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The map label for this gene is pgsA1 [H]

Identifier: 50842557

GI number: 50842557

Start: 1174588

End: 1175241

Strand: Direct

Name: pgsA1 [H]

Synonym: PPA1079

Alternate gene names: 50842557

Gene position: 1174588-1175241 (Clockwise)

Preceding gene: 50842556

Following gene: 50842558

Centisome position: 45.88

GC content: 58.41

Gene sequence:

>654_bases
ATGACTAGGGTGGATGTCGTGACGCGCACCTTGCCGCCTAATGAAGTTTCCGAGGCCAACCCGTGGGATACCGACCGGTT
CTGGACGGTTCCTAATGTCCTGTCGGTCATCCGACTCATCGGTGTACCCATTTTCCTGTGGTTGGCTTTAGGGCCGCGCG
CAGACGGTTGGGCAGTCGCAGTGCTTGCCGTGGCAGGCCTGACGGATTGGCTTGACGGTCGGATAGCCCGCCGCTGGCAC
CAAGTGTCCCGCATTGGGCAGATGCTCGATCCGGTTGCCGACCGTCTCTACATCTTTGCAACCGTTATTGCCCTGACTCT
ACGTGACGTAATTCCGTTATGGCTGGTGATTGTCCTTATCGCTCGCGACGTGTGTATGGCCTGTCTCATGCCAGCTCTGC
GTACACGTGGATTTACATCTCTGCCGGTGCACTTCGTCGGAAAAGCAGCGACCTTTTGCCTGCTGTACTCCTTCCCGCTG
GTGTTACTTGGGCGCTTCGGTACCGGTGGATGGACGGCGTGTAGGGTGCTGGGATGGGCCTTCGCGGTATGGGGGACAGG
TCTCTACTGGTGGGCTTTCTTCCTCTACCTAGTTCAGACCATCCGCATCGTTCGGACGCTGCCACGCATCAGTTCGCGGG
GTGAGTATTCGTGA

Upstream 100 bases:

>100_bases
AGCAATCACCGTCGTCCAACGGATGGTGGCGGTGCGTCGGGCGTGTGAGTCGTGAGAAAGGACTTCACAGGGTGGCCGGG
CTCCCGGATGAGGGATGCCG

Downstream 100 bases:

>100_bases
AGCAGCGTCCAGATGCGTCAATGGACTTGCTGAGGGAGGTTCGCGGGCAGGCCTTGGACCAGGGCTACCAGGAACACCAC
GATCGGAACCCTGGCGCCAC

Product: putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTRVDVVTRTLPPNEVSEANPWDTDRFWTVPNVLSVIRLIGVPIFLWLALGPRADGWAVAVLAVAGLTDWLDGRIARRWH
QVSRIGQMLDPVADRLYIFATVIALTLRDVIPLWLVIVLIARDVCMACLMPALRTRGFTSLPVHFVGKAATFCLLYSFPL
VLLGRFGTGGWTACRVLGWAFAVWGTGLYWWAFFLYLVQTIRIVRTLPRISSRGEYS

Sequences:

>Translated_217_residues
MTRVDVVTRTLPPNEVSEANPWDTDRFWTVPNVLSVIRLIGVPIFLWLALGPRADGWAVAVLAVAGLTDWLDGRIARRWH
QVSRIGQMLDPVADRLYIFATVIALTLRDVIPLWLVIVLIARDVCMACLMPALRTRGFTSLPVHFVGKAATFCLLYSFPL
VLLGRFGTGGWTACRVLGWAFAVWGTGLYWWAFFLYLVQTIRIVRTLPRISSRGEYS
>Mature_216_residues
TRVDVVTRTLPPNEVSEANPWDTDRFWTVPNVLSVIRLIGVPIFLWLALGPRADGWAVAVLAVAGLTDWLDGRIARRWHQ
VSRIGQMLDPVADRLYIFATVIALTLRDVIPLWLVIVLIARDVCMACLMPALRTRGFTSLPVHFVGKAATFCLLYSFPLV
LLGRFGTGGWTACRVLGWAFAVWGTGLYWWAFFLYLVQTIRIVRTLPRISSRGEYS

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=196, Percent_Identity=30.6122448979592, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI10092647, Length=109, Percent_Identity=40.3669724770642, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1788220, Length=131, Percent_Identity=32.824427480916, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71984838, Length=119, Percent_Identity=36.9747899159664, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71984834, Length=119, Percent_Identity=36.9747899159664, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650130, Length=115, Percent_Identity=36.5217391304348, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24650126, Length=115, Percent_Identity=36.5217391304348, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24650128, Length=115, Percent_Identity=36.5217391304348, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 24461; Mature: 24330

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVDVVTRTLPPNEVSEANPWDTDRFWTVPNVLSVIRLIGVPIFLWLALGPRADGWAVA
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VLAVAGLTDWLDGRIARRWHQVSRIGQMLDPVADRLYIFATVIALTLRDVIPLWLVIVLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARDVCMACLMPALRTRGFTSLPVHFVGKAATFCLLYSFPLVLLGRFGTGGWTACRVLGWA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
FAVWGTGLYWWAFFLYLVQTIRIVRTLPRISSRGEYS
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRVDVVTRTLPPNEVSEANPWDTDRFWTVPNVLSVIRLIGVPIFLWLALGPRADGWAVA
CCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VLAVAGLTDWLDGRIARRWHQVSRIGQMLDPVADRLYIFATVIALTLRDVIPLWLVIVLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARDVCMACLMPALRTRGFTSLPVHFVGKAATFCLLYSFPLVLLGRFGTGGWTACRVLGWA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
FAVWGTGLYWWAFFLYLVQTIRIVRTLPRISSRGEYS
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]