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The map label for this gene is aroB

Identifier: 50842664

GI number: 50842664

Start: 1290895

End: 1291980

Strand: Direct

Name: aroB

Synonym: PPA1184

Alternate gene names: 50842664

Gene position: 1290895-1291980 (Clockwise)

Preceding gene: 50842663

Following gene: 161621796

Centisome position: 50.42

GC content: 58.75

Gene sequence:

>1086_bases
GTGAACCTTGTTGAGGTCGCCACGACCAAGCCTTACCGGGTGAGGATCGGTTCAGGAGCGGTCCACGAGTTGGCTGGTTT
GGTGGCAGGACGCCGTGCAGCTGTGGTCTGCCCACAGACTCTGGTGCATCTGGTACCTCGCTTTGGTATTGACGATCTTG
TGGTCATCGAGGTTCCCGACGCTGAGGCCGCCAAAACGCCTGAAGTTCTCGTTAATGGCTGGCGCCGGCTAGCCGAGGCC
AACATGACCCGTGGAGATATCATTGTCGGGTTTGGCGGAGGAGCTACCACCGATGTTGCAGGGTTTCTAGCCGCAACATG
GATGCGAGGGATTGACGTCATCCACGTTCCGACGACTGTGCTGGCTATGGCCGACGCTGCGATTGGCGGCAAAACTGGTG
TCAACATTCCTGCCGGGAAAAACCTTGTTGGAGCCTTCCATGAGCCCATCGGCGTCTTGTGTGACACGGAACTGCTGACG
ACCCTGCCAGCGCGAGAGGTGCGTTCTGGCCTGGCTGAGATCGTCAAATGCGGGTTTATTAAAGACCCGGTGATTCTCGA
CGTCATCTCCAACCATCCGCGGTTGGCCCTCGACGTCACTTCCCAGACCTTCGTTGAGGTGCTGACGCGTGCGATTACCG
TCAAGGCTGGTGTGGTGAGCGCTGATCTGCACGAGCGGACGTCTTCGAGAGAAGAGGTCGGACGCGAGAGGCTCAACTAT
GGTCACACCTTGGCCCACGCTATTGAGGCCCACAAGCATTTCACGTGGCGTCATGGCGAGGCTGACGCGGTGGGCATGGT
GTTTGCGGCCGAACTGTCGCACCGGTACCTGGGACTGTCCGATGAGGTCGTTGCGCGCACCCGCACTATCCTGTCTGAGA
TCGGATTGCCTGTTACCTGTGACGAGATTAAGTGGGCAGATCTGCGCAAGACGATGAACGTGGACAAGAAAACCAGGGTA
GACCCGCAGACCGGGCGTCAAGTGTTGCGGTTTGTCGGTATTCACAAACCCGGTCAGGTCGCCATGATCGTCGACCCTGA
CGAGGCCGCTTTAGCCGAGTGCTACGACCGGTGTTCCGCACGGTAA

Upstream 100 bases:

>100_bases
ACCAGCGCCCCGCAACGATCCGGGTGGCCACCGACACGCTGACACCGGAGCAAGTCGTCGACGTCATCGTGTCTGAACTG
GCCGACTTAAAGGAGTAGCC

Downstream 100 bases:

>100_bases
AAACGTTCGGAAATGAACATGTGGCTGCGGGTCAGTCGGCATTCAGGCCTCCGTGACGCCGTCGACCCCAAGTGATGTGA
CGATTCGGGAAATATCTTGT

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MNLVEVATTKPYRVRIGSGAVHELAGLVAGRRAAVVCPQTLVHLVPRFGIDDLVVIEVPDAEAAKTPEVLVNGWRRLAEA
NMTRGDIIVGFGGGATTDVAGFLAATWMRGIDVIHVPTTVLAMADAAIGGKTGVNIPAGKNLVGAFHEPIGVLCDTELLT
TLPAREVRSGLAEIVKCGFIKDPVILDVISNHPRLALDVTSQTFVEVLTRAITVKAGVVSADLHERTSSREEVGRERLNY
GHTLAHAIEAHKHFTWRHGEADAVGMVFAAELSHRYLGLSDEVVARTRTILSEIGLPVTCDEIKWADLRKTMNVDKKTRV
DPQTGRQVLRFVGIHKPGQVAMIVDPDEAALAECYDRCSAR

Sequences:

>Translated_361_residues
MNLVEVATTKPYRVRIGSGAVHELAGLVAGRRAAVVCPQTLVHLVPRFGIDDLVVIEVPDAEAAKTPEVLVNGWRRLAEA
NMTRGDIIVGFGGGATTDVAGFLAATWMRGIDVIHVPTTVLAMADAAIGGKTGVNIPAGKNLVGAFHEPIGVLCDTELLT
TLPAREVRSGLAEIVKCGFIKDPVILDVISNHPRLALDVTSQTFVEVLTRAITVKAGVVSADLHERTSSREEVGRERLNY
GHTLAHAIEAHKHFTWRHGEADAVGMVFAAELSHRYLGLSDEVVARTRTILSEIGLPVTCDEIKWADLRKTMNVDKKTRV
DPQTGRQVLRFVGIHKPGQVAMIVDPDEAALAECYDRCSAR
>Mature_361_residues
MNLVEVATTKPYRVRIGSGAVHELAGLVAGRRAAVVCPQTLVHLVPRFGIDDLVVIEVPDAEAAKTPEVLVNGWRRLAEA
NMTRGDIIVGFGGGATTDVAGFLAATWMRGIDVIHVPTTVLAMADAAIGGKTGVNIPAGKNLVGAFHEPIGVLCDTELLT
TLPAREVRSGLAEIVKCGFIKDPVILDVISNHPRLALDVTSQTFVEVLTRAITVKAGVVSADLHERTSSREEVGRERLNY
GHTLAHAIEAHKHFTWRHGEADAVGMVFAAELSHRYLGLSDEVVARTRTILSEIGLPVTCDEIKWADLRKTMNVDKKTRV
DPQTGRQVLRFVGIHKPGQVAMIVDPDEAALAECYDRCSAR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=302, Percent_Identity=37.4172185430464, Blast_Score=161, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6320332, Length=297, Percent_Identity=38.7205387205387, Blast_Score=159, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_PROAC (Q6A8I2)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055891.1
- ProteinModelPortal:   Q6A8I2
- SMR:   Q6A8I2
- GeneID:   2932723
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1184
- NMPDR:   fig|267747.1.peg.1168
- HOGENOM:   HBG632303
- ProtClustDB:   CLSK2763796
- BioCyc:   PACN267747:PPA1184-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 38957; Mature: 38957

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVEVATTKPYRVRIGSGAVHELAGLVAGRRAAVVCPQTLVHLVPRFGIDDLVVIEVPD
CCCEEEECCCCEEEEECCCHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCCCEEEEECCC
AEAAKTPEVLVNGWRRLAEANMTRGDIIVGFGGGATTDVAGFLAATWMRGIDVIHVPTTV
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCEEEECCHHH
LAMADAAIGGKTGVNIPAGKNLVGAFHEPIGVLCDTELLTTLPAREVRSGLAEIVKCGFI
HHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHEECHHHHHHCCHHHHHHHHHHHHHCCCC
KDPVILDVISNHPRLALDVTSQTFVEVLTRAITVKAGVVSADLHERTSSREEVGRERLNY
CCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEHHHHHHCCCHHHHHHHHHCC
GHTLAHAIEAHKHFTWRHGEADAVGMVFAAELSHRYLGLSDEVVARTRTILSEIGLPVTC
CHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEE
DEIKWADLRKTMNVDKKTRVDPQTGRQVLRFVGIHKPGQVAMIVDPDEAALAECYDRCSA
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCC
R
C
>Mature Secondary Structure
MNLVEVATTKPYRVRIGSGAVHELAGLVAGRRAAVVCPQTLVHLVPRFGIDDLVVIEVPD
CCCEEEECCCCEEEEECCCHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCCCEEEEECCC
AEAAKTPEVLVNGWRRLAEANMTRGDIIVGFGGGATTDVAGFLAATWMRGIDVIHVPTTV
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCEEEECCHHH
LAMADAAIGGKTGVNIPAGKNLVGAFHEPIGVLCDTELLTTLPAREVRSGLAEIVKCGFI
HHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHEECHHHHHHCCHHHHHHHHHHHHHCCCC
KDPVILDVISNHPRLALDVTSQTFVEVLTRAITVKAGVVSADLHERTSSREEVGRERLNY
CCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEHHHHHHCCCHHHHHHHHHCC
GHTLAHAIEAHKHFTWRHGEADAVGMVFAAELSHRYLGLSDEVVARTRTILSEIGLPVTC
CHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEE
DEIKWADLRKTMNVDKKTRVDPQTGRQVLRFVGIHKPGQVAMIVDPDEAALAECYDRCSA
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA