Click here to switch to the map view.

The map label for this gene is ptsM [H]

Identifier: 50842588

GI number: 50842588

Start: 1203075

End: 1205120

Strand: Reverse

Name: ptsM [H]

Synonym: PPA1109

Alternate gene names: 50842588

Gene position: 1205120-1203075 (Counterclockwise)

Preceding gene: 50842589

Following gene: 50842584

Centisome position: 47.07

GC content: 60.51

Gene sequence:

>2046_bases
ATGTCATCACCCGCGTCCCAGATCGTGGATGCGGTGGGCGGCCCCGACAACATCGTCGGTCTCACTCACTGCGCCACTCG
TCTGAGGTTCCAACTTCGCGATTCCTCGCCTATCGACAAGGCTGAGGTCGAAGCGATCCCCGGCGTCATGGGAGCCGTTC
CTCAGTCGGGCAATCGCTACCAAATCGTCATCGGAGGCGCCGTTGCCGGCGTCTACAACGACATCATGGACCTACCCGCC
ATGAAAGGGCTTTCTTCCAGCAGCGGCAATCAGTCGGACGCGGACGTCAAGGCCGAGCATCGCTCCAAGGGTCCCCGAGG
CAAGTTCTCGTGGCTCGACAACCTCTTCGAGTACCTGTCCGACTCTTTCCGGCCGATCATGGGTGCCCTGCTCGGCGCCT
CCCTGTTCATCACGTTCATGGCCCTCATGGGTTCTCTGGGCGTCATCGGAAACTGGGCCGACTCGCGCGTCACCCTGCCC
CCGAGCTGGCAATTCGTCAACTTGGCTTGGCAGTGTGTCTTCTACTTCCTGCCACTGTTGGTCGCCTACAACGCCACTAA
GCGTCTGAATGCCGACCCGTGGGTTGGGTTCTCCGTCATGGCTGTCGTCATGCTGCCTGCGTTCACCGAGCTCGGCAAGA
CTGCCCATCCACTGACCCTCGGCGGATTCAAAGTCAACGTGGTCGACGTTTTCGGCCTACCGCTGACGATCTTTAATTAC
GGCTCTCAGGTGTTCCCGCCGCTCATCATGGCTGCAATCCTGGCCCCGCTGTACAAATGGCTCAAGAAGATCATCTCCCC
CAATGTCCAGATGATCTTCGTACCCTTCCTCACCATGCTCATCATGATCCCGCTGACGGCCTTCCTCATCGGCCCGATCG
GTGTCTACGCCGGTGCTGGGCTGGCCAACGGGCTCAAGGCGGTCAACGACGTCAGCCCTTTCATCTTCGCGGTCCTCATC
CCCCTGCTGTACCCATTCATGGTTCCGTTGGGCCTACACTGGCCGCTCAACGCTGTCATGCTGCTCAACATCCAGACTCT
GGGTTACGACTACATCCAGGGCCCGATGGGTGCGTGGAACTTCGCCTGTTTCGGTGCTACCGCTGGCGTTCTCTTCCTGT
CTGTGCGTGACAAGGACGTGACAATGCGCCAGACCGCGATTGGCGCCCTAGCCGCCGGTCTGCTCGGTGGTATCTCCGAG
CCCAGCCTCTACGGCATCCACCTGCGTTACAAAAAGATTTACCCATCCATGTTGGTCGGCTGTCTCGTCGGTGGTGTCAT
CATCGGTGCGGGCGGCGGTCTGCACACCCCGGCCTTTGTCTTCACTTCCCTGCTGACCATCCCGGCCTTCGACAAGATCG
GGCTGTACTCGGTAGCGATCGCAGCTTCGTTCTTCACCGCGATGGCTCTGGTTATCGTGCGCGACTATCGTGATAACGAC
GAGAAGGCTGCAGCCAAGGCCCGTCGCCGTCAGGCCAGCGCTCACGAGGCAGAATCAACCGCCGCTGCCCCAGCTGCCGC
CACCGAATCCATAACCGAGACCGCAACAGTCGAGGGGGCCGAGGCCCCGACTGCAGCCGATGTTGCCGCCGAGGCCGTCA
CCGTCACCTCTCCTCTTGAGGGACGTGCCGTGCCAATCTCTGAAATCCCCGATCCGGTTTTCTCCACTGGTGCCGTCGGT
GATGGCATCGCCATCGAGCCCACCAGCAACACTGTTGTCTGCCCAGCCGACGCCACCGTTGTCACCGCCCCGGAGTCCGG
CCACGCTTTCGGGCTCAAACTGGATTCGGGTGTCGAGCTACTCATCCATGTCGGCATCGATACCGTCGAGCTCGGTGGCA
AAGGGTTTGACGTCAAGGTCAAGGCTGGCGATCACGTCAGTGCTGGACAGCCCCTGGTCGTTTTTGATCCCACCGTCATT
GACGAAGCCGGATACTCCAAGATCACCCCGGTGTTAGTGACCAACGGGTTCGACTACTCCAACGTGACCGGCATTCCTGC
TGACGACGTCACTACAGGTACCCCGGTGATCACTGTTGTGAAGTGA

Upstream 100 bases:

>100_bases
GATCAAGCCGGGACCTACCCCGGTGTGGTAACAGCATCCTGGAACGATTAGAATCCTGCCTCGCTGCCCTGGGCGGCAAT
ATTACAGGAGGACCACATAC

Downstream 100 bases:

>100_bases
GTTCGAGGCAAACCGGGTAACCGGACCGCACCGTACCTCCACGATATGGAGGAGGCCGACACCGCGAATGGTGCCGGCCT
CCTCCCGTCGTTATCAGTCT

Product: phosphoenolpyruvate sugar phosphotransferase

Products: NA

Alternate protein names: EII-Man/EIII-Man; EIIBCA-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component [H]

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MSSPASQIVDAVGGPDNIVGLTHCATRLRFQLRDSSPIDKAEVEAIPGVMGAVPQSGNRYQIVIGGAVAGVYNDIMDLPA
MKGLSSSSGNQSDADVKAEHRSKGPRGKFSWLDNLFEYLSDSFRPIMGALLGASLFITFMALMGSLGVIGNWADSRVTLP
PSWQFVNLAWQCVFYFLPLLVAYNATKRLNADPWVGFSVMAVVMLPAFTELGKTAHPLTLGGFKVNVVDVFGLPLTIFNY
GSQVFPPLIMAAILAPLYKWLKKIISPNVQMIFVPFLTMLIMIPLTAFLIGPIGVYAGAGLANGLKAVNDVSPFIFAVLI
PLLYPFMVPLGLHWPLNAVMLLNIQTLGYDYIQGPMGAWNFACFGATAGVLFLSVRDKDVTMRQTAIGALAAGLLGGISE
PSLYGIHLRYKKIYPSMLVGCLVGGVIIGAGGGLHTPAFVFTSLLTIPAFDKIGLYSVAIAASFFTAMALVIVRDYRDND
EKAAAKARRRQASAHEAESTAAAPAAATESITETATVEGAEAPTAADVAAEAVTVTSPLEGRAVPISEIPDPVFSTGAVG
DGIAIEPTSNTVVCPADATVVTAPESGHAFGLKLDSGVELLIHVGIDTVELGGKGFDVKVKAGDHVSAGQPLVVFDPTVI
DEAGYSKITPVLVTNGFDYSNVTGIPADDVTTGTPVITVVK

Sequences:

>Translated_681_residues
MSSPASQIVDAVGGPDNIVGLTHCATRLRFQLRDSSPIDKAEVEAIPGVMGAVPQSGNRYQIVIGGAVAGVYNDIMDLPA
MKGLSSSSGNQSDADVKAEHRSKGPRGKFSWLDNLFEYLSDSFRPIMGALLGASLFITFMALMGSLGVIGNWADSRVTLP
PSWQFVNLAWQCVFYFLPLLVAYNATKRLNADPWVGFSVMAVVMLPAFTELGKTAHPLTLGGFKVNVVDVFGLPLTIFNY
GSQVFPPLIMAAILAPLYKWLKKIISPNVQMIFVPFLTMLIMIPLTAFLIGPIGVYAGAGLANGLKAVNDVSPFIFAVLI
PLLYPFMVPLGLHWPLNAVMLLNIQTLGYDYIQGPMGAWNFACFGATAGVLFLSVRDKDVTMRQTAIGALAAGLLGGISE
PSLYGIHLRYKKIYPSMLVGCLVGGVIIGAGGGLHTPAFVFTSLLTIPAFDKIGLYSVAIAASFFTAMALVIVRDYRDND
EKAAAKARRRQASAHEAESTAAAPAAATESITETATVEGAEAPTAADVAAEAVTVTSPLEGRAVPISEIPDPVFSTGAVG
DGIAIEPTSNTVVCPADATVVTAPESGHAFGLKLDSGVELLIHVGIDTVELGGKGFDVKVKAGDHVSAGQPLVVFDPTVI
DEAGYSKITPVLVTNGFDYSNVTGIPADDVTTGTPVITVVK
>Mature_680_residues
SSPASQIVDAVGGPDNIVGLTHCATRLRFQLRDSSPIDKAEVEAIPGVMGAVPQSGNRYQIVIGGAVAGVYNDIMDLPAM
KGLSSSSGNQSDADVKAEHRSKGPRGKFSWLDNLFEYLSDSFRPIMGALLGASLFITFMALMGSLGVIGNWADSRVTLPP
SWQFVNLAWQCVFYFLPLLVAYNATKRLNADPWVGFSVMAVVMLPAFTELGKTAHPLTLGGFKVNVVDVFGLPLTIFNYG
SQVFPPLIMAAILAPLYKWLKKIISPNVQMIFVPFLTMLIMIPLTAFLIGPIGVYAGAGLANGLKAVNDVSPFIFAVLIP
LLYPFMVPLGLHWPLNAVMLLNIQTLGYDYIQGPMGAWNFACFGATAGVLFLSVRDKDVTMRQTAIGALAAGLLGGISEP
SLYGIHLRYKKIYPSMLVGCLVGGVIIGAGGGLHTPAFVFTSLLTIPAFDKIGLYSVAIAASFFTAMALVIVRDYRDNDE
KAAAKARRRQASAHEAESTAAAPAAATESITETATVEGAEAPTAADVAAEAVTVTSPLEGRAVPISEIPDPVFSTGAVGD
GIAIEPTSNTVVCPADATVVTAPESGHAFGLKLDSGVELLIHVGIDTVELGGKGFDVKVKAGDHVSAGQPLVVFDPTVID
EAGYSKITPVLVTNGFDYSNVTGIPADDVTTGTPVITVVK

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1790159, Length=699, Percent_Identity=29.7567954220315, Blast_Score=255, Evalue=7e-69,
Organism=Escherichia coli, GI48994906, Length=502, Percent_Identity=27.8884462151394, Blast_Score=159, Evalue=7e-40,
Organism=Escherichia coli, GI2367362, Length=430, Percent_Identity=26.046511627907, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788757, Length=149, Percent_Identity=40.2684563758389, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1786894, Length=160, Percent_Identity=38.125, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788769, Length=425, Percent_Identity=25.8823529411765, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011055
- InterPro:   IPR018113
- InterPro:   IPR001127
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013 [H]

Pfam domain/function: PF00358 PTS_EIIA_1; PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 71654; Mature: 71523

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00371 PTS_EIIA_TYPE_1_HIS ; PS51093 PTS_EIIA_TYPE_1 ; PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPASQIVDAVGGPDNIVGLTHCATRLRFQLRDSSPIDKAEVEAIPGVMGAVPQSGNRY
CCCCHHHHHHHCCCCCCEEHHHHHHHHHEEEECCCCCCCHHHHHHCCHHHHCCCCCCCEE
QIVIGGAVAGVYNDIMDLPAMKGLSSSSGNQSDADVKAEHRSKGPRGKFSWLDNLFEYLS
EEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHH
DSFRPIMGALLGASLFITFMALMGSLGVIGNWADSRVTLPPSWQFVNLAWQCVFYFLPLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHHH
VAYNATKRLNADPWVGFSVMAVVMLPAFTELGKTAHPLTLGGFKVNVVDVFGLPLTIFNY
HHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEEEECCCCEEEECC
GSQVFPPLIMAAILAPLYKWLKKIISPNVQMIFVPFLTMLIMIPLTAFLIGPIGVYAGAG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LANGLKAVNDVSPFIFAVLIPLLYPFMVPLGLHWPLNAVMLLNIQTLGYDYIQGPMGAWN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCHHHCCCCCCCC
FACFGATAGVLFLSVRDKDVTMRQTAIGALAAGLLGGISEPSLYGIHLRYKKIYPSMLVG
HHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHH
CLVGGVIIGAGGGLHTPAFVFTSLLTIPAFDKIGLYSVAIAASFFTAMALVIVRDYRDND
HHHHHEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
EKAAAKARRRQASAHEAESTAAAPAAATESITETATVEGAEAPTAADVAAEAVTVTSPLE
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEECCCC
GRAVPISEIPDPVFSTGAVGDGIAIEPTSNTVVCPADATVVTAPESGHAFGLKLDSGVEL
CCCCCHHHCCCCHHCCCCCCCCEEECCCCCEEECCCCCEEEECCCCCCEEEEEECCCCEE
LIHVGIDTVELGGKGFDVKVKAGDHVSAGQPLVVFDPTVIDEAGYSKITPVLVTNGFDYS
EEEECCCEEEECCCCEEEEEECCCCCCCCCCEEEECCCEECCCCCCCCCEEEEECCCCCC
NVTGIPADDVTTGTPVITVVK
CCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SSPASQIVDAVGGPDNIVGLTHCATRLRFQLRDSSPIDKAEVEAIPGVMGAVPQSGNRY
CCCHHHHHHHCCCCCCEEHHHHHHHHHEEEECCCCCCCHHHHHHCCHHHHCCCCCCCEE
QIVIGGAVAGVYNDIMDLPAMKGLSSSSGNQSDADVKAEHRSKGPRGKFSWLDNLFEYLS
EEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHH
DSFRPIMGALLGASLFITFMALMGSLGVIGNWADSRVTLPPSWQFVNLAWQCVFYFLPLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHHH
VAYNATKRLNADPWVGFSVMAVVMLPAFTELGKTAHPLTLGGFKVNVVDVFGLPLTIFNY
HHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEEEECCCCEEEECC
GSQVFPPLIMAAILAPLYKWLKKIISPNVQMIFVPFLTMLIMIPLTAFLIGPIGVYAGAG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LANGLKAVNDVSPFIFAVLIPLLYPFMVPLGLHWPLNAVMLLNIQTLGYDYIQGPMGAWN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCHHHCCCCCCCC
FACFGATAGVLFLSVRDKDVTMRQTAIGALAAGLLGGISEPSLYGIHLRYKKIYPSMLVG
HHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHH
CLVGGVIIGAGGGLHTPAFVFTSLLTIPAFDKIGLYSVAIAASFFTAMALVIVRDYRDND
HHHHHEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
EKAAAKARRRQASAHEAESTAAAPAAATESITETATVEGAEAPTAADVAAEAVTVTSPLE
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEECCCC
GRAVPISEIPDPVFSTGAVGDGIAIEPTSNTVVCPADATVVTAPESGHAFGLKLDSGVEL
CCCCCHHHCCCCHHCCCCCCCCEEECCCCCEEECCCCCEEEECCCCCCEEEEEECCCCEE
LIHVGIDTVELGGKGFDVKVKAGDHVSAGQPLVVFDPTVIDEAGYSKITPVLVTNGFDYS
EEEECCCEEEECCCCEEEEEECCCCCCCCCCEEEECCCEECCCCCCCCCEEEEECCCCCC
NVTGIPADDVTTGTPVITVVK
CCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8039653; 12948626 [H]