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The map label for this gene is argH [H]

Identifier: 50842830

GI number: 50842830

Start: 1469169

End: 1470629

Strand: Reverse

Name: argH [H]

Synonym: PPA1346

Alternate gene names: 50842830

Gene position: 1470629-1469169 (Counterclockwise)

Preceding gene: 50842831

Following gene: 50842829

Centisome position: 57.44

GC content: 61.05

Gene sequence:

>1461_bases
GTGACCACCGAACCGTACGACCATTCTCAGAACAACGCCCAGGCCGATCGCCCGATGGCGCTGTGGGGTGGACGATTCTC
TGGCGGCCCGTCTGAGGCGTTGGCGGCGCTGTCAGTCTCCACCCAATTCGATTGGCGACTAGCCCGCCACGACATTGCTG
GATCGAGTGCTCACGCCGGGGTACTTCATGCCGCAGGTCTCCTCGATGACGATCAGTACGAGGGGATGATGAAGGCTCTT
AACGCCTTGGAGGAGGACGTTGTTTCGGGCCGTTTCGTGGCTCAGCCAGAGGACGAGGATGTCCATACTGCTCTGGAGCG
CGGTCTCATGGAGCGTGCCGGGAAAGATCTCGGAGGACGGCTACGTGCCGGGCGTTCCCGCAACGACCAGATTATTGCTC
TGCTGCGTCGCTACCTTCGTGAGGAAGCCCGCAGTCTTGCTGGGGAGCTTCTGGGACTCGCTCATGTGCTAAGTCGACAA
GCCGAGGACGTCGGTGACGCGGTTATCGCTGGTCGTACCCACATGCAGCACGCCCAGCCGGTGTTGCTGGCTCACCAGCT
GCTGGCCCACGCGTGGCCGCTGCTCCGCGACGTGCAGCGTTTTCGCGATCTCGATGCGCGACTGGATTGTTCGCCATACG
GATCCGGGGCACTAGCAGGATCATCATTGGGTCTGGATCCAGAGGCGGTTGCACGTGATCTGGGGTTCTCGTCGTCAGTC
CCGAATTCCATTGATGGTACTGCGGCTCGAGACGTTGTTGCTGAGTTCGCCTTCGTTGCCGCCCAGGTCGGAGTCGACTT
ATCGCGGTTGAGTGAAGAGATCATCATCTGGAATACCCGCGAGTTCGGTTACGTCACTCTCGACGATTCCTTCTCGACGG
GTTCATCGATCATGCCGCAAAAAAAGAACCCGGACATCGCTGAGCTTGCCCGCGGCAAGGCAGGGCGTCTCATTGGTGAT
CTTGCCGGTCTCATGGCTTCCCTTAAGGGCCTGCCACTGGCCTACGCCCGTGACCTTCAGGAGGATAAAGAGCCGGTTTT
CGACCAGATTGACCAGCTCCACCTGCTGTTGCCAGCTATCACTGGAATGGTGGACACCGCCGTGTTCAACACCGATCGCA
TGGCCGAGATGGCTGGTCAGGGGTTCTCATTGGCTACCGACGTTGCCGAGTGGTTGGTACGCCAGGGGGTTCCCTTCCGG
GTCGCCCACGAGTTGTCCGGGGCTTGCGTGCGCGGGGCAGAGTCTCAGAATAAGGAGTTGGCCGATCTCACCGACCAGGA
ACTTATCGCGATCGATCCCCGTCTAACCCCGCAGGTGCGCGAGGTCATGACAGTTCAGGGGTCAGTACGCTCTCGGGCCG
GACGCGGTGGGACCGCACCTGAGCGCGTCGCTGAGCAGATCACCGAGCTGCGCGAGGCCATTGCGGGCTTGCGCAGTTTC
GGAGAGGCCGAAACCCGATGA

Upstream 100 bases:

>100_bases
GGTGCAGGCCTGACGATCCTCCTTGATGCCGTGGGATGGGGTTTGAAGACGGTGTGAAGGACGGTAGGTAAGCTGAAAAT
CCCCGACAGAGGAGTTCTTT

Downstream 100 bases:

>100_bases
ATTGGGGGACCGACGACTCGTCGCTGCGGGTGACGAATGAGCAGCGAGACCGGGTTCTCGACCACATCAACGACGCTTAT
GCCCACGGTGCCATTGACGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTTEPYDHSQNNAQADRPMALWGGRFSGGPSEALAALSVSTQFDWRLARHDIAGSSAHAGVLHAAGLLDDDQYEGMMKAL
NALEEDVVSGRFVAQPEDEDVHTALERGLMERAGKDLGGRLRAGRSRNDQIIALLRRYLREEARSLAGELLGLAHVLSRQ
AEDVGDAVIAGRTHMQHAQPVLLAHQLLAHAWPLLRDVQRFRDLDARLDCSPYGSGALAGSSLGLDPEAVARDLGFSSSV
PNSIDGTAARDVVAEFAFVAAQVGVDLSRLSEEIIIWNTREFGYVTLDDSFSTGSSIMPQKKNPDIAELARGKAGRLIGD
LAGLMASLKGLPLAYARDLQEDKEPVFDQIDQLHLLLPAITGMVDTAVFNTDRMAEMAGQGFSLATDVAEWLVRQGVPFR
VAHELSGACVRGAESQNKELADLTDQELIAIDPRLTPQVREVMTVQGSVRSRAGRGGTAPERVAEQITELREAIAGLRSF
GEAETR

Sequences:

>Translated_486_residues
MTTEPYDHSQNNAQADRPMALWGGRFSGGPSEALAALSVSTQFDWRLARHDIAGSSAHAGVLHAAGLLDDDQYEGMMKAL
NALEEDVVSGRFVAQPEDEDVHTALERGLMERAGKDLGGRLRAGRSRNDQIIALLRRYLREEARSLAGELLGLAHVLSRQ
AEDVGDAVIAGRTHMQHAQPVLLAHQLLAHAWPLLRDVQRFRDLDARLDCSPYGSGALAGSSLGLDPEAVARDLGFSSSV
PNSIDGTAARDVVAEFAFVAAQVGVDLSRLSEEIIIWNTREFGYVTLDDSFSTGSSIMPQKKNPDIAELARGKAGRLIGD
LAGLMASLKGLPLAYARDLQEDKEPVFDQIDQLHLLLPAITGMVDTAVFNTDRMAEMAGQGFSLATDVAEWLVRQGVPFR
VAHELSGACVRGAESQNKELADLTDQELIAIDPRLTPQVREVMTVQGSVRSRAGRGGTAPERVAEQITELREAIAGLRSF
GEAETR
>Mature_485_residues
TTEPYDHSQNNAQADRPMALWGGRFSGGPSEALAALSVSTQFDWRLARHDIAGSSAHAGVLHAAGLLDDDQYEGMMKALN
ALEEDVVSGRFVAQPEDEDVHTALERGLMERAGKDLGGRLRAGRSRNDQIIALLRRYLREEARSLAGELLGLAHVLSRQA
EDVGDAVIAGRTHMQHAQPVLLAHQLLAHAWPLLRDVQRFRDLDARLDCSPYGSGALAGSSLGLDPEAVARDLGFSSSVP
NSIDGTAARDVVAEFAFVAAQVGVDLSRLSEEIIIWNTREFGYVTLDDSFSTGSSIMPQKKNPDIAELARGKAGRLIGDL
AGLMASLKGLPLAYARDLQEDKEPVFDQIDQLHLLLPAITGMVDTAVFNTDRMAEMAGQGFSLATDVAEWLVRQGVPFRV
AHELSGACVRGAESQNKELADLTDQELIAIDPRLTPQVREVMTVQGSVRSRAGRGGTAPERVAEQITELREAIAGLRSFG
EAETR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=42.2907488986784, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=42.2907488986784, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=40.3083700440529, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=39.647577092511, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1790398, Length=450, Percent_Identity=41.7777777777778, Blast_Score=324, Evalue=6e-90,
Organism=Saccharomyces cerevisiae, GI6321806, Length=462, Percent_Identity=39.3939393939394, Blast_Score=335, Evalue=1e-92,
Organism=Drosophila melanogaster, GI221473854, Length=453, Percent_Identity=40.8388520971302, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI78706858, Length=453, Percent_Identity=40.8388520971302, Blast_Score=329, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52528; Mature: 52397

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEPYDHSQNNAQADRPMALWGGRFSGGPSEALAALSVSTQFDWRLARHDIAGSSAHAG
CCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHH
VLHAAGLLDDDQYEGMMKALNALEEDVVSGRFVAQPEDEDVHTALERGLMERAGKDLGGR
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCH
LRAGRSRNDQIIALLRRYLREEARSLAGELLGLAHVLSRQAEDVGDAVIAGRTHMQHAQP
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VLLAHQLLAHAWPLLRDVQRFRDLDARLDCSPYGSGALAGSSLGLDPEAVARDLGFSSSV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCC
PNSIDGTAARDVVAEFAFVAAQVGVDLSRLSEEIIIWNTREFGYVTLDDSFSTGSSIMPQ
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCC
KKNPDIAELARGKAGRLIGDLAGLMASLKGLPLAYARDLQEDKEPVFDQIDQLHLLLPAI
CCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TGMVDTAVFNTDRMAEMAGQGFSLATDVAEWLVRQGVPFRVAHELSGACVRGAESQNKEL
HHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHCCHHHCCCCCCCCHH
ADLTDQELIAIDPRLTPQVREVMTVQGSVRSRAGRGGTAPERVAEQITELREAIAGLRSF
HHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GEAETR
CCCCCC
>Mature Secondary Structure 
TTEPYDHSQNNAQADRPMALWGGRFSGGPSEALAALSVSTQFDWRLARHDIAGSSAHAG
CCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHH
VLHAAGLLDDDQYEGMMKALNALEEDVVSGRFVAQPEDEDVHTALERGLMERAGKDLGGR
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCH
LRAGRSRNDQIIALLRRYLREEARSLAGELLGLAHVLSRQAEDVGDAVIAGRTHMQHAQP
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VLLAHQLLAHAWPLLRDVQRFRDLDARLDCSPYGSGALAGSSLGLDPEAVARDLGFSSSV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCC
PNSIDGTAARDVVAEFAFVAAQVGVDLSRLSEEIIIWNTREFGYVTLDDSFSTGSSIMPQ
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCC
KKNPDIAELARGKAGRLIGDLAGLMASLKGLPLAYARDLQEDKEPVFDQIDQLHLLLPAI
CCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TGMVDTAVFNTDRMAEMAGQGFSLATDVAEWLVRQGVPFRVAHELSGACVRGAESQNKEL
HHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEHHHHHCCHHHCCCCCCCCHH
ADLTDQELIAIDPRLTPQVREVMTVQGSVRSRAGRGGTAPERVAEQITELREAIAGLRSF
HHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GEAETR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA