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The map label for this gene is gmk

Identifier: 50842670

GI number: 50842670

Start: 1296314

End: 1296913

Strand: Direct

Name: gmk

Synonym: PPA1190

Alternate gene names: 50842670

Gene position: 1296314-1296913 (Clockwise)

Preceding gene: 50842669

Following gene: 50842671

Centisome position: 50.63

GC content: 60.33

Gene sequence:

>600_bases
ATGAGTAGCGTCCCCGTCATCCCTCAGGCCCGAGGGCTTCGTCACACCGGCCCGGTCACCGTGGCTGTCGTCTCCGGACC
TACCGCAGTTGGTAAAGGGACCGTGGTAGGGGCGCTGCTGCGTAGCCATCCGGAGATCGTCGTTTCCAGGTCGGTGACTA
CCCGTCCGCCGCGCCCCACTGAACGCGATGGGATCGATTACGACTTCATCACCCCTGAGCAGTTCGACAAGCTCGTTGAC
GGCGAGGGTCTCCTTGAGTGGGCAACCGTCCATAACAGCCACCGGTACGGCACACCGCGCGGTCCTGTTGAACGGGCAGT
TGCTGACAATCGCACGGTCGTGCTGGAAATCGATCTGCAGGGAGCTCGCCAAGTTCGCGAAACCTATCCTCAGGCGACCC
AGATCTTCCTCGCGCCACCCTCATGGGAGGAGCTAGTCCACCGTCTGATCGGTCGCGGCACGGAAACACCAGAGCAACAG
AAGCAGCGTCTGGAGACTGCAAAGGTTGAGCTGGCCAACGCGGATGAATTTGACGCCGTTGTCGTCAACGACACCGTAGA
TCACGCAGTTGCGCATCTGGTAGAATTACTAAGTCTGTGA

Upstream 100 bases:

>100_bases
CCATCAGATTGCCGGGCTACGCGCTGAGTTTGACCAACGCTCTTAAAGATGACGCGCGCCTCGGCGCAACTGTGTCGCTA
TGGACCATTAAGGTGTTCCT

Downstream 100 bases:

>100_bases
CCATATCTGGAGGACATTCCTTGACTGAGACCACCCCTGAAGGCATCGTCAACCCGCCCATTGACCAGCTCCTCGAGCAC
GTCGACTCGAAGTACCGCCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MSSVPVIPQARGLRHTGPVTVAVVSGPTAVGKGTVVGALLRSHPEIVVSRSVTTRPPRPTERDGIDYDFITPEQFDKLVD
GEGLLEWATVHNSHRYGTPRGPVERAVADNRTVVLEIDLQGARQVRETYPQATQIFLAPPSWEELVHRLIGRGTETPEQQ
KQRLETAKVELANADEFDAVVVNDTVDHAVAHLVELLSL

Sequences:

>Translated_199_residues
MSSVPVIPQARGLRHTGPVTVAVVSGPTAVGKGTVVGALLRSHPEIVVSRSVTTRPPRPTERDGIDYDFITPEQFDKLVD
GEGLLEWATVHNSHRYGTPRGPVERAVADNRTVVLEIDLQGARQVRETYPQATQIFLAPPSWEELVHRLIGRGTETPEQQ
KQRLETAKVELANADEFDAVVVNDTVDHAVAHLVELLSL
>Mature_198_residues
SSVPVIPQARGLRHTGPVTVAVVSGPTAVGKGTVVGALLRSHPEIVVSRSVTTRPPRPTERDGIDYDFITPEQFDKLVDG
EGLLEWATVHNSHRYGTPRGPVERAVADNRTVVLEIDLQGARQVRETYPQATQIFLAPPSWEELVHRLIGRGTETPEQQK
QRLETAKVELANADEFDAVVVNDTVDHAVAHLVELLSL

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=187, Percent_Identity=39.572192513369, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4504221, Length=187, Percent_Identity=39.572192513369, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI226874831, Length=187, Percent_Identity=39.572192513369, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI262118255, Length=174, Percent_Identity=28.735632183908, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4505237, Length=174, Percent_Identity=28.735632183908, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI262118263, Length=176, Percent_Identity=28.4090909090909, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI262118259, Length=174, Percent_Identity=28.735632183908, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI1790080, Length=176, Percent_Identity=39.2045454545455, Blast_Score=126, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=195, Percent_Identity=32.8205128205128, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193203132, Length=185, Percent_Identity=34.0540540540541, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320662, Length=180, Percent_Identity=37.7777777777778, Blast_Score=125, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21356141, Length=171, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_PROAC (Q6A8H6)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055897.1
- ProteinModelPortal:   Q6A8H6
- SMR:   Q6A8H6
- GeneID:   2933186
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1190
- NMPDR:   fig|267747.1.peg.1174
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   CLSK2763801
- BioCyc:   PACN267747:PPA1190-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 21801; Mature: 21670

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVPVIPQARGLRHTGPVTVAVVSGPTAVGKGTVVGALLRSHPEIVVSRSVTTRPPRPT
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCC
ERDGIDYDFITPEQFDKLVDGEGLLEWATVHNSHRYGTPRGPVERAVADNRTVVLEIDLQ
CCCCCCCCCCCHHHHHHHCCCCCCEEHHHHCCCCCCCCCCCHHHHHHCCCCEEEEEEECC
GARQVRETYPQATQIFLAPPSWEELVHRLIGRGTETPEQQKQRLETAKVELANADEFDAV
CHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCCCCEE
VVNDTVDHAVAHLVELLSL
EECCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSVPVIPQARGLRHTGPVTVAVVSGPTAVGKGTVVGALLRSHPEIVVSRSVTTRPPRPT
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCC
ERDGIDYDFITPEQFDKLVDGEGLLEWATVHNSHRYGTPRGPVERAVADNRTVVLEIDLQ
CCCCCCCCCCCHHHHHHHCCCCCCEEHHHHCCCCCCCCCCCHHHHHHCCCCEEEEEEECC
GARQVRETYPQATQIFLAPPSWEELVHRLIGRGTETPEQQKQRLETAKVELANADEFDAV
CHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCCCCEE
VVNDTVDHAVAHLVELLSL
EECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA