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The map label for this gene is gyrA [H]

Identifier: 50842527

GI number: 50842527

Start: 1138134

End: 1140668

Strand: Reverse

Name: gyrA [H]

Synonym: PPA1045

Alternate gene names: 50842527

Gene position: 1140668-1138134 (Counterclockwise)

Preceding gene: 50842528

Following gene: 50842518

Centisome position: 44.55

GC content: 60.99

Gene sequence:

>2535_bases
ATGACTAAAAAGACGGTGGATGACGACTTCACCGAGAACATTATCGACGTCGACGTCTCCCGCGAGATGGAGAACAGCTT
CCTGGAGTACGCATACTCCGTCATCTACTCCCGCGCCCTGCCTGACGCCCGGGACGGCCTCAAGCCCGTACAGCGCCGCA
TCCTTTACACCATGGGAGACATGGGAGTTCGCCCTGACCGTCCCCATGTGAAGTCAGCGCGAGTCGTCGGACAGGTCATG
GGTCAGCTGCACCCCCACGGCGACGCTGCCATCTACGACGCCCTGGTACGCACCGCTCAGCCATGGGCGATGAGGCTCCC
CCTCGTCGACGGTCACGGTAACTTCGGATCCCTTGACGCCGGCCCCGCTGCCATGCGTTACACCGAGTGTCGGATGGCAC
CGCCAGCTCTTACCATGATCGATGGGCTCGACGAAGACACCGTTGACTTCGAACCTAACTACGACGGCAAAGAGACCGAG
CCCTCAGTGTTGCCGGCCGCCTTCCCGAACCTGCTCGTCAACGGGGCTTCGGGTATCGCAGTGGGTATGGCAACCAACAT
CCCACCACATAACCTCGTCGAGGTTGTGGCAGCTCTCCGTCATATGCTCGATCATCCAAACGCCGACCTTGACGAGATCA
TGAGGTTCGTGCCCGGACCGGATCTGCCGACCGGTGGACGAATCATCGGTCTTGATGGCATCGCCGACGCCTACTGCACC
GGCCGTGGCTCCTTCAAGATCCGTGCTACCGCCCGCATCGAGAAGGTTTCTCCACGACGCCGCGGCATCGTCGTCACCGA
GCTGCCGTACATGGTCGGACCAGAGCGAATCATCGACCAAATTAAGACCCTGGTGCAGTCCAAAAAGATCACCGGTATCG
CCGACGTCAAGGACCTCACCGACCTGACCAACGGCACCCGTCTGGTCATTGAGGTCAAGAACGGCATCAACCCTGAAGCC
CTGCTGGAGCGGCTCTACAAACTTACCAAGCTGGAGGATTCCTTCGCCATCAATGCGGTAAGTCTGGTGGAGGGACAACC
CCGCACCTTAGGCCTGCTAGAAATGTTGCAGGTCTACCTCGACCACCGTCTCGACGTCACCCTGCGACGCACGAAGTTCC
AACTCAACAAGGCCCAGGACAGGCTGCACCTCGTCGAGGGTCTGCTATTGGCCATCGTCGACATCGACGACGTCATCGCG
ATCATCCGCTCCTCCGAAGACGCCGCAGCAGCCCGTACCCGCCTCATGGGAACCTTCGACCTCGACGAGGTGCAGGCCAA
CTACATCCTGGACATGCAGCTGCGCCGCCTGACCAAGTTCTCCACTATCGAACTGGAATCTGAGCGTGACGAACTGCGCG
AACGCATCGAAGGGCTAACGCTCATCGTCAATGATAAGGCCGAGTTGCGTCGCGTGGTGTCCGGAGAATTGGTCGAAGTG
TCGTCCAAATACGGCACTCCGCGTCGCACTGTGCTGTTAGGAGCCGCGCCATCGGTCGCAGCAGCATCAGCCCCCCTCGA
GGTGCCAGACGACCCGTGTTGGGTACTGCTGTCGGCAACTGGCTTGCTGGCCCGTATCGATACCGCCGACGGCCTTCCCA
GTGACGGGGACAGGGCCACTCACGATGTCATCATCTCTAGCGCTCGCACCACCGCCCGTGGTGATTTCGGCATCATTACT
AGTGCCGGTCGTCTCGTGCGTGTCCATGCTGTCGAACTCGCAAGCCTGCCGATAACCGCAACTGCGCCGTCAGTAGCCGG
TGGCACCCCGCTAGCCGACCTTGTCGGTTTGGAGAAGGGCGAGCGAGCTCTAGCCGTGACAAGCCTGTCAGGAGCGGGCC
CTTCCTTGGCTCTTGGTACCCGAAACGGCATCGTCAAGAGGGTCAACCCGGAACTACTCGGCAAGGAGTCTTGGGAGGTT
ATCGGTCTTAAGAACGGTGACGAGGTCGTCGGTGCCGTCGAAATGGGCGACGAGGACCTCGAACTGTGCTTCGTCACCCA
GGGCGCCGCCCTGCTTCACTTCCCTGCATCCGCAGTGCGCCCGCAGGGACGCTCAGGTGGCGGTGTGGCCGGTATCAAGG
CCAAGGATCCAGTGATTTTCTTTGGCGCTGCCCCCCGACGCGGATCCTCGGTGGTAACGGTGGCCGCATCTTCCCCCGCC
GCCGCAGGTAAGGAACCCGGCTCGATCAAACTCACCCCCTTCGACCAGTACCCGCCCAAGGGACGAGCCACCGGTGGTAT
GAGGTGTCAGCGATTCCTCAAGGGAGAGACGGCCCTGGTGTTCGCTTGGATCGGCCCCGATCCGGCCGTGGCCTGTGCCG
CGTCCGGGGTGCCCATCGAACTGCCAGCACCTAATATGCGTCGAGACGGCTCCGGTGATCAGGGACGTCAACCGATTCTG
GCCGTCGGGAGTCGTCGTCACGGGTCTAACAAGGGTAATCCGGTATCCGACGGATCGAACGATGCATTGGATTCCGGTGA
CCCGTTATCGACTAATGAGAAGCAGATCGATTCCCAACCCGAACTGTTCAGCTGA

Upstream 100 bases:

>100_bases
CAAGGTGCTCAACCACGAGGATCCCCCTCAGCCCTGATATGCAGATTTCGCGCCAATCAACCAAAATAGGTCGTTAGCGC
GTGCTGCTTGGGAGGTAACG

Downstream 100 bases:

>100_bases
CCGATAGCGAGCGGGTTCTGGCCCGCTTGGCTTAGGCAATGCTCGCTATGCCGAATCCTTTGACCCAGCAGACCCGCCCG
GACTGGCTGCTAGAGGAGTC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 844; Mature: 843

Protein sequence:

>844_residues
MTKKTVDDDFTENIIDVDVSREMENSFLEYAYSVIYSRALPDARDGLKPVQRRILYTMGDMGVRPDRPHVKSARVVGQVM
GQLHPHGDAAIYDALVRTAQPWAMRLPLVDGHGNFGSLDAGPAAMRYTECRMAPPALTMIDGLDEDTVDFEPNYDGKETE
PSVLPAAFPNLLVNGASGIAVGMATNIPPHNLVEVVAALRHMLDHPNADLDEIMRFVPGPDLPTGGRIIGLDGIADAYCT
GRGSFKIRATARIEKVSPRRRGIVVTELPYMVGPERIIDQIKTLVQSKKITGIADVKDLTDLTNGTRLVIEVKNGINPEA
LLERLYKLTKLEDSFAINAVSLVEGQPRTLGLLEMLQVYLDHRLDVTLRRTKFQLNKAQDRLHLVEGLLLAIVDIDDVIA
IIRSSEDAAAARTRLMGTFDLDEVQANYILDMQLRRLTKFSTIELESERDELRERIEGLTLIVNDKAELRRVVSGELVEV
SSKYGTPRRTVLLGAAPSVAAASAPLEVPDDPCWVLLSATGLLARIDTADGLPSDGDRATHDVIISSARTTARGDFGIIT
SAGRLVRVHAVELASLPITATAPSVAGGTPLADLVGLEKGERALAVTSLSGAGPSLALGTRNGIVKRVNPELLGKESWEV
IGLKNGDEVVGAVEMGDEDLELCFVTQGAALLHFPASAVRPQGRSGGGVAGIKAKDPVIFFGAAPRRGSSVVTVAASSPA
AAGKEPGSIKLTPFDQYPPKGRATGGMRCQRFLKGETALVFAWIGPDPAVACAASGVPIELPAPNMRRDGSGDQGRQPIL
AVGSRRHGSNKGNPVSDGSNDALDSGDPLSTNEKQIDSQPELFS

Sequences:

>Translated_844_residues
MTKKTVDDDFTENIIDVDVSREMENSFLEYAYSVIYSRALPDARDGLKPVQRRILYTMGDMGVRPDRPHVKSARVVGQVM
GQLHPHGDAAIYDALVRTAQPWAMRLPLVDGHGNFGSLDAGPAAMRYTECRMAPPALTMIDGLDEDTVDFEPNYDGKETE
PSVLPAAFPNLLVNGASGIAVGMATNIPPHNLVEVVAALRHMLDHPNADLDEIMRFVPGPDLPTGGRIIGLDGIADAYCT
GRGSFKIRATARIEKVSPRRRGIVVTELPYMVGPERIIDQIKTLVQSKKITGIADVKDLTDLTNGTRLVIEVKNGINPEA
LLERLYKLTKLEDSFAINAVSLVEGQPRTLGLLEMLQVYLDHRLDVTLRRTKFQLNKAQDRLHLVEGLLLAIVDIDDVIA
IIRSSEDAAAARTRLMGTFDLDEVQANYILDMQLRRLTKFSTIELESERDELRERIEGLTLIVNDKAELRRVVSGELVEV
SSKYGTPRRTVLLGAAPSVAAASAPLEVPDDPCWVLLSATGLLARIDTADGLPSDGDRATHDVIISSARTTARGDFGIIT
SAGRLVRVHAVELASLPITATAPSVAGGTPLADLVGLEKGERALAVTSLSGAGPSLALGTRNGIVKRVNPELLGKESWEV
IGLKNGDEVVGAVEMGDEDLELCFVTQGAALLHFPASAVRPQGRSGGGVAGIKAKDPVIFFGAAPRRGSSVVTVAASSPA
AAGKEPGSIKLTPFDQYPPKGRATGGMRCQRFLKGETALVFAWIGPDPAVACAASGVPIELPAPNMRRDGSGDQGRQPIL
AVGSRRHGSNKGNPVSDGSNDALDSGDPLSTNEKQIDSQPELFS
>Mature_843_residues
TKKTVDDDFTENIIDVDVSREMENSFLEYAYSVIYSRALPDARDGLKPVQRRILYTMGDMGVRPDRPHVKSARVVGQVMG
QLHPHGDAAIYDALVRTAQPWAMRLPLVDGHGNFGSLDAGPAAMRYTECRMAPPALTMIDGLDEDTVDFEPNYDGKETEP
SVLPAAFPNLLVNGASGIAVGMATNIPPHNLVEVVAALRHMLDHPNADLDEIMRFVPGPDLPTGGRIIGLDGIADAYCTG
RGSFKIRATARIEKVSPRRRGIVVTELPYMVGPERIIDQIKTLVQSKKITGIADVKDLTDLTNGTRLVIEVKNGINPEAL
LERLYKLTKLEDSFAINAVSLVEGQPRTLGLLEMLQVYLDHRLDVTLRRTKFQLNKAQDRLHLVEGLLLAIVDIDDVIAI
IRSSEDAAAARTRLMGTFDLDEVQANYILDMQLRRLTKFSTIELESERDELRERIEGLTLIVNDKAELRRVVSGELVEVS
SKYGTPRRTVLLGAAPSVAAASAPLEVPDDPCWVLLSATGLLARIDTADGLPSDGDRATHDVIISSARTTARGDFGIITS
AGRLVRVHAVELASLPITATAPSVAGGTPLADLVGLEKGERALAVTSLSGAGPSLALGTRNGIVKRVNPELLGKESWEVI
GLKNGDEVVGAVEMGDEDLELCFVTQGAALLHFPASAVRPQGRSGGGVAGIKAKDPVIFFGAAPRRGSSVVTVAASSPAA
AGKEPGSIKLTPFDQYPPKGRATGGMRCQRFLKGETALVFAWIGPDPAVACAASGVPIELPAPNMRRDGSGDQGRQPILA
VGSRRHGSNKGNPVSDGSNDALDSGDPLSTNEKQIDSQPELFS

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=461, Percent_Identity=25.5965292841649, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913406, Length=348, Percent_Identity=26.1494252873563, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=806, Percent_Identity=37.2208436724566, Blast_Score=447, Evalue=1e-126,
Organism=Escherichia coli, GI1789396, Length=678, Percent_Identity=35.5457227138643, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI212645845, Length=487, Percent_Identity=22.7926078028747, Blast_Score=91, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17535065, Length=438, Percent_Identity=26.7123287671233, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=172, Percent_Identity=27.3255813953488, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136538, Length=365, Percent_Identity=27.1232876712329, Blast_Score=91, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90421; Mature: 90290

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKTVDDDFTENIIDVDVSREMENSFLEYAYSVIYSRALPDARDGLKPVQRRILYTMGD
CCCCCCCCCHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCC
MGVRPDRPHVKSARVVGQVMGQLHPHGDAAIYDALVRTAQPWAMRLPLVDGHGNFGSLDA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCC
GPAAMRYTECRMAPPALTMIDGLDEDTVDFEPNYDGKETEPSVLPAAFPNLLVNGASGIA
CCHHHEEHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
VGMATNIPPHNLVEVVAALRHMLDHPNADLDEIMRFVPGPDLPTGGRIIGLDGIADAYCT
EEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCHHCC
GRGSFKIRATARIEKVSPRRRGIVVTELPYMVGPERIIDQIKTLVQSKKITGIADVKDLT
CCCCEEEEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
DLTNGTRLVIEVKNGINPEALLERLYKLTKLEDSFAINAVSLVEGQPRTLGLLEMLQVYL
HCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
DHRLDVTLRRTKFQLNKAQDRLHLVEGLLLAIVDIDDVIAIIRSSEDAAAARTRLMGTFD
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHEECCC
LDEVQANYILDMQLRRLTKFSTIELESERDELRERIEGLTLIVNDKAELRRVVSGELVEV
HHHHCHHHEEHHHHHHHHCCEEEEECCHHHHHHHHHCCEEEEECCHHHHHHHHCCCCEEE
SSKYGTPRRTVLLGAAPSVAAASAPLEVPDDPCWVLLSATGLLARIDTADGLPSDGDRAT
HHHCCCCCEEEEEECCCCHHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCH
HDVIISSARTTARGDFGIITSAGRLVRVHAVELASLPITATAPSVAGGTPLADLVGLEKG
HHHEEECCCCCCCCCCEEEECCCCEEEEEEEEHCCCCEEECCCCCCCCCCHHHHHCCCCC
ERALAVTSLSGAGPSLALGTRNGIVKRVNPELLGKESWEVIGLKNGDEVVGAVEMGDEDL
CCEEEEEEECCCCCCEEEECCCCCEEECCHHHCCCCCEEEEEECCCCCEEEEEECCCCCE
ELCFVTQGAALLHFPASAVRPQGRSGGGVAGIKAKDPVIFFGAAPRRGSSVVTVAASSPA
EEEEEECCCEEEECCHHHCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEECCCC
AAGKEPGSIKLTPFDQYPPKGRATGGMRCQRFLKGETALVFAWIGPDPAVACAASGVPIE
CCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCCHHHHCCCCCEEE
LPAPNMRRDGSGDQGRQPILAVGSRRHGSNKGNPVSDGSNDALDSGDPLSTNEKQIDSQP
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCC
ELFS
CCCC
>Mature Secondary Structure 
TKKTVDDDFTENIIDVDVSREMENSFLEYAYSVIYSRALPDARDGLKPVQRRILYTMGD
CCCCCCCCHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCC
MGVRPDRPHVKSARVVGQVMGQLHPHGDAAIYDALVRTAQPWAMRLPLVDGHGNFGSLDA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCC
GPAAMRYTECRMAPPALTMIDGLDEDTVDFEPNYDGKETEPSVLPAAFPNLLVNGASGIA
CCHHHEEHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
VGMATNIPPHNLVEVVAALRHMLDHPNADLDEIMRFVPGPDLPTGGRIIGLDGIADAYCT
EEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCHHCC
GRGSFKIRATARIEKVSPRRRGIVVTELPYMVGPERIIDQIKTLVQSKKITGIADVKDLT
CCCCEEEEEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
DLTNGTRLVIEVKNGINPEALLERLYKLTKLEDSFAINAVSLVEGQPRTLGLLEMLQVYL
HCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
DHRLDVTLRRTKFQLNKAQDRLHLVEGLLLAIVDIDDVIAIIRSSEDAAAARTRLMGTFD
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHEECCC
LDEVQANYILDMQLRRLTKFSTIELESERDELRERIEGLTLIVNDKAELRRVVSGELVEV
HHHHCHHHEEHHHHHHHHCCEEEEECCHHHHHHHHHCCEEEEECCHHHHHHHHCCCCEEE
SSKYGTPRRTVLLGAAPSVAAASAPLEVPDDPCWVLLSATGLLARIDTADGLPSDGDRAT
HHHCCCCCEEEEEECCCCHHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCH
HDVIISSARTTARGDFGIITSAGRLVRVHAVELASLPITATAPSVAGGTPLADLVGLEKG
HHHEEECCCCCCCCCCEEEECCCCEEEEEEEEHCCCCEEECCCCCCCCCCHHHHHCCCCC
ERALAVTSLSGAGPSLALGTRNGIVKRVNPELLGKESWEVIGLKNGDEVVGAVEMGDEDL
CCEEEEEEECCCCCCEEEECCCCCEEECCHHHCCCCCEEEEEECCCCCEEEEEECCCCCE
ELCFVTQGAALLHFPASAVRPQGRSGGGVAGIKAKDPVIFFGAAPRRGSSVVTVAASSPA
EEEEEECCCEEEECCHHHCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEECCCC
AAGKEPGSIKLTPFDQYPPKGRATGGMRCQRFLKGETALVFAWIGPDPAVACAASGVPIE
CCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCCHHHHCCCCCEEE
LPAPNMRRDGSGDQGRQPILAVGSRRHGSNKGNPVSDGSNDALDSGDPLSTNEKQIDSQP
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCC
ELFS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA