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The map label for this gene is dut

Identifier: 50842536

GI number: 50842536

Start: 1146822

End: 1147280

Strand: Direct

Name: dut

Synonym: PPA1054

Alternate gene names: 50842536

Gene position: 1146822-1147280 (Clockwise)

Preceding gene: 50842535

Following gene: 50842537

Centisome position: 44.79

GC content: 61.66

Gene sequence:

>459_bases
ATGGCTGATGTCGTTGTGCCCACTGTGGCGGTTCCCGAGGCGATGCCTCGATATGCCATGCCTGGCGATGCCGGGGCCGA
CCTCACCTGCCGCCACGATGTCGATCTAGCCCCTGGGGAACGGGCGATGGTTGAGACGGGAGTGCGTGTCGCCCTGCCTG
ACGGTTATGTCGGGTTCGTCAATCCCCGGTCGGGCTTAGCCGCGCGTCACGGACTATCGATCGTCAATGCGCCTGGAACG
ATCGATTCCGGGTACCGCGGGCAGATTAATGTGCTGCTCGTCAATACCGATCCGCGGGAGCCAGTACATCTTGATGCTGG
TTCCAGGATCGCCCAACTCGTCGTCGTCCCGGTAGTGGAGGCTATCTTTGAGCCGGTCGAGGATCTCGACGATACTGAGC
GCGGGCAAGGAGGCTACGGTTCCACCGGCGTTTCTGCTATGCCTCCGGTTGATGGATAG

Upstream 100 bases:

>100_bases
CGTCCTGGCAAGCTGGCGGCCATTGTCGGTGAGTACATTGTGGTGCCGGGATCCCCGTCCAGCTCCGAGAACTTGTCTGA
GAACTCTATGGAGGACAACC

Downstream 100 bases:

>100_bases
ACTGCATTCGTTGACACCACAGTGTCGGTCGAGGAAGGACACAATGTTCGGTCGCAAGAAGCGTAACGACGACGTCGAGA
CGGATGAAGTCATCGACGAG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MADVVVPTVAVPEAMPRYAMPGDAGADLTCRHDVDLAPGERAMVETGVRVALPDGYVGFVNPRSGLAARHGLSIVNAPGT
IDSGYRGQINVLLVNTDPREPVHLDAGSRIAQLVVVPVVEAIFEPVEDLDDTERGQGGYGSTGVSAMPPVDG

Sequences:

>Translated_152_residues
MADVVVPTVAVPEAMPRYAMPGDAGADLTCRHDVDLAPGERAMVETGVRVALPDGYVGFVNPRSGLAARHGLSIVNAPGT
IDSGYRGQINVLLVNTDPREPVHLDAGSRIAQLVVVPVVEAIFEPVEDLDDTERGQGGYGSTGVSAMPPVDG
>Mature_151_residues
ADVVVPTVAVPEAMPRYAMPGDAGADLTCRHDVDLAPGERAMVETGVRVALPDGYVGFVNPRSGLAARHGLSIVNAPGTI
DSGYRGQINVLLVNTDPREPVHLDAGSRIAQLVVVPVVEAIFEPVEDLDDTERGQGGYGSTGVSAMPPVDG

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=120, Percent_Identity=45.8333333333333, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI4503423, Length=120, Percent_Identity=45.8333333333333, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI70906441, Length=120, Percent_Identity=45.8333333333333, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790071, Length=143, Percent_Identity=41.2587412587413, Blast_Score=102, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988561, Length=129, Percent_Identity=45.7364341085271, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319729, Length=121, Percent_Identity=35.5371900826446, Blast_Score=73, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921126, Length=129, Percent_Identity=39.5348837209302, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583610, Length=129, Percent_Identity=39.5348837209302, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_PROAC (Q6A8W1)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055763.1
- ProteinModelPortal:   Q6A8W1
- SMR:   Q6A8W1
- GeneID:   2932091
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1054
- NMPDR:   fig|267747.1.peg.1040
- HOGENOM:   HBG436079
- OMA:   GTIDEGY
- ProtClustDB:   CLSK2763697
- BioCyc:   PACN267747:PPA1054-MONOMER
- BRENDA:   3.6.1.23
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 15799; Mature: 15668

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: NA

Important sites: BINDING 76-76

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVVVPTVAVPEAMPRYAMPGDAGADLTCRHDVDLAPGERAMVETGVRVALPDGYVGFV
CCCEECCCEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHCCCEEEECCCEEEEE
NPRSGLAARHGLSIVNAPGTIDSGYRGQINVLLVNTDPREPVHLDAGSRIAQLVVVPVVE
CCCCCCHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHH
AIFEPVEDLDDTERGQGGYGSTGVSAMPPVDG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADVVVPTVAVPEAMPRYAMPGDAGADLTCRHDVDLAPGERAMVETGVRVALPDGYVGFV
CCEECCCEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHCCCEEEECCCEEEEE
NPRSGLAARHGLSIVNAPGTIDSGYRGQINVLLVNTDPREPVHLDAGSRIAQLVVVPVVE
CCCCCCHHHCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHH
AIFEPVEDLDDTERGQGGYGSTGVSAMPPVDG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA