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The map label for this gene is tesB [H]

Identifier: 50842513

GI number: 50842513

Start: 1120404

End: 1121300

Strand: Direct

Name: tesB [H]

Synonym: PPA1030

Alternate gene names: 50842513

Gene position: 1120404-1121300 (Clockwise)

Preceding gene: 50842512

Following gene: 50842515

Centisome position: 43.76

GC content: 61.32

Gene sequence:

>897_bases
GTGCCATCGACGACTGCTGAACTGCTTGACCTGCTCGATCTTGAAGACCTCGATCTCGATCTGTTTCGAGGCCGGCAACC
ACACACGACGTGGCAGCGGACCTTCGGGGGCCAGGTACTGGCTCAGGCTCTGGTTGCTGGTGCCCGCACTATTCCTGAGC
GGACCGCCCATTCCATGCACGCGCTGTTCCTACATGCTGGACGCACCGATCTGCCGATGATCTTTGATGTCGAGAGAATT
CGTGACGGTCGCACCTTCAGCACTCGCCGTGTCAACGCTCGCCAACACGGTCGGACGATCTTCACCGCGGAACTGTCCTT
CAAGAACCGCGAGGACGGCCCGGAGCACTCCGATCCGATGCCGGACTGTCTTCCGGACCCGGATCGCTGTCCGACCCTAG
CCCAGGCCCTCGAACAGATGTTCGGGCGACCTATGCCCACCGTCAAGGAGTGGGATGCGCTCGACGTGCGGTTGGCCGGT
GACGGATCGCAGCTCGTCGATCCCAACCACGTCACCCACTTGAGTTTGTGGGTACGCACCACCGCGAGCCTTCCTGACGA
CCGCGTTGTGCAGCGTGCGATCCTCGCCTACATTTCCGATATCAGTCTCATGGCTGGTGCTGTTATGCCACACCTGGGAT
CGGTGCCATCGGGTATGGTCGTCAATCCGGCATCGCTGGATCACGCCATGTGGTTCCACCGGACTGCCGAGGCCGACTGC
TGGATGCTCTACGACCAGGTTTCTCCGAGCGCATCAGGCCTGCTCGGTTTCTCCATGGGCCGACTGATGCAGGATGGCAA
ACTCATCGCGTCCTGCTGCCAGGAGGGGGTCATGAGGCTGGTAGATGTGAACGACCTCGACGCCTCAGTAACGTTTCCGC
TTGGCCGTGGCACGTGA

Upstream 100 bases:

>100_bases
TTCCAGGCGCGGATCGATTTCTTCAACCGTTGTTGCTAGTGAGTGCGCCGCCTTGGCGAGAGCTGCCATGACACGTTGCC
TGATCTGGCACAGTGGTTAG

Downstream 100 bases:

>100_bases
TGTCCTCTGAACGCGACGGTGGCCCCGGAAGGGTCCGGAGCCACCGTGTGCAGATGTCAGGCCGCCATCGTGGCGAGGTT
ACGTTGACGCATGCTGGCTA

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MPSTTAELLDLLDLEDLDLDLFRGRQPHTTWQRTFGGQVLAQALVAGARTIPERTAHSMHALFLHAGRTDLPMIFDVERI
RDGRTFSTRRVNARQHGRTIFTAELSFKNREDGPEHSDPMPDCLPDPDRCPTLAQALEQMFGRPMPTVKEWDALDVRLAG
DGSQLVDPNHVTHLSLWVRTTASLPDDRVVQRAILAYISDISLMAGAVMPHLGSVPSGMVVNPASLDHAMWFHRTAEADC
WMLYDQVSPSASGLLGFSMGRLMQDGKLIASCCQEGVMRLVDVNDLDASVTFPLGRGT

Sequences:

>Translated_298_residues
MPSTTAELLDLLDLEDLDLDLFRGRQPHTTWQRTFGGQVLAQALVAGARTIPERTAHSMHALFLHAGRTDLPMIFDVERI
RDGRTFSTRRVNARQHGRTIFTAELSFKNREDGPEHSDPMPDCLPDPDRCPTLAQALEQMFGRPMPTVKEWDALDVRLAG
DGSQLVDPNHVTHLSLWVRTTASLPDDRVVQRAILAYISDISLMAGAVMPHLGSVPSGMVVNPASLDHAMWFHRTAEADC
WMLYDQVSPSASGLLGFSMGRLMQDGKLIASCCQEGVMRLVDVNDLDASVTFPLGRGT
>Mature_297_residues
PSTTAELLDLLDLEDLDLDLFRGRQPHTTWQRTFGGQVLAQALVAGARTIPERTAHSMHALFLHAGRTDLPMIFDVERIR
DGRTFSTRRVNARQHGRTIFTAELSFKNREDGPEHSDPMPDCLPDPDRCPTLAQALEQMFGRPMPTVKEWDALDVRLAGD
GSQLVDPNHVTHLSLWVRTTASLPDDRVVQRAILAYISDISLMAGAVMPHLGSVPSGMVVNPASLDHAMWFHRTAEADCW
MLYDQVSPSASGLLGFSMGRLMQDGKLIASCCQEGVMRLVDVNDLDASVTFPLGRGT

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=285, Percent_Identity=37.8947368421053, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1786657, Length=272, Percent_Identity=40.0735294117647, Blast_Score=185, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71988741, Length=299, Percent_Identity=34.1137123745819, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17531885, Length=301, Percent_Identity=32.5581395348837, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17531889, Length=301, Percent_Identity=32.5581395348837, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI115532456, Length=301, Percent_Identity=32.5581395348837, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17558508, Length=314, Percent_Identity=30.8917197452229, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI212645202, Length=265, Percent_Identity=30.5660377358491, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32941; Mature: 32810

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTTAELLDLLDLEDLDLDLFRGRQPHTTWQRTFGGQVLAQALVAGARTIPERTAHSMH
CCCCHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ALFLHAGRTDLPMIFDVERIRDGRTFSTRRVNARQHGRTIFTAELSFKNREDGPEHSDPM
HHHEECCCCCCCEEEEHHHHCCCCCCCCEECCHHHCCCEEEEEEEECCCCCCCCCCCCCC
PDCLPDPDRCPTLAQALEQMFGRPMPTVKEWDALDVRLAGDGSQLVDPNHVTHLSLWVRT
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEE
TASLPDDRVVQRAILAYISDISLMAGAVMPHLGSVPSGMVVNPASLDHAMWFHRTAEADC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHCCCCCCE
WMLYDQVSPSASGLLGFSMGRLMQDGKLIASCCQEGVMRLVDVNDLDASVTFPLGRGT
EEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
>Mature Secondary Structure 
PSTTAELLDLLDLEDLDLDLFRGRQPHTTWQRTFGGQVLAQALVAGARTIPERTAHSMH
CCCHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ALFLHAGRTDLPMIFDVERIRDGRTFSTRRVNARQHGRTIFTAELSFKNREDGPEHSDPM
HHHEECCCCCCCEEEEHHHHCCCCCCCCEECCHHHCCCEEEEEEEECCCCCCCCCCCCCC
PDCLPDPDRCPTLAQALEQMFGRPMPTVKEWDALDVRLAGDGSQLVDPNHVTHLSLWVRT
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEE
TASLPDDRVVQRAILAYISDISLMAGAVMPHLGSVPSGMVVNPASLDHAMWFHRTAEADC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHCCCCCCE
WMLYDQVSPSASGLLGFSMGRLMQDGKLIASCCQEGVMRLVDVNDLDASVTFPLGRGT
EEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]