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The map label for this gene is zwf [H]

Identifier: 50843037

GI number: 50843037

Start: 1682542

End: 1684116

Strand: Direct

Name: zwf [H]

Synonym: PPA1563

Alternate gene names: 50843037

Gene position: 1682542-1684116 (Clockwise)

Preceding gene: 50843034

Following gene: 50843038

Centisome position: 65.72

GC content: 58.29

Gene sequence:

>1575_bases
GTGGCAGGTCGAGACGCATCAGGAAGCACCACCAGAGCGATCAGCGGACTGCGTGGCGACCGCGTCAACCCATTGCGGGA
CCCCTCAGACCGCAGACTGCCACGCGTCGCCGGGCCGTGCGTTCTAGTCATGTTCGGGGTTACCGGTGACCTTTCACGCA
AGAAACTCATGCCAGCTGTCTACGATCTGGCGAACCGTGGCCTACTCCCACCAGGTTTTGGCCTGGTGGGTTTCGCCCGT
CGAGATTGGGAGGACGAGGACTTCGCCAAGGTCGTACACGACGCCGTGGCCGAGCATGCCCGTACCCCCTTCCGCGAGGA
GGTGTGGGAGCAACTACTCGAAGGCATTCGGTTTGTCCGCGGCGAATTCGACGATAACGACGCCTTCGAGAGATTGGCTA
ACACGATCCGCGAACTTGATGAGGAACGAGGCACTGGTGGTAATCACGCCTTCTACCTGTCGATCCCGCCGAGATCTTTT
GAAGCGGTCATAAGCCAGCTCAAACGTCATGGCATGACCGGCCACGACTCCTCTCACTGGAGCAGAGTCGTCATTGAGAA
ACCCTTCGGACACGATCTGGAAAGTGCCCGCGATCTCGACGAGATCATCAGCAGCGCCTTCAGCCCAGAATCGGTATTCC
GCATTGACCACTACTTGGGCAAAGAGACCGTCCAGAACATCATGGCGTTTCGGTTCGCCAACCAGATTTTCGAGCCGATT
TGGAATAACCATTACGTTTCGCACGTCCAGATCACCATGGCAGAGGACATTGGCATCGCTGGCCGGGCTGGTTATTACGA
CGGTATCGGAGCCTCCCGCGATGTCATCCAGAACCACTTACTGCAACTCATGGCACTGACCGCCATGGAGGAGCCGACGA
GTTTCGACGCCAAGCAATTGTGCGCGGAAAAGATTAAGATCTTAGCTGCAATTCAACCGCCTGACAACATGTTCGCCCAA
ACCTGCCGCGGCCAATACGTGGCTGGTCGCCAAGGAGGCGAAAGGGTGCGCGGCTACCTTGAGGAAGACGGAGTCGATCC
TCGCTCCCGCACCGAAACCTATGCCGCTGTGCGGCTGACCATCGACAATCGACGCTGGGCTGGAGTTCCGTTCTATCTAC
GCACTGCCAAACGAATGCCTCGACGAGTCACTGAGGTCGCCTTGAATCTGCAACGCGCCCCGCATCTACCCTTCTCAGAT
ACCGCAGCTCTCGGCACCAACGCCGTCGTACTGCGTATTCAGCCTGATGAGGGAGTTACTCTGAAATTCGGCGCCAAAGT
GCCCGGCACCCAGATGGAACTTCGCGATGTCACGATGGACTTCGCGTATGGATCTTCCTTCACCGAGGCCAGCCCGGAAG
CCTACGAGAGACTCATTCTTGATGTTCTCTTGGGCGATCCGCCACTGTTCCCCCAACATGAGGAGGTCGAATTGGCTTGG
AAGATCCTTGACCCGGTGCTGGATTTCTGGGCCGAGTCCAACACTCCCCCGTGCGAATATCCGGCCGGTAGTTGGGGACC
GTCGGAGGCTGACGAGATGATCGCCCGCGACGAGTTCGTCTGGCGCAGGCCTTGA

Upstream 100 bases:

>100_bases
GTCAGCCCGTCGCTGAACACAATCACCAGTGGTTCGACCAGCTACCGTTGAGCAGGTGGAATAACGGTTCCGCACAACAT
CACCAGGAAGGACGGGTGAG

Downstream 100 bases:

>100_bases
GGAGGAGACATGATCGTCACGCTCAACGACACCACCGTCTCGAAGATTGGTGGGGCCATCGTGGAGGCCCGTCGTACCGT
TGGTTCTGGGTCTGGGTTGG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MAGRDASGSTTRAISGLRGDRVNPLRDPSDRRLPRVAGPCVLVMFGVTGDLSRKKLMPAVYDLANRGLLPPGFGLVGFAR
RDWEDEDFAKVVHDAVAEHARTPFREEVWEQLLEGIRFVRGEFDDNDAFERLANTIRELDEERGTGGNHAFYLSIPPRSF
EAVISQLKRHGMTGHDSSHWSRVVIEKPFGHDLESARDLDEIISSAFSPESVFRIDHYLGKETVQNIMAFRFANQIFEPI
WNNHYVSHVQITMAEDIGIAGRAGYYDGIGASRDVIQNHLLQLMALTAMEEPTSFDAKQLCAEKIKILAAIQPPDNMFAQ
TCRGQYVAGRQGGERVRGYLEEDGVDPRSRTETYAAVRLTIDNRRWAGVPFYLRTAKRMPRRVTEVALNLQRAPHLPFSD
TAALGTNAVVLRIQPDEGVTLKFGAKVPGTQMELRDVTMDFAYGSSFTEASPEAYERLILDVLLGDPPLFPQHEEVELAW
KILDPVLDFWAESNTPPCEYPAGSWGPSEADEMIARDEFVWRRP

Sequences:

>Translated_524_residues
MAGRDASGSTTRAISGLRGDRVNPLRDPSDRRLPRVAGPCVLVMFGVTGDLSRKKLMPAVYDLANRGLLPPGFGLVGFAR
RDWEDEDFAKVVHDAVAEHARTPFREEVWEQLLEGIRFVRGEFDDNDAFERLANTIRELDEERGTGGNHAFYLSIPPRSF
EAVISQLKRHGMTGHDSSHWSRVVIEKPFGHDLESARDLDEIISSAFSPESVFRIDHYLGKETVQNIMAFRFANQIFEPI
WNNHYVSHVQITMAEDIGIAGRAGYYDGIGASRDVIQNHLLQLMALTAMEEPTSFDAKQLCAEKIKILAAIQPPDNMFAQ
TCRGQYVAGRQGGERVRGYLEEDGVDPRSRTETYAAVRLTIDNRRWAGVPFYLRTAKRMPRRVTEVALNLQRAPHLPFSD
TAALGTNAVVLRIQPDEGVTLKFGAKVPGTQMELRDVTMDFAYGSSFTEASPEAYERLILDVLLGDPPLFPQHEEVELAW
KILDPVLDFWAESNTPPCEYPAGSWGPSEADEMIARDEFVWRRP
>Mature_523_residues
AGRDASGSTTRAISGLRGDRVNPLRDPSDRRLPRVAGPCVLVMFGVTGDLSRKKLMPAVYDLANRGLLPPGFGLVGFARR
DWEDEDFAKVVHDAVAEHARTPFREEVWEQLLEGIRFVRGEFDDNDAFERLANTIRELDEERGTGGNHAFYLSIPPRSFE
AVISQLKRHGMTGHDSSHWSRVVIEKPFGHDLESARDLDEIISSAFSPESVFRIDHYLGKETVQNIMAFRFANQIFEPIW
NNHYVSHVQITMAEDIGIAGRAGYYDGIGASRDVIQNHLLQLMALTAMEEPTSFDAKQLCAEKIKILAAIQPPDNMFAQT
CRGQYVAGRQGGERVRGYLEEDGVDPRSRTETYAAVRLTIDNRRWAGVPFYLRTAKRMPRRVTEVALNLQRAPHLPFSDT
AALGTNAVVLRIQPDEGVTLKFGAKVPGTQMELRDVTMDFAYGSSFTEASPEAYERLILDVLLGDPPLFPQHEEVELAWK
ILDPVLDFWAESNTPPCEYPAGSWGPSEADEMIARDEFVWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=38.0952380952381, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=38.0952380952381, Blast_Score=322, Evalue=6e-88,
Organism=Homo sapiens, GI52145310, Length=499, Percent_Identity=28.2565130260521, Blast_Score=156, Evalue=5e-38,
Organism=Escherichia coli, GI1788158, Length=495, Percent_Identity=39.5959595959596, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17538218, Length=513, Percent_Identity=36.6471734892787, Blast_Score=350, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6324088, Length=487, Percent_Identity=36.5503080082135, Blast_Score=316, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24643350, Length=493, Percent_Identity=35.6997971602434, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24643352, Length=493, Percent_Identity=35.6997971602434, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI221513548, Length=487, Percent_Identity=27.5154004106776, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58875; Mature: 58744

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRDASGSTTRAISGLRGDRVNPLRDPSDRRLPRVAGPCVLVMFGVTGDLSRKKLMPAV
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHH
YDLANRGLLPPGFGLVGFARRDWEDEDFAKVVHDAVAEHARTPFREEVWEQLLEGIRFVR
HHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GEFDDNDAFERLANTIRELDEERGTGGNHAFYLSIPPRSFEAVISQLKRHGMTGHDSSHW
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCC
SRVVIEKPFGHDLESARDLDEIISSAFSPESVFRIDHYLGKETVQNIMAFRFANQIFEPI
CEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
WNNHYVSHVQITMAEDIGIAGRAGYYDGIGASRDVIQNHLLQLMALTAMEEPTSFDAKQL
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
CAEKIKILAAIQPPDNMFAQTCRGQYVAGRQGGERVRGYLEEDGVDPRSRTETYAAVRLT
HHHHHHHHEEECCCHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCHHCCEEEEEEEE
IDNRRWAGVPFYLRTAKRMPRRVTEVALNLQRAPHLPFSDTAALGTNAVVLRIQPDEGVT
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEECCCCEE
LKFGAKVPGTQMELRDVTMDFAYGSSFTEASPEAYERLILDVLLGDPPLFPQHEEVELAW
EEECCCCCCCCEEHHHHEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
KILDPVLDFWAESNTPPCEYPAGSWGPSEADEMIARDEFVWRRP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AGRDASGSTTRAISGLRGDRVNPLRDPSDRRLPRVAGPCVLVMFGVTGDLSRKKLMPAV
CCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHH
YDLANRGLLPPGFGLVGFARRDWEDEDFAKVVHDAVAEHARTPFREEVWEQLLEGIRFVR
HHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GEFDDNDAFERLANTIRELDEERGTGGNHAFYLSIPPRSFEAVISQLKRHGMTGHDSSHW
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCC
SRVVIEKPFGHDLESARDLDEIISSAFSPESVFRIDHYLGKETVQNIMAFRFANQIFEPI
CEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
WNNHYVSHVQITMAEDIGIAGRAGYYDGIGASRDVIQNHLLQLMALTAMEEPTSFDAKQL
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
CAEKIKILAAIQPPDNMFAQTCRGQYVAGRQGGERVRGYLEEDGVDPRSRTETYAAVRLT
HHHHHHHHEEECCCHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCHHCCEEEEEEEE
IDNRRWAGVPFYLRTAKRMPRRVTEVALNLQRAPHLPFSDTAALGTNAVVLRIQPDEGVT
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEECCCCEE
LKFGAKVPGTQMELRDVTMDFAYGSSFTEASPEAYERLILDVLLGDPPLFPQHEEVELAW
EEECCCCCCCCEEHHHHEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
KILDPVLDFWAESNTPPCEYPAGSWGPSEADEMIARDEFVWRRP
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]