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The map label for this gene is coaBC [H]

Identifier: 50842672

GI number: 50842672

Start: 1297294

End: 1298526

Strand: Direct

Name: coaBC [H]

Synonym: PPA1192

Alternate gene names: 50842672

Gene position: 1297294-1298526 (Clockwise)

Preceding gene: 50842671

Following gene: 50842673

Centisome position: 50.67

GC content: 61.56

Gene sequence:

>1233_bases
GTGAGTGTCGTCGTTCTTGGTGTCGGGGGAGGGATCGCCGCCTACAAGGCATGCCTGCTCGCGCGGCTCCTCTCTGAGGT
CGGCCACGAGGTCCACGTTGTCCCCACTAGGGCTGCCCTTGAATTCGTCGGACGCCCGACGTGGGAGGCGCTGAGTGGGC
ATCCGGTCCACACCGAGGTTTTTGACGACGTTCCCGATGTGGAGCATATCCGCTTGGCTGAGCGCGCCGACGCCATCGTG
GTGGCTCCAGCAACTGCCGATCTCTTGGCGCGCCTTGCGGGAGGCCATGCCGACGACCTCCTGACGACGACGGTTCTCGC
CACGTCAGCGCCGGTGCTGCTCGCACCTGCTATGCACACCGGAATGTGGCAAAACGCAGCAACCGTCGATAATGTCGCGA
CCCTACGTCGCCATGGCCTTGTCGTTAAGGCCCCAGCTACTGGGCGCCTTACTGGTCGTGACTCAGGCCCGGGGCGTCTA
CCTGATCCCGACGAGATTGCAGAATTCGTTGATCTTCTCATCACTGTTCCTGAGTGCGCCGCCGCGATGGCCCAGCAGGA
CCTTGCTGGAAAACGCGTCGTCATCTCCCTGGGTGGAACCCGGGAAGCCATCGACCCTGTGCGTTACCTCGGTAACTCGT
CGTCAGGTCGAATGGGCAGGGCTATCGCTCAAGTCGCCGCTGCTCGCGGGGCCGATGTCCACGTTGTCGCTGCCCACGTT
GACGTCGCTATACCGTCAGACGTGCAGATTACCCGCATTGATAGCACCGAAGACCTTGCTGAGGCCATGGACGACTTAGC
CAAGCAAGCCGATATTGTCATCCAAGCCGTTGCGGCAGCTGACTTTGCGCCAGTCGCTGTTGACACCAAGATTAAAAAAC
ACGAGGGCGACGACGCCACAGGTGCAACGATGGCCCTCCAACTTCACCAGACTCCCGACGTCCTGGCCCGCATCTGTTCT
CAATCGGTACAGAACAGGGTTGTCGTCGGATTTGCCGCCGAAACGGCACCAGACCGTGACCAGTTCTTGAAGCTGGCCCA
GGCCAAGCTCGCACGCAAGGGTTGCGACCTTATGGTCGTGAACGATGTGAGCGGCGGAAAGGTGTTCGGCAAGGTCGGCA
CCGACGTAACCATGGTTCACCAGCAGGGGCCGGGTCGTCGTATCACCGGATCGAAGTCGCAGGCGGCTGTCGCCATCCTT
GACGAGGTCCGCGCGCTGCTGGCTACTCAGTAA

Upstream 100 bases:

>100_bases
GATCGCCGCCCAGGCCGCTGCGGCCCAAGAGGCCCCGGCTATTGAGCTGGATGACCCCTTCGCTGACCTCGCTGATCCGA
ACGCCTGATCTGAGACCGGC

Downstream 100 bases:

>100_bases
CACGATGCGCGGCTTGTGGCCGCGCGGACAGGAAACGTCATGCCTACTCGTCTGTTCACATCGGAATCAGTAACGGAAGG
CCACCCGGACAAGATTGCCG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSVVVLGVGGGIAAYKACLLARLLSEVGHEVHVVPTRAALEFVGRPTWEALSGHPVHTEVFDDVPDVEHIRLAERADAIV
VAPATADLLARLAGGHADDLLTTTVLATSAPVLLAPAMHTGMWQNAATVDNVATLRRHGLVVKAPATGRLTGRDSGPGRL
PDPDEIAEFVDLLITVPECAAAMAQQDLAGKRVVISLGGTREAIDPVRYLGNSSSGRMGRAIAQVAAARGADVHVVAAHV
DVAIPSDVQITRIDSTEDLAEAMDDLAKQADIVIQAVAAADFAPVAVDTKIKKHEGDDATGATMALQLHQTPDVLARICS
QSVQNRVVVGFAAETAPDRDQFLKLAQAKLARKGCDLMVVNDVSGGKVFGKVGTDVTMVHQQGPGRRITGSKSQAAVAIL
DEVRALLATQ

Sequences:

>Translated_410_residues
MSVVVLGVGGGIAAYKACLLARLLSEVGHEVHVVPTRAALEFVGRPTWEALSGHPVHTEVFDDVPDVEHIRLAERADAIV
VAPATADLLARLAGGHADDLLTTTVLATSAPVLLAPAMHTGMWQNAATVDNVATLRRHGLVVKAPATGRLTGRDSGPGRL
PDPDEIAEFVDLLITVPECAAAMAQQDLAGKRVVISLGGTREAIDPVRYLGNSSSGRMGRAIAQVAAARGADVHVVAAHV
DVAIPSDVQITRIDSTEDLAEAMDDLAKQADIVIQAVAAADFAPVAVDTKIKKHEGDDATGATMALQLHQTPDVLARICS
QSVQNRVVVGFAAETAPDRDQFLKLAQAKLARKGCDLMVVNDVSGGKVFGKVGTDVTMVHQQGPGRRITGSKSQAAVAIL
DEVRALLATQ
>Mature_409_residues
SVVVLGVGGGIAAYKACLLARLLSEVGHEVHVVPTRAALEFVGRPTWEALSGHPVHTEVFDDVPDVEHIRLAERADAIVV
APATADLLARLAGGHADDLLTTTVLATSAPVLLAPAMHTGMWQNAATVDNVATLRRHGLVVKAPATGRLTGRDSGPGRLP
DPDEIAEFVDLLITVPECAAAMAQQDLAGKRVVISLGGTREAIDPVRYLGNSSSGRMGRAIAQVAAARGADVHVVAAHVD
VAIPSDVQITRIDSTEDLAEAMDDLAKQADIVIQAVAAADFAPVAVDTKIKKHEGDDATGATMALQLHQTPDVLARICSQ
SVQNRVVVGFAAETAPDRDQFLKLAQAKLARKGCDLMVVNDVSGGKVFGKVGTDVTMVHQQGPGRRITGSKSQAAVAILD
EVRALLATQ

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=162, Percent_Identity=36.4197530864198, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI87082301, Length=366, Percent_Identity=39.344262295082, Blast_Score=199, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42817; Mature: 42686

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVVLGVGGGIAAYKACLLARLLSEVGHEVHVVPTRAALEFVGRPTWEALSGHPVHTEV
CEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCCHHHCCCCCCCHHH
FDDVPDVEHIRLAERADAIVVAPATADLLARLAGGHADDLLTTTVLATSAPVLLAPAMHT
HCCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECHHHC
GMWQNAATVDNVATLRRHGLVVKAPATGRLTGRDSGPGRLPDPDEIAEFVDLLITVPECA
CCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AAMAQQDLAGKRVVISLGGTREAIDPVRYLGNSSSGRMGRAIAQVAAARGADVHVVAAHV
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEE
DVAIPSDVQITRIDSTEDLAEAMDDLAKQADIVIQAVAAADFAPVAVDTKIKKHEGDDAT
EEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCCCCCCC
GATMALQLHQTPDVLARICSQSVQNRVVVGFAAETAPDRDQFLKLAQAKLARKGCDLMVV
CCEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEE
NDVSGGKVFGKVGTDVTMVHQQGPGRRITGSKSQAAVAILDEVRALLATQ
ECCCCCEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVVVLGVGGGIAAYKACLLARLLSEVGHEVHVVPTRAALEFVGRPTWEALSGHPVHTEV
EEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCCHHHCCCCCCCHHH
FDDVPDVEHIRLAERADAIVVAPATADLLARLAGGHADDLLTTTVLATSAPVLLAPAMHT
HCCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECHHHC
GMWQNAATVDNVATLRRHGLVVKAPATGRLTGRDSGPGRLPDPDEIAEFVDLLITVPECA
CCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AAMAQQDLAGKRVVISLGGTREAIDPVRYLGNSSSGRMGRAIAQVAAARGADVHVVAAHV
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEEE
DVAIPSDVQITRIDSTEDLAEAMDDLAKQADIVIQAVAAADFAPVAVDTKIKKHEGDDAT
EEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCCCCCCC
GATMALQLHQTPDVLARICSQSVQNRVVVGFAAETAPDRDQFLKLAQAKLARKGCDLMVV
CCEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEE
NDVSGGKVFGKVGTDVTMVHQQGPGRRITGSKSQAAVAILDEVRALLATQ
ECCCCCEEEEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]