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The map label for this gene is yqjI [H]

Identifier: 50843097

GI number: 50843097

Start: 1769855

End: 1771303

Strand: Direct

Name: yqjI [H]

Synonym: PPA1629

Alternate gene names: 50843097

Gene position: 1769855-1771303 (Clockwise)

Preceding gene: 50843095

Following gene: 50843098

Centisome position: 69.13

GC content: 60.73

Gene sequence:

>1449_bases
ATGAGTGACACTGCGCCACAGACCGCCGAGGTCGGCGTCATCGGAATGGCCGTCATGGGCTCTAATCTGGCCCGAAATAT
GGCCCGTAAGGGCTTCCGTGTCGCCATCTATAACCGCACCGCATCACGTACCGACGAGGTGATAGCCGGGCATGGCAACG
AAGGGACGTTCCTGCCCTTCCATGACCTGGCCAATTTCGTAGCCAGCCTCGAGCGCCCGCGTCGCGTCGTCATGATGGTT
AAGGCGGGGTGCGGCACCGATGCCGTCATTAAAGAGATCACCCCTCTCCTCCAACCTGGTGATGTCCTCGTCGACGGTGG
TAATGCTTATTTTGGTGATACCCGCCGCCGTGAGGAGGAAATACGTCCCACCGGCATTCACTATGTTGGTACTGGCATCT
CCGGTGGGGAAGTCGGGGCCCTTGAGGGTCCATCAATTATGCCTGGCGGGTCTAAGGAATCTTACGAAATCATCGGACCG
GTCTTAGAAAAAATCTCCGCCCACGTCGACGGTGAACCCTGCTGCGCATGGATGGGTACTGACGGCGCCGGACACTTCGT
CAAGATGGTCCATAATGGCATCGAGTACGCCGATATGCAGTTCATTGGCGAGGCGCACTCCCTTTTGCGTGCCGCCGGTT
TGACCAATGCTGAGGCCGCCGATGCCTTCGAGTCGTGGAACCATGGCGACCTCAATTCCTACCTCGTCGAAATCACTTCT
CGGGTACTGCGTGCCAAGGATCCTCGTAACCCCGACACAGACCTCCTCGACGTCATCCGCGACGAGGCGGGAATGAAGGG
AACGGGCACCTGGACCGTCCAGACTGCTCTCGAGCTTGGAGTGGATGTCTCCACTATCAGCGAGGCGGTCTTCGCCCGAT
CCGTTTCCAGCGCCGTGCCGCTGCGCACGGTCGGTCAGCATGTCCTTGCGGGGCCGGAGCACACCATCACTGTTGAGGAC
CGGCAAACCTTCCTTACCGATGTTCGTGATGCCCTATGGTCGGCGAAGGTGGTGGCCTACGCACAAGGTCTCGACGAGAT
TCGTACGGCGGCCGCCGAGTACAACTGGGAGGTCGATATGGGCCAAATCGCGTCAATCTGGCGCGATGGCTGCATCATTC
GCGCGCGTCTGCTCCAACGCATCAGGGATGAATACGCCGCCGGTGACCTCGTATCCCTCCTTGAGGCCCCGTCCGTGAAG
GCCGAGCTCGCACGCTGCCAGCAAGCGTGGCGCCGGGTCGTCGCCTGTGCTGTCGAGGCCGGTGTTCCAGTTCCGGGATT
CTCTTCAGCCCTGGGCTACTACGACCAAGTCCGAGCCCCTCGTCTTAACGCCGCTCTCACCCAGGGTCTGCGCGACCTTT
TCGGTGCCCACACGTACCGGCGCGTTGACGACGAAGGTTCTTGGCACCTCAACTGGTCAGGCGACGGTCGCGAAGTCCGC
GCCAACTGA

Upstream 100 bases:

>100_bases
CACACGCGCGCGGCATCTCATAACCTCACCAGATCCGCCCTCAACTGCATCAAGAGTGAATCACTGGAAAGATGGGGACG
AGACACCGAGGAGGAAACGC

Downstream 100 bases:

>100_bases
GTCTTCCCTCCACGAGAGTGGCCAGCCCTGGCCGTCGTGTCTGTTCCTACCCCACGCAACCCCATAAGGAGCCCCATGAC
CACCTCCCCTACGATCAACG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSDTAPQTAEVGVIGMAVMGSNLARNMARKGFRVAIYNRTASRTDEVIAGHGNEGTFLPFHDLANFVASLERPRRVVMMV
KAGCGTDAVIKEITPLLQPGDVLVDGGNAYFGDTRRREEEIRPTGIHYVGTGISGGEVGALEGPSIMPGGSKESYEIIGP
VLEKISAHVDGEPCCAWMGTDGAGHFVKMVHNGIEYADMQFIGEAHSLLRAAGLTNAEAADAFESWNHGDLNSYLVEITS
RVLRAKDPRNPDTDLLDVIRDEAGMKGTGTWTVQTALELGVDVSTISEAVFARSVSSAVPLRTVGQHVLAGPEHTITVED
RQTFLTDVRDALWSAKVVAYAQGLDEIRTAAAEYNWEVDMGQIASIWRDGCIIRARLLQRIRDEYAAGDLVSLLEAPSVK
AELARCQQAWRRVVACAVEAGVPVPGFSSALGYYDQVRAPRLNAALTQGLRDLFGAHTYRRVDDEGSWHLNWSGDGREVR
AN

Sequences:

>Translated_482_residues
MSDTAPQTAEVGVIGMAVMGSNLARNMARKGFRVAIYNRTASRTDEVIAGHGNEGTFLPFHDLANFVASLERPRRVVMMV
KAGCGTDAVIKEITPLLQPGDVLVDGGNAYFGDTRRREEEIRPTGIHYVGTGISGGEVGALEGPSIMPGGSKESYEIIGP
VLEKISAHVDGEPCCAWMGTDGAGHFVKMVHNGIEYADMQFIGEAHSLLRAAGLTNAEAADAFESWNHGDLNSYLVEITS
RVLRAKDPRNPDTDLLDVIRDEAGMKGTGTWTVQTALELGVDVSTISEAVFARSVSSAVPLRTVGQHVLAGPEHTITVED
RQTFLTDVRDALWSAKVVAYAQGLDEIRTAAAEYNWEVDMGQIASIWRDGCIIRARLLQRIRDEYAAGDLVSLLEAPSVK
AELARCQQAWRRVVACAVEAGVPVPGFSSALGYYDQVRAPRLNAALTQGLRDLFGAHTYRRVDDEGSWHLNWSGDGREVR
AN
>Mature_481_residues
SDTAPQTAEVGVIGMAVMGSNLARNMARKGFRVAIYNRTASRTDEVIAGHGNEGTFLPFHDLANFVASLERPRRVVMMVK
AGCGTDAVIKEITPLLQPGDVLVDGGNAYFGDTRRREEEIRPTGIHYVGTGISGGEVGALEGPSIMPGGSKESYEIIGPV
LEKISAHVDGEPCCAWMGTDGAGHFVKMVHNGIEYADMQFIGEAHSLLRAAGLTNAEAADAFESWNHGDLNSYLVEITSR
VLRAKDPRNPDTDLLDVIRDEAGMKGTGTWTVQTALELGVDVSTISEAVFARSVSSAVPLRTVGQHVLAGPEHTITVEDR
QTFLTDVRDALWSAKVVAYAQGLDEIRTAAAEYNWEVDMGQIASIWRDGCIIRARLLQRIRDEYAAGDLVSLLEAPSVKA
ELARCQQAWRRVVACAVEAGVPVPGFSSALGYYDQVRAPRLNAALTQGLRDLFGAHTYRRVDDEGSWHLNWSGDGREVRA
N

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=478, Percent_Identity=45.1882845188285, Blast_Score=413, Evalue=1e-115,
Organism=Escherichia coli, GI1788341, Length=466, Percent_Identity=51.7167381974249, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17542558, Length=480, Percent_Identity=43.125, Blast_Score=410, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321695, Length=484, Percent_Identity=43.1818181818182, Blast_Score=413, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321977, Length=486, Percent_Identity=45.4732510288066, Blast_Score=412, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24639279, Length=476, Percent_Identity=46.0084033613445, Blast_Score=417, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52193; Mature: 52062

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTAPQTAEVGVIGMAVMGSNLARNMARKGFRVAIYNRTASRTDEVIAGHGNEGTFLPF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCEEEH
HDLANFVASLERPRRVVMMVKAGCGTDAVIKEITPLLQPGDVLVDGGNAYFGDTRRREEE
HHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
IRPTGIHYVGTGISGGEVGALEGPSIMPGGSKESYEIIGPVLEKISAHVDGEPCCAWMGT
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECC
DGAGHFVKMVHNGIEYADMQFIGEAHSLLRAAGLTNAEAADAFESWNHGDLNSYLVEITS
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHH
RVLRAKDPRNPDTDLLDVIRDEAGMKGTGTWTVQTALELGVDVSTISEAVFARSVSSAVP
HHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHCCC
LRTVGQHVLAGPEHTITVEDRQTFLTDVRDALWSAKVVAYAQGLDEIRTAAAEYNWEVDM
HHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GQIASIWRDGCIIRARLLQRIRDEYAAGDLVSLLEAPSVKAELARCQQAWRRVVACAVEA
HHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GVPVPGFSSALGYYDQVRAPRLNAALTQGLRDLFGAHTYRRVDDEGSWHLNWSGDGREVR
CCCCCCCHHHHCHHHHHCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEECCCCCEEC
AN
CC
>Mature Secondary Structure 
SDTAPQTAEVGVIGMAVMGSNLARNMARKGFRVAIYNRTASRTDEVIAGHGNEGTFLPF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEECCCCCCCEEEH
HDLANFVASLERPRRVVMMVKAGCGTDAVIKEITPLLQPGDVLVDGGNAYFGDTRRREEE
HHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
IRPTGIHYVGTGISGGEVGALEGPSIMPGGSKESYEIIGPVLEKISAHVDGEPCCAWMGT
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECC
DGAGHFVKMVHNGIEYADMQFIGEAHSLLRAAGLTNAEAADAFESWNHGDLNSYLVEITS
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHH
RVLRAKDPRNPDTDLLDVIRDEAGMKGTGTWTVQTALELGVDVSTISEAVFARSVSSAVP
HHHHCCCCCCCCHHHHHHHHHHCCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHCCC
LRTVGQHVLAGPEHTITVEDRQTFLTDVRDALWSAKVVAYAQGLDEIRTAAAEYNWEVDM
HHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GQIASIWRDGCIIRARLLQRIRDEYAAGDLVSLLEAPSVKAELARCQQAWRRVVACAVEA
HHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GVPVPGFSSALGYYDQVRAPRLNAALTQGLRDLFGAHTYRRVDDEGSWHLNWSGDGREVR
CCCCCCCHHHHCHHHHHCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEECCCCCEEC
AN
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]