCCCCEECCCCCCCEEEEEEHHHHHCCHHH
FRAALQHGFDLANTDPTALVTFGVVPTEPNTGFGYLHRGGRLRPGSRAHQVLEFVEKPSA
HHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCH
EVARQYLDSGEYWWNSGMFVWRAATLLDCLSQLKPQTRHHVDELVADPSRLAEVYPCMEK
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHH
VSVDIAVMEPASHGGCGVHVAAIPLEIQWYDVGSYEALAPHLPSDGMGNNVSGLTVSVDS
HEEEEEEECCCCCCCCEEEEEEEEEEEEEEECCCCHHHCCCCCCCCCCCCCCEEEEEECC
AGNLLINDRPDAVLAVAGLHDMAVVSTDRATLVVPMSQSQQVKAVVAEVAARVGARYA
CCCEEEECCCCEEEEEECCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7515042; 9004408 [H]