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The map label for this gene is lrp [H]

Identifier: 50842700

GI number: 50842700

Start: 1328367

End: 1328858

Strand: Direct

Name: lrp [H]

Synonym: PPA1220

Alternate gene names: 50842700

Gene position: 1328367-1328858 (Clockwise)

Preceding gene: 50842699

Following gene: 50842701

Centisome position: 51.88

GC content: 57.72

Gene sequence:

>492_bases
ATGACCAAACACCACGACGAAGAGGATGAGGATCGGTCGCCGATCCTCGAAGCCACCGATCGTCACATCCTCGCCCTGCT
TGAAAAAGACGGTCGGATGTCGTGGACCGAGCTCGGCCACCAGACCGGCCTATCGACCTCAGCCGCCCAACAACGTGTCA
AACGTCTTGAAGCCAAGGGGATCATCACTGGATATCACGCCACGCTGAACCTTGAGGCGATCGGTGTGGGTATCACCGCA
TTTATCTTCCTCAACCCCATCGATCCCGAAGAAGACGAAACGATACCCGGTATTCTACGTACCTTCCCCGAAGTACGAGG
CTGTCACTCCATCGCTGGGGCAGCGTCCTATCTGGCACGAGTCCAAGCGCCCAGCGCCGGCCACCTCGATCAGTTGCTCA
CGCGTATTCGCAAAGAATGTCTTTGCGGCACAGAGACAGTCGTCGTCCTCGACACCATGTTCGACGACCTCGGCATGTTG
GGAACCCGGTGA

Upstream 100 bases:

>100_bases
CATCGCGGGTAGCATCTGCCGCACCAAACTTGCTCGCCGGATCAACCATTCGTGTGCTGAAATCCCATTGGGTCGAGCCG
GGGACAGGGAGGAACCATTC

Downstream 100 bases:

>100_bases
TTTCTCGCCTGCGGCGCACCTCGTGGCTGCGTGGTACAGCTGCTGTTGCCGCCGGGGCCGCGACCGGTACCGGGTTCCAA
CCACTGAACTGGTGGATCCT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MTKHHDEEDEDRSPILEATDRHILALLEKDGRMSWTELGHQTGLSTSAAQQRVKRLEAKGIITGYHATLNLEAIGVGITA
FIFLNPIDPEEDETIPGILRTFPEVRGCHSIAGAASYLARVQAPSAGHLDQLLTRIRKECLCGTETVVVLDTMFDDLGML
GTR

Sequences:

>Translated_163_residues
MTKHHDEEDEDRSPILEATDRHILALLEKDGRMSWTELGHQTGLSTSAAQQRVKRLEAKGIITGYHATLNLEAIGVGITA
FIFLNPIDPEEDETIPGILRTFPEVRGCHSIAGAASYLARVQAPSAGHLDQLLTRIRKECLCGTETVVVLDTMFDDLGML
GTR
>Mature_162_residues
TKHHDEEDEDRSPILEATDRHILALLEKDGRMSWTELGHQTGLSTSAAQQRVKRLEAKGIITGYHATLNLEAIGVGITAF
IFLNPIDPEEDETIPGILRTFPEVRGCHSIAGAASYLARVQAPSAGHLDQLLTRIRKECLCGTETVVVLDTMFDDLGMLG
TR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=140, Percent_Identity=35, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI87081742, Length=124, Percent_Identity=34.6774193548387, Blast_Score=74, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17920; Mature: 17788

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHHDEEDEDRSPILEATDRHILALLEKDGRMSWTELGHQTGLSTSAAQQRVKRLEAKG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCC
IITGYHATLNLEAIGVGITAFIFLNPIDPEEDETIPGILRTFPEVRGCHSIAGAASYLAR
EEEEEEEEEEEEHHHHCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VQAPSAGHLDQLLTRIRKECLCGTETVVVLDTMFDDLGMLGTR
HCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKHHDEEDEDRSPILEATDRHILALLEKDGRMSWTELGHQTGLSTSAAQQRVKRLEAKG
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCC
IITGYHATLNLEAIGVGITAFIFLNPIDPEEDETIPGILRTFPEVRGCHSIAGAASYLAR
EEEEEEEEEEEEHHHHCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VQAPSAGHLDQLLTRIRKECLCGTETVVVLDTMFDDLGMLGTR
HCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]