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The map label for this gene is tdk

Identifier: 50842531

GI number: 50842531

Start: 1143596

End: 1144246

Strand: Direct

Name: tdk

Synonym: PPA1049

Alternate gene names: 50842531

Gene position: 1143596-1144246 (Clockwise)

Preceding gene: 50842530

Following gene: 50842533

Centisome position: 44.67

GC content: 59.29

Gene sequence:

>651_bases
ATGGCTGAGCTTGTTTTCCACACCGGTCCGATGGACTCTGGCAAGTCCACCCTCGCACTGCAGATGGACCATGCGCAGTC
CGCTCACGACCGCCAAGGGGTGCGATACGCGATGCACGACCGCTCTGGTGGAGCTCGGATCACCTCGCGGATTGGTTTGA
GTGTCGAAGCTGTCGAGGTCACTGACTCCCTGGACCTCTACCAGGACATCGTCTCGCGGCTGAGTCGCGGAGGACGAATT
GATTACCTCATTTGCGACGAGGCCCAGTTCTACCGAACTAAGCAGATCGACCAGCTGGCTCGAGTCGTCGATGACCTCGA
CATCGACGTCTACTGCTTCGGAATCCTGGCCGATTTTCGGACAGAGCTATTTCCCGGATCAAAACGTCTCGTTGAGTTGG
CCGACCGCGTCGTTGAGCCCCCGGTCTCGCCGTTGTGCTGGTGCGGCCGTCCTGCCACCCATAATGCCCGCATCGTGGAT
GGGAAGTTGGTGCGTGAGGGTGACCAGGTCGGCGTCGGAGACATCGGTGGTGGATCAGAGATCCATTATGAGGTGCTATG
CCGCCGTCACCACCGTCAAGGGATTACCGGGGAAATTTCCAGGGCGACCTTGTCGGAGCAGACCCTACCTTTTGATGGCT
CCAGGTCCTGA

Upstream 100 bases:

>100_bases
GCGCTACCCCCAAGGAACTCACCCTCGTGGGCATGCACGGATCGCTCACTCCGTGTGAAATGCGGATCCCATTGCTGGCC
CAGATCTGTGAAGGATGAGG

Downstream 100 bases:

>100_bases
CGAGCGTGGCCCCAGGGTTCGCGTGCGGTCAAGGATTTTCCCGCGGTGGGTGGTATATCAGGTATGCGGGGTGGGGCCGC
CGAACATGATCTCATCCCAA

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MAELVFHTGPMDSGKSTLALQMDHAQSAHDRQGVRYAMHDRSGGARITSRIGLSVEAVEVTDSLDLYQDIVSRLSRGGRI
DYLICDEAQFYRTKQIDQLARVVDDLDIDVYCFGILADFRTELFPGSKRLVELADRVVEPPVSPLCWCGRPATHNARIVD
GKLVREGDQVGVGDIGGGSEIHYEVLCRRHHRQGITGEISRATLSEQTLPFDGSRS

Sequences:

>Translated_216_residues
MAELVFHTGPMDSGKSTLALQMDHAQSAHDRQGVRYAMHDRSGGARITSRIGLSVEAVEVTDSLDLYQDIVSRLSRGGRI
DYLICDEAQFYRTKQIDQLARVVDDLDIDVYCFGILADFRTELFPGSKRLVELADRVVEPPVSPLCWCGRPATHNARIVD
GKLVREGDQVGVGDIGGGSEIHYEVLCRRHHRQGITGEISRATLSEQTLPFDGSRS
>Mature_215_residues
AELVFHTGPMDSGKSTLALQMDHAQSAHDRQGVRYAMHDRSGGARITSRIGLSVEAVEVTDSLDLYQDIVSRLSRGGRID
YLICDEAQFYRTKQIDQLARVVDDLDIDVYCFGILADFRTELFPGSKRLVELADRVVEPPVSPLCWCGRPATHNARIVDG
KLVREGDQVGVGDIGGGSEIHYEVLCRRHHRQGITGEISRATLSEQTLPFDGSRS

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Escherichia coli, GI1787490, Length=198, Percent_Identity=35.8585858585859, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_PROAC (Q6A8W6)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055758.1
- ProteinModelPortal:   Q6A8W6
- SMR:   Q6A8W6
- GeneID:   2932350
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1049
- NMPDR:   fig|267747.1.peg.1035
- HOGENOM:   HBG522108
- OMA:   ATHNARI
- ProtClustDB:   PRK04296
- BioCyc:   PACN267747:PPA1049-MONOMER
- BRENDA:   2.7.1.21
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 23926; Mature: 23795

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 87-87

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELVFHTGPMDSGKSTLALQMDHAQSAHDRQGVRYAMHDRSGGARITSRIGLSVEAVEV
CCCEEEECCCCCCCCCEEEEEECCCCCCHHHCCCEEEEECCCCCCEEEHHCCCEEEEEEE
TDSLDLYQDIVSRLSRGGRIDYLICDEAQFYRTKQIDQLARVVDDLDIDVYCFGILADFR
HHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TELFPGSKRLVELADRVVEPPVSPLCWCGRPATHNARIVDGKLVREGDQVGVGDIGGGSE
HHHCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEECCCEEECCCCCCCCCCCCCCC
IHYEVLCRRHHRQGITGEISRATLSEQTLPFDGSRS
HHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AELVFHTGPMDSGKSTLALQMDHAQSAHDRQGVRYAMHDRSGGARITSRIGLSVEAVEV
CCEEEECCCCCCCCCEEEEEECCCCCCHHHCCCEEEEECCCCCCEEEHHCCCEEEEEEE
TDSLDLYQDIVSRLSRGGRIDYLICDEAQFYRTKQIDQLARVVDDLDIDVYCFGILADFR
HHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TELFPGSKRLVELADRVVEPPVSPLCWCGRPATHNARIVDGKLVREGDQVGVGDIGGGSE
HHHCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEECCCEEECCCCCCCCCCCCCCC
IHYEVLCRRHHRQGITGEISRATLSEQTLPFDGSRS
HHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA