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The map label for this gene is thiL [H]

Identifier: 50842841

GI number: 50842841

Start: 1481873

End: 1482835

Strand: Reverse

Name: thiL [H]

Synonym: PPA1357

Alternate gene names: 50842841

Gene position: 1482835-1481873 (Counterclockwise)

Preceding gene: 50842843

Following gene: 50842840

Centisome position: 57.92

GC content: 63.34

Gene sequence:

>963_bases
ATGGCCACCACGACGACCATTTCCCAGGTAGGGGAGTTTCCCCTCATCTCCTCGATGGTCGGCGACTTGACGATGGGCCA
GGCTGTCACTCTCGGCCCGGGAGACGATGGCGCGGTGTTCCAGGTAGACGGTTCCGCAGTTGTCTCGACCGACGTCCTCG
TCGAGGAGGTTCACTTCCGGCGTCGATGGTCGACGGCGACCGACGTGGGCCGAAAGGCCGTCGCCGTCAACGTTTCCGAC
ATCGAGGCAATGGGCGCCGTACCAGTAGCCCTCGTCGTCGGGTTTTCCGCTCCCGGTGATCTTCCGGCGTCCTGGGCCCG
CGAATTCATGGCCGGGATGACCGCCGAGTCCCAGAAGGCAGGAGTCAGCGTCGTCGGTGGGGACACCACGGGCGGCCCGG
TTGTCAGCATCGCCGTAACAGTTATCGGACAGACCGCTGGCATGGCACCTGTGCGTCGTGACGGTGCTGTACCCGGCGAT
GAAGTTGCGGTGATTGGCCAACTCGGTTTGGCAGCTGCCGGACTGGCCCTTCTCGGACGCGGTTTCCGTTCTCCACGTGC
CGTTGTGGCTGCCCAGCGTTGTCCCGAGGTTCCCTACGGTCAAGGACGGGTGGCGGCTAAGGCTGGAGTACACGCCATGA
TTGACGTGTCGGATGGTCTGCTGGCTGATTTGGGCCATATCGCGGAGGCATCCGGATTCGCCATGGATATCGACACTGCG
AAGCTGGATATCACCGAGTCAGTCCGCACCGTCGGTATGGCCACCGGTGTGGACCCGCTGACGTGGGTGCTTGCCGGTGG
GGAGGATCATGCGTTGGCAGCGACTTTCGCTCCCGGCACTGTTCCGGATGGGTGGACCGTCGTCGGACGGGTCCTACCTC
CCGATGAGGCACCAGATCCCACGGTTCTCGTTGATGGCCAAGTCTGGCAACAGGAACGAGGTTGGACCCACTTCCATTCC
TGA

Upstream 100 bases:

>100_bases
TGGTCAGGAGGAAGACCACTAGCAGGGTTGCGACCGGGGATGCATGATAGATGCGCACATATTCACGCTAGCGCCGATGA
CCGGTTGATAAGGAGATCCC

Downstream 100 bases:

>100_bases
GGTGGCGACGGCGTTTACAGTGCCGTCGAGTTTCGCGCCACGACTACCAATCCCGTGACTCCCCGCTTCACCTCTGGGCG
GGTGGTGGCCATGGTTGATA

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MATTTTISQVGEFPLISSMVGDLTMGQAVTLGPGDDGAVFQVDGSAVVSTDVLVEEVHFRRRWSTATDVGRKAVAVNVSD
IEAMGAVPVALVVGFSAPGDLPASWAREFMAGMTAESQKAGVSVVGGDTTGGPVVSIAVTVIGQTAGMAPVRRDGAVPGD
EVAVIGQLGLAAAGLALLGRGFRSPRAVVAAQRCPEVPYGQGRVAAKAGVHAMIDVSDGLLADLGHIAEASGFAMDIDTA
KLDITESVRTVGMATGVDPLTWVLAGGEDHALAATFAPGTVPDGWTVVGRVLPPDEAPDPTVLVDGQVWQQERGWTHFHS

Sequences:

>Translated_320_residues
MATTTTISQVGEFPLISSMVGDLTMGQAVTLGPGDDGAVFQVDGSAVVSTDVLVEEVHFRRRWSTATDVGRKAVAVNVSD
IEAMGAVPVALVVGFSAPGDLPASWAREFMAGMTAESQKAGVSVVGGDTTGGPVVSIAVTVIGQTAGMAPVRRDGAVPGD
EVAVIGQLGLAAAGLALLGRGFRSPRAVVAAQRCPEVPYGQGRVAAKAGVHAMIDVSDGLLADLGHIAEASGFAMDIDTA
KLDITESVRTVGMATGVDPLTWVLAGGEDHALAATFAPGTVPDGWTVVGRVLPPDEAPDPTVLVDGQVWQQERGWTHFHS
>Mature_319_residues
ATTTTISQVGEFPLISSMVGDLTMGQAVTLGPGDDGAVFQVDGSAVVSTDVLVEEVHFRRRWSTATDVGRKAVAVNVSDI
EAMGAVPVALVVGFSAPGDLPASWAREFMAGMTAESQKAGVSVVGGDTTGGPVVSIAVTVIGQTAGMAPVRRDGAVPGDE
VAVIGQLGLAAAGLALLGRGFRSPRAVVAAQRCPEVPYGQGRVAAKAGVHAMIDVSDGLLADLGHIAEASGFAMDIDTAK
LDITESVRTVGMATGVDPLTWVLAGGEDHALAATFAPGTVPDGWTVVGRVLPPDEAPDPTVLVDGQVWQQERGWTHFHS

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=277, Percent_Identity=34.2960288808664, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 32642; Mature: 32511

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTTTISQVGEFPLISSMVGDLTMGQAVTLGPGDDGAVFQVDGSAVVSTDVLVEEVHFR
CCCCCCHHHHCCCCHHHHHHCCCCCCCEEEECCCCCCCEEEECCCEEEEHHHHHHHHHHH
RRWSTATDVGRKAVAVNVSDIEAMGAVPVALVVGFSAPGDLPASWAREFMAGMTAESQKA
HHCCCHHHCCCEEEEEEHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHC
GVSVVGGDTTGGPVVSIAVTVIGQTAGMAPVRRDGAVPGDEVAVIGQLGLAAAGLALLGR
CEEEECCCCCCCCEEEEEEEEHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHC
GFRSPRAVVAAQRCPEVPYGQGRVAAKAGVHAMIDVSDGLLADLGHIAEASGFAMDIDTA
CCCCCHHHHHHHHCCCCCCCCCCEEHHCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCC
KLDITESVRTVGMATGVDPLTWVLAGGEDHALAATFAPGTVPDGWTVVGRVLPPDEAPDP
EEEHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCC
TVLVDGQVWQQERGWTHFHS
EEEECCHHHHHCCCCCCCCC
>Mature Secondary Structure 
ATTTTISQVGEFPLISSMVGDLTMGQAVTLGPGDDGAVFQVDGSAVVSTDVLVEEVHFR
CCCCCHHHHCCCCHHHHHHCCCCCCCEEEECCCCCCCEEEECCCEEEEHHHHHHHHHHH
RRWSTATDVGRKAVAVNVSDIEAMGAVPVALVVGFSAPGDLPASWAREFMAGMTAESQKA
HHCCCHHHCCCEEEEEEHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHC
GVSVVGGDTTGGPVVSIAVTVIGQTAGMAPVRRDGAVPGDEVAVIGQLGLAAAGLALLGR
CEEEECCCCCCCCEEEEEEEEHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHC
GFRSPRAVVAAQRCPEVPYGQGRVAAKAGVHAMIDVSDGLLADLGHIAEASGFAMDIDTA
CCCCCHHHHHHHHCCCCCCCCCCEEHHCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCC
KLDITESVRTVGMATGVDPLTWVLAGGEDHALAATFAPGTVPDGWTVVGRVLPPDEAPDP
EEEHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCC
TVLVDGQVWQQERGWTHFHS
EEEECCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]