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The map label for this gene is 50842469

Identifier: 50842469

GI number: 50842469

Start: 1067968

End: 1068882

Strand: Reverse

Name: 50842469

Synonym: PPA0985

Alternate gene names: NA

Gene position: 1068882-1067968 (Counterclockwise)

Preceding gene: 50842470

Following gene: 50842468

Centisome position: 41.75

GC content: 60.33

Gene sequence:

>915_bases
ATGAAAGCAGCAATCATCGGAGCCGGGGCCATCGGCGGTTTCTACGGGGCGGCCCTCGCAGATGCCGGGATGGACGTCTC
CTTCATCGCCCGTGGCAAAACCCTCATCGCCATCCGCGAGCACGGTCTGCGCCTGGTCGGCAATACGGAGTTGACCCTTG
ATGTACCCGTCACTGACGACGCAGCCGAGATCGGCCAGGTTGACGTCGTCTTGCTATGTACCAAGACCTTTCAAGTTGCA
GAGGCCGCACGCACATACCTGCCCGCGCTTATGGGCCCCCACACCCTGGTCGTAACCACCCAAAATGGCGTCATCGCGCC
GCACGAGCTTTCGGCGATTATTGGCCCTGAGCACGTCGCACCAGGGGTATGCCGACAGTGGGTCAAGATCGTGGAGCCAG
GTCTGATTATGGACTTGGGCGGCCCTCGAATGTTCGAGGTCTCGACCATTGACGATTCCCCCAATACCCTCGTCAATGAG
TTGCGAGAGGCTTGCCGGAAGGGCGGTCTCACCTCTCCCGACGTGGAGAACATCACCACCACTTTGTGGGTCAAGATGTG
TTCCGTCGTCCCCCAAGGAGCCTGTGGTGCAGTACTCGACGTCTCCTTGGGCGACCTCCTTGGTCCCTACCGCGATGTCT
TCGCTCGGTGTATCGACGAAACTGTTCAGGTGGCTCGCGCTCACAGCGCCAGGATCGCCGACGACTTCATCGAGAAGAAC
CTCACATTCCTTGCTGGGCAGGATCCCGCGTCAACAACCTCCTTCCAGCGCGACATCCTTGCTGGACGCCCCAGCGAATA
CGCTGCTCAGGTAGGAGCTGTCCCCCGATTGGGTGACGAGGTCGGCGTCGATACTCCGATCAATGACGTCATTGCTGCCG
TCCTAGGACGACGGGAAGCTCAGAATCGCGCCTGA

Upstream 100 bases:

>100_bases
TGAAGGTCCCGTTACTGCCGGCCACGTTGCCTCGTGCTAGGGAATCAGTGGAGCACGCCATGATTTCGGCATATGCGGAC
ACCAAGGGCACGGAGGAATC

Downstream 100 bases:

>100_bases
TACGACCCACACATCCGGTTTTTGGAGGATCCCCCCTGTCATTTTGTGGGGATCCCACAATGACCACCGTGGGTACTTCG
TCGGTTCCCTGTCTCGCGTC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKAAIIGAGAIGGFYGAALADAGMDVSFIARGKTLIAIREHGLRLVGNTELTLDVPVTDDAAEIGQVDVVLLCTKTFQVA
EAARTYLPALMGPHTLVVTTQNGVIAPHELSAIIGPEHVAPGVCRQWVKIVEPGLIMDLGGPRMFEVSTIDDSPNTLVNE
LREACRKGGLTSPDVENITTTLWVKMCSVVPQGACGAVLDVSLGDLLGPYRDVFARCIDETVQVARAHSARIADDFIEKN
LTFLAGQDPASTTSFQRDILAGRPSEYAAQVGAVPRLGDEVGVDTPINDVIAAVLGRREAQNRA

Sequences:

>Translated_304_residues
MKAAIIGAGAIGGFYGAALADAGMDVSFIARGKTLIAIREHGLRLVGNTELTLDVPVTDDAAEIGQVDVVLLCTKTFQVA
EAARTYLPALMGPHTLVVTTQNGVIAPHELSAIIGPEHVAPGVCRQWVKIVEPGLIMDLGGPRMFEVSTIDDSPNTLVNE
LREACRKGGLTSPDVENITTTLWVKMCSVVPQGACGAVLDVSLGDLLGPYRDVFARCIDETVQVARAHSARIADDFIEKN
LTFLAGQDPASTTSFQRDILAGRPSEYAAQVGAVPRLGDEVGVDTPINDVIAAVLGRREAQNRA
>Mature_304_residues
MKAAIIGAGAIGGFYGAALADAGMDVSFIARGKTLIAIREHGLRLVGNTELTLDVPVTDDAAEIGQVDVVLLCTKTFQVA
EAARTYLPALMGPHTLVVTTQNGVIAPHELSAIIGPEHVAPGVCRQWVKIVEPGLIMDLGGPRMFEVSTIDDSPNTLVNE
LREACRKGGLTSPDVENITTTLWVKMCSVVPQGACGAVLDVSLGDLLGPYRDVFARCIDETVQVARAHSARIADDFIEKN
LTFLAGQDPASTTSFQRDILAGRPSEYAAQVGAVPRLGDEVGVDTPINDVIAAVLGRREAQNRA

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 32108; Mature: 32108

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAIIGAGAIGGFYGAALADAGMDVSFIARGKTLIAIREHGLRLVGNTELTLDVPVTDD
CCCEEEECCHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCEEEECCCEEEEEECCCCC
AAEIGQVDVVLLCTKTFQVAEAARTYLPALMGPHTLVVTTQNGVIAPHELSAIIGPEHVA
HHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECHHHHHHHCCCHHCC
PGVCRQWVKIVEPGLIMDLGGPRMFEVSTIDDSPNTLVNELREACRKGGLTSPDVENITT
HHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
TLWVKMCSVVPQGACGAVLDVSLGDLLGPYRDVFARCIDETVQVARAHSARIADDFIEKN
HHHHHHHHHCCCCCCCCEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTFLAGQDPASTTSFQRDILAGRPSEYAAQVGAVPRLGDEVGVDTPINDVIAAVLGRREA
CEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
QNRA
CCCC
>Mature Secondary Structure
MKAAIIGAGAIGGFYGAALADAGMDVSFIARGKTLIAIREHGLRLVGNTELTLDVPVTDD
CCCEEEECCHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCEEEECCCEEEEEECCCCC
AAEIGQVDVVLLCTKTFQVAEAARTYLPALMGPHTLVVTTQNGVIAPHELSAIIGPEHVA
HHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECHHHHHHHCCCHHCC
PGVCRQWVKIVEPGLIMDLGGPRMFEVSTIDDSPNTLVNELREACRKGGLTSPDVENITT
HHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
TLWVKMCSVVPQGACGAVLDVSLGDLLGPYRDVFARCIDETVQVARAHSARIADDFIEKN
HHHHHHHHHCCCCCCCCEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTFLAGQDPASTTSFQRDILAGRPSEYAAQVGAVPRLGDEVGVDTPINDVIAAVLGRREA
CEEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
QNRA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]