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The map label for this gene is trpC1 [H]

Identifier: 50842609

GI number: 50842609

Start: 1226541

End: 1227341

Strand: Direct

Name: trpC1 [H]

Synonym: PPA1130

Alternate gene names: 50842609

Gene position: 1226541-1227341 (Clockwise)

Preceding gene: 50842608

Following gene: 50842610

Centisome position: 47.91

GC content: 57.55

Gene sequence:

>801_bases
ATGCCGCCCACTGTTACCGGAACGGTCCTTGACGGAATCATTTCCGGTGTTCTCGAAGATCTTCATGAGCGCCAACTCAT
GGTTACCTCGGACAATCTTCGTGAGGCCACTGAGCTCGTGGCCCCTGCTATCGATCCGATCCCGAGGCTGACAGCGCCTG
GCCTGTCGGTTATCTCAGAAATCAAGCGGTCGAGCCCGTCAAACGGCCAGCTGGCTGCTATTCATGACCCTGCCGCACTG
GCTGATCAGTACCGCTCCGGTGGAGCCGCTGCTATCAGCGTTCTGACTGAGGAGCGCCGATTTCAAGGATCCCTGGCCGA
CCTTGACGCGGTGCGTGCGAAAGTTGAGATCCCAGTACTCCGCAAGGATTTCGTTGTCGCGGAATACCAGGTGCTCGAAG
CCCGTGCACACGGGGCAGACCTTATCCTCCTCATCGTTGCCGCGTTATCTGACGACGACTTGCAACGCCTATATGACCTT
GCCATCGAGCTGGGCATGACCCCGCTAGTTGAAGTTCATACCCCTGAAGAGGTAAGTCGAGCTACAGCCCTTGGTGCCCG
TGTGGTGGGTGTGAATGCGCGCAACCTCAAGACCCTCGAAGTCGATAAGACCATTTTCAGGGAACTCCTTGGTGAGCTGC
CTGAAAACGTCGTTAAGGTGGCGGAATCCGGAATTCTTTGCGTGGACGAGGCCGTCGAGGTATATGACCTTGGTGCTGAC
GCGGTGTTGGTGGGGGAGATGCTGGTCCGCCACGGTGAACCAGCACAAGTATTGCGCAAGATCCACCGTGCCACCGTGTG
A

Upstream 100 bases:

>100_bases
GCCAAGTTGGACTACCTGCATCATGGGTGCCGCCTTAGTTGTGCTGGGTGGAGTCGTCACCCTGGTGATGCGCGCTATGG
GCTACGGCGGGGCTCGCTGA

Downstream 100 bases:

>100_bases
CCCTGACATTCAATGGAAAGGACGATCATGTCCGCACGAGACTTGCCCGACGCTCGGGGACACTTCGACCGTTTCGGTGG
CCGATTCGTTCCAGAAGCTC

Product: indole-3-glycerol phosphate synthase 1

Products: NA

Alternate protein names: IGPS 1 [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MPPTVTGTVLDGIISGVLEDLHERQLMVTSDNLREATELVAPAIDPIPRLTAPGLSVISEIKRSSPSNGQLAAIHDPAAL
ADQYRSGGAAAISVLTEERRFQGSLADLDAVRAKVEIPVLRKDFVVAEYQVLEARAHGADLILLIVAALSDDDLQRLYDL
AIELGMTPLVEVHTPEEVSRATALGARVVGVNARNLKTLEVDKTIFRELLGELPENVVKVAESGILCVDEAVEVYDLGAD
AVLVGEMLVRHGEPAQVLRKIHRATV

Sequences:

>Translated_266_residues
MPPTVTGTVLDGIISGVLEDLHERQLMVTSDNLREATELVAPAIDPIPRLTAPGLSVISEIKRSSPSNGQLAAIHDPAAL
ADQYRSGGAAAISVLTEERRFQGSLADLDAVRAKVEIPVLRKDFVVAEYQVLEARAHGADLILLIVAALSDDDLQRLYDL
AIELGMTPLVEVHTPEEVSRATALGARVVGVNARNLKTLEVDKTIFRELLGELPENVVKVAESGILCVDEAVEVYDLGAD
AVLVGEMLVRHGEPAQVLRKIHRATV
>Mature_265_residues
PPTVTGTVLDGIISGVLEDLHERQLMVTSDNLREATELVAPAIDPIPRLTAPGLSVISEIKRSSPSNGQLAAIHDPAALA
DQYRSGGAAAISVLTEERRFQGSLADLDAVRAKVEIPVLRKDFVVAEYQVLEARAHGADLILLIVAALSDDDLQRLYDLA
IELGMTPLVEVHTPEEVSRATALGARVVGVNARNLKTLEVDKTIFRELLGELPENVVKVAESGILCVDEAVEVYDLGADA
VLVGEMLVRHGEPAQVLRKIHRATV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=206, Percent_Identity=39.8058252427184, Blast_Score=130, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6322638, Length=202, Percent_Identity=43.5643564356436, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28564; Mature: 28433

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPTVTGTVLDGIISGVLEDLHERQLMVTSDNLREATELVAPAIDPIPRLTAPGLSVISE
CCCCCHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
IKRSSPSNGQLAAIHDPAALADQYRSGGAAAISVLTEERRFQGSLADLDAVRAKVEIPVL
HHHCCCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCH
RKDFVVAEYQVLEARAHGADLILLIVAALSDDDLQRLYDLAIELGMTPLVEVHTPEEVSR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCHHHHHH
ATALGARVVGVNARNLKTLEVDKTIFRELLGELPENVVKVAESGILCVDEAVEVYDLGAD
HHHHHHHEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCC
AVLVGEMLVRHGEPAQVLRKIHRATV
HHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PPTVTGTVLDGIISGVLEDLHERQLMVTSDNLREATELVAPAIDPIPRLTAPGLSVISE
CCCCHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
IKRSSPSNGQLAAIHDPAALADQYRSGGAAAISVLTEERRFQGSLADLDAVRAKVEIPVL
HHHCCCCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCH
RKDFVVAEYQVLEARAHGADLILLIVAALSDDDLQRLYDLAIELGMTPLVEVHTPEEVSR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCHHHHHH
ATALGARVVGVNARNLKTLEVDKTIFRELLGELPENVVKVAESGILCVDEAVEVYDLGAD
HHHHHHHEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCC
AVLVGEMLVRHGEPAQVLRKIHRATV
HHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10361288; 12000953 [H]