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The map label for this gene is murQ

Identifier: 50842620

GI number: 50842620

Start: 1240383

End: 1241297

Strand: Direct

Name: murQ

Synonym: PPA1141

Alternate gene names: 50842620

Gene position: 1240383-1241297 (Clockwise)

Preceding gene: 50842616

Following gene: 50842621

Centisome position: 48.45

GC content: 60.98

Gene sequence:

>915_bases
ATGGACAGTCTGACGAATCTTGCAACGACTGAGGGAAGGAACCCGGCCAGCGAAGAACTCGACCAGTTGCCGACCCTCGA
CGTGCTCCGCCTCATGAATGACGAGGATCACCGCGTCCCGGATGCTATCGCGTCTCAACTTCCAGCCATCGCCGCCGTCG
TGGAGGCTGCAGTGAAGGGTCTGTCGGCCGGAGGCCGTTTGATCTATGCCGGTGCCGGAACGAGTGGGCGTTTAGGGGTC
CTCGATGCGGCGGAATGCCCACCGACGTTTAGCACCAACCCCACGATGGTCGTCGGCCTCATCGCAGGTGGACAGCAGGC
GATGTTTCAGGCTGTGGAGGGAGCTGAAGACGATGCGGATCGTGGCGCTGAGGAGTTGAACGTGCTTCAGCCAGGACCCC
ACGACGTCGTCGTCGGTCTGGCAGCCTCAGGACGAACTCCTTGGGTTGTAGGCGTGGTGCGCGCTGCGAAGCGAGCTGGG
GCGGTGACGGCTTCAGTGTGTTGCAACCATCGTGCGGTCATCAGCAGCGAGGTAGACCTTCCGGTGGAAATCGACGCTGG
CCCTGAGGTTCTCACCGGATCGACCCGCCTTAAAGCAGGGACCGTGCAGAAGCTGGTCCTCAACATGATCTCCACGGCGA
CCATGGTCGGCTTAGGTAAAACATACGGCAACCTTATGGTTGACGTCTCTCCGAGCAACGAGAAGCTACGGCAGCGGGCC
ATGTCCATTGTCATGGCTGCCACGGGATGCTCTTGTGATGATGCCATCACGGCGTTACACGAGGCTGGCGGACATGCCAA
GACGGCCATTGTCATGGTGCTGTTGGGGATGACTGCGACTCAAGCTCGAGCCCGACTGGCTGAAGTGGGCGGCGTAGTCC
GGGTAGCCGTCGATGAGAACCACCTTCGCCTGTGA

Upstream 100 bases:

>100_bases
GATTTTGTGTATAATCATTTCACGTCGTGGGGGCGGCGCGTTTCGTGGTGTGTCATCGCAGATATGGAACCACAAAGTCT
TGATTCGGGGAGGAGATTCC

Downstream 100 bases:

>100_bases
ATCTTCCAGGGAGGAAGTCATGGACTATCACTTGCTTGCACGAGAAATACTCGATCTTGTTGGAGGGCCCGACAATATCG
AGTCTTTTACCAATTGCATG

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MDSLTNLATTEGRNPASEELDQLPTLDVLRLMNDEDHRVPDAIASQLPAIAAVVEAAVKGLSAGGRLIYAGAGTSGRLGV
LDAAECPPTFSTNPTMVVGLIAGGQQAMFQAVEGAEDDADRGAEELNVLQPGPHDVVVGLAASGRTPWVVGVVRAAKRAG
AVTASVCCNHRAVISSEVDLPVEIDAGPEVLTGSTRLKAGTVQKLVLNMISTATMVGLGKTYGNLMVDVSPSNEKLRQRA
MSIVMAATGCSCDDAITALHEAGGHAKTAIVMVLLGMTATQARARLAEVGGVVRVAVDENHLRL

Sequences:

>Translated_304_residues
MDSLTNLATTEGRNPASEELDQLPTLDVLRLMNDEDHRVPDAIASQLPAIAAVVEAAVKGLSAGGRLIYAGAGTSGRLGV
LDAAECPPTFSTNPTMVVGLIAGGQQAMFQAVEGAEDDADRGAEELNVLQPGPHDVVVGLAASGRTPWVVGVVRAAKRAG
AVTASVCCNHRAVISSEVDLPVEIDAGPEVLTGSTRLKAGTVQKLVLNMISTATMVGLGKTYGNLMVDVSPSNEKLRQRA
MSIVMAATGCSCDDAITALHEAGGHAKTAIVMVLLGMTATQARARLAEVGGVVRVAVDENHLRL
>Mature_304_residues
MDSLTNLATTEGRNPASEELDQLPTLDVLRLMNDEDHRVPDAIASQLPAIAAVVEAAVKGLSAGGRLIYAGAGTSGRLGV
LDAAECPPTFSTNPTMVVGLIAGGQQAMFQAVEGAEDDADRGAEELNVLQPGPHDVVVGLAASGRTPWVVGVVRAAKRAG
AVTASVCCNHRAVISSEVDLPVEIDAGPEVLTGSTRLKAGTVQKLVLNMISTATMVGLGKTYGNLMVDVSPSNEKLRQRA
MSIVMAATGCSCDDAITALHEAGGHAKTAIVMVLLGMTATQARARLAEVGGVVRVAVDENHLRL

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=290, Percent_Identity=50.3448275862069, Blast_Score=280, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_PROAC (Q6A8M7)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055847.1
- HSSP:   P44862
- ProteinModelPortal:   Q6A8M7
- SMR:   Q6A8M7
- GeneID:   2931291
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1141
- NMPDR:   fig|267747.1.peg.1124
- HOGENOM:   HBG703490
- OMA:   HLLTEQI
- ProtClustDB:   PRK05441
- BioCyc:   PACN267747:PPA1141-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- TIGRFAMs:   TIGR00274

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 31318; Mature: 31318

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 85-85 ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSLTNLATTEGRNPASEELDQLPTLDVLRLMNDEDHRVPDAIASQLPAIAAVVEAAVKG
CCCHHCCHHCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
LSAGGRLIYAGAGTSGRLGVLDAAECPPTFSTNPTMVVGLIAGGQQAMFQAVEGAEDDAD
CCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCHH
RGAEELNVLQPGPHDVVVGLAASGRTPWVVGVVRAAKRAGAVTASVCCNHRAVISSEVDL
CCHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEHHHHHCCCEEEECCCCC
PVEIDAGPEVLTGSTRLKAGTVQKLVLNMISTATMVGLGKTYGNLMVDVSPSNEKLRQRA
CEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
MSIVMAATGCSCDDAITALHEAGGHAKTAIVMVLLGMTATQARARLAEVGGVVRVAVDEN
HHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEECCC
HLRL
CCCC
>Mature Secondary Structure
MDSLTNLATTEGRNPASEELDQLPTLDVLRLMNDEDHRVPDAIASQLPAIAAVVEAAVKG
CCCHHCCHHCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
LSAGGRLIYAGAGTSGRLGVLDAAECPPTFSTNPTMVVGLIAGGQQAMFQAVEGAEDDAD
CCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCHH
RGAEELNVLQPGPHDVVVGLAASGRTPWVVGVVRAAKRAGAVTASVCCNHRAVISSEVDL
CCHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEHHHHHCCCEEEECCCCC
PVEIDAGPEVLTGSTRLKAGTVQKLVLNMISTATMVGLGKTYGNLMVDVSPSNEKLRQRA
CEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
MSIVMAATGCSCDDAITALHEAGGHAKTAIVMVLLGMTATQARARLAEVGGVVRVAVDEN
HHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEECCC
HLRL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA