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The map label for this gene is sbnA [H]

Identifier: 50842771

GI number: 50842771

Start: 1401896

End: 1402897

Strand: Reverse

Name: sbnA [H]

Synonym: PPA1290

Alternate gene names: 50842771

Gene position: 1402897-1401896 (Counterclockwise)

Preceding gene: 50842773

Following gene: 50842770

Centisome position: 54.79

GC content: 45.31

Gene sequence:

>1002_bases
ATGATTGCAGGATCTATTGAAGAACTAGATGAAAACTCTCAATTTGTCCGCTTGAAAAATTCATTTCCTAAACATGATGT
TTACGCAAAATTAGAAGGTTTAAACACTGCTGGTTCCGTAAAACTCAAGACGGCTATTGCACTCGTCGATAGCTTAGAAA
AGCTTCGTGGTCTTCAGCCAGGAGGTTGGGTCGTAGAGTCTTCTTCTGGGAGTTTAGGCATAGCACTTTCCGGTGTATGT
GCGCGCCGAGGATACAAATTAACAATTGTTACAGATGTGAATGCAAATTCAAGGTCGATTTCGCATATGCGTGCACTGGG
CGCGGAAGTGGAAGTTGTTCAATCATTGGATGCAGCGGGCGGATTTCTTGGGACGCGACTTGCTAGAGTTCGCGAATTAG
TAGAGATGCCAGGAGGGCCTTTATGGACAAACCAGTACGAAAATGTAGCCAATCCTGAGGTTCATTCCAAGAAGACATAT
AGAGCGATCGTCGAAGAGTTAGGAGATCCTGATTACCTATTTGTAGGTGCTGGTACCACTGGCACGCTTATGGGTGTATC
TAGGGCTGTCATGAAGCGTGGTTCATGCACCAAAGTTTGTGCTATTGATAGCACTGGTTCAGTGACTTTCGGAGGAGCTC
CTTCGCGGCGATATATCCCTGGTCTAGGCGCTAGTGTAAAGCCACCAATCTTTGACGAAAAATTTCCTCTAAAACGGTAT
TATATTGATGAAATCGATACCGTGAGACAGTGCCGACGCATTGCGCAGGTAGAAGGATTTTTACCGGGTGGATCGACTGG
CACTGTGCTAGCAGCTTTTGATGCTCTTCGAGATAAAATTCCCGAGGGAAGCCGCGTTGTCATTATTGCGCCGGATCTTG
GTGAAAGGTATCTGGATGGAGTATATAACGACGATTGGGTTATGGAAAACTTTGGGGAATCAGCATTTAATTATGCCATT
CGTCCTGTTGCGCACGAAGTGAAAGAAACGGAAGGTATTTAA

Upstream 100 bases:

>100_bases
TTCTAATAACGCCCATAGCCTGTACAAGACTCCTCATTATAATTTGCTTGTATGTTATGAAAACTTCCGATGGCATGTCA
TGCGCAGTAGGAGCACATAA

Downstream 100 bases:

>100_bases
ATGACGAAATATGGTGAAATGCTAATTATAGACGCCAAGCTTGTCGAAACATTTTTAAAAGGCAGAGAGTCGTTTCTCAT
CGATCTTGTTGAACGTGTTT

Product: cystathionine beta-synthase

Products: cystathionine; H2O

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIAGSIEELDENSQFVRLKNSFPKHDVYAKLEGLNTAGSVKLKTAIALVDSLEKLRGLQPGGWVVESSSGSLGIALSGVC
ARRGYKLTIVTDVNANSRSISHMRALGAEVEVVQSLDAAGGFLGTRLARVRELVEMPGGPLWTNQYENVANPEVHSKKTY
RAIVEELGDPDYLFVGAGTTGTLMGVSRAVMKRGSCTKVCAIDSTGSVTFGGAPSRRYIPGLGASVKPPIFDEKFPLKRY
YIDEIDTVRQCRRIAQVEGFLPGGSTGTVLAAFDALRDKIPEGSRVVIIAPDLGERYLDGVYNDDWVMENFGESAFNYAI
RPVAHEVKETEGI

Sequences:

>Translated_333_residues
MIAGSIEELDENSQFVRLKNSFPKHDVYAKLEGLNTAGSVKLKTAIALVDSLEKLRGLQPGGWVVESSSGSLGIALSGVC
ARRGYKLTIVTDVNANSRSISHMRALGAEVEVVQSLDAAGGFLGTRLARVRELVEMPGGPLWTNQYENVANPEVHSKKTY
RAIVEELGDPDYLFVGAGTTGTLMGVSRAVMKRGSCTKVCAIDSTGSVTFGGAPSRRYIPGLGASVKPPIFDEKFPLKRY
YIDEIDTVRQCRRIAQVEGFLPGGSTGTVLAAFDALRDKIPEGSRVVIIAPDLGERYLDGVYNDDWVMENFGESAFNYAI
RPVAHEVKETEGI
>Mature_333_residues
MIAGSIEELDENSQFVRLKNSFPKHDVYAKLEGLNTAGSVKLKTAIALVDSLEKLRGLQPGGWVVESSSGSLGIALSGVC
ARRGYKLTIVTDVNANSRSISHMRALGAEVEVVQSLDAAGGFLGTRLARVRELVEMPGGPLWTNQYENVANPEVHSKKTY
RAIVEELGDPDYLFVGAGTTGTLMGVSRAVMKRGSCTKVCAIDSTGSVTFGGAPSRRYIPGLGASVKPPIFDEKFPLKRY
YIDEIDTVRQCRRIAQVEGFLPGGSTGTVLAAFDALRDKIPEGSRVVIIAPDLGERYLDGVYNDDWVMENFGESAFNYAI
RPVAHEVKETEGI

Specific function: Probable pyridoxal phosphate-dependent enzyme involved in siderophore biosynthesis [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=297, Percent_Identity=27.6094276094276, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI295821200, Length=297, Percent_Identity=27.6094276094276, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI4557415, Length=297, Percent_Identity=27.6094276094276, Blast_Score=118, Evalue=9e-27,
Organism=Escherichia coli, GI2367138, Length=320, Percent_Identity=30.3125, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788754, Length=310, Percent_Identity=33.2258064516129, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=31.3993174061433, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17534315, Length=350, Percent_Identity=31.1428571428571, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=31, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=29.8657718120805, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25147552, Length=299, Percent_Identity=29.0969899665552, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115535073, Length=309, Percent_Identity=30.0970873786408, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17561720, Length=293, Percent_Identity=30.7167235494881, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321594, Length=306, Percent_Identity=28.7581699346405, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=29.3051359516616, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24643623, Length=330, Percent_Identity=30, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20129101, Length=330, Percent_Identity=30, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: 4.2.1.22

Molecular weight: Translated: 35992; Mature: 35992

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAGSIEELDENSQFVRLKNSFPKHDVYAKLEGLNTAGSVKLKTAIALVDSLEKLRGLQP
CCCCCHHHHCCCCCEEEECCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC
GGWVVESSSGSLGIALSGVCARRGYKLTIVTDVNANSRSISHMRALGAEVEVVQSLDAAG
CCEEEECCCCCEEEEEECHHHHCCEEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCC
GFLGTRLARVRELVEMPGGPLWTNQYENVANPEVHSKKTYRAIVEELGDPDYLFVGAGTT
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
GTLMGVSRAVMKRGSCTKVCAIDSTGSVTFGGAPSRRYIPGLGASVKPPIFDEKFPLKRY
HHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
YIDEIDTVRQCRRIAQVEGFLPGGSTGTVLAAFDALRDKIPEGSRVVIIAPDLGERYLDG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCC
VYNDDWVMENFGESAFNYAIRPVAHEVKETEGI
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIAGSIEELDENSQFVRLKNSFPKHDVYAKLEGLNTAGSVKLKTAIALVDSLEKLRGLQP
CCCCCHHHHCCCCCEEEECCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC
GGWVVESSSGSLGIALSGVCARRGYKLTIVTDVNANSRSISHMRALGAEVEVVQSLDAAG
CCEEEECCCCCEEEEEECHHHHCCEEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCC
GFLGTRLARVRELVEMPGGPLWTNQYENVANPEVHSKKTYRAIVEELGDPDYLFVGAGTT
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
GTLMGVSRAVMKRGSCTKVCAIDSTGSVTFGGAPSRRYIPGLGASVKPPIFDEKFPLKRY
HHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
YIDEIDTVRQCRRIAQVEGFLPGGSTGTVLAAFDALRDKIPEGSRVVIIAPDLGERYLDG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCC
VYNDDWVMENFGESAFNYAIRPVAHEVKETEGI
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-serine; L-homocysteine

Specific reaction: L-serine + L-homocysteine = cystathionine + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA