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The map label for this gene is mutM [C]

Identifier: 50843091

GI number: 50843091

Start: 1760969

End: 1761868

Strand: Reverse

Name: mutM [C]

Synonym: PPA1623

Alternate gene names: 50843091

Gene position: 1761868-1760969 (Counterclockwise)

Preceding gene: 50843092

Following gene: 50843090

Centisome position: 68.82

GC content: 59.33

Gene sequence:

>900_bases
ATGAAGCTATCCTGCCTCAACTCGTTGCGCCTGTTCGACTTCCATGACGCTATGACTACTTATCCGAGAGGACAACCAAC
CGTGCCTGAAGGCCACGTCATCCATCGTCTTGCCAATGCCATCGACTTGGCCTTCGCCGGTTCACGGGTTGAGGTCACTT
CTCCGCAGGGACGATTCGCCGAATCCGCAGCCATGCTGGATGGGACAGTGCTGGCCTCAGCTCAGGCATGGGGCAAACAT
CTCGTCGTGGACTTCGATAATCATCGTCCTGACCACCTGTTACACATCCACTTGGGATTGATTGGCAAGCTGGCAGTCGA
GCCGACAGTTCCTGTGGTCGGTCAGGTGCGGTTACGCATCACCGACGGCGTTACTGCAGCTGATCTACGCGGTCCGCAAA
CGTGCGAGCTCATCAACGACGACGAGTGGGGGACGGTCGCAGCCACTATTGGCCCCGACCCCATCCGCGACGATGCAGAT
CCGGACGTTGCATGGGACAAGGTACGACGGTCGTCACGGCGAATCAGCGATGTGTTGTTAGACCAAAGGGTTGCGGCCGG
AGTTGGCAATATTTACCGAGCTGAGGTGTTATTTCGCCACCGCGTTGATCCAGCCACCCCTGGCAAGCAGATTTCCCACT
CAACGTGGTTGGCGATGTGGGATGATCTGGTCATGCTCATGCGCGCCGGAGTTGAGTCAGGGCGCATCGACACCGTGCAG
CCAGAGCACACTCCGGAGGCGATGGGTCGGCCCCCTCGGGTAGATCATCATGGCGGTGAGGTGTACGTCTACCGGCGCGA
GGACCAGCCCTGTTTGGTGTGTAATACGCCGGTGCGGATGGTCGCACAGGGAGGGCGTCACCTGTTTTGGTGCCCACGGT
GTCAGCGTCGGCGTCACTGA

Upstream 100 bases:

>100_bases
AAGTTCGCGCGTCCTCATAGCGCGATCTCCTTTAAGGATTGACCCATGACCACGCCGGTGGTCATGGTTTCGGTGCTGTT
TGCCGTGGTCAGAGGCATTC

Downstream 100 bases:

>100_bases
CGGTTGTTGGTTTTGGAGGTCAGAATGAACCGCGTCACCGTTAGTCCACCGTGGACACTGGTGTCATGCCAGGAGTCCGA
TCACGAGTCCTCGTGGATGT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Putative DNA-(apurinic or apyrimidinic site) lyase Rv2464c/MT2539; Putative AP lyase Rv2464c/MT2539 [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKLSCLNSLRLFDFHDAMTTYPRGQPTVPEGHVIHRLANAIDLAFAGSRVEVTSPQGRFAESAAMLDGTVLASAQAWGKH
LVVDFDNHRPDHLLHIHLGLIGKLAVEPTVPVVGQVRLRITDGVTAADLRGPQTCELINDDEWGTVAATIGPDPIRDDAD
PDVAWDKVRRSSRRISDVLLDQRVAAGVGNIYRAEVLFRHRVDPATPGKQISHSTWLAMWDDLVMLMRAGVESGRIDTVQ
PEHTPEAMGRPPRVDHHGGEVYVYRREDQPCLVCNTPVRMVAQGGRHLFWCPRCQRRRH

Sequences:

>Translated_299_residues
MKLSCLNSLRLFDFHDAMTTYPRGQPTVPEGHVIHRLANAIDLAFAGSRVEVTSPQGRFAESAAMLDGTVLASAQAWGKH
LVVDFDNHRPDHLLHIHLGLIGKLAVEPTVPVVGQVRLRITDGVTAADLRGPQTCELINDDEWGTVAATIGPDPIRDDAD
PDVAWDKVRRSSRRISDVLLDQRVAAGVGNIYRAEVLFRHRVDPATPGKQISHSTWLAMWDDLVMLMRAGVESGRIDTVQ
PEHTPEAMGRPPRVDHHGGEVYVYRREDQPCLVCNTPVRMVAQGGRHLFWCPRCQRRRH
>Mature_299_residues
MKLSCLNSLRLFDFHDAMTTYPRGQPTVPEGHVIHRLANAIDLAFAGSRVEVTSPQGRFAESAAMLDGTVLASAQAWGKH
LVVDFDNHRPDHLLHIHLGLIGKLAVEPTVPVVGQVRLRITDGVTAADLRGPQTCELINDDEWGTVAATIGPDPIRDDAD
PDVAWDKVRRSSRRISDVLLDQRVAAGVGNIYRAEVLFRHRVDPATPGKQISHSTWLAMWDDLVMLMRAGVESGRIDTVQ
PEHTPEAMGRPPRVDHHGGEVYVYRREDQPCLVCNTPVRMVAQGGRHLFWCPRCQRRRH

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA b

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=249, Percent_Identity=26.5060240963855, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786932, Length=284, Percent_Identity=25.3521126760563, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR012319
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 33317; Mature: 33317

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSCLNSLRLFDFHDAMTTYPRGQPTVPEGHVIHRLANAIDLAFAGSRVEVTSPQGRFA
CCCCCCCCCEEEEEHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECCCEEEEECCCCCHH
ESAAMLDGTVLASAQAWGKHLVVDFDNHRPDHLLHIHLGLIGKLAVEPTVPVVGQVRLRI
HHHHHHCCHHEECHHHCCCEEEEEECCCCCCEEEEEEECCHHHEECCCCCCCEEEEEEEE
TDGVTAADLRGPQTCELINDDEWGTVAATIGPDPIRDDADPDVAWDKVRRSSRRISDVLL
ECCCEEHHCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DQRVAAGVGNIYRAEVLFRHRVDPATPGKQISHSTWLAMWDDLVMLMRAGVESGRIDTVQ
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
PEHTPEAMGRPPRVDHHGGEVYVYRREDQPCLVCNTPVRMVAQGGRHLFWCPRCQRRRH
CCCCHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHCCCCEEEECCCHHCCCC
>Mature Secondary Structure
MKLSCLNSLRLFDFHDAMTTYPRGQPTVPEGHVIHRLANAIDLAFAGSRVEVTSPQGRFA
CCCCCCCCCEEEEEHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECCCEEEEECCCCCHH
ESAAMLDGTVLASAQAWGKHLVVDFDNHRPDHLLHIHLGLIGKLAVEPTVPVVGQVRLRI
HHHHHHCCHHEECHHHCCCEEEEEECCCCCCEEEEEEECCHHHEECCCCCCCEEEEEEEE
TDGVTAADLRGPQTCELINDDEWGTVAATIGPDPIRDDADPDVAWDKVRRSSRRISDVLL
ECCCEEHHCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DQRVAAGVGNIYRAEVLFRHRVDPATPGKQISHSTWLAMWDDLVMLMRAGVESGRIDTVQ
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
PEHTPEAMGRPPRVDHHGGEVYVYRREDQPCLVCNTPVRMVAQGGRHLFWCPRCQRRRH
CCCCHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHCCCCEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]